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muscle at biology news

Lack of enzyme turns fat cells into fat burners

...sing water) fat, and passingit on to the heart and muscle because there is an increase in oxidationof fat in those organs. It also starts oxidizing glucose. In otherwords, the adipose tissue is becoming a little more oxidative and lessinvolved in the synthesis and storage of fat. We feel this contributesto ...

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

...one marrow to releasestem cells that "home" to the muscle that is not getting enough blood.These stem cells include endothelial progenitor cells (EPCs), which isthe type of cell needed to make new blood vessels and to repair damagedones.Patients in the clinical trial will be given an injection of either agr...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

Gene therapy methods that specifically target muscle may reverse the symptoms of a rare form of muscula...ators either injected the viral particles into the muscle or injected it intravenously in Pompe disease mice. Six weeks after muscular injection with the vir...

X-Ray Beams And Fruit Fly 'Flight Simulator' Aid Scientists' View Of Muscle Power

...for generating the rapid contractions of the fly’s muscle with a resolution of 6/10,000th of a second. The f...eam to capture X-ray images at different stages of muscle contraction. By combining the technologies, the researchers could reconstruct a ‘movie?of the molecu...

UCSD team discovers specialized, rare heart stem cells in newborns

...stem cells that have been programmed to form heart muscle during fetal growth. Until this new discovery, the...programmed to become spontaneously beating cardiac muscle cells simply by exposure to other neighboring heart cells. And, since these rare cardiac progenitor...

Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments

...f the heart, the VEGF-2 is injected into the heart muscle region with inadequate blood supply. The DNA plasmid is then taken up by the middle muscular layer of the heart wall near the injection site. Inside the cell, the DNA encoded VEGF-2 expresses itself which in turn stimulates the growth of new blood ve...

Supercomputer Dedicated To Bioengineering, Computational Biology Installed

...ular structures such as nerve synapses and cardiac muscle cells, to multicellular tissue and the whole heart. Bioengineering professor David Gough (left), principal investigator of NBCR Peter Arzberger, Bioengineering vice chair Andrew McCulloch, director of SDSC's Advanced CyberInfrastructure Lab Phil Pap...

Polymers with copper show promise for implanted sensors

...e blood vessel walls, where it relaxes surrounding muscle cells and increases blood flow. It also diffuses into the lumen of the blood vessel, where it plays another important role: it inhibits platelet function and prevents platelets from sticking to the surface of the blood vessels." Over the years, Meye...

Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks

... these cardiac myocytes die, and the damaged heart muscle is replaced by scar tissue that isn’t able to contract and help the heart beat. This problem is one of the biggest clinical issues faced by heart patients in the United States today,?says Dr. Lough. In looking at ways to use ES cells, the research t...

Researchers identify protein crucial for survival of Lyme-disease bacterium

...nfection causes fever, malaise, fatigue, headache, muscle and joint aches, and a characteristic "bull's-eye" rash that surrounds the site of infection. In the study, researchers genetically altered the Bb bacterium to make a "knockout" form that lacked a gene that codes for the protein BptA. Without the pr...

Heart repair gets new muscle

...l with injury better than others. A flesh wound or muscle tear might hurt, but, assuming you are otherwise h...yocytes, or Spoc cells) isolated from the skeletal muscle of adult mice can turn into beating cardiomyocytes in a test tube within days of isolation. When the...

Brain-mapping technique aids understanding of sleep, wakefulness

...excessive daytime sleepiness and experience sudden muscle weakness called cataplexy. Because orexin-producing neurons play such a key role in regulating sleep, determining how they are connected to other neurons in the brain is an important step toward understanding how and why we sleep. Mapping the neuro...

Researchers report new pro-inflammatory role for anti-inflammatory enzyme

...vity of immune cells and growth of vascular smooth muscle cells," explains Dr. Hobbs. "iNOS is not expressed under normal physiological conditions, but is up-regulated for host-defense purposes." Now, the researchers have validated their hypothesis in vivo using mice that do not produce eNOS. These mutant ...

