Liposomes in Biological News

New cancer drug delivery system is effective and reversible

... molecules that target receptors on cancer cells, liposomes can enter and dump their cancer-killing contents ... have spent more than a decade trying to direct liposomes to specific cancer cells, with limited success. A ... however, and the process of attaching them to liposomes is difficult to control. Antibodies spur an ...

Long-lasting nerve block could change pain management

... specially designed fat-based particles called liposomes to package saxitoxin, a potent anesthetic, and ... various formulations -- various types of liposomes containing saxitoxin with or without ... the action of encapsulated anesthetics. The best liposomes produced nerve blocks lasting two days if they ...

Scientists can predict nano drug outcome

... agents encapsulated in tiny fat bubbles called liposomes to determine if breast tumors in rodents could be breached by liposomes loaded with a cancer drug called liposomal doxorubicin. The liposomes were administered intravenously. When ...

Nanoengineers mine tiny diamonds for drug delivery

... five times the amount of drug carried by conventional materials. liposomes and polymersomes, both spherical nanoparticles, currently are used for ... even healthy cells that are encountered as they travel to their target. liposomes and polymersomes also are very large, about 100 times the size of ...

Potential for non-invasive brain tumor treatment

... system in conjunction with chemotherapy drugs encased in heat-sensitive microbubbles called liposomes. "Physicians would inject drug-carrying liposomes into a patient's bloodstream, and then insert a catheter via a blood vessel to the site of the brain tumor," said Carl Herickhoff, fourth-year ...

Nanotechnology holds promise for STD drug delivery

... past work has focused on delivery of siRNAs with liposomes, bubble-like carriers made of phospholipids similar to those found in cell membranes, liposomes are potentially more toxic to the mucosal tissues and are unable to provide sustained release. In the current work, the researchers demonstrated that ...

Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer

... for chemotherapy resistance. In collaboration with the University of the Basque Country and the Swiss firm Merk Serono International, a model in liposomes simulating the composition of the mitochondrial membrane was developed in order to check the effects of cholesterol on its fluidity and response to ...

Cells get sprayed

... way into the cell through a cell membrane that has been made porous, through treatment with electrical current or UV lasers, for example. Viruses and liposomes can be used as genetic transporters and the genetic material can be injected or shot into the cell with a particle gun. These methods all have the ...

Sandia researchers discover way to see how a drug attaches to a cell

... nanoscopic, hollow platinum spheres by using liposomes as blueprints. (Liposomes are microscopic, ... double layer of lipid (detergent) molecules. The liposomes are placed in a solution containing a platinum salt. When these liposomes are irradiated with light, photocatalysts located ...

Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial

... cancer were treated for 3-5 weeks. They received liposomes that contained either the FAK siRNA, a control siRNA, or were empty. Some mice received siRNA liposomes plus the chemotherapy docetaxel. Mice ... advantage over positively or negatively charged liposomes when it comes to binding with and penetrating ...

Liposome finding implies electrical effect on cell development

... Experiments with liposomes ?cell-like "water balloons" composed of ... Mark Hayes and Michele Pysher have found that liposomes have a tendency to form tube-like extensions in ... In the experiments, the researchers placed liposomes in a droplet of water and applied very low ...

'Micro-boxes' of water used to study single molecules

... Water offers several advantages over other methods for containing single molecules, such as attaching them to surfaces or placing them inside liposomes (artificial cells). The water droplets can be held far from any surface that might interfere, can readily encapsulate biomolecules (which prefer ...

Nano-particles effective in killing cancer with one-two punch of chemotherapeutics

... and has been simulated with supercomputers by Michael F. Klein and Goundla Srinivas of Penn's Department of Chemistry. While cell membranes and liposomes (vesicles often used for drug-delivery) are created from a double layer of fatty molecules called phospholipids, a polymersome is comprised of two ...