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Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer

...he majorintermediate in UV-induced cellular damage leading to non-melanoma skincancer. Importantly, it also suggests that photolyases may besuccessfully employed as a genetic tool to combat UV-induced skincancer....

Yellowstone microbes fueled by hydrogen, according to U. of Colorado study

...ts led by Professor Norman Pace, one ofthe world's leading experts on molecular evolution and microbiology,published their report "Hydrogen and bioenergetics in the Yellowstonegeothermal system" this week in the online edition of the Proceedingsof the National Academy of Sciences.The team's findings, based o...

Neuronal 'traffic jam' marks early Alzheimer's disease

...duction of an abnormal protein that clogs neurons, leading to their failure and eventual death. The researchers said their findings could provide information that might be used to develop drugs to preserve the molecular transport system and thus the viability of brain cells otherwise lost in Alzheimer's. Th...

Mouse brain cells rapidly recover after Alzheimer's plaques are cleared

...spects that this transport breaks down inthe mice, leading to pileups that become swellings. Scientists havepreviously demonstrated that such swellings make it difficult orimpossible for nerve-cell branches to send signals.After showing that the swellings were mostly stable in number and sizeover the course ...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

...e of the parasitic amoeba Entamoeba histolytica, a leading cause of severe diarrheal disease in developing countries, includes an unexpectedly complex repertoire of sensory genes as well as a variety of bacterial-like genes that contribute to the organism's unique biology. The report, which appears in the F...

Key molecule in plant photo-protection identified

...spects that this transport breaks down inthe mice, leading to pileups that become swellings. Scientists havepreviously demonstrated that such swellings make it difficult orimpossible for nerve-cell branches to send signals.After showing that the swellings were mostly stable in number and sizeover the course ...

Researchers Uncover Key Step In Manufacture of Memory Protein

...to better understand the learning process, perhaps leading to better treatments for disorders of learning and memory,?said Duane Alexander, M.D., Director of the National Institute of Child Health and Human Development. The research team was led by Y.Peng Loh Ph.D, of NICHD’s Section on Cellular Neurobiolog...

The secret to longevity in tubeworms

...ved tubeworm colony size and individual longevity, leading Cordes et al. to propose that L. luymesi also uses its roots to release sulfate back to the microbial consortia from which it draws its sulfide. Without this return of sulfate, the model predicts an average lifespan of only 39 years in a colony of 1,...

Inexpensive, mass-produced genes core of synthetic biology advances at UH

...ent of biology and biochemistryat UH, works at the leading edge of this field. Her recent findings onhow to mass produce multiple genes on a single chip are described in apaper titled “Accurate multiplex gene synthesis from programmable DNAmicrochips,?appearing in the current issue of Nature, the weeklyscien...

U-M scientist to talk about tissue engineering at AAAS

...ad and neck, in part because U-M Dentistry plays a leading role in the effort. Dentists have a long tradition of finding ways to fill tooth cavities that will not heal on their own, Krebsbach said, and that has led to research in biomaterials, bone and connective tissue function, and then tissue engineering....

Breakthrough Microarray-based Technology for the Study of Cancer

...ognostic and diagnostic tools."Genomic alterations leading to changes in the number of gene copiespresent in cells are important events in the genesis and progression ofcancer," said Michael Bittner of the Translational Genomics ResearchInstitute. "Agilent has now taken array-CGH experiments into a newrealm ...

Learning to fight an adversary that won't stay down

...t the defences of disease-causing bacteria, says a leading Canadian specialist in antibiotic resistance. Techniques such as genomic sequencing and high throughput screening were expected to make the development of new antibiotic compounds easier and more productive. But in most cases the microbes continue t...

Improved Outcomes Releases GeneLinker(TM) Gold and Platinum Version 4.6

... easy to use and produces better results thanother leading array image analysis software programs." added VPBioinformatics Mark Chatterley. IOS and Koada Technology will also soonbe announcing details of co-marketing discount offers on GeneLinker andKoadarray. Further information about Koadarray image analys...

Scientists seek answers on what activates deadly anthrax spores

...s that promote germination will enable discoveries leading to drugs that block the process." The research is being paid for by a $152,687 grant from the Southeast Regional Center of Excellence in Biodefense and Emerging Infections, based at Duke University, one of eight such regional centers funded by the N...

U of M researcher examines newly emerging deadly disease

...ins that activate large numbers of T cells), often leading to death due to hypertension and shock. Purpura fulminans has been identified in five cases in the Minneapolis-St. Paul, Minn., metropolitan area during 2000-2004, as described in the April 1, 2005 issue of Clinical Infectious Diseases. This new dise...

