Myeloma in Biological News

TGen helps promote cancer awareness for vast Navajo Nation

... and Advocacy Conference, sponsored by the Arizona myeloma Network, is planned 8:30 a.m.-5 p.m. July 18 at ... and chief executive officer of the Arizona myeloma Network, which provides outreach and education ... who is investigating breast cancer and multiple myeloma in TGen's Integrated Cancer Genomics Division. ....

U of MN study shows link between gene variations and cancer survival

... used genetic information that the International myeloma Foundation has gathered from myeloma patients worldwide through its program, Bank On A ... of the major treatment and research centers for myeloma worldwide and thousands ...

The IMF says journal editorial documents dramatic increase in survival since the 1980s

... CA September 11, 2008 - The International myeloma Foundation (IMF)supporting research and providing education, advocacy and support for myeloma patients, families, researchers and ... 25 years ago only 48 percent to 66 percent of myeloma patients survived two years, depending on which ...

Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream

... cells is important in diseases like multiple myeloma because the number of cancer cells in the ... cells nevertheless can be relentless. Multiple myeloma starts when cancerous immune system cells ... out other cells in the bloodstream. Multiple myeloma cells can invade bones throughout the body, ...

Getting down to cancer basics

... gene on the X chromosome called UTX - is found in 10% of cases of multiple myeloma and 8% of esophageal cancers. UTX plays a role in overall regulation of ... they found mutations in many cancer types - including one in ten multiple myeloma and one in twelve esophageal cancer cases. "This work shows that ...

Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma

... the development of more effective therapies for individuals with multiple myeloma (MM), a common and incurable blood cell cancer. The research, published by ... targeted disruption of the classical NF-κB signaling blocked myeloma proliferation and induced cell death. These genetic and functional data ...

CWRU receives $5 million from Ohio Third Frontier Commission

... as by having access to leading-edge clinical therapies at our region's clinical institutions." The use of stem cells has focused on leukemia and myeloma treatments with recent applications in cardiovascular disease. Current healthcare is limited to the use of drugs or devices to treat disease and ...

Scientists identify key gene that protects against leukemia

... engraftment. This finding may have important ramifications for patients undergoing bone marrow transplants, for leukemia, lymphoma, multiple myeloma and certain cancers. "Currently, patients undergoing bone marrow transplants may not be getting enough of the quiescent transplanted HSCs that are ...

Small molecules block cancer gene

... in cancers of the head and neck. Further research showed that it also was important in breast, lung and prostate cancers as well as multiple myeloma (a cancer affect blood-forming cells) and acute myelogenous leukemia. Stat3 also plays a role in chronic virus infections, asthma, psoriasis and ...

Stress may hasten the growth of melanoma tumors

... patients. That supports the clinical importance of the results. Two earlier studies on different tumor cell lines one prepared from a multiple myeloma and the other from a nasopharyngeal carcinoma also showed that exposure to norepinephrine increased the levels of proteins responsible for ...

Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds

... off cancer. "This is very promising research, but it is too early to say this is chemo-protective." Hematological cancers leukemia, lymphoma and myeloma accounted for an estimated 118,310 new cancer cases and almost 54,000 deaths in 2006, ranking these cancers as the fourth leading cause of cancer ...

GEN reports growing focus on PI3-kinase pathway in cancer research

... and developed models to better understand gene function. Also covered in the GEN article is research taking place at Eli Lilly, the Multiple myeloma Research Foundation, Semafore Pharmaceuticals, Calistoga Pharmaceuticals, and Harvard Medical School. ...

On the trail of a targeted therapy for blood cancers

... effects of chemotherapy in children and adults. Their findings may one day help in the development of targeted therapies for leukemia, multiple myeloma and other cancers of the blood. The researchers, led by Kristin T. Chun, Ph.D., assistant professor of pediatrics and of biochemistry and ...

Researchers uncover key trigger for potent cancer-fighting marine product

... pathway, said Moore. The Salinispora derivative salinosporamide A is currently in phase I human clinical trials for the treatment of multiple myeloma and other cancers. A team led by Moore and Scripps Daniel Udwary solved the genome of S. tropica in June, an achievement that helped pave the way for ...

