Study finds genetic links to age of first menstrual period and menopause
... paper, "Genome-wide association studies identify loci
associated with age at menarche and at natural ... statistical power and revealed a total of two loci
for timing of menarche and four for timing of ... at Harvard Medical School, added, "Of the loci
for timing of menopause, three were already ...
Estimation of isolation times in the Drosophila simulans complex
New DNA sequence variation data for 17 loci
corroborate the prior observation from 13 loci
that DNA sequence divergence is reduced in genes ... size) from the multilocus DNA sequence data.
in regions of low recombination have lower ...
A tall story: New research adds to growing body of knowledge of genetics of height
... Switzerland, the researchers have identified 20 loci
(regions of genetic code), common variations of ... tumour growth, for example."
Half of the new loci
identified by Dr Frayling and colleagues contain ... growth of cartilage.
However, of the twenty loci
identified by Dr Frayling and colleagues, half ...
Evolution of the sexes: What a fungus can tell us
... of DNA called "mating-type loci."
have been found in a number of higher-level ... Heitman said.
To identify the mating-type loci
in Phycomyces, the researchers used a computer search to compare known mating-type loci
in the genomes of other fungal lineages and then ...
Domestication of Capsicum annuum chile pepper provides insights into crop origin and evolution
... and his team examined DNA sequence variation and patterns at three nuclear loci
in a broad selection of semiwild and domesticated individuals. Dr. Kim et ... long-distance seed dispersal by birds and mammals.
Across the three loci
studied, Dr. Kim and colleagues found an average reduction in diversity of ...
New and improved tomato analyzer
A main objective of the study was to investigate the quantitative trait loci
(QTL), which are parts of the genetic code that control fruit shape. The ... the exterior silhouette alone.
In the 'Sausage' species of tomato, two loci
were identified as controlling more than 50% of the internal shape index, ...
Land iguanas under continuing threat on Galapagos archipelago
... obtain blood or tissue samples from subjects and examine multiple loci
across their genome. In so doing, researchers are able to draw conclusions ... the authors investigated genetic variation at nine nuclear microsatellite loci
among more than 700 land iguanas from six island habitats. For comparison, ...
Plants in the fourth dimension
... the clock genes in other plants and have found quantitative trait loci
(QTLs) for these genes in the model crop species Brassica rapa (rapeseed). ... a trait, resulting in, for example, a range of heights or eye color. Such loci
are consistent with multiple interlocking genes in the clock mechanisms of ...
Complexity of Crohn's disease revealed as 'gene' count tops 30
... at some point.
Previous studies have already identified 11 genes and loci
(regions of the genome typically including one or more genes) that ... number has now almost trebled to thirty-two.
Amongst the findings are loci
containing genes known to be implicated in a number of other common ...
The 21st century tomato
... genes located together in chromosomal regions called quantitative trait loci
(QTLs), because they produce a range of values in fruit or plant size or ... species. In this way, over 1200 metabolic QTLs or quantitative metabolic loci
(QMLs) were identified and analyzed. Almost 900 of these QMLs were found ...
Evolution of fruit size in tomato
... of genes that influence a particular trait are called quantitative trait loci
(QTLs). When a trait is influenced by one gene, it is much simpler to ... both well-known and obscure solanaceous species. Conservation of genes and loci
across a number of these species suggests that the knowledge gained from ...
Microarray sequence capture speeds large-scale resequencing of targeted genomic regions
... all genes or exons. The study, entitled Direct Selection of Human Genomic loci
by Microarray Hybridization, appears online (ahead of print) in the ... enables high-performance targeting of thousands of specific genes or loci
using a single microarray hybridization-based enrichment process. The ...
Prostate Cancer Translational Research in Europe meeting: Search for biomarkers continues
... on PSA genetics may improve utility in screening. Rafnar also pointed out that although ... work remains. finding causative variants at known loci
The lecture by Prof. Freddie Hamdy (Oxford, UK), 'What is the best practice in bio-banking?' focussed on the dilemmas in ...
