laboratory

Man and mouse share genome structures

...ral fellowship who works in the Harvard University laboratory of HHMI investigator Stuart L. Schreiber. Other co-authors are from the Broad Institute of MIT and Harvard, and Affymetrix. Their findings are published in the January 28, 2005 issue of Cell. "Now that the human genome has been sequenced, it is vita...

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

...apacity and the need for the development of better laboratory tests for such studies. "When DNA repair capacity can be measured easily and quickly, the scientific community will be able to clearly understand the role of DNA repair capacity in the development of cancer and possibly to develop interventions to re...

Source of molecular triggers in cutaneous T cell lymphoma identified

...arch scientist in dermatology set up a physiologic laboratory system mimicking the tight relationship in vivo between CTCL cells and LC. The research team considered three broad categories of antigen as the source of the signal: the protein products of tumor viruses, of mutated genes, and of normal but usually ...

Priming embryonic stem cells to fulfill their promise

...te it with off-the-shelf chemicals andstandardized laboratory machinery. "We think other researchers couldeasily use this technique with any other tissue in mouse, or human, orany other species," said Bhatia.Scientists have identified about 100 proteins - including laminin,fibronectin, and several kinds of coll...

Growth in the sea comes down to a struggle for iron

... the data they collected and conducting additional laboratory experiments. UMaine scientists are planning to return to the Pacific in 2007, but they have a different destination in mind. Work by Japanese and Canadian researchers has already shown that the consequences of iron additions may vary from the easter...

Fox Chase Cancer Center scientists identify immune-system mutation

...s appears in the Feb. 24 issue of Nature. Kappes' laboratory first discovered the mice with this naturally occurring defect in Fox Chase's laboratory animal facility in 1997. Known as "helper deficient" or HD mice, they are proving to be useful for e...

Termites feed through good vibrations

... intelligence. CSIRO entomologist Theo Evans says laboratory experiments have found that termites use their ability to detect vibrations to determine which food source is most suitable. The termites can also detect how the vibrations are made. This ability could be likened to a form of sonar. Dr Evans says di...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...the stem cells when they are grown or derived from laboratory culturesthat contain animal sources of the non-hum...s done with human embryonic stemcells grown in the laboratory of Fred Gage, Ph.D., professor,Laboratory of Genetics, the Salk Institute, La Jolla, California, ana...

Timing is everything: First step in protein building revealed

...released completelyin living creatures, but in our laboratory experiments that is clearlythe case," adds Lorsch. "Even if it isn't released completely in intactcells, our results would indicate that it must be very looselyassociated for translation [protein building] to begin."To monitor what was happening to e...

UW's Rosetta software to unlock secrets of many human proteins

...hey are structured," said Lars Malmstroemof the UW laboratory that developed the program, "And how they arestruc... shape of the protein.Rosetta was developed in the laboratory of UW Professor David Baker bya large team of scientists and students. Former post-doctoral fellowRi...

Plants, animals share molecular growth mechanisms

...Chunhua Zhang and Gregore Koliantz; Eileen Malley, laboratory manager, all of the Department of Agronomy; and Shanjin Huang, postdoctoral student, and Christopher Staiger, professor, both of the Department of Biological Sciences. Staiger and Szymanski also are members of the Purdue Motility Group. Related Webs...

Researchers find how protein allows insects to detect and respond to pheromones

...hey are structured," said Lars Malmstroemof the UW laboratory that developed the program, "And how they arestruc... shape of the protein.Rosetta was developed in the laboratory of UW Professor David Baker bya large team of scientists and students. Former post-doctoral fellowRi...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

...etermine causes of variability, and they foundthat laboratory practices comprised the smallest source of variation inthese studies. Measurement errors common to all labs were the next mostcommon contributor, and biological differences in different sampleswere the largest source of variation.“This study indicate...

Ancient olfaction protein is shared by many bugs, offering new pest control target

...ent insect species. Research by Leslie Vosshall's laboratory had previously shown that of 62 odorant-receptor proteins expressed by fruit flies, 61 are exclusively expressed in non-overlapping sub-populations of neurons, indicating that these proteins participate in sensing particular types of odors. However, ...

Genome-wide mouse study yields link to human leukemia

...l Therapeutics Programs. While it was Caligiuri's laboratory that designed the mouse model, it was Plass who supervised the methylation studies. He and his colleagues used a system called Restriction Landmark Genome Sequencing (RLGS) to compare methylation patterns among the three groups of mice ?a method of u...

