ischemic

Bioartificial kidney under study at MCG

... Szerlip explains. As examples, kidneys can become ischemic and begin to fail if blood pressure drops because of a long surgery with significant blood loss. Infection can further reduce blood flow to the kidneys. Ironically, some antibiotics patients need for these infections also can harm the kidneys. Even t...

US life expectancy about to decline, researchers say

...d the current life-shortening effects of cancer or ischemic heart disease. The findings are contrary to what some scientists predict about human life expectancy, which assumes that past increases will continue indefinitely. Most forecasts of life expectancy are based on historical trends, but the authors con...

Stem cells bring fast direct improvement, without differentiation, in acute renal failure

...dministered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-indepe...mon and the most treatment-resistant type of human ischemic ARF." Next steps * Current studies are investigating the collective and individual renoprotect...

Researchers Find Drug May Give Some Cardiac Protection 24 Hours After Heart Attack

...that the drug Darbepoietin alpha would protect the ischemic heart. Darbepoietin is a long-acting cousin of erythropoietin (EPO), which has been shown to offer some protection to the heart from injury from ischemia, or a lack of oxygen. In previous studies, Dr. Koch had given EPO at the time of simulated heart...

Molecular cabal contributes to stroke damage

...lcium permeable] ASICs have now been implicated in ischemic neuronal damage. "Our finding…sheds new light on the development of therapeutic agents against excitotoxic and acidotoxic neuronal damage," concluded the researchers. Also, they added, since such NMDARs and ASIC1a are involved in seizures and pain s...

Cord blood cells may widen treatment window for stroke

...hington, DC. The only drug currently approved for ischemic stroke treatment is tPA (tissue plasminogen activa...g, even eliminating, the disabling effects of both ischemic and hemorrhagic stroke. What's more, the treatment can be delivered much later than the current stri...

Feds give researchers ok for safety test of adult stem cells in patients with heart disease

...he coronary arteries of patients suffering chronic ischemic coronary artery disease, a condition in which one or more of the primary arteries supplying blood flow to the heart are clogged. The study will include patients who are not candidates for angioplasty, stent placement or coronary artery bypass grafti...

Phenolic compounds may explain Mediterranean diet benefits

...ng a blood pressure cuff. The response is known as ischemic reactive hyperemia. Poor responsiveness to this so...vailability are behind the observed improvement in ischemic reactive hyperemia," Dr. Pérez Jiménez said. Dr. Pérez Jiménez said that olive oil may be superior ...

Scientists show how thinking can harm brain cells

...ted with diazoxide, a drug investigated for use in ischemic heart disease and strokes. Pretreatment before exposure to PAF prevented dendritic beading and preserved synaptic functions, the studies showed. "Stressing the cells with small amounts could trigger protective genes and induce adaptations that will ...

Serious adverse reactions to smallpox vaccine appear to be limited

... of a membrane that surrounds the heart) and 10 as ischemic cardiac events that were not anticipated based on historical data. Two cases of generalized vaccinia (a skin eruption in reaction to vaccination) and 1 case of postvaccinial encephalitis (inflammation of the brain) were detected. No preventable life-...

Potential heart benefit found in stem cells

...st perfusion defect (scar tissue) in patients with ischemic cardiomyopathy, or blockages in the arteries leadi... heart infarction. In the study, 17 patients with ischemic cardiomyopathy were treated with a combined percutaneous injection (both intramyocardial and intraco...

Stem cell transplants improve recovery in animal models for stroke, cerebral palsy

...w improvement over time." In the newborn model of ischemic injury, enhanced recovery was found within two wee... seven days after the intitial injury. Currently, ischemic stroke patients may be treated with tPA, the only FDA-approved stroke treatment available, but must ...

Possible brain hormone may unlock mystery of hibernation

...a treatment that is effective for preventing brain ischemic damage." In cryosurgery, physicians use extreme cold to destroy abnormal tissue, such as cancerous tumors. ...

Proteins spur diabetic mice models to grow blood vessels, nerves

...etrins not only accelerated blood vessel growth in ischemic mice (those with constricted blood flow) but they also restored blood vessel and nerve growth in diabetic mice. Dean Y. Li, M.D., Ph.D., a cardiologist and associate professor of internal medicine at the University's School of Medicine, is the study'...

New tool tracks brain development in babies

...a result of complications during delivery. Hypoxic ischemic injury can result in severe motor problems. "The pattern and extent of the brain injury largely determine the neurological and developmental consequences for the newborn," Dr. van Pul said. "The detection of injury at an early stage is essential for...

New compound reduces stroke damage

... and the most common cause of adult disability. An ischemic stroke occurs when a cerebral vessel occludes, obstructing blood flow to a portion of the brain. Currently, there is only one approved stroke therapy, tissue plasminogen activator, which targets the thrombus within the blood vessel. Because of the l...

Free radical cell death switch identified

...amage in a variety of disorders, including stroke, ischemic heart disease, neurodegenerative diseases, and diabetes, identification of the MST-FOXO switch mechanism could provide potential new targets for the diagnosis and treatment of many common age-associated diseases. ...

Stem cells decrease ischemic injury and restore brain function

...spite the recent advancements in the management of ischemic patients (early diagnosis, thrombolysis, stroke un...rn into neurons in order to protect the brain from ischemic injury and restore brain functions. Their presence in brain tissue is sufficient to induce a protect...

Are one-third of costly implanted heart devices unnecessary? New study suggests yes

...caused by lack of blood flow -- a condition called ischemic cardiomyopathy. Each patient received a test ca...ing, they published results from the same group of ischemic cardiomyopathy patients, showing that the MTWA test was able to predict the risk of death from any c...

Glucose triggers brain cell death in rats after hypoglycemic coma

...oxidative stress in other settings –?especially in ischemic stroke, where the blood supply to the brain is dim...as agents of oxidative stress in a rodent model of ischemic stroke. "So far, the results are very promising," he says. ...

Mice with a migraine show signs of brain damage

...curs to the brain from repeated TIAs, or transient ischemic attacks,?said Takano. “It’s long been known that patients having a migraine attack are functionally impaired from the pain. It’s also been shown recently that with repeated migraines, a person’s cognitive abilities decrease. But actually doing damage...

Human stem cell treatment restores motor function in paralyzed rats

...dings could offer great hope to people with spinal ischemic injury who suffer from resulting spasticity and rigidity,” said Marsala. ...