myocardial

Single stem cells from bone heal a broken heart

...ow–derived stem cells with therapeutic potency for myocardial tissue regeneration following myocardial infarction. In their study, featured in the February 1 issue of the Journal of Clinical Investigati...

Mouse gene shows new mechanism behind cardiac infarction in man

...as been shown to play a role in the development of myocardial infarction. The results of the study is published this week on Nature Genetics Online. Researchers at Karolinska Institutet, in collaboration with the Jackson Laboratory in the USA, AstraZeneca and a Japanese research group, have scrutinised an are...

Stem cell therapy successfully treats heart attack in animals

...can be used effectively to treat heart attacks, or myocardial infarction, in pigs. In just two months, stem cells harvested from another pig's bone marrow and injected into the animal's damaged heart restored heart function and repaired damaged heart muscle by 50 percent to 75 percent. The Hopkins findings, fi...

Morphine for Chest Pain Increases Death Risk

...9 high-risk patients with non-ST-segment elevation myocardial infarction (non-STEMI), a categorization of heart attack based on electrocardiogram (ECG) readings. These patients typically arrive at emergency rooms with chest pain, but often will not have telltale signs of a heart attack on the initial ECG. They ...

Survival of heart patients on beta-blockers varies greatly with genetic variation

...nts," Lanfear says. "Data from patients with acute myocardial infarction have shown that beta-blockers are generally effective. They are known to decrease the size of the infarct and seem to prolong survival, on average." Recent research, however, reveals that variations in the beta-adrenergic receptor genes a...

Bone marrow stem cells may heal hearts even years after heart attacks

...atients with chronic coronary artery disease after myocardial infarction, even many years after heart attack. Th...pe for this large amount of patients with previous myocardial infarction and non-treatable complaints," said Bodo E. Strauer, M.D. from the Heinrich-Heine-Univers...

Stem cell mobilization therapy appears to be ineffective in repairing damage caused by heart attack

...atients, diagnosed with ST-segment elevation acute myocardial infarction (a certain pattern on an electrocardiog...e left ventricular recovery in patients with acute myocardial infarction after successful mechanical reperfusion," they write. ...

Potential heart benefit found in stem cells

...llow-up evaluation, the investigators reviewed the myocardial viability and local wall motion abnormalities, as well as the size of resting and stress-induced perfusion defects. They also measured the global EF and the wall motion score index, which measures the percentage of normal functioning muscle tissue i...

Statins have neutral effect on risk of cancer

... these trials, statins reduced the risk of a first myocardial infarction (heart attack) and overall mortality. With long-term follow-up and collection of cancer data in a majority of studies, insight into the risk of cancer among statin-naïve persons and statin users can be derived," the authors write. C. Mic...

Use of amino acid supplement following a heart attack provides no benefit, may be harmful

...to patients following a first ST-segment elevation myocardial infarction (STEMI; a certain pattern on an electro...herapy should not be given to patients following a myocardial infarction. It neither alters noninvasive measures of vascular stiffness nor improves left ventricul...

Little known DNA repair enzyme may be a tumor suppressor gene

...to patients following a first ST-segment elevation myocardial infarction (STEMI; a certain pattern on an electro...herapy should not be given to patients following a myocardial infarction. It neither alters noninvasive measures of vascular stiffness nor improves left ventricul...

An elephant tail

...to patients following a first ST-segment elevation myocardial infarction (STEMI; a certain pattern on an electro...herapy should not be given to patients following a myocardial infarction. It neither alters noninvasive measures of vascular stiffness nor improves left ventricul...

Man-made heart tissue improves cardiac performance

...ineered heart muscle can be used to treat cases of myocardial infarction and to repair congenital heart defects, as well as in the use of drug development to provide insight into cardiac developmental biology. ...

Researches discover gene critical for protection against septic-shock-induced death

...e inflammatory response may lead to tissue damage, myocardial injury, acute respiratory failure, multiple organ failure or death. Controlling inflammation is thus a central focus of treating sepsis. Researchers have been hunting for novel host genes that regulate inflammation as potential targets for the next g...

Adult stem cell research at UB targets damaged hearts

...s -- into the down-regulated tissue can change the myocardial adaptive responses and improve the function of the hibernating myocardium. "My colleagues and I already have carried out initial stem-cell transplantation studies with promising results," said Lee. "Additional studies will be needed to determine w...

Healing the heart with bone marrow cells

...t+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines," published today in The Journal of Clinical Investigation. "When damaged heart tissue sends out an 'SOS' distress signal, this subset of bone marrow cells mobilizes quickly and stimulates the growth of new blood vesse...

A surprise about our body clock

...t+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines," published today in The Journal of Clinical Investigation. "When damaged heart tissue sends out an 'SOS' distress signal, this subset of bone marrow cells mobilizes quickly and stimulates the growth of new blood vesse...

Getting to the heart of the heart

... single cardiac progenitor cell gives rise to both myocardial cells, which form the beating muscle and electrica...es rise to the right-sided heart chambers, forming myocardial cells, smooth muscle cells, and endothelial cells. Since these different cell types were thought t...

76 percent of workers older than 60 years of age are overweight or obese

...cond place, it is a self-generating spur for acute myocardial infarction, cerebrovascular incidents, and peripheral arteriopathy. Diverse research groups from the department of Cardiology at the University Hospital are working to fight against these illnesses, which have become the primary cause of death in...

Rescuing injured hearts by enhancing regeneration

...the heart to regain its function after a simulated myocardial infarction. The study will appear in the October 17 issue of the Proceedings of the National Academy of Sciences (posted online during the week of October 9). Normally, after a heart attack, the damaged heart muscle cannot grow back and is instead...

Protein therapy may reduce infarct size in heart attack patients

...low to the heart muscle in patients who experience myocardial infarction (MI), or heart attack. In a study pr...indicate that KAI-9803 may be associated with less myocardial necrosis with lower CK-MB AUC values at all dose levels. Furthermore, improved tissue perfusion (mea...

New research shows that flu is a trigger of heart attacks

..." They found that 11,892 people died from acute myocardial infarction (AMI) (47.8% men and 52.2% women), and 23,000 died from chronic ischaemic heart disease (IHD) (40.1% men and 59.9% women). The peaks in deaths from both AMI and IHD coincided with the times when influenza epidemics and acute respiratory di...

UW launches study testing adult stem cells for heart damage repair

...oms and clinical outcomes in patients with chronic myocardial ischemia (CMI), a severe form of coronary artery d...ow to the heart. A person who suffers from chronic myocardial ischemia continues to experience insufficient flow of oxygen-rich blood to the heart despite optimum...