intravenous

U of M researcher examines newly emerging deadly disease

... is mediated by superantigens, it is possible that intravenous immunoglobulin therapy may be indicated. Of the five patients observed in the Minneapolis-St. Paul area during the period of 2000-2004, four of the patients were previously healthy and four of the patients were women. Schlievert and colleagues hypoth...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

... was not limited to muscle, they found. Moreover, intravenous administration of the muscle-targeted gene reduced the glycogen content of heart and skeletal muscle and corrected individual muscle fibers. The effect persisted for 24 weeks post-injection, the team reported. A second gene therapy strategy, in whic...

Studies reveal methods viruses use to sidestep immune system

...rne infection. It is transmitted primarily through intravenous drug use, blood transfusions or blood products, as well as through sexual contact and is the leading cause of cirrhosis and liver cancer. UT Southwestern Medical Scientist Training Program (MSTP) student Eileen Foy was an author on all three papers....

Simple drug has the potential to save many lives threatened by malaria

...re malaria where qualified staff and equipment for intravenous therapy is not available. These are encouraging results, say experts in an accompanying editorial. Although a single trial of this size cannot alone be the basis for policy change, rectal artemisinins might be one safe and effective way to reduce th...

HIV vaccine trial breaks ground for future research

...ized study of healthy participants who did not use intravenous drugs. The volunteers were men who have sex with men or women at high risk for heterosexual transmission. The vaccine and placebo were given by injection seven times over 30 months and the participants were assessed for risk. At each visit the partic...

PGA on a tour under the skin

...h prosthetic joints, replacement heart valves, and intravenous catheters, and antibiotic resistance makes it tough to battle. Moreover, the mechanism through which the organism becomes so pathogenic once the protective barrier of the skin is removed remains unclear. In their study appearing online on February 3...

Buying Time Through Hibernation on Demand

...elivery of such treatment could be as simple as an intravenous infusion of saline solution mixed with trace amounts of an agent that would interfere with the body's ability to use oxygen, Roth said. Using oxygen deprivation to depress metabolic activity also might extend the amount of time that organs and tissu...

U-M team recovers ancient whale in Egyptian desert

...elivery of such treatment could be as simple as an intravenous infusion of saline solution mixed with trace amounts of an agent that would interfere with the body's ability to use oxygen, Roth said. Using oxygen deprivation to depress metabolic activity also might extend the amount of time that organs and tissu...

Scalpel-free surgery could reduce risk of HIV and hepatitis exposure for health care workers

...esults, type of operation, age, sex and history of intravenous drug use. The researchers found that 38 percent o... in up to 65 percent of patients with a history of intravenous drug use and in as many as 71 percent of patients undergoing a soft-tissue abscess procedure or lymp...

Hepatitis C responds best to combo of ribavirin and interferon, study concludes

...through a variety of means such as sexual contact, intravenous drug use and needle stick accidents. The disease progresses slowly over 10 to 30 years, causing inflammation and severe scarring of the liver. If untreated, it can lead to liver failure, liver cancer and death. According to the Centers for Disease C...

Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy

...mage in the hearts of mdx mice. They found that an intravenous infusion of P188 in mdx mice restored the volume of the heart's main pumping chamber to the volume of normal mice ?a direct effect of P188's ability to restore normal elastic properties in individual cardiac myocytes. To examine the effects of P188 ...

AIDS expert says global strategy needed to combat feminization of HIV/AIDS

... due to heterosexual transmission (81 percent) and intravenous drug use (16 percent). In the developing world, heterosexual transmission is responsible for nearly all of the infections among women, and mother-to-child transmission during childbirth further contributes to the spread of the disease. Women are par...

Promising therapies for haemophilia & heart disease

...rate or mild form. People with haemophilia rely on intravenous infusion of recombinant Factor VIII clotting protein. Professor Denisa Wagner and her Harvard colleagues have made ground-breaking discoveries that provide hope of an alternative treatment option for haemophilia sufferers. Presenting this research,...

Defective Gene Linked to Two Inherited Immune Deficiencies

...rapy still consists of prophylactic antibiotics or intravenous immunoglobulin infusions every three weeks,?he says. ...

Agreement will speed research on microbicides for women

...rapy still consists of prophylactic antibiotics or intravenous immunoglobulin infusions every three weeks,?he says. ...

