Intramuscular in Biological News

Tips from the journals of the American Society for Microbiology

... intranasally with H1N1 VLPs mice were highly protected against a lethal challenge with both the 1918 and H5N1 virus. In contrast, mice receiving two intramuscular immunizations of 1918 VLPs were only protected against the 1918 viral challenge. Mucosal vaccination with 1918 VLPs induced higher levels of ...

Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue

... by up to 50 percent. "This work demonstrates a novel non-invasive mesenchymal stem cell (MSC) therapeutic regimen for heart failure based on an intramuscular delivery route," said Techung Lee, Ph.D., UB associate professor of biochemistry and senior author on the paper. Mesenchymal stem cells are found ...

Tips from the Journals of the American Society for Microbiology

... dengue virus vaccine by combining genes and proteins from all four dengue virus types as well as incorporating an adenovirus agent. Following intramuscular vaccination, rhesus macaques showed high antibody levels that neutralized all four of the dengue virus types. To further test the sustainability of ...

New technology may prevent vitamin B12 deficient seniors and vegetarians from needing injections

... TORONTO, Canada (June 17, 2008) For those patients who receive the nearly 40 million intramuscular injections per year to treat their B12 deficiency, a new oral option may soon exist. According to the National Institutes of Health, vitamin B12 ...

New computer applications allow to classify Iberian pig meat automatically

... breed, Iberian pig, lamb, cow of the Galician Blonde breed, Kobe ox and pigeon. The designed application permitted to quantify automatically the intramuscular connective tissue and the retraction of the muscular fibres in images taken by a system or artificial vision coupled to a microscopy. Second, the ...

Testosterone replacement theraphy beneficial in men 60 and older

... of enrollment. (Normal limits are considered 250-800.) Each was enrolled in one of three double-blinded groups: (1) those receiving continuous weekly intramuscular injections of testosterone (100 mg testosterone-enanthate) for the entire five month period (TE; n=4); (2) those receiving weekly testosterone every ...

Ibuprofen or acetaminophen in long-term resistance training increases muscle mass/strength

... one day. Over three months, says Dr. Trappe, the chronic consumption of ibuprofen or acetaminophen during resistance training appears to have induced intramuscular changes that enhance the metabolic response to resistance exercise, allowing the body to add substantially more new protein to muscle. The amount ...

Peramivir protects mice from lethal H5N1 infection

... peramivir (intramuscular injections alone versus intramuscular injections followed by oral administration) and ... 100 percent survival among 10 infected mice given intramuscular injections of peramivir daily for eight days. The ... treatment for eight days. In contrast, a single intramuscular injection resulted in a 40 percent survival rate, ...

Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy

... any known disease. In earlier studies, Dr. Xiao's team found that direct intramuscular injection of AAV was effective in transferring a gene into muscle cells in ... where many organs and tissues are affected throughout the body, intramuscular injection is not practical for delivering a corrective gene to the body's ...

'Smart' genetic therapy helps the body to heal itself

... Duchenne Parent Projects, and governmental and charity funds, Dr. J. van Deutekom and her team will soon start a clinical trial, based on intramuscular injection of a single dose of an anti-sense drug that induces the skipping of exon 51 from the DMD gene. Six Dutch DMD patients aged between 8 and ...

Plant-derived vaccines safeguard against deadly plague

... we've come to the realization that plants also have the potential for the production of antigens that can be purified and delivered by typical intramuscular or subcutaneous injections -- the way most vaccines are normally given," said Mason, an associate professor in the School of Life Sciences. "This new ...

Ebola DNA vaccine produces immune responses in all fully vaccinated volunteers in Phase 1 trial

... strain, and the internal nucleoprotein (NP) from the Zaire strain. Subjects received three doses of vaccine or placebo at one-month intervals via intramuscular needleless injection. Three cohorts tested progressively higher doses of the vaccine at 2 mg (5 subjects), 4 mg (8 subjects), or 8 mg (8 subjects ...

Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned

... agent has a long history of use in espionage. Participants in the study, however, reported only mild side effects that were consistent with any intramuscular vaccine injection, such as a sore arm or mild headache that might be experienced with a tetanus or a flu shot, said Dr. Robert Munford, a professor ...

No small feat: First ever gene therapy success for muscular dystrophy achieved

... described and which they used for the first time in this study to transfer a therapeutic gene. The AAV-2 vector was delivered locally, given by intramuscular injection to different muscles of the leg. With both approaches, muscle cells were able to assimilate and copy the genetic instructions for making ...