Intravenous in Biological News

Device prevents potential errors in children's medications

... in identifying the proper formulations of seven intravenous drugs. Five potentially serious medication ... said. However, the primary safeguard for intravenous drugs compounded in hospital pharmacies today ... company about developing applications to check intravenous drug compounds prepared in the pharmacy for ...

Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck

... care antibiotics (metronidazole or vancomycin) were randomized to receive intravenous CDA-1/CDB-1 or intravenous placebo. An oral presentation of the Phase II data is scheduled at the ...

MIT student develops new innovations to selectively kill cancer cells

... to date," states Dr. Bhatia. "Pre-clinical trials reveal that a single intravenous nanoparticle injection eradicated 100 percent of tumors in mice using a ... Von Maltzahn's second invention aims to fundamentally improve the intravenous delivery of therapeutics to tumors by taking a 'systems' approach to their ...

Fewer deaths with preventive antibiotic use

... received antibiotics through a gastric tube in the intestinal tract and by intravenous drip. The third group was the control group and received the standard ICU ... (oral antibiotic paste, and antibiotics in the intestinal tract and by intravenous drip) and 2.9 percent (oral antibiotic paste). The difference between the ...

Battling bacteria in the blood: Researchers tackle deadly infections

... their weakened immune systems, but also because they often have long-term intravenous catheters that allow medicines to be given directly into the bloodstream. While this helps patients avoid repeated intravenous needles, it also gives bacteria an easy pathway straight into the blood. ...

Positive results in Phase 2 trial of treatment of C-difficile-associated diarrhea

... (metronidazole or vancomycin) were randomized to receive either intravenous placebo or intravenous administration of a combination of MDX-066 (CDA-1) and MDX-1388 (CDB-1), ...

Phase III data show efficacy/safety of iclaprim in patients with complicated skin infections

... of America (IDSA) 46th annual meeting in Washington, DC. In these studies, intravenous iclaprim, a novel antibiotic, showed high clinical cure rates which were ... profile that compared favorably to linezolid. A New Drug Application for intravenous iclaprim in cSSSI will be discussed at the meeting of the U.S. Food and ...

Recurrence of group B strep high in subsequent pregnancies, say UT Houston obstetricians

... is therefore considered colonized, she will most likely be treated with intravenous (IV) antibiotic therapy during labor. The antibiotics will help protect ... the women be given IV antibiotics during labor. The recommended regimen is intravenous penicillin. ...

Hyperviscous fluids: Better treatment for severe blood loss

... intravenous administration of isotonic fluids is the standard emergency treatment in ... Building on earlier studies in humans that have shown benefits of intravenous fluids that are eight times saltier than normal saline, the researchers ...

A genetic cause for iron deficiency

... anemia who didnt respond to oral supplements, and only poorly to intravenous iron. The cause of their condition termed iron-refractory ... to hold on to iron. This explains the patients poor response to intravenous iron the iron is trapped in macrophages and cannot be used for red blood ...

Intravenous gene therapy protects normal tissue of mice during whole-body radiation

... during exposure to whole-body irradiation. Dr. Greenberger added that intravenous administration could potentially offer wide-reaching protection to the ... that systemic MnSOD-PL treatment was not harmful to survival. intravenous administration of gene therapy appears to prevent the damaging effects of ...

Test helps in fight against lung infections and for treating other life-threatening infections

... with cystic fibrosis at the University of Alberta hospital CF clinic. The patients ranged from 9 to 51 years of age. One patient was receiving intravenous antibiotics for a lung infection but continued to decline in health and lung function. The same antibiotics had been used for an earlier infection ...

Plant microbe shares features with drug-resistant pathogen

... produce glue-like substances, or biofilms, which allow them to adhere to plant roots, in one case, and medical devices such as ventilation tubes and intravenous catheters, in the other. Such devices are a common source of exposure to opportunistic pathogens for hospital patients. Implications "Soil ...

Chemical found in medical devices impairs heart function

... at the Johns Hopkins University School of Medicine have found that a chemical commonly used in the production of such medical plastic devices as intravenous (IV) bags and catheters can impair heart function in rats. Appearing online this week in the American Journal of Physiology , these new findings ...

