Lipid in Biological News

Lipid droplets lead a Spartin existence

... role for Spartin in regulating the cell's lipid storage depots. Cells transport excess fats into lipid droplets (LDs), where they are kept until needed ... Paul Bieniasz points to precedents of defects in lipid turnover triggering neuronal disorders, such as ...

Artificial cells, simple model for complex structure

... is possible using large polymeric molecules and a lipid membrane. Keating uses lipids to create vesicles, tiny cell-sized bubbles of lipid membrane in an aqueous solution of two large ... PEG, a small amount of dextran, water and dried lipid allowed ...

In India: A search for more effective tuberculosis drugs

... the way Mycobacterium tuberculosis builds the lipid layer that coats its surface. Unlike other ... Some scientists have suggested that these long lipid molecules contribute to the bacteria's ability to ... enzymes involved in the assembly line that is lipid use and degradation. These enzymes are required ...

Nearly a century later, new findings support Warburg theory of cancer

... of mouse brain tumors, specifically a complex lipid known as cardiolipin (CL). They reported their findings in the December edition of the Journal of lipid Research . Abnormalities in cardiolipin can ... Bioinformatic models were used to compare the lipid characteristics of the normal and the tumor ...

The genetic heart of the lipids

... novel genetic variants that are associated with lipid levels, a common indicator of heart or artery ... New, more powerful studies, such as our work on lipid levels, will illuminate the areas and the ... find previously known genetic associations with lipid levels: of the 22 regions we describe, 16 have ...

People with heart disease still have trouble controlling blood lipid levels

... need to do a better job controlling overall blood lipid levels, according to a UC Irvine Heart Disease ... can further compound risks associated with high lipid levels. Wong recommends that all adults have a lipid profile done and speak to their healthcare ...

Compound that helps rice grow reduces nerve, vascular damage from diabetes

... New research, published online in the Journal of lipid Research , shows the growth factor acylated ... or white rice. They showed a then-unidentified lipid helped protect the nerve membrane and increase ... levels. However the MCG scientists have shown the lipid has a more powerful impact on HTase activity. ...

Nanotubes could help study retrovirus transmission between human cells

... In their labs, they experimented with giant lipid vesicles that appeared to mimic key aspects of the cellular membrane. Giant lipid vesicles resemble micron-sized spherical soap bubbles that exist in water. They are composed of a lipid bilayer membrane only five nanometers thick. ...

Europe-wide investment in lipid research will help tackle disease, says new report

... research effort across Europe to understand lipid function and the roles of lipids in health and disease Integration of European lipid databases and the facilitation of their ... This would allow the 'holistic' interpretation of lipid data and provide a greater understanding of the ...

UT Southwestern's Mangelsdorf elected to National Academy of Sciences

... is an internationally prominent researcher in lipid biology and has made major contributions to the ... receptors and ligands play in the regulation of lipid and bile acid metabolism and the governance of ... major insights to the understanding of lipid metabolism, especially cholesterol metabolism, ...

Researchers reveal HIV peptide's possible pathway into the cell

... out to uncover how the peptide interacts with a lipid bilayer that is used to model the cell membrane. ... system, the cell membrane is composed of a lipid bilayer (made up of two monolayers) designed to ... cell by preventing the influx of material. Each lipid in the bilayer has a polar, or charged, end and a ...

Study locates cholesterol genes; finds surprises about good, bad cholesterol

... or confirm genetic variants that influence lipid levels, and secondly, to see if those variants ... influence a person's cholesterol and blood lipid levels. "Finding new gene regions associated ... than a quarter of the genetic contributions to lipid levels. The completion of the map of human ...

New genetic variants associated with lipid levels, risk for coronary artery disease

... genetic factors influence a persons blood fat, or lipid levels, important risk factors for coronary ... variants in 18 genes connected to cholesterol and lipid levels. Seven of the 18 genes previously had not ... and physical activity greatly affect a persons lipid profiles. This study is an important, basic step ...