Found: Missing sequence of the human Y chromosome

...males in the human population, members ofRappold's laboratory ?including Stefan Kirsch, Ph.D., lead author onthe paper ?tested 100 men of different ethnic origin for the presenceof this 554-kilobase fragment. Indeed, the sequence was present in all100 individuals tested, but not in any female controls, confirmi...

Marburg virus disease in Angola - update

...ted in Uige Province. Ten of these cases have been laboratory confirmed by the Centers for Disease Control and P...icrobiology Laboratory will be setting up a mobile laboratory in Uige and CDC will be providing laboratory support in Luanda. UNICEF is carrying out social mobili...

Leukemia Drug Breakthrough Study In New England Journal Of Medicine

...ial of Revlimid for treatment of MDS following his laboratory observations that the agent improved the growth of red blood cell precursors from MDS bone marrow. Celgene will submit the seminal findings of List's phase I trial - along with data from two recent confirmatory phase II clinical trials performed nati...

Novel Therapy Tested in Mice Could Chase Away Cat Allergies

...rgies successfully prevented allergic reactions in laboratory mice, as well as in human cells in a test tube, University of California, Los Angeles (UCLA) researchers report in the April issue of Nature Medicine, available online now. In the future, the investigators say, these promising results could lead to a...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

Research in the laboratory of Assistant Professor Frank J. Slack at Yale University has identified a new way that a familiar gene is regulated in lung cancer, presenting new possibilities for diagnosis and treatment. The work is reported in March issues of the journals Cell an...

Spider Venom Could Yield Eco-Friendly Insecticides

...virus would not end up in the food supply. Recent laboratory research on cockroaches and tobacco budworms demonstrates that the toxins can disrupt the insects?nervous systems or induce paralysis in just a few minutes. King and his colleagues are now developing both engineered viruses and small-molecule mimics ...

Enzyme shown to help protect genomic stability

...ys N.C. Tolga Emre, a graduate student in Berger's laboratory and lead author on the study. The Ubp10 enzyme acts on histones, molecules that have attracted increasing attention from scientists as they move beyond sequencing the human genome to trying to better understand how DNA is managed and its activity re...

Needling Chromosomes Reveals Cell Division Secret

...s said. "But that’s theusual outcome of work in my laboratory and a sign that we're doing goodscience since we raise new questions. We lay the mechanistic groundworkfor the molecular explanations that have to be made. So, our colleagueswho do molecular work are both provoked and challenged by us," he said....

First 'atlas' of key brain genes could speed research on cancer, neurological diseases

...ed in thesensation of specific types of pain. Ma’s laboratory is focused on thestubborn problem of cancer pain: He and his students are screening theatlas for transcription factors that regulate development of theneurons that generate the severe pain that is a common symptom ofmetastatic tumors.The research was...

Vital step in cellular migration described by UCSD medical researchers

... of the cell, to maintain directional movement. In laboratory experiments with human and animal cells, the UCSD team discovered that the alpha4 integrin recruits enzymes that block Rac activity only at the rear of a crawling cell. The scientists noted that alpha4 integrins are widely expressed in neural crest ...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

...o something more potent. In collaboration with the laboratory of Dr. Samuel Danishefsky at the Memorial Sloan-Kettering Cancer Center, the team went to work creating what's called a "synthetic analogue." "Starting with the basic migrastatin molecule, we cut a piece there, add a piece here," he explained, "and ...

Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine

... to bind to humancells,?said Beth Mann, a research laboratory specialist in Tuomanen’slab who developed the bacteria carrying mutated CbpA. Mann, co-authorof the paper, also showed that the long, paddle-shaped extensions ofthe protein must be folded in a specific way in order for CbpA to work.The discovery of t...

New comparative toxicogenomics database

... to bind to humancells,?said Beth Mann, a research laboratory specialist in Tuomanen’slab who developed the bacteria carrying mutated CbpA. Mann, co-authorof the paper, also showed that the long, paddle-shaped extensions ofthe protein must be folded in a specific way in order for CbpA to work.The discovery of t...

Taking Aim With Nanoparticle PEBBLEs

...with=Kopelman&SubmitButton=Search) * Kopelman laboratory (http://www.umich.edu/%7Ekoplab/) * Fighting Cancer, Cell by Cell (http://lifesciences.umich.edu/research/featured/cancer.html) * American Chemical Society (http://www.chemistry.org/) ...

Genetically modified natural killer immune cells attack, kill leukemia cells

...ade by the St. Jude team were the development of a laboratory technique for rapidly producing a large, pure population of NK cells from a small sample of blood; and developing a technique for genetically modifying NK cells so that they would become potent killers when they encountered leukemic cells. In order ...

