Lymphatic in Biological News

Ambati study published in PNAS

... blood vessels, but also to the cells lining the lymphatic channels. These findings reinforce the note of ... in the human body, including those that line the lymphatic system, a critical component of immune responses. ... that siRNAs block not only blood vessels but also lymphatic vessels. In the cornea, the clear part of the ...

Festschrift Issue honoring Judah Folkman, M.D. in Lymphatic Research and Biology

... special double issue (Volume 6, Number 3-4) of lymphatic Research and Biology includes a series of papers ... physician-scientists of his generation. lymphatic Research and Biology is a peer-reviewed journal ... and Chair of the Scientific Advisory Board of the lymphatic Research Foundation. Dr. Rockson, who is the ...

Reprogrammable cell type depends on a single gene to keep its identity

... to reprogram a specialized type of cell, called a lymphatic endothelial cell (LEC). In the absence of active ... Endothelial cells line the inside of blood and lymphatic vessels. The results of the study appear in the ... a critical set of vessels called the lymphatic vasculature arises from veins; and ...

NTDs burden in Latin America and the Caribbean may exceed that of HIV/AIDS, TB and malaria

... trachoma, dengue fever, leishmaniasis, lymphatic filariasis (LF), and onchocerciasis. NTDs ... in the Caribbean, and that transmission of lymphatic filariasis and onchocerciasis could be eliminated ... the world's poorest people received treatment for lymphatic filariasis at a cost of 10 cents per person, ...

St. Jude settles century-old debate on origin of mammalian network of lymphatic vessels

... century-old debate on the origin of the mammalian lymphatic vasculaturethe network of vessels and capillaries ... promise for the development of new therapies for lymphatic system disorders, the researchers said. The ... used various mouse models to demonstrate that the lymphatic vasculature arises in the embryo from veins by ...

Venous origin of the mammalian lymphatic vasculature

... debate over the origin of the mammalian lymphatic vasculature. Understanding the development of the lymphatic vasculature is integral to understanding its ... tumor metastasis). The adult mammalian lymphatic vasculature is derived from a few embryonic lymph ...

How cancer spreads by aggregating platelets

... also found that podoplanin present within lymphatic vessels which carry plasma and white blood cells ... bind together may provide information on how lymphatic vessels form and work. Suzuki-Inuoue and ... formation of blood clots and the development of lymphatic vessels. ...

No more big stink: scent lures mosquitoes, but humans can't smell it

... species, which transmit such diseases as West Nile virus, encephalitis and lymphatic filariasis. Oviposition or gravid female traps draw blood-fed ... mosquitoes, they set up traps in Recife, Brazil, a city endemic for lymphatic filariasis. ...

DFG to establish 10 new collaborative research centers

... Centre 54 Growth and Survival, Plasticity and Cellular Interactivity of lymphatic Malignancies will study how cancer cells adapt to their surroundings in ... Hodgkin's lymphoma, multiple myelomas and other malignant diseases of the lymphatic system. (Host institution: Charit University Hospital of the Humboldt ...

Cancer's distinctive pattern of gene expression could aid early screening and prevention

... Researchers are comparing chemical alterations, called DNA methylation, in the body's basic building block in healthy colon, breast, brain and lymphatic cells and their cancerous counterpart to find telltale patterns that could one day be detected in the blood, urine or feces. The patterns could ...

Colorectal cancer

... metastases." Metastases arise when single cells break off from the primary tumor and spread to other body regions via the blood vessels or the lymphatic system. In colorectal cancer, these cells usually settle in the liver, lungs, or lymph nodes. Since the affected patient seldom feels pain or shows ...

DNA barcoding of mosquito species deployed in bid to end elephantiasis

... Philadelphia-based JRS Biodiversity Foundation, is pioneering the use of DNA "barcodes" to map menacing mosquito species in West Africa that spread lymphatic filariasis (LF), commonly known as elephantiasis. Using a short DNA sequence from a particular genome region, scientists can obtain a species' ...

