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22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey

... complex mental functions such as thinking, learning, memory or emotion is mediated by a large number of chemical neurotransmitters and neuromodulators. ... minimising adverse events. For instance, the signalling of serotonin is mediated by 14 receptor subtypes. As one of the main mediators of the ...

Potential new therapeutic molecular target to fight cancer

... potent lipid mediator sphingosine-1-phosphate in the death of cancer cells mediated by the chemotherapeutic drug, doxorubicin. Doxorubicin is able to kill ... p21 regulates the cell cycle, and apoptosis or programmed cell suicide, mediated by doxorubicin. Human colon and breast cancer cells were killed more ...

Ultra-low-dose aspirin might decrease bleeding severity in portal hypertension

... cell alterations and bleeding time. Further, this effect is mediated by Cyclooxygenase 2 inhibition. This study, performed by a team led ... shown that the prothrombotic properties of ultra-low-dose aspirin are not mediated by platelets but by endothelial cells, and as such they have the potential ...

Stem cell research: From molecular physiology to therapeutic applications

... properties of stem cells and developing nonhuman primate models for stem cell-based therapy of degenerative diseases. He has developed a stem cell mediated expression system for treating Parkinson's disease and his research using pancreatic progenitor cells for treating diabetes has demonstrated efficacy ...

The SIB recognizes the next generation of bioinformaticians

... of protein sequences. A key feature of the method is that it is able to disentangle direct interactions from indirect interactions that are mediated via other residues. As such the method greatly improves the prediction of contacting amino acids in the 3-dimensional structure of proteins and is ...

One size does not fit all

... of MS, allowing MNI researchers to determine the direct effect of long-term statin therapy on remyelination, independent of its indirect effects mediated via immune modulation. "The results of our study indicate that simvastatin has in fact, a slightly deleterious effect on myelin under ...

FANTOM findings boost for biologists

... open access journals, including Genome Biology and BMC Bioinformatics , provide further insight into HCNE (highly conserved non-coding element) mediated long-range gene regulation at the core of animal multicellularity regulation. Now at its fourth stage, FANTOM4, prominently led by OSC's Yoshihide ...

2009 ASPB Summer Undergraduate Research Fellowship award announcement

... at the annual ASPB meeting in 2010. David Seung, University of Sydney Mentor: Jan Marc The interaction of abscisic acid and phospholipase D mediated pathways in environmental stress signaling: The role of the cytoskeleton It is with great honor and excitement that I accept this award. I would ...

Weizmann Institute scientists develop a unique approach for splitting water into hydrogen and oxygen

... devised is divided into a sequence of reactions, which leads to the liberation of hydrogen and oxygen in consecutive thermal- and light-driven steps, mediated by a unique ingredient a special metal complex that Milstein's team designed in previous studies. Moreover, the one that they designed a metal ...

Getting down to cancer basics

... gene transcription were noted. Genes with the most significant changes in expression were highly enriched in those most susceptible to control by UTX mediated histone modification. The work identifies a new class of cancer genes that researchers can now pursue. These are genes that occupy the central ...

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

... included in highly active antiretroviral therapy (HAART) regimen for the treatment of HIV-1 patients, induce deleterious effects on insulin secretion mediated through the oxidative stress pathway. They report a significant decrease in the levels of the antioxidants, cytosolic superoxide dismutase (Cu/Zn ...

Stopping autoimmunity before it strikes

... therefore provide a new tool in the evaluation of early autoimmune therapies. The article from Zangani et al "indicate[s] that NF-κB mediated bioluminescence is a very sensitive and early indicator of inflammation and disease", allowing precise identification of incipient disease sites for ...

Protein function and chromatin structure methods featured in Cold Spring Harbor Protocols

... ) contribute a method for the "Combined 3C-ChIP-Cloning (6C) Assay: A Tool to Unravel Protein mediated Genome Architecture." 6C technology combines multiple techniques to identify the proteins that bridge distant genomic regions, while simultaneously ...

Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone

... de Rijck, Ph.D./Mentor: Zeger Debyser, M.D., Ph.D. Katholieke Universiteit Leuven, Leuven, Belgium $125,000 Characterization of transportin-SR2 mediated nuclear import of HIV: Studies in the past year have identified hundreds of proteins in host cells that play mostly as yet unidentified roles in ...

