Lymph in Biological News

Building the lymphatic drainage system

... vessels are built, the same was not true for lymph vessels. Now though, Norrmn et al. have ... Foxc2 and NFATc1. Foxc2 had been implicated in lymph vessel development already, but Norrmn and ... the factor specifically regulates a late stage of lymph development when large, valve-containing vessels ...

New origin found for a critical immune response

... were thought to move from peripheral tissues into lymph nodes to stimulate T cell responses. The Duke ... cell type in the blood, that moved directly into lymph nodes after infection. "The result speaks to ... dendritic cells from peripheral tissues to lymph nodes. The Duke researchers generated a TH1 ...

New technique for cancer screening

... cells in the background of non-tumor cells in lymph nodes and other organs. Most importantly, because ... methylation analysis to predict the presence of lymph node metastases and to detect very small tumor deposits in lymph nodes with known micrometastatic disease in a ...

Novel technique changes lymph node biopsy, reduces radiation exposure

... Louis, have used gold nanocages to map sentinel lymph nodes (SLN) in a rat noninvasively using PAT. ... Their work can minimize invasive surgical lymph node biopsy procedures to determine if breast ... a Geiger counter held to the breast to locate the lymph nodes. Then, the doctors surgically open the ...

Novel technique changes lymph node biopsy, reduces radiaiton exposure

... Louis, have used gold nanocages to map sentinel lymph nodes (SLN) in a rat noninvasively using PAT. ... Their work can minimize invasive surgical lymph node biopsy procedures to determine if breast ... a Geiger counter held to the breast to locate the lymph nodes. Then, the doctors surgically open the ...

Making flies sick reveals new role for growth factors in immunity

... Johnson's project. Since both the heart and the lymph glands in the fly originate from the same tissue ... goes awry in fruit fly Dpp mutants that the lymph glands might also be affected. "One of the functions of the lymph gland in fruit flies is to produce blood cells," ...

UCLA researchers locate and image prostate cancer as it spreads to lymph nodes

... locate the diseased cells as they spread to the lymph nodes, the first place prostate cancer goes ... The tiny cancer metastases in the pelvic lymph nodes are very difficult to find using ... . The spread of prostate cancer to the pelvic lymph nodes is the most reliable indicator that the ...

Breast cancers behave differently before and after the age of 70

... with aggressive tumours that have spread to the lymph nodes. But after 70, the cancer is increasingly ... there has been conflicting evidence on aging and lymph node involvement and this study is the first to ... other sites in the body. The effect of age of lymph node positivity is not straightforward. There ...

St. Jude settles century-old debate on origin of mammalian network of lymphatic vessels

... from the spaces surrounding the cells. Failure of lymph transport promotes lymphoedema, a disfiguring, ... These LEC progenitor cells were thought to form lymph sacsstructures from which the entire lymphatic ... labeled LECs as they left the veins, formed the lymph sacs and spread through the entire mouse embryo. ...

Lymph nodes can be key in spreading prion infectivity

... lymph nodes can be crucial for spreading low doses of ... Research. While we can show that the regional lymph node plays no pivotal role in the neuroinvasion ... we cannot rule out the possibility that lymph nodes are still involved in the distribution of ...

Presence of gene mutation helps guide thyroid cancer treatment

... toward a higher rate of cancer formation in the lymph node due to metastasis (the transfer of tumor ... PTC, the mutation was associated with older age, lymph node and other metastasis, and was an independent ... approach to surgery, such as removing the central lymph node along with the diseased thyroid, to avoid ...

JCI table of contents: Aug. 16, 2007

... (IDO) and that are isolated from the lymph nodes that drain the site of the tumor. Now, ... mouse IDO-expressing pDCs from tumor-draining lymph nodes directly activate the suppressive function ... Importantly, immune suppression in tumor-draining lymph nodes was abrogated by treating mice with both a ...

DNA barcoding of mosquito species deployed in bid to end elephantiasis

... is identifying species spreading the worm larvae that clog the human lymph system, often causing grotesque swelling. By revealing the menace ... often appear years after infection. The disease can permanently damage the lymph system and kidneys, which results in fluid collecting and swelling in the ...

Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection

... a cell-surface antenna that receives signals telling T cells to leave the lymph nodes and patrol the body. When this antenna was disabled, the T cells failed to leave the lymph nodes (chemotaxis), reducing their numbers in the bloodstream. Taking this ...

Team finds breast cancer gene linked to disease spread

... to 27.1 percent for patients with cancer that has traveled beyond the lymph nodes to bodily organs, according to the federal agency's statistics. ... thought that breast cancer spreads first to nearby tissue and underarm lymph nodes before spreading to other parts of the body. They now believe cancer ...

Immune cells reveal fancy footwork

... Suzanne van Helden discovered that before dendritic cells move to the lymph nodes they lose their sticky feet. This helps them to move much faster. ... process. During this maturation the dendritic cells migrate to the lymph nodes to activate T cells. Suzanne van Helden studied the adhesion and ...

Biomarkers allow doctors to match therapy to patient

... CVDP has conducted clinical trials with the HER2 E75-peptide vaccine in lymph nodepositive and lymph nodenegative patients with breast cancer who demonstrated varying levels ...

PET/CT imaging proves golden for detecting cancer in children

... in Baltimore, Md. In our study, we found that PET/CT can detect small lymph node lesions diagnosed as negative with conventional (or anatomical) ... system malignancies (30 patients had lymphomacancer that affects the bodys lymph nodes and other organs that are part of the bodys immune and blood-forming ...

New nanoparticle vaccine is more effective but less expensive

... they flow through the skins extracellular matrix, making a beeline to the lymph nodes. Within minutes, theyve reached a concentration of DCs thousands of ... as a danger signal, and to exploit the slow interstitial flow towards the lymph nodes are completely new. But it meant that our particles had to be much ...

'Western' diet linked to increased risk of colon cancer recurrence

... as being localized to the large bowel area with cancer cells in the lymph nodes near the tumor. The investigators found that those who most closely ... for factors such as gender, age, body mass, degree of cancer spread to lymph nodes, and physical activity level. Investigators do not know why such a ...

Colorectal cancer

... spread to other body regions via the blood vessels or the lymphatic system. In colorectal cancer, these cells usually settle in the liver, lungs, or lymph nodes. Since the affected patient seldom feels pain or shows other symptoms, the tumor is frequently not discovered until it has already formed ...

IMPAKT -- Breast cancer conference highlights

... Friday, 8 May 2009 (15:15) A new rapid test can confirm quickly and accurately that breast cancer has most likely not spread into adjacent lymph nodes, offering reassurance to patients and reducing the need for a second operation. The new technique allows you to make the diagnosis of micro ...

Ambati study published in PNAS

... it "stunning." But these side effects could themselves find useful application, for example, in cornea transplantation, where growth of new blood and lymph vessels is believed to be a major cause of graft failure. The new findings are published in this week's online issue of Proceedings of the ...

UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs

... Kermit Carraway, senior author of the study, knew that Muc4 was not always expressed in primary breast cancer tumors, yet it could be present in lymph node metastases. He suspected that it may have a specialized function in the process of metastasis. "Breast cancer deaths are caused by ...

Amniotic fluid may provide new source of stem cells for future therapies

... blood of the transplanted mice was examined every four weeks, and after 16-18 weeks the blood-forming organs (bone marrow, spleen, thymus, and lymph nodes) of the mice were dissected. Transplants using mouse AFKL cells were found to be successful; newly formed white blood cells of all lineages ...

A new way to assemble cells into 3-D microtissues

... we can study how systems of cells work together to produce complex organ functions. Examples include how T cells and B cells work together in the lymph nodes to mount an immune response against foreign antigens." Practical challenges remain, such as scaling up the production of tailored ...

Shades of 1918? New study compares avian flu with a notorious killer from the past

... specifically, dendritic cells whose job it is to phagocytize protein components from the virus and present these to T cells, either locally or at the lymph nodes that drain the lungs. Normally, through this process, specific antibodies are then produced to combat the viral infection. Tissue sampling for ...