UAB microbiologist wins top Czech science honor

... IgA researchers like Mestecky continue to break ground on a better understanding and new treatment options for deadly conditions like kidney failure, myeloma and AIDS, and for immunizing against a variety of microbial infections. Mestecky travels the world lecturing on mucosal immunity and talking about ...

NCI renewal grant to develop new cancer therapies

... of IKK-beta and a class of agents known as proteasome inhibitors. Further, proteasome inhibitors have already proven very active in multiple myeloma and certain types of lymphoma, said Grant. "Our goal is to elucidate the mechanisms by which such agents increase histone deacetylase inhibitor ...

Scientists discover new genetic subtypes of common blood cancer

... out of a landscape of many DNA alterations in the myeloma genome, the researchers report in the April issue ... results "define new disease subgroups of multiple myeloma that can be correlated with different clinical ... they also narrow down areas of the chromosomes in myeloma cells likely to contain undiscovered genetic ...

Compound from marine bacteria shows potential as multiple myeloma therapy

... to be a potent killer of drug-resistant multiple myeloma cells, and potentially with less toxicity than ... MD, director of the Jerome Lipper Multiple myeloma Center at Dana-Farber, and senior author of the ... combination with other treatments. Multiple myeloma is a currently incurable cancer of the bone ...

Investigating the measles virus as a tool to kill multiple myeloma

... Angela Dispenzieri, M.D., hematologist and lead researcher on the multiple myeloma clinical trial in the measles virus investigation. “We are very hopeful ... tumors and monitor regression. Eligible candidates for the multiple myeloma study will be adults with relapsed or refractory (that is, having had more ...

An advanced genetic diagnostic method for multiple myeloma

... Sáez Ochoa, has proposed a new genetic diagnostic method for multiple myeloma (MM), a type of bone marrow cancer, which permits the detection of this ... of this pathology. A disease associated with old age Multiple myeloma is a disease which primarily affects persons above 60 years of age. In ...

Genome changes tracked during multiple myeloma initiation, progression and treatment

... genetic events associated with the development and progression of multiple myeloma (MM), an incurable malignancy that is the second most common cancer of the ... of Memorial Sloan-Kettering Cancer Center, and John Shaughnessy of the myeloma Institute for Research and Therapy at the University of Arkansas for ...

Researchers wake up viruses inside tumors to image and then destroy cancers

... and oncologists from Johns Hopkins Medical Institutions describe how they used two agents already on the market ?one of which is the multiple myeloma drug Velcade ?to light up tumor viruses on a gamma camera. The technique is the first in the new field of in vivo molecular-genetic imaging that ...

Firefighters face increased risk for certain cancers

... found that half the studied cancers--including testicular, prostate, skin, brain, rectum, stomach and colon cancer, non-Hodgkin's lymphoma, multiple myeloma and malignant melanoma--were associated with firefighting on varying levels of increased risk. "There's a critical and immediate need for ...

'Erectile dysfunction' drugs heighten natural anti-cancer activity

... Lab-grown cancer cells treated with sildenafil showed similar results, as did tissue samples taken from 14 head and neck cancer and multiple myeloma patients. Sildenafil, marketed under the trade name Viagra, is one of a class of drugs used to treat erectile dysfunction in millions of men, ...

New tool helps blood specialists improve patient care

... their practice, and, most importantly, enhance the quality of care they provide." ASH is developing additional measures in the area of multiple myeloma to be released within the next several months. In addition to the evaluation component, each set of measures will be accompanied by physician ...

How can we protect patients with weakened immune systems from influenza?

... researchers in the University of Pennsylvania Health System. Two projects involve cancer patients: those receiving stem cell transplants for multiple myeloma (a cancer originating in bone marrow) and patients with ovarian cancer receiving an experimental treatment--an anti-cancer vaccine made from ...

BiovaxID?yields 89 percent survival in patients with aggressive non-Hodgkins

... to immune stimulation ("cellular" immunity). B-cell lymphocytes can undergo malignant transformation to become non-Hogkins lymphoma, multiple myeloma or chronic lymphocytic leukemia. "This is the first human cancer vaccine study to see T-cell responses in the absence of B-cells," said the ...