Leukemia Drug Breakthrough Study In New England Journal Of Medicine

...r Network, a prestigious alliance of the country's leading cancer centers, and is listed in the U.S. News & World Report as one of the top cancer hospitals in America. Moffitt's sole mission is to contribute to the prevention and cure of cancer. ...

Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey

...acterium known asEnterococcus faecalis, one of the leading causes of hospital-acquiredinfections, to find new ways to treat them. These infections arefrequently resistant to many, and sometimes all, antibiotics. Tens ofthousands of deaths due to antibiotic resistant infection occur eachyear in the US, adding...

An HIV Protein Plays a Surprising Role in Gene Activation

...ppear to stimulate transcription complex assembly, leading the authors to ask whether Tat could play a similar role. To study this question in living human cells, Green and colleagues turned to chromatin immunoprecipitation, a technique that detects proteins bound (directly or indirectly) to DNA. Working wi...

Scientists decipher genome of fungus that can cause life-threatening infections

... of the mostcommon opportunistic infections, and a leading cause of meningitis andbloodstream infection," says Joseph Heitman, a senior communitycollaborator on the project who is James B. Duke Professor of MolecularGenetics and Microbiology at the Duke University Medical Center and aninvestigator at the How...

First 'atlas' of key brain genes could speed research on cancer, neurological diseases

...iate of theHarvard Medical School and is among the leading cancer research andcare centers in the United States. It is a founding member of theDana-Farber/Harvard Cancer Center (DF/HCC), designated a comprehensivecancer center by the National Cancer Institute....

Vital step in cellular migration described by UCSD medical researchers

...esses at the front end and back end are different, leading only to forward movement. One of the first steps in cell migration is the initiation of activity by Rac that extends protrusions out of the cell. These protrusions serve as tractor sites for migration as the cell moves toward its intended target. If ...

Studies reveal methods viruses use to sidestep immune system

...ucts, as well as through sexual contact and is the leading cause of cirrhosis and liver cancer. UT Southwestern Medical Scientist Training Program (MSTP) student Eileen Foy was an author on all three papers. MSTP student Rhea Sumpter and postdoctoral researcher Dr. Yueh-Ming Loo were authors on two of the p...

Scientists document complex genomic events leading to the birth of new genes

...py in humans. "Gene duplication is known to play a leading role in evolution for the creation of new genes," ...y may confer a selective advantage to an organism, leading to the rise of lineage-specific genes over evolutionary time. Bork's team identified a total of 22 ...

Beyond lithium for bipolar disorder

...dings "suggest a coordinated upregulation of genes leading to increased dopamine signaling. In the light of the recent clinical data and human genetic linkage, it is tempting to speculate that PACAP night be a therapeutic effector of lithium in bipolar disorder." They concluded that "the data presented here...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

...turned up no previous description of the chemical, leading the scientists to believe they had discovered a new chemical compound with a unique biological function. When the scientists tested the compound's ability to inhibit Ras function in living cells, they found it blocked the ability of colon cancer cel...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

...uses them to lose control over their proliferation leading to tumors. Now Klaus Kaestner from the University... growths called polyps in their colons, eventually leading to death. Inactivating the APC gene was found, as in human cells, to cause the accumulation of a pro...

NJIT Presidential Award winner takes stem cell research another step

...l engineering and chemistry at NJIT. "She's at the leading edge of modern biology and if anyone can take stem-cell research forward, she can." ...

Breakthrough method in nanoparticle synthesis paves the way for new pharmaceutical and biomedical applications

...oundbreaking research was recently featured in the leading Chemistry journal, Angewandte Chemie, and a United States patent has been filed on the invention. Research Scientist Dr. Yu Han and IBN Executive Director Prof. Jackie Y. Ying have developed a fluorocarbon-mediated-synthesis technique that produces ...

RNA project to create language for scientists worldwide

...n, France, Canada and Australia. Participating are leading researchers from Stanford, Duke, Yale, Rutgers and Georgia Tech universities, the University of California-Berkeley, the University of North Carolina, the University of Rochester, the University of Montréal, Lawrence Berkeley National Laboratory, the...

South America's vast pantanal wetland may become next everglades, UNU experts warn

...p on the grass, it gets dry and more easily burns, leading to more frequent fires which destroy flood-adapted trees, in which aquatic birds nest, while killing swamp deer and other animals. (The Pantanal's other fauna includes giant anteaters, armadillos, capybara, the Brazilian tapir and jaguar, and endange...