Nano-bumps could help repair clogged blood vessels

...sed attachment for endothelial and vascular smooth muscle cells lining the insides of arteries, said Thomas Webster, an associate professor of biomedical engineering at Purdue. The stents are small metal scaffolds that are inserted inside arteries to prop them open during or after surgery to remove dangero...

Double triumph in stem cell quest

...tiate into a number of cell types, including heart muscle cells, neurons and blood stem cells, although the results have not yet been published. Trounson, whose team has been experimenting with a similar approach, says far more detailed studies will be needed. Besides looking at further cell surface marker...

NIAID begins clinical trial of West Nile virus vaccine

...jected into the muscle, the inner machinery of the muscle cells "reads" the DNA and converts it into two WNV...ns. Recognizing that the proteins are foreign, the muscle cells display them on their surface to alert the body's immune system--both helper T cells, which sp...

Genetic therapy reverses nervous system damage in animal model of inherited human disease

...compared to diseased cats, with better balance and muscle control and fewer tremors." Although the disease itself is rare, AMD is one of about 50 lysosomal storage diseases, a class of diseases that accounts for a significant portion of the instances of mental retardation in children. Other examples includ...

One gene links newborn neurons with those that die in diseases such as Alzheimer's

...er to form part of the brain pathway that controls muscle movements related to singing. The neurons that are not replaced send their projections to a different brain region, one that controls the song learning pathway. In order to label the two cell types, the scientists injected dyes of different colors, o...

Disease progression model of pancreatic cancer developed by Penn researchers

...ic cancer patients, such as abdominal swelling and muscle loss. Similarly, the progression of pancreatic cancer metastases paralleled that seen in the human disease. "In this model, pancreatic cancer metastasizes to the liver, lungs, diaphragm, and adrenal glands, all the same places that human pancreatic c...

Scientists generate patient-specific stem cells, Science study says

... display characteristics of skin and retina cells, muscle cell bundles, bone matrix cells and cells of the gastrointestinal and respiratory lining. One of the next preclinical steps, according to the authors, is to evaluate, in the lab, differentiated patient-specific human embryonic stem cell lines for im...

SuperLigands - a database of ligand structures derived from the Protein Data Bank

... display characteristics of skin and retina cells, muscle cell bundles, bone matrix cells and cells of the gastrointestinal and respiratory lining. One of the next preclinical steps, according to the authors, is to evaluate, in the lab, differentiated patient-specific human embryonic stem cell lines for im...

Python a 'hearty' eater

...owth coincided with an increased production of the muscle protein, myosin. Myosin is involved in muscle contraction, and hence, plays a key role in pumping blood. Hicks and his colleagues propose that th...

Future diabetes drugs may target new protein interaction

...g sirtuin1 and PGC1 in other tissues, particularly muscle and fat, two other energy-producing tissues in mammals. The study was funded by the Ellison Medical Foundation, the American Federation for Aging Research, and start-up funds from the Department of Cell Biology at the Johns Hopkins School of Medicin...

PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information

...g sirtuin1 and PGC1 in other tissues, particularly muscle and fat, two other energy-producing tissues in mammals. The study was funded by the Ellison Medical Foundation, the American Federation for Aging Research, and start-up funds from the Department of Cell Biology at the Johns Hopkins School of Medicin...

Computational verification of protein-protein interactions by orthologous co-expression

...g sirtuin1 and PGC1 in other tissues, particularly muscle and fat, two other energy-producing tissues in mammals. The study was funded by the Ellison Medical Foundation, the American Federation for Aging Research, and start-up funds from the Department of Cell Biology at the Johns Hopkins School of Medicin...

Eliminate Data Analysis Bottlenecks in Drug Discovery

...g sirtuin1 and PGC1 in other tissues, particularly muscle and fat, two other energy-producing tissues in mammals. The study was funded by the Ellison Medical Foundation, the American Federation for Aging Research, and start-up funds from the Department of Cell Biology at the Johns Hopkins School of Medicin...