Scientists associate 6 new genetic variants with heart disease risk factor

... identify genetic variants associated with blood lipid levels, Kathiresan and his colleagues scanned the ... of the SNPs were already known to influence lipid levels, underscoring the power of the genome ... are not immediately clear. They may influence lipid levels by regulating the expression of nearby ...

Biophysical Society announces winners of 2008 Student Travel Awards

... Molecular Mechanism of Phospholipid Transfer by lipid Transporter Protein Sec14p. Hao Chen, ... Correlation Lengths, and Critical Exponents in lipid Membranes Near Critical Points. Alexandra ... of Phospholamban and Ca2+-ATPase(SERCA) in lipid Bilayers by Solid-State NMR. Srinivasan P. ...

Powerful integration of lipid metabolic profiling with gene expression analysis

... GmbH. The study elucidated the effects on Mouse lipid metabolism by the disruption of hepatic ... could demonstrate that though gene expression and lipid metabolism in extrahepatic tissues being ... and networks, observed expression changes and lipid profiling led to the conclusion that POR can be ...

Media highlights in the November issues of Biophysical Journal

... in synthetic drug design, the absence of large lipid rafts in cells, and the structure of a Na+/H+ ... diseases, such as cardiac arrhythmia. Why are lipid rafts not observed in vivo? Arun Yethiraj, ... The cell membrane consists of many types of lipid and protein molecules. Some years ago the ...

American Chemical Society's Weekly PressPac -- Sept. 12, 2007

... FOR IMMEDIATE RELEASE New way to watch the lipid flip flippases, flopases, and scramblases Bioconjugate Chemistry The lipid flip may sound like a rock and roll dance craze ... these enzymes control the process in which lipid molecules literally summersault from the outer ...

Chemists get grip on slippery lipids

... in this process by protein molecules called lipid binding domains. Understanding how these ... and various inflammatory diseases. Studying lipid binding domains is a specialty of Wonhwa Cho, ... can recognize and interact with a large number of lipid molecules and other proteins," said Cho. "We ...

Story ideas from the Journal of Lipid Research

... in the September 2007 issue of the Journal of lipid Research (Vol. 48, No. 9) ARTICLE ... discovered Scientists have discovered that a lipid known to protect the heart from inflammation and ... reticulum (ER) that makes proteins and lipid droplets and senses the amount of nutrients that ...

Abnormal fat metabolism underlies heart problems in diabetic patients

... heart cells of diabetic mice lose an important lipid from cellular components that generate energy for ... this change in metabolism distorts the lipid composition of cell membranes causing abnormal ... and cellular dysfunction." The important lipid that the researchers found to be decreased in ...

American Chemical Society's weekly PressPac -- May 27, 2009

... describe development of a first-of-its-kind microcapsule made from lipid oils and nanoparticles 1/50,000th the width of a human hair. Although ... RELEASE "Dry Hybrid Lipid-Silica Microcapsules Engineered from Submicron lipid Droplets and Nanoparticles as a Novel Delivery System for Poorly Soluble ...

Synthesizing the most natural of all skin creams

... Its outstanding properties come from the addition of just 10% each of lipid molecules and dead skin cells (corneocytes), so the exact composition of ... content. But equally important is how the mixture arranges itself. lipid molecules are shaped something like lollipops, with a round end that ...

High-fat diets inflame fat tissue around blood vessels, contribute to heart disease

... "However, many patients who consume high fat diets do not exhibit abnormal lipid profiles but still develop atherosclerosis nonetheless. "These new ... a problem because their weight and cholesterol levels are under control. lipid profiles don't hold all the answers. "Bad dietary habits can lead to a ...

Phytoplankton cell membranes challenge fundamentals of biochemistry

... desert. How are they doing it? These creative plankton build a membrane lipid called SQDG, a molecule based on sulfur rather than phosphorus. Van Mooy ... the ocean. Of his future research working out the dynamics of the membrane lipid substitutions Van Mooy says, "You could think of it like a tool. Something ...

New scientific knowledge on juvenile diabetes

... the development of type 1 diabetes. They discovered disturbances in lipid and amino acid metabolism in children who later progressed to type 1 ... physiological response to the early metabolic disturbances. The observed lipid changes were not attributable to HLA-associated genetic risk. Metabolic ...