Falling ants glide back to trunk to avoid dangers of forest floor

... what they do." "Steve's first observation may be leading to a whole Pandora's Box of gliding arthropods," added Kaspari. "Steve, Robert and I right now are exploring how pervasive such directed descent might be ?we are, in fact, finding it in a variety of wingless arthropods that glide in using a variety o...

UF Researchers Map Bacterial Proteins That Cause Tooth Loss

...n the spaces between teeth and gums. It’s also the leading cause of tooth loss ?secreting proteins that destroy the soft tissues and bone that support teeth to cause periodontal disease. Now scientists have identified the thousands of proteins the bacterium produces, shedding light on how it interacts with ...

Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance

...n of genomics in patient care by bringing together leading clinical research institutes with advanced Affymet... diagnostic and biotechnology companies as well as leading academic, government and not-for-profit research institutes. More than 1,200 systems have been shipp...

New Treatment Rivals Chemotherapy For Lymphoma, Study Finds

...sease. Non-Hodgkin's lymphoma, the nation's sixth leading cause of cancer death, is a cancer of the lymph system, which is part of the immune system. Lymphoma spreads easily through the lymph system and the bloodstream and consequently tends to be widespread when it is diagnosed. Traditional treatment often...

VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain

...o how much a given gene is "turned on," eventually leading to more or less protein being produced by that par...ed in certain biological pathways, such as the one leading to the production of myelin. Myelin is a form of molecular insulation that allows nerve cells to sen...

How an AIDS-Related Cancer Unleashes Inflammation

...vered that the binding of kaposin B activated MK2, leading to higher levels of cytokines in the cell. Activated MK2 does this by prolonging the stability of cytokine messenger RNA ?the genetic blueprint for cytokine proteins. The longer these messenger RNAs remain in the cell, the more cytokine proteins the ...

Kinovate Life Sciences Launches Nittophase?High Performance Solid Support For Oligonucleatide Synthesis

...eholder, Nitto Denko Corporation (Osaka, Japan), a leading multi-national polymer synthesis company and Isis Pharmaceuticals, Inc. (NASDAQ: ISIS), a leader in RNA-based drug discovery and development. Through utilization of the unparalleled polymer synthesis and R&D capabilities of Nitto Denko Corporati...

Nonlinear Dynamics announces more details of its global partnership with PerkinElmer

Nonlinear Dynamics Ltd, a leading provider of bioinformatics solutions, today announ... partnership with PerkinElmer, Inc. (NYSE: PKI), a leading provider of drug discovery, life science research and analytical solutions. As detailed in a press ...

Yale researchers identify molecule for detecting parasitic infection in humans

...mune system for detection of parasitic infections, leading the way for development of future vaccines to combat these infections. Published in the April 28 issue of Science Express, the study provides insight into understanding how infectious parasites interface with the immune system--a problem of great sc...

US life expectancy about to decline, researchers say

...mplications. Obesity and overweight are the second leading cause of preventable death in the United States. And the largest increases in obesity have occurred among children and minorities. Body weight is affected by many genetic, psychological and environmental factors that influence diet or physical activ...

A new study examines how shared pathogens affect host populations

...ciety of Naturalists, The American Naturalist is a leading journal in the fields of ecology and evolutionary biology and animal behavior. For more information, please see our website: www.journals.uchicago.edu/AN Volker H. W. Rudolf and Janis Antonovics, "Species coexistence and pathogens with frequency-dep...

How the environment could be damaging men's reproductive health

...ished online today (Thursday 28 April) in Europe's leading reproductive medicine journal Human Reproduction, ...fect the distribution of sex chromosomes in sperm, leading to a slight increase in the number of sperm bearing the Y chromosome Aleksander Giwercman, professo...

UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders

...nd neurological disorders. "As one of the world's leading research universities, UCLA has long been engaged in adult and embryonic stem cell research with activities in areas ranging from the AIDS Institute to the Brain Research Institute to the UCLA College," said UCLA Chancellor Albert Carnesale. "The new...

Norovirus, AIDS vaccine and Hepatitis Virus

...oroviruses (NoV's) are considered to be one of the leading causes of nonbacterial gastro-related illnesses resulting in over 23 million cases annually. In the study stool samples were collected from 34 patients with traveler's diarrhea and tested for the presence of norovirus. The virus was detected in 65 p...

DuPont's first biologically derived polymer receives global recognition

... Green Chemistry Award" for the company's research leading to the development of Bio-PDOTM. DuPont is a science company. Founded in 1802, DuPont puts science to work by creating sustainable solutions essential to a better, safer, healthier life for people everywhere. Operating in more than 70 countries, DuP...