Implants mimic infection to rally immune system against tumors

... enter an implant's pores, where they are exposed to antigens specific to the type of tumor being targeted. The dendritic cells then report to nearby lymph nodes, where they activate the immune system's T cells to hunt down and kill tumor cells throughout the body. "Much as an immune response to a ...

For fats, longer may not be better

... were found in mouse studies; high amounts of dietary oleic acid, but not butyric acid, promoted significant absorption of LPS into the blood and lymph nodes and subsequent expression of inflammatory genes. Eckhardt and colleagues believe these findings may pave the way for future therapies for ...

TGen, Scottsdale Healthcare, Mayo Clinic study new drug to stimulate immune system of cancer victims

... Healthcare, said the new drug appears promising. "VTX-2337 is a new, novel, small molecule aimed at stimulating the immune cells in the blood, lymph nodes, and in and around the tumor. It represents an exciting new class of agents for cancer therapy with good preclinical evidence of activity,'' ....

Reprogrammable cell type depends on a single gene to keep its identity

... is also part of the immune system that traps and attacks invading organisms and is a primary route for malignant tumor dissemination to the regional lymph nodes. "The new finding adds to a growing body of evidence showing that some fully differentiated cell types can exhibit great plasticity and ...

Seemingly suicidal stunt is normal rite of passage for immune cells

... homing of lymphocytes," says Sleckman. "Lymphocytes are made in the bone marrow and the thymus, and they have to move to other niches, including the lymph glands, to do their work." In addition to the young lymphocyte, scientists are aware of other instances where DNA is normally and regularly ...

When particles are so small that they seep right through skin

... and Biomedical Engineering and an expert on the properties of nanoparticles. Other scientists have found that the particles can accumulate in the lymph system, the liver, the nervous system, and in other areas of the body. In her study, she found that the particles accumulate around the hair ...

New synthetic form of protein holds promise to stop cancer spread

... target cellular receptor, CXCR4, played an important role in the migration of cancer cells to common sites of tumor formation, such as bone marrow, lymph nodes, liver and lung tissue. Dr. Dwinell's laboratory established that CXCL12 expression was key to interfering with the progression of cancer. ...

Anti-tumor therapy with endoscopic ultrasound may fight cancer more safely and effectively

... with real time imaging, EUS can help physicians to detect blood flow in blood vessels in and around tumors as well as detect and biopsy tumors and lymph nodes as small as 3-5 mm. This allows doctors to avoid puncturing blood vessels when sampling tissue, get the most accurate view of the cancer and ...

Researchers devise means to create blood by identifying earliest stem cells

... These hemangioblasts go on to become either blood cells or endothelial cells, which form the inner lining of the heart, veins and arteries, and lymph vessels. The research grew out of Zambidis' interest in understanding the complex biological processes of blood development and the ...

From foe to friend: Researchers use salmonella as a way to administer vaccines in the body

... of the bacteria causing pneumonia that itself is not deadly." In experiments, the genetically modified Salmonella enterica bacterium colonizes the lymph tissues of the host and manufactures a protein from the S. pneumoniae bacterium, which then triggers a strong antibody response. Unlike most ...

Treatment delays result in poor outcomes for men with breast cancer

... was that the disease often had already reached an advanced stage when the men were diagnosed. In 50% of cases the cancer had already reached the lymph nodes, a development that increases the likelihood of metastatic spread to other parts of the body. All the men underwent surgery to remove their ...

New chemotherapy combo produces side effects, but no extra efficacy, in early breast cancer patients

... and rate of breast conservations, said Professor von Minckwitz. The overall rate of pathologic complete responses (pCRs) no cancer in the breast or lymph nodes was 29.7%. Nor did the length of treatment appear to make a statistically significant difference. What the scientists did find was that ...

DFG to establish 10 new collaborative research centers

... Cellular Interactivity of Lymphatic Malignancies will study how cancer cells adapt to their surroundings in patients suffering from diseases of the lymph nodes, thus possibly making it harder or even impossible for them to recover. Participating researchers from Berlin and Munich will combine animal ...