'Experiment of nature' examines how mother's diet may impact on child's health

... or hungry seasons. If a mother's diet does affect her offspring's methylation patterns, this could prove very important as epigenetic changes mediated by DNA methylation are likely to have long term effects on the health and physical characteristics of offspring. Animal studies have shown that ...

High-fat diets inflame fat tissue around blood vessels, contribute to heart disease

... develop atherosclerosis nonetheless. "These new findings suggest a direct link between poor dietary habits and inflammation of blood vessels, mediated by the fat cells surrounding the blood vessel wall." Weintraub adds that the diet fed to the mouse models was not unlike the diets consumed by ...

Research yields new clues to how we locate objects in space

... who will be performing surgeries. Seeing the indentation and feeling the change in pressure do not require higher levels of processing but are mediated by direct perception. To ensure proper placement of the surgical tool, the doctor needs to be able to look at the image on the screen and know how ...

Impaired energy metabolism linked with initiation of plaques in Alzheimer's brain

... in humans with AD. "Here, for the first time we provide evidence linking impaired energy metabolism, an AD-relevant stress, with BACE1 translation mediated by eIF2? phosphorylation," says Dr. Vassar. "Our findings implicate phosphorylated eIF2? in both the initiation and progression of sporadic AD. ...

SUNY Downstate researchers find that memory storage molecule preserves complex memories

... said the research "shows that PKMzeta is fundamental for storing many different forms of memory, which previously has been viewed as potentially mediated by distinct mechanisms." ...

Shared survival mechanism explains why 'good' nerve cells last and 'bad' cancer cells flourish

... protein involved in the process of cell death called cytochrome c. "What we show is that both neurons and cancer cells inhibit the cell death process mediated by cytochrome c," Deshmukh said. Specifically, according to the study, cytochrome c's ability to induce death can be turned off if the cellular ...

Rice University study finds possible clues to epilepsy, autism

... Chun-Jen Lin, research technician William Lavery and Michael Stern, a professor of biochemistry and cell biology, discovered that negative feedback mediated by PI3K regulates the excitability of neurons, an issue in a number of ailments that include neurofibromatosis, and that a mutation in a glutamate ...

December 2008 Geology and GSA Today media highlights

... sequence of events involving several episodes of crystallization of different minerals. What is more remarkable is that these reactions are all mediated by the earthworm and completed very quickly, probably in less than a day. These results illustrate very clearly how the granules form, but Darwin's ...

Mitochondria could be a target for therapeutic strategy for Alzheimer's disease patients

... Alzheimer's disease. Recent studies have provided substantial evidence that mitochondria serve as direct targets for amyloid beta (Aβ) protein mediated neuronal toxicity. The observations that Aβ progressively accumulates in cortical mitochondria from Alzheimer's disease patients and in brains ...

Apelin to rescue diabetics

... by Philippe Valet's team make it possible to short-circuit this mechanism and achieve sugar assimilation by a completely different pathway from that mediated by insulin. Normally, this second pathway is only responsible for a small proportion of sugar integration. However, as proved by tests conducted ...

Stress may make you itch

... in patients suffering from inflammatory skin conditions. This cross talk between stress perception, which involves the brain, and the skin is mediated the through the "brain-skin connection". Yet, little is know about the means by which stress aggravates skin diseases. Researchers lead by Dr. ...

American Chemical Society's Weekly PressPac -- Sept. 10, 2008

... drugs that focus on new disease targets, including the glutamate neurotransmitter system, a nicotinic acetylcholine receptor, and a signaling pathway mediated by cyclic nucleotides. These substances appear to help relieve a wider range of symptoms while causing fewer side effects, the researchers note. ...

Mate selection more biologically determined in some human populations

... the Major Histocompatibility Complex (MHC), a large genomic region involved in immune response, influences mating selections and that this may be mediated by preferences based on body odor. Some previous studies have reported a tendency for humans to prefer MHC-dissimilar mates, encouraging ...