UCSD researchers maintain stem cells without contaminated animal feeder layers

...ue of the journal Stem Cells, the study shows that laboratory culture media enriched by a human protein called activin A are capable of maintaining human embryonic stem cells in a continuous undifferentiated state, ready for research. Undifferentiation means the stem cells have not begun the developmental path ...

Nanogen Issued Patent for Electronic Microarray With Memory

... value to the company and to research and clinical laboratory customers," said Howard C. Birndorf, Nanogen chairman of the board and CEO. This new patent expands Nanogen's intellectual property portfolio to include 114 patents issued in the U.S. About Nanogen, Inc. Nanogen's advanced diagnostics provide phys...

Same mutation aided evolution in many fish species, Stanford study finds

After decades of laboratory work studying how animals evolve, researchers some... gene in question, called Eda, is an old friend to laboratory researchers who have found that mutations in the same gene in mice cause altered hair patterns. Howe...

Papers of DNA Pioneer and Nobel Laureate Francis Crick Added to National Library of Medicine’s Profiles in Science Web Site

...ence, lecture notes, draft and published articles, laboratory notebooks, and photographs from the Francis Crick collection at the Wellcome Library. Visitors to the site can view, for example, an early photo of Watson and Crick as research students at the Cavendish Laboratory, drafts of articles on the structure...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

...l don't understand.?/p> The recent findings in laboratory animals were a joint effort of Lund University in Lund, Sweden, the University of Cambridge in the United Kingdom, and the McKnight Brain Institute and the Genetics Institute of the University of Florida. Scientists included internationally renowned ...

Development of portable infectious disease detector

...asure sperm motility with anaccuracy comparable to laboratory analyses."I'm thrilled at how well the VIIBRE and PRIA technologies mesh," saysJohn P. Wikswo, professor of biomedical engineering, physiology andphysics at Vanderbilt and director of VIIBRE. "We are already makingrapid progress on prototyping portab...

Nano-Probes Allow an Inside Look at Cell Nuclei

...rkeley Lab is a U.S. Department of Energy national laboratory located in Berkeley, California. It conducts unclassified scientific research and is managed by the University of California. Visit our Website at www.lbl.gov. ...

Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells

...idal BPA on human prostate cancer tumorimplants in laboratory animal models will shed additional light onwhether the synthetic pseudo-estrogen encourages tumor growth in wholeanimal systems.“We’ll know more about the ‘hormone sensitizing?ability of BPA inprostate cancer cells from studies on animals. It is also...

FDA Warns Consumers Not to Use Home-Use Diagnostic Kits Marketed by Globus Media

...es to be taken at home which people then send to a laboratory for testing. No home-use test kits intended for diagnosing syphilis and dengue fever are approved for sale in the U.S. The FDA has issued an import alert which alerts FDA field personnel to the possible importation of the Globus Media devices, provi...

Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells

...Laboratories researcher Paul Gourley, has provided laboratory demonstrations of accurate, real-time, high-throughput identification of liver tumor cells at their earliest stages, and without invasive chemical reagents. The technique generates a laser beam in single human cells pumped from a flask through tiny ...

International trial of two microbicides begins

... shown activity against HIV and other STIs in both laboratory and animal testing. It is believed to act by inhibiting the entry of HIV and other pathogens into body cells. BufferGel, a product of ReProtect, Inc., Baltimore, MD, boosts the natural acidity of the vagina in the presence of seminal fluid that neutr...

MetaChip provides quick, efficient toxicity screening of potential drugs

... shown activity against HIV and other STIs in both laboratory and animal testing. It is believed to act by inhibiting the entry of HIV and other pathogens into body cells. BufferGel, a product of ReProtect, Inc., Baltimore, MD, boosts the natural acidity of the vagina in the presence of seminal fluid that neutr...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

...y ?that regulates Ras. Several years ago, Casey's laboratory was one of a handful to unravel how the prenylation pathway works. This accomplishment led pharmaceutical companies to test compounds that block another key player in the pathway, a protein called farnesyltransferase. Blocking this protein inhibits R...

Tiny scaffolding allows stem cells to become working fat cells

...ree-dimensional scaffolding for cell growth in the laboratory is so important. The researchers' focus on fat cells as a test bed for this approach to cell growth offers important medical potential. While experts once thought a persons number of fat cells was set at birth, they now know individuals can either l...