Scientists can predict nano drug outcome

... 100 nanometers. Nano drugs for cancer like liposomal doxorubicin are designed to increase the amount of drug reaching tumors. Currently, when an intravenous cancer drug is administered, very little reaches its intended target. The remaining drug circulates in the bloodstream and can cause side effects. ...

Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover

... many substances in the blood from penetrating into the brain. Because of this, orexin cannot reach the brain when it is given orally or as an intravenous or subcutaneous injection. "Fortunately, however, high-orexin mice show no sleep/wake disturbance or other serious side effects," Dr. Yanagisawa ...

UT faculty members win American Heart Association awards for advancing research

... recognize leaders in this field. Holcomb's contributions to trauma medicine include increased hemorrhage control through dressings, tourniquets and intravenous methods, as well as trauma informatics and systems. "Each year the American Heart Association selects one surgeon to receive a Lifetime ...

New research lights up chronic bacterial infection inside bone

... in newborns, and can cause abortion and stillbirth. When the infection is caught in time, treatment can be difficult and take weeks to clear with intravenous administration of antibiotics. Therefore, in order to understand how this pathogen can be so elusive and difficult to treat, a research team ...

Donation for new Center for Pharmaceutical Nanotechnology and Nanotoxicology

... molecular discoveries into benefits for patients. Research into delivery and targeting of pharmaceutical, therapeutic, and diagnostic agents via intravenous and interstitial routes of administration with particulate drug carriers and nanoconstructs is at the forefront of projects in nanomedicine, but the ...

Apelin hormone injections powerfully lower blood sugar

... type 2 diabetes. Those findings led the researchers to suspect that apelin and insulin might have other similarities. Now, they show that acute intravenous injections of apelin have a powerful blood sugar-lowering effect on mice. They also show evidence that apelin stimulates muscle and fat tissue to ...

New test promises quicker, more accurate evaluation for cystic fibrosis patients

... The researchers evaluated 18 CF patients who were suffering severe exacerbations of their disease. They withdrew blood before and after two weeks of intravenous antibiotic therapy. The severe exacerbation and antibiotic therapy served as a condensed model of illness and response to therapy; in these cases ...

Common treatment to delay labor decreases preterm infants' risk for cerebral palsy

... BIRMINGHAM, Ala. -- intravenous magnesium sulfate supplementation before preterm delivery cuts the risk for handicapping cerebral palsy in half, according to research led by ...

Experimental chemotherapy regimen shows promise in treating advanced lung cancer

... 5-FU production at a steady level and a third part is designed to counteract 5-FU's toxic effects, such as nausea and vomiting. Irinotecan, an intravenous drug originally developed and tested in Japan and approved for use in the U.S. in 1994, is most often used to treat colon cancer. It is currently ...

Weill Cornell science briefs June/July 2008

... medications for Crohn's disease are enrolled in the trial to test the safety and efficacy of the procedure. Each subject receives four infusions -- intravenous transplantation -- of mesenchymal stem cells, which are universally compatible in all people, like type-O blood. For more information: Please ...

Following traumatic brain injury, balanced nutrition saves lives

... from basic research and applying the knowledge directly to the care we give to patients," says Dr. Hrtl. "For a long time, clinicians thought that intravenous fluids were enough -- based on anecdotal situations and some basic biochemical knowledge -- but now we know that this level of care is not meeting ...

Eribulin mesylate demonstrated anti-tumor activity in patients with advanced breast cancer

... The median age of those patients was 56 years (range: 26-80 years). Eribulin mesylate was administered at a dose of 1.4mg/m2 as a 2- to 5-minute intravenous infusion on Days 1 and 8 of a 21-day cycle. Patients received a median of four cycles of eribulin mesylate (range 1-27). No premedication to ...

Sugar linkage could lead to better treatment for autoimmune diseases

... Jeffrey Ravetch of Rockefeller University. The work revolves around immunoglobulin G (IgG), the most abundant antibody in blood plasma. intravenous immunoglobulin (IVIG) has within it a trace amount of a very active material that is effective in relieving the inflammatory affects of lupus, ...