Biologists Crack Genetic Code for Specialized Spider Silk

...rapy still consists of prophylactic antibiotics or intravenous immunoglobulin infusions every three weeks,?he says. ...

Hepatitis C complicated by morphine withdrawal

...entary. Hepatitis C virus (HCV) is common among intravenous drug users, with 70 to 80% of abusers infected in the United States. This high association has peaked interest in determining the effects of drug abuse, specifically opiates, on progression of the disease. The discovery of such an association would...

Grabbing addiction by the tail

...." In contrast, addicted animals who received an intravenous injection of the artificial peptide displayed no sensitized behavior. "The effect was immediate and very noticeable," said Wang. There are several types of glutamate receptors involved in memory and learning, but because the artificial peptide spec...

Compound from marine bacteria shows potential as multiple myeloma therapy

...to normal cells. Bortezomib is currently given by intravenous infusion. "NPI-0052 can be given orally, although the first clinical trials will be using the intravenous route," says Paul Richardson, M.D, who is also a co-author in this study and will be leading the Pha...

Implantable pumps extend lives of patients too sick for transplant

... for the trial, patients had to be taking powerful intravenous drugs in the hospital just to keep their hearts pumping, and they were also too sick to be considered for a heart transplants. Most were in intensive care units. "Despite the shortcomings of the device, the results of this trial speak to our ability...

Cord blood cells may widen treatment window for stroke

...ed 48 hours after the brain attack, which was when intravenous delivery of the cells appeared most beneficial. "We were very surprised," said principal investigator Alison Willing, PhD, a neuroscientist at the USF Center of Excellence for Aging and Brain Repair. "In some animals, the stroke initially damaged ha...

Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates

... systemic microvasculature, making their use after intravenous administration therapeutically relevant. The investigators also used high magnification microscopy and 3-D image reconstruction to study the localisation of the bioconjugates after incubation with the prostate cancer cells and confirmed that the part...

Researchers use 'trickery' to create immune response against melanoma

... systemic microvasculature, making their use after intravenous administration therapeutically relevant. The investigators also used high magnification microscopy and 3-D image reconstruction to study the localisation of the bioconjugates after incubation with the prostate cancer cells and confirmed that the part...

Human albumin from tobacco plants

Human serum albumin (HSA) is the intravenous protein most commonly used in the world for therapeutic ends. It is employed to stabilise blood volume and to avoid risk of a heart attack, its administration in operating theatres being almost a daily occurrence. It is used for haemorrhages, burns, ...

Stem cell study for patients with heart attack damage seeks to regenerate heart muscle

...rience a first heart attack. The study involves an intravenous infusion of adult mesenchymal stem cells from healthy donor bone marrow that might possibly reverse damage to heart tissue. A unique benefit of the stem cell product is that it is given to patients through a standard IV line. Other therapies requir...

Patients now surviving once-fatal immune disease

...isease." Forty of the 41 patients were receiving intravenous infusions of gamma globulin every two to four weeks and 16 (39 percent) were taking chronic (long-term) antibiotics in order to prevent infections, the St. Jude team reported. In addition, 17 patients (41 percent) had not been hospitalized for infe...

UF scientists test improved gene therapy method for hereditary heart conditions

...s into the heart muscle in primates after a single intravenous injection, and the effects are long lasting. "AAV-9 had a particular affinity for heart muscle that AAV-8 didn't," Byrne said. "Right now AAV-9 seems to be our best solution for heart problems. "The primates were done to give us insight into how ...

Production of key Alzheimer's protein monitored for first time in humans

...advances has become sufficiently sensitive. Via an intravenous drip, scientists give test subjects a form of the amino acid leucine that has been very slightly altered to label it. Inside the leucine are carbon atoms with 13 neutrons and protons in their nucleus instead of the more common 12 neutrons and protons...

Bubbles go high-tech to fight tumors

...on liquid droplets goes into the body by way of an intravenous injection. The droplets are small enough that they don't lodge in vessels. Doctors image the droplets with standard ultrasound, and once the droplets reach their destination, scientists hit them with high intensity ultrasound. The ultrasound acts lik...

Gene transfer using mutant form of good cholesterol cuts vascular plaque and inflammation

...d to human trials at the Cleveland Clinic in which intravenous injections were found to shrink plaque in human coronary arteries. The Cedars-Sinai researchers, collaborating with researchers from Sweden, also are developing vaccine against LDL cholesterol (bad cholesterol) that one day may be administered in ...

