Lupus in Biological News

UT Southwestern researchers probe kidney damage, protection in lupus

... damage associated with the autoimmune disease lupus is linked to a malfunction of immune cells that ... the kidney. When the researchers treated the lupus mice with a substance that blocks CXCR4, the symptoms of lupus significantly diminished; many symptoms of kidney ...

Gene linked to lupus might explain gender difference in disease risk

... also shows that blocking IRAK1 action shuts down lupus in an animal model. Though many genes may be ... also represents a breakthrough in explaining why lupus seems to be sex-linked, Dr. Mohan said. For ... gene as a disease susceptibility factor in human lupus raises the possibility that the gender difference ...

The Alliance for Lupus Research announces 2008 grantees

... The Alliance for lupus Research (ALR) recently announced it will award ... be funded through ALRs Target Identification in lupus (TIL) and Pilot Grant programs. TIL ... of Health, the ALR, or other funding agencies. lupus causes unpredictable symptoms ranging from ...

Genes linked with lupus are revealed, giving hope for new treatments

... found evidence of an association between lupus (systemic lupus erythematosus or SLE) and mutations in several ... potentially opening up options for new therapies. lupus is a complex condition, mostly affecting women, ...

DNA variations signal lupus risk

... in human DNA that signal a higher risk for lupus in women who carry them. Some of these variations are more common in relatives of lupus patients, which may help future studies examining whether lupus is more prevalent among certain racial and ethnic ...

Steps toward Stopping Autoimmune Disease

... has identified multiple genes linked to systemic lupus erythematosus (SLE), or lupus, a debilitating ... affects an estimated 1.4 million Americans. lupus can affect the joints, kidneys, heart, lungs, ... to diagnose. In 2005 the Alliance for lupus Research (ALR) formed and supported the ...

UT Southwestern secures $5 million NIH grant for lupus research

... will investigate the autoimmune disease systemic lupus erythematosus (SLE). There are a limited ... turning them into new ways to help patients with lupus and other autoimmune diseases. Under principal ... Baylor Institute of Immunological Research. lupus research brings together all of these researchers ...

New approach for attacking lupus identified

... part. We tested that in an animal model of lupus and we were able to show, in vivo, that you can ... but maintain the antiviral effects. lupus is an autoimmune disease that can affect various ... even life-threatening problems. According to the lupus Foundation of America, an estimated 16,000 ...

Profound immune system discovery opens door to halting destruction of lupus

... (New York, NY) A researcher funded by the lupus Research Institute (LRI) has discovered an ... kinasesdeveloped an autoimmune illness similar to lupus in humans. In the Cell article, Dr. Lemke now ... as relatively tranquil. But in people with lupus and certain other autoimmune illnesses, the TAM ...

Lupus gene finding prompts call for more DNA samples

... study the underlying causes of the disease. lupus or Systemic lupus Erythematosus (SLE) is an autoimmune disease ... in the OX40L gene that amplify the risk of lupus do so by increasing the amount of OX40L present ...

Lupus Research Institute strategy delivers $30 million in national funding

... NEW YORK, NY The lupus Research Institute (LRI) strategy of backing ... advance new scientific approaches to how and why lupus occurs, and what can be done to prevent and treat ... in the prime of their lives. No one knows why lupus occurs, or how to prevent or cure it. There hasnt ...

Study identifies genetic risk factor for rheumatoid arthritis, lupus

... diseases: rheumatoid arthritis (RA) and systemic lupus erythematosus (lupus). These research findings ... with disease in large collections of RA and lupus patients and controls. Among the variants were ... STAT4 pathway plays such a crucial role in RA and lupus that new therapies targeting this pathway would ...

UT pathologists believe they have pinpointed Achilles heel of HIV

... abzymes are derived from HIV negative people with the autoimmune disease lupus and a small number of HIV positive people who do not require treatment and ... student, said, "We discovered that disturbed immunological events in lupus patients can generate abzymes to the Achilles heel of HIV. The human ...