New gene variants present opportunities in nutrigenomics

... and lower chronic disease risk. "Practically all genes related to lipid levels in the bloodstream respond to changes in the diet," says Jose M. ... "Having identified a total of 30 gene variants is a landmark in lipid research," says Ordovas, also a professor at the Friedman School of ...

Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections

... antibodies could be valuable contributors to the field." PS is a lipid molecule normally found on the inside of cell membranes that "flips" and ... target for preventing HIV infection. He commented, "Targeting a host cell lipid such as PS as an anti-viral strategy is an intriguing concept that may ...

Overweight mums have chubby bubs

... to have babies with more body fat, who are at greater risk of diabetes and lipid metabolic disorders later in life. Previous research shows that around ... impacts of pre- and postnatal overfeeding on fat accumulation, circulating lipid levels, glucose metabolism, and brain appetite regulators. In a ...

Tracking down the cause of mad cow disease

... protein attaches to cell membranes by way of an anchor made of sugar and lipid components (a glycosylphosphatidylinositol, GPI) anchor. The anchoring of ... to which further sugars are attached through branches. Details of the lipid component have not been determined before. As a synthetic target, the ...

NIH doles out $3M in new innovator awards to 2 UC San Diego faculty

... a multi-pronged, systematic approach to understanding the function of lipid molecules that transmit signals within cells. Despite the importance of ... little is known about their functions. Field plans to study these seven lipid signaling molecules, called phosphoinositides, and their roles in ...

Generation innovation: Young UC San Diego bioengineer to use NIH grant to fuel tissue engineering

... Innovator Award winner. Field will use his grant to study a group of seven lipid signaling molecules called phosphoinositides, which are known to play ... a multi-pronged, systematic approach to understanding the function of lipid molecules that transmit signals within cells. Despite the importance of ...

Cortisol and fatty liver: Researchers find cause of severe metabolic disorders

... as an energy reserve. Under certain conditions the delicate balance of the lipid metabolism gets out of control and fat is accumulated in the liver, ... body's own glucocorticoid hormones contribute to this disruption of the lipid metabolism. The researchers in Herzig's team specifically switched off ...

Researchers seeking to identify Alzheimer's risk focus on specific blood biomarker

... similar that is seen in heart attack patients, who typically have elevated lipid levels in their bloodstream prior to a heart attack, but post-heart attack lipid levels may decrease. Using more specific antibodies developed by the ...

Nutritionists of the UGR suggest diet improvements during Ramadan

... The feeding of those who followed Ramadan suffered an increase of lipid ingestion, which involved 48% of total energy, against the recommended ... have published it in scientific journals such as the 'European journal of lipid science and technology', 'Nutrition', 'Analytical Chimica Acta' and ...

Oxidative stress: Mechanism of cell death clarified

... were performed to describe, in greater detail, the source and nature of lipid peroxides. Pharmacological and reverse genetic analyses showed that lipid peroxides in GPx4-depleted cells do not appear by coincidence, but ...

New discoveries from Harvard and Baylor get to the heart of cardiovascular disease

... how we prevent inflammation from running amok. The scientists identified lipid mediators that the body uses to resolve inflammation once it has started. By targeting these lipid mediators and the mechanisms used to make them, scientists should be able ...

Engineer develops detergent to promote peripheral nerve healing

... using the detergent solution, the donor nerve is stripped of the cellular lipid components, which causes the immune rejection response when implanted. ... ends of the severed nerve to promote regrowth. And because the immunogenic lipid components have been extracted, patients don't require immunosuppressant ...

Scientists 'paint' viruses to track their fate in the body

... mixed purified proteins (glycosylphophatidylinositol anchor proteins) with lipid membranes to make it possible to bind these proteins to the outer skin (the lipid envelope) of viruses. Even with the new paint job, the viruses remained ...

Simple model cell is key to understanding cell complexity

... recent paper, they describe an asymmetric membrane containing a mixture of lipid molecules. Some of these lipid molecules contained tiny pieces of PEG, which interacted with the PEG in ...