Not-for-profit publishers call NIH public access rule a missed opportunity

...ting efforts, according to a group of the nation's leading not-for-profit medical and scientific publishers. The final rule ignores significant free access policies already existing in the not-for-profit publishing community that offer more cost-effective public access to the science in their journals. NIH'...

Flocking together: Study shows how animal groups find their way

...formed" individuals was just about as effective in leading a large group as a small one. When the size of the group increased from 10 to 200, the percentage of informed individuals needed to accurately guide the group reduced from approximately 50 percent to less than 5 percent. As a result, the number of in...

PGA on a tour under the skin

...idermidis is harmless on human skin, but it is the leading cause of hospital-acquired infections and infections of indwelling medical devices. S. epidermidis is associated with an enormous number of infections in people with prosthetic joints, replacement heart valves, and intravenous catheters, and antibiot...

Reducing malarial transmission in Africa

... of 497 children in Uganda treated with one of two leading combination therapies. One regimen was an artemisinin-based combination consisting of artemether and lumefantrine (co-artemether, trade names CoArtem and Riamet). The other was a combination of CQ and SP - currently under consideration in several Afr...

Iron exporter revealed that may explain common human disorder

...ailure to control iron export through ferroportin, leading to increased iron release from macrophages and enhanced intestinal absorption. Indeed, patients with the disease exhibit a deficiency of hepcidin, a hormone that binds ferroportin and targets it for destruction. Drugs that inhibit or degrade ferropo...

Increased risk of osteoporosis associated with gene that one in five people have

...nzyme that breaks down estrogen faster than usual, leading to low serum estrogen levels and high levels of estrogen metabolites," Villareal says. "Low levels of estrogen put a woman at risk for osteoporosis, and our data showed a strong correlation between the genetic variant and low bone density." The rese...

Affymetrix Licenses Microfluidics Technology From Caliper Life Sciences

...to Affymetrix' customers." "We are pleased that a leading life sciences company like Affymetrix recognizes the vast potential of LabChip technologies," said Kevin Hrusovsky, President and CEO at Caliper. "Affymetrix is moving beyond basic research applications and is pioneering areas such as pharmacogenomic...

Researchers find new genes necessary to make embryo

...o make an embryo beyond what was previously known, leading them to conclude that many more genes will be found in the future. The researchers estimate that at least 2,600 genes are required for embryonic development in C. elegans, of which about 70% are currently known. The majority of genes required for em...

Researchers uncover sequence of major rice pathogen

...rnal Nature. It is estimated that rice blast, the leading cause of rice loss, is responsible each year for killing enough rice to feed 60 million people worldwide. In the Nature paper, Dean and his co-authors shed some light on the adaptations required by a fungus to cause disease. The researchers identify...

Researchers make gains in understanding antibiotic resistance

...ome of these medications. The findings are already leading to new experimental antibiotics that are being eng...to the development of new antibiotics. One company leading the way is Rib-X Pharmaceuticals, which was founded by Steitz and colleagues at Yale. "About half of...

Disease diagnosis, biodefense among UH chemical research projects

...e 26 percent of global mortality and are the third leading cause of death in the United States. Microbial identification also is important in food safety and biodefense. Traditional culturing and growth-testing methods are being replaced by molecular biology-based methods as genome sequencing advances. This ...

Super predators and mass extinctions

... to occur on Earth roughly every 26 million years, leading some scientists to propose that they may be caused by rare collisions with comets or asteroids. A researcher in Poland thinks it may be possible that extraordinary predators are at fault instead. Adam Lipowski (Adam Mickiewicz University) constructe...

NASA study finds snow melt causes large ocean plant blooms

...rface winds over the Arabian Sea have strengthened leading to more intense upwelling and more widespread bloo... oxygen deficiencies in the Arabian Sea to spread, leading to fish mortality. Oxygen-depleted waters also provide the perfect environment for the growth of a ...

Live vaccines more effective against horse herpes virus

...logical form of equine herpes and were euthanized, leading to concern at the May 22 Preakness Stakes at Pimlico Race Course near Baltimore. In anticipation of the June 11, $1 million Belmont Stakes, the third leg of the Triple Crown, in Belmont, N.Y., the New York Racing Association (NYRA) on May 18 issued t...