American Chemical Society's Weekly PressPac -- Sept. 26, 2007

... muscles, joints, kidneys and other body parts. Current treatments for lupus also known as SLE include high doses of steroids and other medications ... of Symptoms and Prolonged Survival in Two Murine Models of Systemic lupus Erythematosus DOWNLOAD PDF ...

UAB professor receives HudsonAlpha Innovation Prize

... cancer, but when T cells overreact and turn on the body, we see immune-mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, lupus and multiple sclerosis. "Our studies have contributed to the identification of a new class of T cells, called Th17 cells, which are now recognized as ...

Fireflies and jellyfish help illuminate quest for cause of infertility

... infertility. Prolactin has been linked to more than 300 biological functions. It is believed to play a role in autoimmune diseases, such as lupus and rheumatoid arthritis, as well as in the inflammation of cells and tissues. Scientists from the Universities of Edinburgh, Manchester and ...

Researchers identify 4 genetic hotspots associated with psoriasis

... induced inflammation of psoriasis and psoriatic arthritis. Polymorphisms of TNFAIP3 and TNI1 are also associated with two other autoimmune diseases, lupus and rheumatoid arthritis. The number of DNA sites discovered to have strong associations with psoriasis has increased from one to 10 in the past ...

Jefferson scientists discover a key protein regulator of inflammation and cell death

... said. "Such therapeutics may be useful for the treatment of nucleic aciddependent pathogenic and autoimmune diseases, such as arthritis and systemic lupus erythematosus," Dr. Alnemri said. ...

LSUHSC awarded patent for compound inhibiting cancer and other diseases

... of the retina, hyperparathyroidism, carotid obstructive disease, chronic uveitis/vitritis, mycobacterial infections, Lyme disease, systemic lupus erythematosis, psoriasis, myopia, optic pits, Stargarts disease, chronic retinal detachment, hyperviscosity syndrome, toxoplasmosis, trauma, ...

Pre-eclampsia may be autoimmune disease

... Unlike antibodies which attack foreign substances and clear diseases from the body, autoantibodies attack their own cells and cause conditions like lupus in which a person's immune system attacks the body's own organs and tissues, said Xia, the senior author. In the case of pre-eclampsia, ...

Montreal Heart Institute and Mount Sinai Hospital researchers contribute to Crohn's disease study

... lead to Crohn's disease as well as which of these pathways are in common with other immune mediated diseases such as autoimmune diabetes, lupus and rheumatoid arthritis," says Dr. Rioux, co-author of the current study. "This is breakthrough research for patients with Crohn's disease and ...

Sugar linkage could lead to better treatment for autoimmune diseases

... structure that confers anti-inflammatory activity to a glycoprotein antibody that could lead to improved treatment of autoimmune diseases like lupus or rheumatoid arthritis. The study, reported in a recent edition of the journal Science, was led by immunologist Jeffrey Ravetch of Rockefeller ...

Immunosuppressant further linked to birth defects

... diseases, such as generalized lupus. In fact, 3 out of 10 babies described in the literature regarding these defects had mothers on MMF because of lupus nephritis. Led by Dr. Antonio Perez-Aytes and Dr. Maximo Vento of the Newborn Research Unit at the Hospital Universitario Materno-Infantil La Fe, ...

Scientists associate 6 new genetic variants with heart disease risk factor

... to identify genetic differences that influence a variety of disorders, including type 2 diabetes, Crohns disease, rheumatoid arthritis, systemic lupus erythematosus, obesity, age-related macular degeneration, and prostate cancer. ...

UT Southwestern scientist honored among best in Texas research

... to cancer, aging, neurodegenerative diseases such as Alzheimers, infectious diseases and potentially to autoimmune disorders such as systemic lupus erythematosus. The ultimate goal of our research is to develop new drugs that will increase beclin 1 expression and autophagy to help treat ...

2 genes are important key to regulating immune response

... (IL-10). The discovery fills in an important "missing link" in a biochemical pathway that's long been tied to disorders ranging from lupus and Type 1 diabetes, to cancer and AIDS. "IL-10 production has to be kept in a delicate balance for health," explains study senior researcher Dr. ...