Gov't Creates Gene Database of Normal Human Tissues

...ction" genes were found in skeletal muscle, smooth muscle tissue, and the heart -- all organs that share a common way of functioning. To illustrate the kind of useful data that can emerge from using this tool, Khan's team analyzed 100 samples of the most common pediatric solid tumor cancer, neuroblastoma (...

Scientists analyze chromosomes 2 and 4

...equence ?a 280,000 base pair gene that codes for a muscle protein, called titin, which is 33,000 amino acids long. One of the central goals of the effort to analyze the human genome is the identification of all genes, which are generally defined as stretches of DNA that code for particular proteins. The ne...

Young Blood Revives Aging Muscles, Stanford Researchers Find

...died specialized cells called satellite cells, the muscle stem cells, that dot muscle tissue. These normally lie dormant but come to the rescue in response to damaged muscle-at least the...

At the molecular level, the predator is the prey

...bsolutely fundamental to every aspect of nerve and muscle function and are highly specific gateways for sodium ions," said IUB biologist Edmund Brodie III, one of the paper's coauthors. "If the channels change too much or in the wrong way, they can't perform their basic, everyday functions. Sodium channel g...

Disabling gene defuses rheumatoid arthritis in mice

...y include morning stiffness, fatigue and joint and muscle pain. In severe cases, rheumatoid arthritis can damage cartilage, tendons, ligaments and bone, leading to joint deformity and instability. Rheumatoid arthritis has long been recognized as a condition that involves defensive cells from the body's imm...

15 generations of untrained jocks, couch potatoes show big physiological adaptations

...ce at G15 was due in part to an increased skeletal muscle oxygen conductance that allowed for better transport of the oxygen to the muscle mitochondria of the athletic rats." according to Richard A. Howlett, lead author of one of three pap...

Protein synthesis can be controlled by light, opening way for new scientific, medical applications

...s, for example, differentiate into skin, brain and muscle cells, among many others, researchers want to know the controlling mechanisms for how these cells are chosen for their specific roles. "If we had a way to selectively abolish protein synthesis in subcellular compartments and observe the effects, the...

Stem cell therapy successfully treats heart attack in animals

...restored heart function and repaired damaged heart muscle by 50 percent to 75 percent. The Hopkins findings...ent to repair and reverse the damage done to heart muscle that has been infarcted, or destroyed, after losing its blood supply," says cardiologist Joshua Hare...

Combination therapy leads to partial recovery from spinal cord injury in rats

... resulting electrical current was transmitted to a muscle in one of the hind legs. Most of the rats treated with the combination of precursor cells and gene therapy improved significantly on both tests, the researchers found. The combination therapy led to an improvement in the rats' ability to walk and ab...

Small worm yields big clue on muscle receptor action

...elegans which may open new pathways of research on muscle function. The neurotransmitter acetylcholine bind...d as necessary for this receptor's contribution to muscle contraction. Janet Richmond, assistant professor of biological sciences at UIC, along with graduate...

Researchers grow stem cells from human skin

... the laboratory and coaxed them into becoming fat, muscle and bone cells. The study, one of the first studie... factors to coax the stem cells into becoming fat, muscle and bone cells. When the differentiated cells were seeded onto three-dimensional molds and implante...

Researchers extend mouse lifespan by protecting against free radicals

...ondrion-targeted catalase mice had healthier heart muscle tissue, indicating that the catalase helped protect from age-related heart problems seen in wild-type mice. The MCAT mitochondria also had fewer mutations, and the MCAT nuclear DNA had fewer oxidized components. "This study is very supportive of the...

Scientists reveal how disease bacterium survives inside immune system cell

...typically causes mild symptoms that include fever, muscle aches and nausea. Some 362 U.S. cases were reported to the Centers for Disease Control and Prevention in 2003. HGA is considered an emerging infectious disease, and Dr. Borjesson is working to understand how it affects blood cells -- and neutrophils...

New defibrillator signals doctor of patient's irregular heartbeat or device malfunction

...treatment of arrhythmias. Because patients' heart muscle pumping action can be poor as a result of the heart attack, it is important to monitor heart activity. Now it can be done 24-hours-a-day, seven-days-a-week. Varma implanted the device into a Loyola patient on Friday, August 26, 2005. Loyola Univer...