Plants defy Mendel's inheritance laws, may prompt textbook changes

...y; and Jessica Young, a botany and plant pathology laboratory technician. Lolle, a Purdue research scientist, is currently at the National Science Foundation. ...

Scientists identify new model Of NK cell development

...e senior author of the study, says research in his laboratory shows that the precursors to NK cells are actually found in cellular nurseries deep inside the body's lymph nodes. The findings, appearing in the Mar. 22 issue of the journal Immunity, may offer clinicians new direction in determining how to manipul...

Bird Brains Show How Trial and Error May Contribute to Learning

...n the final months of her doctoral training in the laboratory of co-author Allison Doupe at the University of California, San Francisco's Keck Center for Integrative Neuroscience. A similar brain pathway in humans may explain how children learn to talk by listening to themselves and others, and how adults lear...

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

...rdone, Ph.D., a postdoctoral student in Grosveld's laboratory who did much of the work on this project. "TEL2 should be considered a new diagnostic marker, especially in patients who don't have the classic genetic mutations that physicians normally use to diagnose the disease. It will also be very interesting t...

Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

...itory contains the results of tens of thousands of laboratory measurements of physical interactions of proteins in more than 100 species. Ideker and his colleagues developed a computerized tool called PathBLAST to search through the Database of Interacting Proteins for protein interactions that are conserved in...

UCSD team discovers specialized, rare heart stem cells in newborns

...from an individual's heart tissue, multiplied in a laboratory setting, then re-implanted into the patient. Furthermore, the developmental lineage marker which identifies undifferentiated cardiogenic precursors suggests the feasibility of isolating isl1+ cardiac progenitors from mouse and human embryonic stem ce...

Gene therapy for Parkinson's disease moves forward in animals

...e still don't understand." The recent findings in laboratory animals were a joint effort of Lund University in Lund, Sweden, the University of Cambridge in the United Kingdom, and the McKnight Brain Institute and the Genetics Institute of the University of Florida. Scientists included internationally renowned ...

Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin

... takes advantage of years of effort in the Therien laboratory focused on the design of highly fluorescent compounds. Polymersomes, which were developed by Penn professors Daniel A. Hammer and Dennis Discher in the mid-1990s, function much like the bilayered membranes of living cells. Whereas cell membranes are ...

New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines

...es, like the antibodies made by innate B cells. In laboratory tests, the antibodies reacted with multiple types of human molecules, most prominently with a fat molecule called cardiolipin. "It appears the most vulnerable spots on the outer coat protein of HIV, to which the most protective antibodies bind, are ...

Antibiotic might fight HIV-induced neurological problems

...eatment. Studies with the animals are augmented by laboratory experiments with cells to clarify observations. Notably, these laboratory experiments have shown that minocycline somehow suppresses replication of HIV and SIV in macrophages...

Mayo Clinic Researchers Create 'Obedient Virus'; First Step To Use Measles Virus Against Cancer

...d, rather than healthy cells. The work was done on laboratory animals implanted with two kinds of human cancer cells -- ovarian cancer and lymphoma -- and is probably still years away from use as a human therapy. But the concept has at last been proved in mice with human cancer tumors -- and that's an essential...

Programmable cells: Engineer turns bacteria into living computers

...ful for the detection of chemicals or organisms in laboratory tests. "The bull's-eye could tell you: This is whe...the ends of the embryo. In addition to conducting laboratory experiments, Weiss and colleagues are creating computer models of their engineered systems, which al...

UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders

...ns, salaries and expansion of highly sophisticated laboratory space, infrastructure, and supplies. Dr. Owen Witte, a renowned scientist whose laboratory research laid the groundwork for development of the targeted leukemia therapy Gleevec, is director o...

Researchers devise way to mass-produce embryonic stem cells

That's important because traditional laboratory methods used to grow these cells are costly and do... the number of stem cells produced by conventional laboratory methods. That's several hundreds of millions more stem cells. Mass-producing cells like this could ...

Substance protects resilient staph bacteria

...ot depend on PGA, but other research in Dr. Otto's laboratory has indicated that PGA production is greater when a biofilm is present. Further, Dr. Otto says all 74 strains of S. epidermidis that his group tested also produced PGA, as did six other genetically related Staphylococcus pathogens. "This could be ver...

Chemists identify immune system mechanism for methamphetamine binges

... Scripps Research Institute have found evidence in laboratory studies that the immune system may be able to reco...ecific methamphetamine antibodies can be made in a laboratory and then used as a clinical treatment for addiction. In theory, antibodies to the drug could be mass...