Building the lymphatic drainage system

... Our bodies' tissues need continuous irrigation and drainage. Blood vessels feeding the tissues bring in the fluids, and drainage occurs via the lymphatic system. While much is known about how blood vessels are built, the same was not true for lymph vessels. Now though, Norrmn et al. have identified two ...

Brain structure assists in immune response, according to Penn vet study

... Toxoplasma, a common parasite of humans, is found in the brains of approximately 30 percent of the population. Yet, because the brain lacks its own lymphatic system for localized immune response and the blood brain barrier limits antibody entry, researchers have found it provides unique challenges for the ...

Novel technique changes lymph node biopsy, reduces radiation exposure

... patients to determine if the cancer has metastasized. "To find the SLN, doctors inject radioactive particles and a blue dye into the breast. The lymphatic system gobbles up the injected material, treating it as foreign matter and accumulating it in the SLN. The radioactive particles can be detected ...

Novel technique changes lymph node biopsy, reduces radiaiton exposure

... patients to determine if the cancer has metastasized. "To find the SLN, doctors inject radioactive particles and a blue dye into the breast. The lymphatic system gobbles up the injected material, treating it as foreign matter and accumulating it in the SLN. The radioactive particles can be detected ...

Worm genome offers clues to evolution of parasitism

... malayi , whose genome was sequenced in 2007, only have about 20,000 and 12,000 protein-coding genes, respectively. Infection with B. malayi causes lymphatic filariasis, which can lead to elephantiasis, a grotesque enlargement of the arms, legs and genitals. Interestingly, the P. pacificus genome ...

Fuzzy logic water quality

... irrigation development, and flood mitigation have led to an increased incidence of diseases, such as malaria, Japanese encephalitis, schistosomiasis, lymphatic filariasis and others. Water quality assessment is an essential part for maintaining good water quality, explained by Ramani Bai Gopinath and ...

Quantitative PET imaging finds early determination of effectiveness of cancer treatment

... to quantify images, added Meignan. Diffuse large B-cell lymphoma is a fast-growing, aggressive form of non-Hodgkin lymphoma, a cancer of the bodys lymphatic system. Although there are more than 20 types of NHL, DLBCL is the most common type, making up about 30 percent of all lymphomas. In the United ...

Migration alert -- How tumor cells home in on the lymphatic system

... description of how tumor cells migrate to the lymphatic system in the early stages of tumor metastasis. ... Scientists know that tumor cells spread via the lymphatic system, but they don’t understand the details of ... percolates from the tumor towards nearby lymphatic vessels. The EPFL research shows how tumor cells ...

Malaria parasites develop in lymph nodes

... However, many of the parasites also invaded lymphatic vessels. About 25 percent of the parasites injected by the mosquito bites were drained by lymphatic vessels and ended up in lymph nodes close to the ... believed that, although both blood and lymphatic vessels take up Plasmodium parasites, they all ...

Tadpole soon to help in the fight against cancer and lymphedema

... in our bodies through a complex network of lymphatic vessels, of which little is known. This network ... of tadpoles. This accelerates research of the lymphatic vessel network. With tadpoles one can now very ... a part in the development and functioning of the lymphatic vessel network. This is a first step in the ...

Risk of lymphoma increases with hepatitis C virus infection

... are at an increased risk of developing certain lymphomas (cancers of the lymphatic system), according to a study published in the May 8, 2007, issue of the ... at the relationship between hepatitis C virus infection and cancers of the lymphatic system," said NCI Director John E. Niederhuber, M.D. "Since so much is ...

Scientists discover why cornea is transparent and free of blood vessels, allowing vision

... C and D also bind with VEGFR-3, which is usually found on cells lining lymphatic vessels, to stimulate the growth of lymphatic vessels. Dana's team began to suspect the involvement of VEGFR-3 in ...

APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal

... foreign invaders, rip them apart and bring the pieces (antigens) via the lymphatic system to the nearest lymph node. When the dendritic cell arrives at the ... starts with a flea that deposits a few bacteria, which travel via the lymphatic system to the lymph node and proliferate to huge numbers. One of the ...

A New Era of Hope for the World's Most Neglected Diseases

... Chagas Disease (American trypanosomiasis), Schistosomiasis, lymphatic Filariasis (elephantiasis), Onchocerciasis (river blindness), ... a single delivery mechanism in order to simultaneously target lymphatic filariasis, onchocerciasis, soil-transmitted helminthiases, ...

Scientists develop nanotech-laser treatment that kills cancer cells without harming healthy tissue

... kind of cancer cell." One example is lymphoma, or cancer of the lymphatic system. Like many cancers, lymphoma cells have well-defined surface ... determine if shining near-infrared light on the animal's skin will destroy lymphatic tumors, while leaving normal cells intact. "It's a really interesting ...

Enzyme delivered in smaller package protects cells from radiation damage

... & Trade Center, Seattle. Combined with intensive chemotherapy, high dose whole-body irradiation often is given to patients with blood and lymphatic cancers to wipe out their bone marrow cells prior to subsequent transplantation of hematopoietic stem cells, bone marrow stem cells or peripheral ...

The quest for an effective HIV vaccine presents new possibilities, challenges

... the body." Once HIV enters the body, it infects crucial CD4+ T cells, replicates, spreads throughout the body and establishes HIV reservoirs in lymphatic tissues. Within weeks of exposure, virus levels peak and then decline to levels that may remain low for months or years. It is believed that CD8+ T ...

Cancer-killing invention also harvests stem cells

... way of obtaining stem cells that can be differentiated into other, useful cells. King's team can capture significant amounts of cells of the lymphatic and circulatory systems, and potentially mesenchymal stem cells, which are unspecialized cells that form tissue, bone, and cartilage. Current ...

Development of gene therapy

... deficiency and chronic granulomatous disease. There are also initial indicators that point to the efficacy of gene therapy in treating chronic lymphatic leukaemia and haemophilia B. But successes in clinical testing come with their share of setbacks, such as the currently slight margin of therapeutic ...

Scientists find a key to immune system's ability to remember

... which initiate the fast and furious response when that same pathogen comes calling again years later. Unlike naïve T cells, which are confined to the lymphatic system, memory T cells are found everywhere in the body, enabling them to sense and react more quickly when an infectious agent is reencountered. ...

Speeding discovery of the 'human cancer genome'

... is a multistep process that requires and selects for tumor cells capable of escaping their normal microenvironment, traversing into and out of lymphatic or blood vessels, and proliferating in new "soil," the researchers said. Metastasis is particularly important in skin cancer, Chin added, as the ...

Researchers discover why melanoma is so malignant

... process that requires cancer cells to jump through many hoops. The cells first must invade a nearby tissue, then make their way into the blood or lymphatic vessels. Next they must migrate through the bloodstream to a distant site, exit the bloodstream, and establish new colonies. Researchers have ...

A bacterial genome reveals new targets to combat infectious disease

... Slatko and colleagues present the complete DNA sequence of the Wolbachia pipientis strain within Brugia malayi, a parasitic nematode responsible for lymphatic filariasis. This Wolbachia genome is small, only about a million base pairs, and many metabolically critical genes have degraded through mutation ...

Enzyme allows B cells to resist death, leading to leukemia

... the most common leukemia in adults and is characterized by the progressive accumulation of mature B lymphocytes in the blood, bone marrow, and lymphatic tissues. It is believed that in the early stages of disease, B-CLL is the result of an undefined defect in the programmed signals that trigger normal ...

Imaging Lymph Nodes with Nanoparticles

... of prognosis and determination of the most appropriate treatment. And an essential part of this work up is assessing whether or not there has been lymphatic spread. Current methods include surgical removal of nodes for examination and various types of imaging, ranging from ultrasound to newer technologies ...