Turning on cell-cell communication wipes out staph biofilms

... "Current treatment for endocarditis -- a potentially life threatening infection where a staph biofilm forms on heart valves -- involves weeks of intravenous antibiotics, and sometimes requires surgery," Boles explained. "One thing we'd like to test is whether we can treat biofilms in models of diseases ...

Environmental enrichment can reduce cocaine use, researchers find

... placed next to another social group for 15 minutes, acting as an intruder to that group. The monkeys were then given their usual choice of an intravenous cocaine mixture or food pellets. The enrichment reduced the drug response of all the animals; however, the detrimental affect of the stress ...

Chloroform provides clue to 150 year old medical puzzle

... which anaesthesia works, says Dr Bahnasi. Dr Bahnasi then carried out further experiments with several other modern anaesthetic compounds, both intravenous and inhaled, and found that the blocking effect on the TRPC5 ion channel was the same. He says that the discovery opens up the opportunity to ...

Improved foam for varicose veins found to be safe in preliminary results from phase II trial

... vein (GSV) to prevent the backflow, called reflux. The Varisolve foam injection procedure is a less invasive alternative to surgical techniques and intravenous techniques that close the vein with radiofrequency ablation or laser energy. Although any air-based foam carries a theoretical risk to the patient ...

New hope for hepatitis C sufferers

... 264,000 people have been infected with the hepatitis C virus and there are approximately 10,000 new infections per year. A proportion of these are intravenous drug users, with alcohol playing a significant role in disease progression, Dr Beard said. He said vaccines had been trialled for HIV, but with ...

Diabetes makes it hard for blood vessels to relax

... or even adverse effects of oral L-arginine in some clinical studies, in particular patients with coronary artery disease and infarction. A short intravenous course of L-arginine may provide short-term improvement in blood vessel tone, Dr. Romero notes. However most of L-arginine ingested goes directly to ...

Stroke victims may benefit from stem cell transplants

... scar size and cell death and improvements in neurological function when compared to controls that received no BMSCs. Researchers concluded that the intravenous delivery of bone marrow-derived cells may enhance tissue repair and, in turn, functional recovery after a stroke. While the potential mechanisms for ...

Team IDs weakness in anthrax bacteria

... Anthrax occurs naturally around the world and can infect all warm-blooded animals including humans. Treatment usually includes large doses of intravenous and oral antibiotics, but the disease can often be fatal-especially if treatment is not started right away. In the human immune system, ...

Cell Therapy for Cardiovascular Diseases

... (TOPCARE, REPAIR-AMI) of bone-marrow- or blood-derived progenitor cells for acute myocardial infarction will be reviewed by Dr. Andreas M. Zeiher intravenous allogeneic mesenchymal stem cells for acute myocardial infarction will be presented by Dr. Joshua M. Hare MAGIC 5: combined approach using ...

Oncolytics Biotech, Inc. announces publication of research

... of reovirus and cyclophosphamide in vivo. The paper, entitled Cyclophosphamide Facilitates Antitumor Efficacy against Subcutaneous Tumors following intravenous Delivery of Reovirus appears online in the January 1, 2008 issue of Clinical Cancer Research. This exciting Mayo Clinic work supported the ...

Osteoarthritis risk linked to finger length ratio

... OA of the knees or hips, requiring consideration of joint replacement surgery. Recruited from hospital lists of patients who had undergone intravenous urography (IVU) within the past five years, 1,123 individuals with no radiographic evidence of hip or knee OA, no present hip or knee symptoms, and ...

Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients

... disease. The study will begin with 20 non-Hodgkin lymphoma patients who have failed standard therapy. Each study participant will be given varied intravenous doses of vitamin C three times a week. The patients will be evaluated and monitored for progression of their disease. The studys goals are to show ...

Eltrombopag effective for hepatitis C patients with low blood-platelet counts

... infected individuals have either received blood transfusions prior to 1990 (when screening of the blood supply for HCV was implemented) or have used intravenous drugs. More rarely, it can also be transmitted through sexual intercourse and perinatally (mother to baby). The virus causes inflammation and ...