Novel compounds show promise as safer, more potent insecticides

... species of tropical plant, has been used to study muscle physiology in a wide variety of organisms, includi... insects and mammals. Ryanodine receptors regulate muscle and nerve activities by modifying levels of internal calcium in these cells. These receptors exist i...

Unexpected lock and key mechanism found for the assembly of tumor blood vessels

...only work when both endothelia and vascular smooth muscle are bound together. Previous work on integrin alph...looked for evidence of VCAM in the vascular smooth muscle cells, called pericytes. Indeed, Varner's team found VCAM on the nascent blood vessel's pericytes, ...

New complete muscle grown in the lab

A multinational team of researchers has grown new muscle complete with its own network of blood vessels in the laboratory, and implanted the new muscle in a living mouse. The accomplishment is a first for tissue engineering, according to a report in th...

Exercise training in ordinary people affects the activity of 500 genes

...tockholm shows that hundreds of genes in the thigh muscle are activated in regular cycle training. The study...ning and the situation in patients with Duchenne's muscle dystrophy, a muscle wasting disease. Most of the muscle genes previously claimed to be specific for ...

Pinpointing the cause of a neurodegenerative disorder

... SCA1 lose balance and motor coordination. Loss of muscle control worsens until patients can no longer eat or breathe. "We had known that the expansion of the glutamine tract within Ataxin-1 probably interfered with normal clearance of Ataxin-1, meaning that it accumulated in cells," said Zoghbi. She noted...

Spiders help scientists discover how muscles relax

Using muscle tissue from tarantulas, an HHMI international rese... provides new insights into the molecular basis of muscle relaxation, and perhaps its activation too. "We have solved the structure of the array of miniatur...

Scientists discover stem cell origin of neck and shoulders

... of groups of stem cells creating the skeletal and muscle structure separately they actually appear to make them together as a sort of 'composite'. This could have significant implications for clinical medicine and our understanding of vertebrate evolution. Scientists at the Wolfson Institute for Biomedica...

Thinking the pain away? Study shows the brain's painkillers may cause 'placebo effect'

...t of concentrated salt water being injected in the muscle as the scans continued, in order to keep the participants' rating of their pain within the same point range throughout the experiment. The placebo, a small amount of hydrating solution, was then given intravenously every four minutes. As the researc...

Can't serve an ace? Could be muscle fatigue

Fatigue could reduce skills and cause injuries and muscle weakness during sport because the brain does not consider the extra effort required for movement, Monash University researchers have found. Professor Uwe Proske, from Monash's Department of Physiology, found when muscles were weakened from overuse o...

Researchers devise new technique for creating human stem cells

...nduced to mature into nerve cells, hair follicles, muscle cells and gut endoderm cells. And, since these cell types are derived from three different parts of the embryo, this really demonstrated the ability of these cells to give rise to a variety of different cell types." Furthermore, Eggan noted that gen...

Lance Armstrong through a physiological lens: hard training boosts muscle power 8%

...Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity i...ests an improved efficiency of ATP turnover within muscle fibers during contraction." (ATP, or adenosine triphosphate, is a nucleotide present that serves as ...

Gene therapy to lower blood pressure just enough

...f hypertension, including the relaxation of smooth muscle cells in blood vessels, increasing the vessels' diameters, and reducing the manner in which the vessels react to agents that can constrict those vessels. ANP also improves the manner in which the kidney eliminates sodium or salt from the body and inh...

Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy

...maceutical industries can repair damage to cardiac muscle cell membranes and prevent heart failure in mice w...ause it is the first to show what happens to heart muscle cells called myocytes in the absence of dystrophin, and the first study to demonstrate a new, promis...

MicroRNA tweaks protein that controls early heart development

... to allow proliferation and expansion of a pool of muscle progenitor cells that can eventually develop into ... in their development and differentiate into heart muscle cells. We identified Hand2 as the target for this particular microRNA." Dr. Srivastava is a former ...