Identification of genetic variants affecting age at menopause could help improve fertility treatment
... menopausal age, and a possible indication of the gene involved, but not a total proof of function", said Ms Stolk. "When we have a larger group of loci
we intend to perform functional studies to study the exact biology and effect of this association."
The scientists say that it may be several year ...
When every photon counts
... of the conventional architecture is that the central positioning of the active eurochromatin allows more interactions between neighbouring gene loci
and with the transcription apparatus in three dimensions; euchromatin in a peripheral shell factually has only two dimensions for contacts. However, ...
Genomatix gets patent for comparative genomics method
... that it was issued patent No. EP 1 800 232 B1, "Identification and assignment of functionally corresponding regulatory sequences for orthologous loci
in eukaryotic genomes" by the European Patent Office.
The Patent relates to a sophisticated method for identification of networks of functionally ...
Gene to reduce wheat yield losses
... small influence, but recent work led by the John Innes Centre has challenged this view. Several stretches of the genome, known as quantitative trail loci
(QTLs) have been identified that exert large effects on yield, in different environments. Dr Uauy will lead the effort to find the precise genetic ...
Mayo Clinic researchers suspect a novel gene is causing restless legs syndrome in a large family
... that problem with drug therapy," he says. They can also trace the molecular route from the gene mutation to the disorder, and see if the other loci
linked to the syndrome lie along this pathway. So far, no one has found a definitive link between restless legs syndrome and a specific gene ...
Scientists uncover new class of non-protein coding genes in mammals with key functions
... of four different types of mouse cells (including embryonic stem cells and cells from various tissue types), they found an astounding 1,586 such loci
that had not been previously described. The researchers also found that the vast majority of these genomic regions are transcribed into lincRNAs, and ...
Easton honored with inaugural AACR Outstanding Investigator Award in Breast Cancer Research
... previously been associated with breast cancer: FGFR2, TNRC9, MAP3K1, LSP1 and a locus on 8q. Subsequently, he demonstrated how variations in these loci
are associated with increased risk of breast cancer in BRCA mutation carriers. These observations may become important in counseling women who carry ...
Two from one: Pitt research maps out evolution of genders from hermaphroditic ancestors
... said, a gradual decline in the number of hermaphroditic plants is to be expected. Consequently, fewer chromosomes with both fertility versions of the loci
will be passed on and the frequency of single-sex individuals will increase.
Yamanaka eliminates viral vector in stem cell reprogramming
... integration into the genome also lays to rest concerns that the reprogramming event might be dependent upon viral integration into specific genomic loci
that could mediate the genetic switch.
"The iPS field and stem cell research in general is progressing rapidly," said GICD Director Deepak ...
Genetic finding implicates innate immune system in major cause of blindness
... are seven-times higher for patients with AMD than for those unaffected.
Researchers have previously identified a number of other genes or genetic loci
(regions of the genome) which affect a person's susceptibility to the disease. Now, in research part-funded by the Wellcome Trust, researchers at the ...
Mate selection more biologically determined in some human populations
... based on body odor. Some previous studies have reported a tendency for humans to prefer MHC-dissimilar mates, encouraging heterozygosity at MHC loci
in offspring and resulting in improved immune response. However, other studies, both directly in couples and also indirectly in "sweaty T-shirts" ...
SEX4, starch and phosphorylation
... from the versions traditionally described in textbooks. Specifically, mutations at the Starch Excess 4 (SEX4), Maltose Excess 1 (MEX1) and other loci
produce plants unable to metabolize starch to a usable form.
When we use starch in the lab or cook with it, we tend to think of it as an ...
Genetic breakthrough explains dangerously high blood glucose levels
... worked with data collected from a large genome study originally conducted for diabetes research that looked at over 390,000 different locations or loci
on the human genome. The studys first important diabetes results were published in 2007 and received worldwide media attention.
In this study, ...
