lymphocytic

Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine

...d three of the world's foremost experts on chronic lymphocytic leukemia (CLL) to write an authoritative update co...s about the development and progression of chronic lymphocytic leukemia require revision. With new molecular and protein markers now identified, patients with feat...

Enzyme allows B cells to resist death, leading to leukemia

B cell chronic lymphocytic leukemia (B-CLL)is the most common leukemia in adults and is characterized by theprogressive accumulation of mature B lymphocytes in the blood, bonemarrow, and lymphatic tissues. It is believed that in the early stagesof disease, B-CLL is the result ...

The very unexpected life and death of a leukemic cell

B cell chronic lymphocytic leukemia (CLL) is an incurable disease in which ce... document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells View the PDF of this article at: https://www.the-jci.org/press/23409.pdf ...

Researchers identify genes associated with lung transplant rejection

...o (UCSF) have identified six genes associated with lymphocytic bronchitis, which is thought to lead to obliterati...ent. They identified six genes that correlate with lymphocytic bronchitis, potentially opening the way to a genetic test that would identify OB before it manifests...

BiovaxID?yields 89 percent survival in patients with aggressive non-Hodgkins

... non-Hogkins lymphoma, multiple myeloma or chronic lymphocytic leukemia. "This is the first human cancer vaccine study to see T-cell responses in the absence of B-cells," said the study's first author, Sattva Neelapu, M.D., Assistant Professor in the Department of Lymphoma at the University of Texas M. D. Ander...

MiRNA fingerprint identified in platelet formation

...l development, especially in diseases like chronic lymphocytic leukemia and lymphoma. Relatively little was known, however, about miRNA functionality in platelet formation. Platelets are created from stem cells in the bone marrow. They evolve through a process called megakaryocytopoiesis, which generates megaka...

Mouse mimics chronic leukemia, will aid drug development

... develops a malignancy that closely mimics chronic lymphocytic leukemia (CLL). The lack of an animal model has greatly hampered the development of new treatments for CLL as well as research into its causes and the changes that drive drug resistance. "This mouse strain shares many of the molecular and genetic ...

Pair of microRNA molecules controls major oncogene in most common leukemia

...responsible for a dangerous form of B-cell chronic lymphocytic leukemia (B-CLL), the most common human leukemia i...ight work as a future treatment for B-cell chronic lymphocytic leukemia, he said. These molecules could also be combined with 12 other miRNAs known to be associate...

Scientists discover new virus caused deaths of transplant recipients from single donor

... The previously unknown virus, which is related to lymphocytic choreomeningitis virus (LCMV), was found using rapid sequencing technology established by 454 Life Sciences and bioinformatics algorithms developed in the Greene Laboratory with support from the National Institute of Allergy and Infectious Diseases. ...

Knocking out survival protein could aid leukemia treatment

...-two punch against drug-resistant forms of chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL). The two forms of cancer kill about 20,500 Americans yearly. The survival protein is called Mcl1. It usually helps keep normal cells healthy and is involved in the development of the component...

Massey researchers induce cell death in leukemia

...tential of a new combination treatment for chronic lymphocytic leukemia (CLL). In this study, led by Steven Grant, M.D., Massey's associate director of translational research, interactions between bortezomib and romidepsin (Gloucester Pharmaceuticals) and bortezomib with belinostat (aka PXD101 from CuraGen Co...

Synthetic peptide targets latent papilloma virus infections

...e cause of mononucleosis and an aggressive form of lymphocytic leukemia called Burkitt's leukemia, and the Kaposi's sarcoma virus, which can develop to cancer in those with AIDS. ...

Researchers discover inherited mutation for leukemia

...utation that increases a person's risk for chronic lymphocytic leukemia (CLL), one of the most common forms of the disease. The study shows that the inherited mutation greatly reduces the gene's protective activity. Furthermore, a second kind of change occurs later that turns the gene off altogether, leading t...