Elderly mice yield clues to the process of growing old

...eight loss, hearing and vision impairment, loss of muscle mass, weakened bones and fewer circulating red blo...ging -- including graying, hair loss and atrophied muscle and bone -- at a pace much faster than the typical laboratory mouse. "It's like a broken spellcheck...

The synapse is a shotgun

... a defect in nerve impulse transmission results in muscle weakness. In this and other neurological diseases, "there may be an anomaly at the receptor level, but it is impossible to pinpoint the problem with existing techniques. With our modeling technique, we can explore the detailed geometry of the damaged...

Discovery of T-cell 'traffic control' boosts new drug promise

... as well, and some of these control heart rate and muscle development. In clinical trials of some of these k...od flow and a tendency for airways to constrict as muscle walls develop abnormally, Goetzl says. "Fully exploiting this approach for treatment of autoimmune ...

Discovery suggests why stem cells run through stop signs

...type found in the body, from a red blood cell to a muscle cell to a brain cell. But no one really knows why stem cells continue to divide and renew themselves long after the point where other cells stop dividing. Now scientists at Northwestern University and the University of Washington offer one of the fi...

When in danger humans are similar to a deer in the headlights

...ficant reduction in body sway along with increased muscle stiffness following the unpleasant/mutilation block of pictures compared to the neutral pictures. The number of heartbeats per minute was also lower after viewing the mutilation pictures than after looking at the others. "This pattern resembles the '...

Why do aneurysms form? New studies suggest leading role for white blood cells

...sponse doesn't work. Something eats away at smooth muscle cells in the wall of the aorta until it starts to fall apart." Researchers have found that AAAs appear to be associated with high levels of enzymes that are capable of doing that eating. But the question of how those enzymes get there, and what prom...
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(Date:10/7/2008)...ober 7, 2008 Burnham Institute for Medical Resear...peptide that binds to Bcl-2, a protein that protec...nverts it into a cancer cell killer. The research,...e October 7 edition of Cancer Cell , may lead to ...ong been implicated in protecting cancer cells fro...
(Date:10/7/2008)...er research, the silver bullet theory always gets ...ong. , For geologists who study mass extinctions...o earth. , But an asteroid is the prime suspect ...said USC earth scientist David Bottjer. The catacl..., "The other four have not been resolvable to a ...
(Date:10/6/2008)...riff,s Office Replaces Passwords with Fingerprint ...ms, CHANHASSEN, Minn. and WALL, N.J., Oct. 6 /PRN...OTC Bulletin Board: BKYI), a leader in,finger-base...ety solutions,and its partner Sig-Tec, a leader i...s, announced today the successful deployment of a,...
(Date:10/6/2008)... Institute researchers have developed a new prenat...me and two other serious chromosomal defects in a ...larger trials, they say, the test would offer a sa...sts such as amniocentesis that pose a small risk o...a pregnant woman,s blood contains small amounts of...
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(Date:10/8/2008)... Juva Skin & Laser Center is ...etic skin treatments in New York City. The facilit...re:fine, one of the latest skin resurfacing treatm...nvasive laser equipment. , ...etic surgery and laser treatment industry is in th...
(Date:10/7/2008)...MBUS, Ohio, Oct. 7 /PRNewswire-USNewswire/ -- The ...ity (ONA-PCE) announced today its,final round of e...on,including:, Ohio Senate:, SD 26 Karen Gillmo... 23 Cheryl Grossman (R) Grove City;, HD 28 Connie...g (R) Cincinnati, "These ONA-endorsed candidates ...
(Date:10/7/2008)...out of bed sooner helped quality of life after dis...(HealthDay News) -- The best medicine for intensiv... of bed and moving as soon as they,re able, a new ...t data, Johns Hopkins University School of Medicin...ep sedation and bed rest may cause unnecessary and...
(Date:10/7/2008)...gists at the Moores Cancer Center at the Universit...hoping to stave off the relentless march of advanc...ind of cancer vaccine. While many vaccines attempt...r, the new vaccine, Lucanix, is genetically engine... immune system-suppressing activities. , The fir...
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