localize

New, automated tool successfully classifies and relates proteins in unprecedented way

... University, outperformsexisting visual methods to localize proteins inside cells, saysProfessor Robert F. Murphy, whose report, "Data Mining in Genomics andProteomics," appears in an upcoming special issue of the Journal ofBiomedicine and Biotechnology. "Ourapproach really enables the new field of location ...

Imaging Lymph Nodes with Nanoparticles

...ity. When injectedintravenously, the nanoparticles localize to lymphoid tissue, and areinternalized into macrophages. There is then a decrease in signalintensity on T2- and T2*-weighted images, and when metastases arepresent there is a recognizably abnormal pattern on MRI scans. Ina previous paper published ...

Vital step in cellular migration described by UCSD medical researchers

... believe the mechanism used by alpha4 integrins to localize Rac activity may participate in a wide variety of cell migratory and pathfinding events. In addition to Nishiya and Ginsberg, additional authors were William B. Kiosses, Ph.D., The Scripps Research Institute, La Jolla, California; and Jaewon Han, Ph...

Scientists discover that host cell lipids facilitate bacterial movement

...ting actin assembly and PIP2 and PIP3 are known to localize to regions of new actin assembly, Dr. Southwick and his colleagues decided to explore the roles these lipids play in Listeria infection. "We had expected to see PIP2 and PIP3 only at the very back of Listeria where new actin assembly was taking plac...

Study shows humans have ability to track odors, much like bloodhounds

...left and right nostrils sense, much the way it can localize sounds by contrasting input from the ears. "It ha... von Bekesy claimed that humans had the ability to localize odors, based on experiments in 1964 with human subjects. He suggested this was done the same way we ...

Scientists discover genetic pathway responsible for breast cancer cell growth

...ately 19,000 genes. Dr. Giguère's team was able to localize where the estrogen receptor was bound in the genome of breast cancer cells, thereby identifying a large number of genes that respond to this hormone in a single experiment. "This technology, first developed for the study of yeast, now offers the oppo...

Junk DNA may not be so junky after all

...mon disease is that we lack the power to precisely localize DNA sequences that are associated with disease, often leaving us immense stretches of DNA to look at," says one of the study's corresponding authors, Andy McCallion, Ph.D., an assistant professor in the McKusick-Nathans Institute. Most often one is l...

Infused spleen cells found not to impact islet recovery and reversal of type 1 diabetes in mice

...mon disease is that we lack the power to precisely localize DNA sequences that are associated with disease, often leaving us immense stretches of DNA to look at," says one of the study's corresponding authors, Andy McCallion, Ph.D., an assistant professor in the McKusick-Nathans Institute. Most often one is l...

New possibilities to fight pests with biological means

...f worm. Parasitic wasps use these plant scents to localize the caterpillar and deposit their eggs on it, so that their offspring can feed on the caterpillar. Soon after, the caterpillar dies and the plant is relieved from its attacker. In the case of corn, only one gene, TPS10, has to be activated to attrac...

Oops! Researchers publish new findings on the brain's response to costly mistakes

... the fMRI technique has allowed the researchers to localize this response even more precisely. The fMRI scanner uses magnetic fields to create images based on blood flow, and can detect tiny changes in the rate of blood flow in and out of various areas of the brain. The more blood flowing to a specific area, ...

Sandia work launched on space shuttle shows live cells influence growth of nanostructures

...infection or the course of therapy. The cells also localize proteins at the cellular interface. Assistant Professor Graham Timmins of UNM's College of Pharmacy notes that the encapsulated cells' unusual longevity may serve as a model for persistent infections such as tuberculosis, which has a long latency p...

New light microscope sharpens scientists' focus

...part to see each molecule individually and thereby localize its center, Hess said. When a final image is created that includes the center of each individual molecule, it has a resolution previously only achievable with an electron microscope. Unlike electron microscopy, however, the new technique allows for m...

Pathway toward gene silencing described in plants

...nt and noting that the rest of the proteins didn't localize properly. In the RNA-dependent RNA polymerase 2 (RDR2) mutant, Pol IVa is unaffected, but the function of all the other proteins downstream is lost, inferring that it came into the act second. The picture that emerged from this logical approach is ...

Snakes' virtual glasses, leopard spots and all-optical transistors

... deep. However, studies have shown that snakes can localize heat sources to a surprisingly accurate resolution of five degrees (roughly the angular width of "Snakes on a Plane" costar Rachel Blanchard at three meters). Physicists at the Technische Universität München believe the solution to the paradox coul...

One-dimensional diffusion accelerates molecular motors

...singly efficient and successful. It allows MCAK to localize microtubule ends very quickly. Howard says, "when it gets there, MCAK eats like a Pacman into the end of the microtubule." The chromosome halves follow this movement and are this way accurately distributed on the daughter cells. ...

New understanding of parasite cell structures may provide treatments for serious tropical diseases

...y of Georgia have developed new tools to study and localize GPIs in living organisms and are discovering a new understanding of how they work in tropical parasites that cause human disease and suffering. The research was published in the May 9 issue of The FEBS (Federation of European Biochemical Societies) ...

Circadian gene helps the brain predict mealtime

... tool in hand, it will be possible to anatomically localize areas of the brain that are involved in food anticipation. Looking forward, the researchers expect that this will allow the study of how these areas interact with other brain regions responsible for other types of behavior, such as learning, memory, ...

Slow brain waves play key role in coordinating complex activity

...sured up to a week beforehand so that surgeons can localize important areas they need to avoid, such as center...he brain's frontal and temporal lobes to precisely localize the source of the seizure so it could be removed in a subsequent surgical procedure. Knight, Canolty...

Fast-freeze snapshot yields new picture of nerve-muscle junction

...membrane packets, or vesicles, of neurotransmitter localize in places scientists have never before seen. "It tells us that specific proteins are required to transition vesicles in close apposition to pre-synaptic membranes," said Richmond. "That prediction had been made, but hasn't before been demonstrated."...

Biologically inspired sensors can augment sonar, vision system in submarines

...he researchers?artificial lateral line was able to localize a nearby underwater vibrating source, and could detect the hydrodynamic wake (such as the wake formed behind a propeller-driven submarine) for long-distance tracking. With further advances in engineering, man-made underwater vehicles should be able t...

New study challenges 'critical period' in childhood vision development

...discern between separate objects, determine depth, localize faces amongst a background of natural scenes, and match faces by their identity. This case demonstrated that a person can acquire visual function even after being deprived of sight for an extended period during childhood. The evidence gathered fro...

Do fruit flies have free will?

...ffer". The next step will be to use genetics to localize and understand the brain circuits responsible for the spontaneous behavior. This step could lead directly to the development of robots with the capacity for spontaneous nonrandom behavior and may help combating disorders leading to compromised sponta...

Surprising origin of cell's internal highways

...with the plus ends of microtubules, called CLASPs, localize to a specific compartment of the Golgi (the Trans Golgi Network) and stabilize the microtubule "seeds" at the Golgi. Golgi-originating microtubules could also be an important factor influencing how cancer cells invade distant tissues. Because...