introns

Breakthrough Microarray-based Technology for the Study of Cancer

...terations at the scale of individual genes andeven introns and exons. This advancement, along with the possibility itprovides to correlate genomic copy alterations with mRNA abundance andprotein abundance, is going to incite a huge body of experimentationand publication among the cancer research community."I...

Molecular machine may lead to new drugs to combat human diseases

...point in its work cycle. When frozen, crystallized introns reveal their structure and the sites at which they...ular Biology. "In terms of human health, Group I introns are interesting because they cause their own removal and also splice the ends of the surrounding RNA...

Researchers find missing genes of ancient organism

...ing the process of tRNA maturation. The known tRNA introns in organisms like yeast, however, appear to have no function. Therefore, modern tRNA introns might be remnants of an old essential process of tRNA biosynthesis. "These results may point to ext...

Carnegie Mellon University research reveals how cells process large genes

... non-coding elements (introns). During processing, introns are snipped out and exons pasted together to form ...t how a cell's molecular machinery eliminates long introns without making errors has puzzled scientists for years. Now, investigators at Carnegie Mellon Univ...

Reversal of role for a viral protein associated with the development of lymphoma

... non-coding elements (introns). During processing, introns are snipped out and exons pasted together to form ...t how a cell's molecular machinery eliminates long introns without making errors has puzzled scientists for years. Now, investigators at Carnegie Mellon Univ...

Study provides insight into cellular defenses against genetic mutation

...de for the building of proteins, and pieces called introns that do not code for proteins. For mRNA to mature, it must be cut and pasted by cellular machines that re-assemble end to end only exons in the final template for protein construction. In recent years, Maquat's team has confirmed that complexes that ...

The earliest animals had human-like genes

...usually contain extra bits of DNA sequence, called introns ?information which has to be removed as cells create new molecules. The number of introns in genes, however, varies greatly among animals. While humans have many introns in their genes, comm...

RNA splicing occurs in nerve-cell dendrites

...re mRNA regions destined to code for proteins) and introns (non-coding regions). mRNA splicing works by cutting out introns and merging together the remaining exon pieces, resulting in an mRNA capable of being translated int...

Tandem transcripts team together

...tandard eukaryotic splicing machinery that removes introns from RNA transcripts. Following a similar whole-genome survey of splicing events, Guigó's laboratory focused on the ENCODE regions, a set of DNA sequences, representing 1% of the genome, that have been chosen by a large research consortium for more ...

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription

... intergenic regions near their 3?end. In addition, introns (internal non-coding regions in genes) are significantly less stable than exons (coding sequences in genes), suggesting that stable sense duplexes are characteristic of the coding sequences. Next, the authors showed a relationship between the patt...

Exploring the dark matter of the genome

...he coding sections of the gene (exons); unlike the introns in euchromatic genes, these long gaps consisted almost entirely of repeating sequences derived from disabled transposons. The evidence suggests that heterochromatic genes are regulated differently from euchromatic ones. Besides protein-coding gen...