Got inexpensive contrast agent? Milk plays new role in imaging

...a barium-based oral contrast agent that works with intravenous contrast to allow better visualization of the bowe...k, while the intestinal wall appears bright due to intravenous contrast enhancement. The dark intestinal cavity contrasting with the bright intestinal wall makes a...

Molecular 'on/off switch' controls immune defenses against viruses

...is C virus, a blood-borne infection transmitted by intravenous drug use, blood transfusions and sexual contact. It affects 4 million U.S. residents and is the nation's leading cause of cirrhosis and liver cancer. In 2005 Dr. Gale and his team completed several breakthrough studies on hepatitis C, discovering...

Gene therapy for hereditary lung disease advances

...ymptoms of emphysema can be treated through weekly intravenous injections of alpha-1 protein derived from human plasma. The injections must continue throughout a patient's life, according to the American Lung Association. It does not cure, but it does appear to slow the progression of this disease. Patients ...

'Trojan Horse' agent halts bone metastasis in mice

... staggered doses of VEGF121/rGel delivered through intravenous injections. Half of the treated mice did not develop any bone tumors, Rosenblum says. "There was no evidence of cancer growth," he says, adding, "We don't know why the treatment didn't work in the other half of the mice, but we may have started t...

To slow AIDS in Russia, treat HIV-positive addicts, Stanford study says

...day. "If they can get the treatment and support, intravenous drug users can do well taking their medications," said Owens. The study has important implications for Russia's approach to combating AIDS. Antiretroviral therapy is expanding in Russia, but it remains to be seen whether drug addicts will receiv...

Intravenous gene therapy protects normal tissue of mice during whole-body radiation

...hole-body irradiation." Dr. Greenberger added that intravenous administration could potentially offer wide-reaching protection to the public in the event of a terrorist attack since experts believe a significant number of the population would die within 30 days of receiving a large dose of radiation to the entir...

New study aims to stop sepsis in its tracks

...blood pressure drops or is no longer responsive to intravenous fluids does the team realize it is suddenly behind the eight ball. By then, the patient is quickly spiraling into multisystem organ failure. Starting resuscitation at this point may already be too late." To test ways of managing the disease during ...

Growth hormone to boost athletic performance risks diabetes

...ated, and diagnosed with diabetes. He was given intravenous fluids and gradually increasing amounts of insulin over five days, after which he was discharged. His symptoms completely cleared up, and he was no longer diabetic. The use of growth hormone has steadily risen among amateur athletes and bodybuilde...

Stem cell therapy shows promise in regenerating damaged muscle in heart attack patients

Heart attack patients who received an new intravenous adult stem cell therapy, Provacel? experienced a l...preparation of adult stem cells pre-formulated for intravenous delivery by the drug's manufacture, Osiris Therapeutics. Patients were administered an infusion of ...

Prenatal cocaine's lasting cellular effects

...tulates a key feature of human abuse -- that being intravenous exposure to low doses of cocaine," Stanwood said. ...rabbits. They found that exposure to low levels of intravenous cocaine during a very short window of time during gestation -- equivalent to the late first trimeste...

Dealing deadly cancers a knockout punch

...nced it had initiated a Phase II trial to evaluate intravenous administration of Reolysin in patients with sarcomas that have metastasized to the lung. For patients with deadly soft tissue sarcoma, the lungs are the most common site of metastatic disease. To date, surgery has been the only effective therapy for ...

An 'elegant' idea proves its worth 25 years later

...March 2005. The regimen consisted of high-dose intravenous sodium phenylacetate and sodium benzoate for two hours followed by "maintenance infusions" until blood ammonia levels were normal. The patients’ overall survival rate was 84 percent, and 96 percent survived episodes of severe ammonia poisoning. A...

Blood-brain barrier breached by new therapeutic strategy

...a strip of therapeutic material into the brain via intravenous administration. Once delivered to the nerve cells of the brain, the strip, called a small interfering RNA (siRNA), was shown to protect mice from infection caused by the Japanese encephalitis virus (JEV). Manjunath N. Swamy, M.D., of the CBR Instit...

Enzyme delivered in smaller package protects cells from radiation damage

... gland. Based on previous studies showing that intravenous gene therapy delivery of the enzyme manganese superoxide dismutase (MnSOD) could protect mice from whole body irradiation, and in preparation for a potential clinical trial of systemic MnSOD in humans, the University of Pittsburgh and Stanford resear...