HGS announces positive Phase 2 LymphoStat-B at ACR meeting

... disease flares over time, and was well tolerated through 2.5 years on treatment in combination with standard of care in patients with active systemic lupus erythematosus (SLE). The results will be the subject of an oral presentation today in Boston at the Annual Scientific Meeting of the American ...

Study reveals a key to blood vessel growth and possible drug target

... basis of how endothelial cell-related pathologies such as cancer, diabetic eye complications, known as retinopathies, atherosclerosis and system lupus develop, Santoro said. It can also help us design new therapeutic strategies for these diseases. The team hopes that future researchers will ...

Cracking open the black box of autoimmune disease

... Autoimmune diseases such as type 1 diabetes, lupus and rheumatoid arthritis occur when the immune system fails to regulate ... Ptpn22 is strongly associated with type 1 diabetes, rheumatoid arthritis, lupus and Graves' disease, but the gene had not been previously linked to ...

Can you hear me now? Scientists find previously unknown receptors on adult stem cells

... implications for treating leukemias and autoimmune diseases such as lupus and rheumatoid arthritis. "We have long known that so-called ... responses. That could provide a powerful tool to fight cancer, lupus and many other diseases." ...

Researchers map of genetic variations implicated in disease

... to a wide range of diseases, including type 1 diabetes, systemic lupus erythematosus and myasthenia gravis. The PGF haplotype provides protection ... and predisposes to other diseases such as multiple sclerosis and systemic lupus erythematosus. The QBL haplotype is positively associated with Graves' ...

Langerhans cells regulate immune reactions in the skin

... of the mechanisms underlying many skin disorders such as psoriasis, lupus and skin cancer. Dendritic cells are found throughout the body and are ... this mechanism could result in chronic inflammatory skin conditions like lupus and psoriasis, said Shlomchik. "This is the new theory we would now like ...

Yale scientists identify structure for RNA quality control

... mechanism of RNA quality control. In the autoimmune disorders systemic lupus erythematosus and Sjogren's syndrome, Ro is known to be an autoantigen, ... mechanism of RNA quality control. In the autoimmune disorders systemic lupus erythematosus and Sjogren's syndrome, Ro is known to be an autoantigen, ...

A revolution in the monitoring of unborn babies

... device will be especially helpful in monitoring fetuses whose mothers have medical conditions like diabetes, autoimmune conditions such as systemic lupus erythematosus and Sjogren’s syndrome and obstetric cholestasis. It will also be useful in monitoring fetuses identified as growing poorly or where it ...

New insights into autoimmunity and depression

... Systemic lupus erythomatosus (SLE), often simply called lupus, is a complex autoimmune disease marked by joint pain, skin rashes, extreme fatigue, and depression, ...

Research suggests beta agonists may alter the immune system

... medications ?as well as similar chemicals our bodies produce during times of high stress ?may worsen diseases such as asthma, heart failure and lupus that involve inflammation. The scientific team led by Raymond Penn, Ph.D., and Matthew Loza, Ph.D, found that beta-agonists, such as those used in ...

Drug dials down the energy within cells, UM researchers find

... medications such as Valium and Xanax. In previous work, Glick's group showed that Bz-423 reduces effects of arthritis and the autoimmune disease lupus in mice and may be useful in treating psoriasis. Unlike conventional drugs for these conditions, which can't discriminate between healthy and ...

A single sugar found responsible for an antibody's ability to treat inflammation

... and inhibitory receptors on the cells that trigger inflammation, rendering the pro-inflammatory autoantibodies in autoimmune diseases, like lupus and arthritis, less inflammatory. The next logical step then, Ravetch says, was determining how the IgG molecules in IVIG preparation could have an ...

Big hips, big belly? It's in your genes, Joslin-led study shows

... system, as it does in MS. "The mounting evidence that relates Epstein-Barr virus infection to other autoimmune diseases, particularly systemic lupus erythematosus (lupus), suggests that Epstein-Barr virus may have a broad role in predisposing to autoimmunity," or failure of the immune system to ...