Charting the epigenome
... confirmed increased methylation precisely within the stretch of DNA that matched the sequence of the smRNA. Conversely, heavily methylated smRNA loci
tended to spawn more smRNAs.
We looked at a plant genome but our method can be applied to any system, including humans, says Lister. Although the ...
Concentrating on different aspects of pain leads to breakthrough in migraine genetics
... of migraine genetics: different types of pain such as pain that pulsates or pain that is unilateral are more closely linked to specific genetic loci
than general pain, Palotie states.
In this study, researchers were able for the first time to convincingly demonstrate a genomic locus to be ...
Team finds an economical way to boost the vitamin A content of maize
... and gives a more detailed picture of the genetic endowment of individual lines. One technique the researchers employed, called quantitative trait loci
(QTL) mapping, allowed them to identify regions of the maize chromosomes that influence production of the precursors of vitamin A. They also used ...
Scientists associate 6 new genetic variants with heart disease risk factor
... cholesterol and triglyceride levels that arises from genes. With the potential to help predict a patients genetic risk of heart disease, the six new loci
may point to novel aspects of cholesterol metabolism and could also spur new cholesterol-lowering drugs.
Heart disease is a leading cause of death ...
New plant study reveals a 'deeply hidden' layer of the transcriptome
... of non-coding RNAs, the vast majority of which hadnt been described before. These strange transcripts are associated with small RNA-producing loci
as well as with repetitive sequence elements, says Gregory. They are under very tight regulation by the exosome, but we still dont know exactly what ...
DNA replication behavior in complex organisms may foreshadow leaps in genomic discoveries
... published in PLoS ONE in August 2007, GIS scientists described how they were able to determine the replication timing and efficiency at the various loci
in the genome. Specifically, replication efficiency was found to be low at the beginning of the S-phase, and increased at the later stage of this ...
Does the desire to consume alcohol and tobacco come from our genetic makeup?
... 1. They found another area relating to alcohol on chromosome 3. On chromosome 4, they uncovered an area relating to smoking and found sex-specific loci
inside some of these areas.
The results are based on the study entitled, Genome-wide Scan for Genomic Determinants of Alcohol and Tobacco Use in ...
Improved statistical tools reveal many linked loci
... earlier approaches to understanding how multiple loci
interact, the new technique can distinguish ... to distinguish whether one or both of the loci
being tested are responsible for altered ... to search for even larger numbers of linked loci
and to provide insights into the many ...
'Insulator' helps silence genes in dormant herpes virus
... of silenced chromatin. The patterns found resemble well-studied regions where insulators are found in both yeast and chicken, namely the yeast mating loci
and chicken globin locus.
To see if insulators play a role in silencing viral genes during the latent phase, Zhou and his group studied cells ...
Susceptibility to Crohn's disease -- an important new clue
... advances in SNP genotyping technology have allowed systematic association scanning of the entire genome for the detection of novel susceptibility loci
?fixed positions on a chromosome, such as the position of a gene. Libioulle and colleagues applied this approach to Crohn’s disease and identified ...
Pathway toward gene silencing described in plants
... combination of DNA FISH and protein localization allowed us to say which proteins are sitting on the DNA that give rise to the siRNAs and also the loci
that are modified by the siRNAs," Pikaard said.
Pontes found the other half of the team located within a special nuclear compartment known as the ...
Alcoholism, smoking and genetics among Plains American Indians
... (201 women, 141 men) community-based Plains American Indians, establishing their lifetime drinking and smoking histories. Additionally, five COMT loci
?including Val158Met ?were genotyped.
"There are three key findings," said Enoch. "One, Plains Indians have very different drinking patterns. ...
Dog genome sequenced
... Lark's group reports forty QTL, or quantitative trait loci, that are responsible for determining skeletal size in dogs. A striking aspect of these loci
is that they control functionally related skeletal traits. "For example," says Lark, "one of the QTL that we identified controls both pelvic size ...