Blood pressure response to daily stress provides clues for better hypertension treatment

... a delayed recovery unless they are missing an endothelin receptor gene. "It cures it," says Dr. Jennifer Pollock. "This early life stressor is being mediated through the endothelin pathway." Her postdoctoral fellow, Dr. Analia Loria, found these early life stressor models also have more constrictive blood ...

Ikaria(R) Receives FDA Orphan Drug Designation for Inhaled Carbon Monoxide for Delayed Graft Function in Solid Organ Transplants

... that the compound may possess anti-inflammatory, cytoprotective and anti-apoptotic properties that could potentially improve ischemic-reperfusion mediated malfunction in transplanted organs and allow for an important advance in solid organ transplantation. We look forward to advancing our research of ...

Chronic exposure to estrogen impairs some cognitive functions

... this week in the journal Behavioral Neuroscience . The researchers made the discovery when studying the effects of estradiol on activities mediated by the prefrontal cortex, a brain region that is vital to working memory and to the ability to plan, respond to changing conditions and moderate or ...

Ikaria(R) Receives FDA Orphan Drug Designation for Inhaled Carbon Monoxide for Delayed Graft Function in Solid Organ Transplants

... that the compound may possess anti-inflammatory, cytoprotective and anti-apoptotic properties that could potentially improve ischemic-reperfusion mediated malfunction in transplanted organs and allow for an important advance in solid organ transplantation. We look forward to advancing our research of ...

Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway

... our data," Dr. Zagon said, "brings a paradigm shift to our thinking about a drug widely used in the clinics. Rather than imiquimod activity being mediated by induction of various cytokines, including interferon (IFN)-α, IFN-γ, tumor necrosis factor-α (TNFα) interleukin (IL)-1α, ...

Montreal Heart Institute and Mount Sinai Hospital researchers contribute to Crohn's disease study

... study is indicating which biological pathways specifically lead to Crohn's disease as well as which of these pathways are in common with other immune mediated diseases such as autoimmune diabetes, lupus and rheumatoid arthritis," says Dr. Rioux, co-author of the current study. "This is breakthrough ...

Study of marine snail leads to new insights into long-term memory

... associates in Glanzman's laboratory believe they are the first scientists ever to see the synthesis of a specific presynaptic protein that is mediated by postsynaptic calcium during a learning-related synaptic change. Current Biology is a premier journal for general biology. Glanzman's ...

VaxInnate to discuss seasonal and pandemic flu vaccines during BIO 2008 this week

... VaxInnate's approach to developing and producing influenza vaccines is based upon a proprietary combination of toll-like receptor (TLR) mediated immune enhancement and recombinant bacterial production of vaccine antigen. This proprietary technology could significantly reduce the time required ...

Getting better with a little help from our 'micro' friends

... place to live; it's like creating bacterial nirvana," says Mazmanian. If bacteria are actively modifying the gut, their work would have to be mediated by molecules. In their recent work, Mazmanian and his colleagues have identified one such molecule, a sugar called polysaccharide A, or PSA, which is ...

Natural compounds in cocoa tied to blood flow improvements for adults with type 2 diabetes

... hours following consumption. The researchers found a positive correlation between the flavanol dose consumed and immediate improvements in FMD (flow mediated dilation, a measure of vessel health, i.e. the ability of a vessel to relax). In a subsequent controlled 30-day, double-masked clinical trial, ...

Scientists find stem cells for the first time in the pituitary

... notes that hormones strongly influence human neuropsychiatric phenomena, including stress and depression that are his main research focus. All are mediated through the pituitary, he said, so changes that happen during the later growth of the gland could have lasting effects. ...

Clumps of red and white blood cells may contribute to sickle cell disease

... been found in whole blood from sickle cell patients. The study also shows how the red and white blood cells adhere to one another: the interaction is mediated by a particular protein, integrin alpha four beta one. First author Julia E. Brittain, Ph.D., a research assistant professor in the medical ...

Researchers uncover details about how dietary restriction slows down aging

... appears in the April 18 issue of the journal Cell. Previous research has shown that the lifespan-extending properties of dietary restriction are mediated in part by reduced signaling through TOR, an enzyme involved in many vital operations in a cell. When an organism has less TOR signaling in response ...
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