Brain-injury rehabilitation depends on acetylcholine circuitry

...ce rehabilitation to recover from such injuries by leading to the development of drugs or other treatments to enhance the "cholinergic system." The researchers said that their finding that the cholinergic system is involved in brain recovery is particularly intriguing in light of the fact that deficits in t...
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(Date:8/20/2008)...espite popular theories to the contrary, early hum... of many predators. , "Humans are no more born t...W. Sussman, Ph.D., professor of anthropology at Wa...ated version of the controversial book "Man the Hu... The soft cover book, released in July by Westvie...
(Date:8/20/2008)...amily of biodegradable polymers called polyketals ...ch inflammatory illnesses as acute lung injury, ac...y delivering drugs, proteins and snips of ribonucl...e polyketal microparticles we developed are simply... diseased area as quickly as possible," said Niren...
(Date:8/20/2008)... study in the September issue of the Journal of L...ance may have a role in the rising rate of diabete... United States. , DNA is the primary mechanism of...nd half from dad. However, scientists are just sta...e like metabolic programming, which occurs when an...
(Date:8/19/2008)...a group of University of Oklahoma researchers bega...um, a problem that has plagued the energy industry...olate a community of microorganisms capable of con...searchers found that the groundbreaking processkno...to stimulate methane gas production from older, mo...
Breaking Biology News(10 mins):New book further supports controversial theory of 'Man the Hunted' 2New book further supports controversial theory of 'Man the Hunted' 3New book further supports controversial theory of 'Man the Hunted' 4New book further supports controversial theory of 'Man the Hunted' 5Biodegradable polymers show promise for improving treatment of acute inflammatory diseases 2Biodegradable polymers show promise for improving treatment of acute inflammatory diseases 3OU researchers isolate microorganisms that convert hydrocarbons to natural gas 2OU researchers isolate microorganisms that convert hydrocarbons to natural gas 3VIA Pharmaceuticals Names Rebecca Taub Senior Vice President of Research and Development 2611 1VIA Pharmaceuticals Names Rebecca Taub Senior Vice President of Research and Development 2611 2VIA Pharmaceuticals Names Rebecca Taub Senior Vice President of Research and Development 2611 3VIA Pharmaceuticals Names Rebecca Taub Senior Vice President of Research and Development 2611 4Start Licensing Inc Welcomes FDAs Finding of Safety of Food From Cloned Animals 2609 1CeNeRx BioPharma Announces Successful Completion of Phase l Clinical Program for Novel Antidepressant Agent Tyrima 28TM 29 1211 1CeNeRx BioPharma Announces Successful Completion of Phase l Clinical Program for Novel Antidepressant Agent Tyrima 28TM 29 1211 2CeNeRx BioPharma Announces Successful Completion of Phase l Clinical Program for Novel Antidepressant Agent Tyrima 28TM 29 1211 3Morria Biopharmaceuticals Plc Announces Preliminary Safety and Tolerability Results From Its Phase I Clinical Study of MRX 4 in Allergic Rhinitis Pati 1209 1Morria Biopharmaceuticals Plc Announces Preliminary Safety and Tolerability Results From Its Phase I Clinical Study of MRX 4 in Allergic Rhinitis Pati 1209 2
(Date:8/20/2008)...very -- that calorie-burning brown fat can be prod... mice -- raises the prospect of new ways to fight ...arber Cancer Institute. , Reporting in the Aug. ...demonstrated that brown fat, which is known as the...calories and releases energy, unlike "bad" white f...
(Date:8/20/2008)...spital (MGH) investigators have found that infusio...to protect gastrointestinal tissue from autoimmune...ed in the journal Stem Cells , the team from the ... mesenchymal stem cells (MSCs), known to control s...eration of the gastrointestinal lining in mice wit...
(Date:8/20/2008)...a to Launch Summit Conversations Series, WASHINGT...genda: Health,Care for All will be honoring Rep. R... leader, for his leadership and commitment to affo...Democratic National Convention,in Denver, Colorado...",America,s Agenda will also be launching its new ...
(Date:8/20/2008)...Newswire/ --You,re late for work, your toddler,spi.... How do you deal with,the rising anger? Whether y...ation, how you deal with anger affects not only yo...en your career., As hard as we may try to stay ca... While feeling anger isn,t a bad thing, it is impo...
Breaking Medicine News(10 mins):Health News:Making 'good' fat from muscle and vice versa 2Health News:Making 'good' fat from muscle and vice versa 3Health News:Bone marrow stem cells may help control inflammatory bowel disease 2Health News:Bone marrow stem cells may help control inflammatory bowel disease 3Health News:America's Agenda to Honor Former House Majority Leader Richard Gephardt at Democratic National Convention 2Health News:Taming Your Temper: Learning to Turn Down the Heat 2
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