Ischemia in Biological News

Promising 3-year data: Saving limbs with drug-eluting stents

... (March 10, 2009)Attempts to treat critical limb ischemia in peripheral arterial disease (PAD) patients ... prospective registry who had critical limb ischemia and who underwent infrapopliteal ... drug-eluting stents in critical limb ischemia treatment," he added. In the United States, ...

Mental stress reduces blood flow to the heart in patients with gene variation

... blood flow to the heart a condition doctors call ischemia than heart disease patients without it. ischemia increases the chance these patients will suffer a ... in patients who do not have mental stress-induced ischemia in terms of overall adverse events and also ...

Ovarian transplantation: New technique gives greatly improved results in this delicate operation

... the tiny blood vessels supplying the ovary are directly linked, and ischemia time, during which blood supply is restricted, is minimised. However, this ... in most reproductive centres. With the cortical grafting technique, ischemia time for revascularisation was always thought to be a limiting factor, not ...

A missing enzyme conveys major heart protection in pre-clinical work

... oxide, the heart can grow new blood vessels in the absence of chronic ischemia (inadequate circulation)," said Howard Rockman, M.D., Duke professor of ... cardiology at Duke Heart Center and senior author of the study. Chronic ischemia usually occurs in people with severe coronary blockages, and who are at ...

Society of Interventional Radiology hosts 34th annual scientific meeting

... Seeing the Promise of Drug-Eluting Stents for Critical Limb ischemia Interventional radiologists are helping peripheral arterial disease (PAD) patients with critical limb ischemia avoid amputation by exploring the treatment of the smaller blood vessels ...

US Air Force grant targets medical evacuation procedures

... of traumatic military combat injuries: controlled hemorrhage, hepatic ischemia reperfusion and scald/burn. The controlled hemorrhage model, ... reach a field hospital to receive fluids for several hours. Hepatic ischemia reperfusion model represents a patient who needs serious abdominal surgery ...

Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia

... Goette added Our results have several clinical implications. Atrial ischemia produces an increase in cellular calcium load and oxidative stress in the atria. Thereby, atrial ischemia provides a specific substrate for AF. Recent experimental and clinical ...

Laughing hyenas, wailing levees, the sound of cheese and blaring bagpipes

... vessels using UMGD with microbubbles carrying a gene for vascular endothelial growth factor. This therapeutic use could be important for treating ischemia in patients who have had a heart attack, peripheral artery disease, or stroke. The team is also investigating using the bubbles to transport small ...

'First aid' for brain cells comes from blood

... In acute ischemic stroke, the blood supply to the brain is restricted. Initially, brain cells die from lack of oxygen. In addition, ischemia activates harmful inflammatory processes in the affected area of the brain. For the first time, scientists at the Neurology Clinic at Heidelberg ...

Cardiac cell transplant studies show promise in cardiac tissue repair

... to vascular SMCs (smooth muscle cells)." Sartore noted that in previous studies when AF-MSCs were transplanted into porcine models of myocardial ischemia they were converted to vascular cells, but not to cardiomyocytes. "Both of these papers further help delineate the evolving role of bone marrow ...

Exercise could be the heart's fountain of youth

... into an energy-deprived state, which may raise the risk of heart attack. But if it can increase glucose uptake, the heart is better protected against ischemia (low oxygen) and heart attack. Based on heart glucose metabolism, both the men and women in the study had the same rejuvenating benefit from their ...

ASBMB taps 8 scientists for top awards

... or public enlightenment. Schwartz-Bloom's past research looked at novel pharmacologic approaches to prevent neuronal death caused by cerebral ischemia associated with cardiac arrest and stroke. Her current research program, which she started in 1996, focuses exclusively on science education. ...

Findings released from 1 of the largest percutaneous coronary intervention trials ever

... rates of major cardiovascular adverse events. Bivalirudin has previously been shown to result in less bleeding and similar rates of composite ischemia compared to heparin plus GPI in patients undergoing angioplasty for stable angina, unstable angina and non-ST-elevation myocardial infarction ...

The endocannabinoids: Functional roles and therapeutic opportunities

... enhance brain 2-AG levels in mice. 2-AG, both of endogenous and exogenous origin, has been shown to be neuroprotective in closed head injury, ischemia and excitotoxicity in mice. These effects may derive from the ability of cannabinoids to act through a variety of biochemical mechanisms. 2-AG also ...

Human stem cell treatment restores motor function in paralyzed rats

... by next year. Paraplegia from spinal cord ischemia is a serious complication that occurs in 20 to 40 ... “The important difference between spinal cord ischemia and spinal cord trauma, such as might occur in a diving or car accident, is that in the ischemia model, no mechanical damage has occurred to the ...

UW launches study testing adult stem cells for heart damage repair

... Cellular Therapy CD34-Chronic Myocardial ischemia (ACT34-CMI) Trial. The first patient underwent ... outcomes in patients with chronic myocardial ischemia (CMI), a severe form of coronary artery disease. ... A person who suffers from chronic myocardial ischemia continues to experience insufficient flow of ...

New tool tracks brain development in babies

... depicts the diffusion, or displacement, of water molecules through tissue. ischemia results in tissue changes that are visible with diffusion tensor imaging ... fiber abnormalities ultimately correlate with outcomes." Hypoxic ischemia remains an important cause of infant mortality and morbidity, with an ...

Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke

... Previous work by others had shown that certain events, such as cerebral ischemia (stroke) and seizures, that interrupt oxygen flow to the brain also cause ... treatment. This provided additional evidence that brain damage caused by ischemia depends in large part on the stimulation of EP1 receptors, the researchers ...

pHLIP, a novel technology to locate and treat tumors

... pHLIP could also be used for monitoring of disease development and therapeutic outcomes. It might play very important role in the study of arthritis, ischemia and stroke.? Lead author Oleg Andreev said, “We believe that universal medical tests to reveal many health problems at earlier stages may be ...

Protein may hold key to decreasing organ dysfunction rates in heart transplants

... complications involved with many transplantations is the damage done to the transplanted heart during and immediately following surgery, known as ischemia and reperfusion (IR). In particular, inflammatory cells infiltrate the donated heart, which then releases enzymes and other proteins that attack the ...

New study shows antibiotic may protect the heart

... ATP, the key fuel for cellular function. "Rapamycin may one day be beneficial as a potential therapeutic strategy to limit cell death caused by ischemia or reperfusion injury, and possibly long-term prevention of ventricular remodeling ?the changes in size, shape and function that may occur to the ...

Molecular cabal contributes to stroke damage

... ASICs open to admit calcium into the cell, and calcium overload is central to neuronal death. In their experiments, Gao and colleagues induced ischemia in rat brains, or deprived cultured neurons of oxygen, and analyzed the molecular effects. Their analyses revealed that such deprivation triggered ...

Researchers Find Drug May Give Some Cardiac Protection 24 Hours After Heart Attack

... in an another animal model, and found it protected the animals. But in further studies, Dr. Koch gave Darbepoietin to animals at the time of ischemia and heart attack, one to two hours after, and 24 hours later. In each case, the scientists saw that the drug offered significant protection to heart ...