Intron in Biological News

CSHL scientists clarify editing error underlying genetic neurodegenerative disease

... unedited RNA molecule, the boundaries between an intron and its two flanking exons are called splice ... guided to the splice site at the beginning of an intron by one of its components, a small nuclear RNA ... to recognize this splice site at the start of the intron is strongest when up to 11 bases are paired up. ...

Yale scientists visualize the machinery of mRNA splicing

... research team into the nature of group II introns , a particular type of intron within gene transcripts that catalyzes its own removal during the ... II introns hold promise in the future as agents of gene therapy. A free intron is an infectious element that is special because it targets DNA sites very ...

Stowers Institute's Baumann Lab identifies key step in maturation pathway of telomerase

... could have such a function, as the two steps of removing an internal piece of RNA and gluing the flanking ends together are tightly coupled during intron removal. To our knowledge this is the first example where uncoupling of the first and second step of splicing generates a functional product in a ...

Researchers develop new self-training gene prediction program for fungi

... the exon-intron structure of eukaryotic genes, we didn't search for branch point sites, but doing so in the new program helps to better delineate intron regions inside fungal genes," added Borodovsky, who is also a Regents' Professor in the Coulter Department of Biomedical Engineering and the ...

Evolution of fruit size in tomato

... into proteins, they are nevertheless structurally and functionally important, as demonstrated in this locus. The presence of an insertion in this intron reduces expression of the fas gene. The scientists looked at where and when the gene is expressed and found it dramatically reduced in developing ...

Scientists find a fingerprint of evolution across the human genome

... consequences. Other sequences must likewise be preserved in the regions to be retained. The scientists found a preference for some letters across intron regions, and the opposite preference in coding regions. Together, these regions make up at least a third of the genome, which is thus under selective ...

Scientists find missing evolutionary link using tiny fungus crystal

... fungus, had adapted to take over some of the RNA molecule's chemical reaction jobs inside cells. The protein stabilizes the RNA molecule - called an intron - so that the RNA can cut out non-functional genetic material and splice together the ends of a functional gene, Paukstelis said. "The RNA ...

Reversal of role for a viral protein associated with the development of lymphoma

... mutations occur at standard signals where intron removal takes place through direct splicing. ... tools to analyze the lariats released from any intron during splicing in vivo. In his analyses, he ... these ratchetting points mediate the removal of intron subfragments in one direction as the gene is ...

Carnegie Mellon University research reveals how cells process large genes

... mutations occur at standard signals where intron removal takes place through direct splicing. ... tools to analyze the lariats released from any intron during splicing in vivo. In his analyses, he ... these ratchetting points mediate the removal of intron subfragments in one direction as the gene is ...

Program finds lost genes in nematode genome

... C. Elegans is able to use more accurate models of intron length than previous analyses. This is important ... the coding machinery of proteins. While getting intron length is helpful for gene annotation, the ... less accurate methods. Being able to define intron length has implications for the human genome, ...

Molecular machine may lead to new drugs to combat human diseases

... can use this knowledge to manipulate the intron to splice out malfunctioning genes, said Barbara ... Golden said. She and her research team used an intron from a bacteriophage, a molecule that attacks bacteria, to obtain an intron crystal structure trapped in the middle of the ...

RNA splicing occurs in nerve-cell dendrites

... proteins within the human body arises in part from the many ways that mRNAs can be spliced and reconnected. Specifically, splicing removes pieces of intron and exon regions from the RNA, with the resulting spliced RNA often being made into protein. Should the RNA have different exons spliced in and out ...

Genes linked to treatment resistance in children with leukemia

... the CNS. For patients in the high-risk arm, the VDR FokI genotype was found to be prognostic for CNS relapse, especially when combined with a VDR intron 8 genotype. In the low-risk group, the TYMS 3/3 genotype was a risk factor. For children with these unfavorable genotypes, a potential solution ...