Interference in Biological News

Princeton team's analysis of flu virus could lead to better vaccines

... interactive process -- known as antibody interference -- to advantage, the scientists believe it may be ... of Sciences . "We have proposed that antibody interference plays a major role in determining the ... suggested that a phenomenon known as antibody interference was at play. It arises when a virus prompts the ...

Class of antibiotics can enhance gene-silencing tool

... known as fluoroquinolones can make RNA interference more effective in the laboratory and reduce ... safe." The most powerful enhancer of RNA interference was enoxacin, which has been used to treat ... ciprofloxacin. The antibiotics' effect on RNA interference appears to be chemically separate from their ...

U. Mass Medical School and Carnegie announce licensing agreements with Oxford BioMedica

... that grants the company rights to key RNA interference (RNAi) patent rights. The technology was ... within a living cell. The process, called RNA interference (RNAi), can shut down disease-causing genes or ... rights for human gene therapy applications of RNA interference using lentiviral vectors. A lentiviral vector is ...

UMMS and CIW grant key RNAi rights to Oxford Biomedica

... that grants the company rights to key RNA interference (RNAi) patent rights. The technology was ... within a living cell. The process, called RNA interference (RNAi), can shut down disease-causing genes or ... rights for human gene therapy applications of RNA interference using lentiviral vectors. A lentiviral vector is ...

Nanotechnology holds promise for STD drug delivery

... May 4 as an advance online publication of Nature Materials . "RNA interference is a promising approach for prevention and treatment of human disease," ... nanoparticles were safer than the best current lipid vehicles. Gene interference therapy is moving rapidly from basic research to application. The PLGA ...

8 National Medals of Science awardees to be honored at gala, then the White House

... standards for digital cellular telephony utilize the Viterbi algorithm for interference suppression, as do most digital satellite communications systems. ... QualComm with Irwin Jacobs. He created the Viterbi Algorithm for interference suppression and efficient decoding of a digital transmission sequence, ...

Europe develops new technologies to boost health of livestock

... A range of new technologies including genetic modification (GM) and RNA interference are being deployed to improve the health of farm animals in a series of ... techniques apart from GM may be appropriate. The huge potential of RNA interference was discussed at the conference, whereby the ability of viruses to produce ...

'Smart' holograms help patients help themselves

... in Februarys Physics World. A hologram is a recording of an optical interference pattern created when laser light shone on an object is made to overlap ... light that does not pass through the object. When light is shone onto the interference pattern, a 3D image of the original object is recreated. Traditional ...

RNA interference therapy heals growth deficiency disorder in a live animal

... was published online Nov. 15 by the journal Endocrinology, shows that RNA interference can rescue a strain of mouse that has been genetically engineered to ... error would lead to cell death, says Patton. Meanwhile, progress in RNA interference research gave Patton and Phillips an idea for a way to correct this ...

Researchers view swimming tactics of tiny aquatic predators

... a sample volume with a collimated laser beam and recording the interference pattern generated by light scattered from organisms with the remainder of the beam. The interference patternthe hologramis magnified and recorded by a high-speed digital ...

New field-deployable biosensor detects avian influenza virus in minutes instead of days

... antibodies to detect avian influenza virus. The sensor utilizes the interference of light waves, a concept called interferometry, to precisely determine ... beams from the sensing and reference channels are combined to create an interference pattern. The pattern of alternating dark and light vertical stripes, or ...

Challenges remain in reintroducing American chestnut

... used to thrive, such as the Great Smoky Mountains National Park, human interference is strongly discouraged and often illegal. But Jacobs said some interference and harvesting will be necessary to reintroduce the chestnut, calling for ...

AGU journal highlights -- Aug. 6, 2009

... in the amount of solar energy reaching the Earth can affect society, the environment, and the economy. A growing body of evidence supports that human interference has affected the amount of solar radiation that is able to penetrate the atmospherein general, aerosol pollutants have been shown to scatter or ...

Parasites ready to jump

... also detectable when multiple copies of a mobile element were present in the cell but not yet incorporated into the genome. The phenomenon of RNA interference first came to light only a short time ago, but has already become a well established field of study. Thanks to more recent findings, the known ...

UTMB study identifies women at risk of gaining excessive weight with injectable birth control

... that possible mechanisms include glucocorticoid-like activity, how the body breaks down simple carbohydrates such as glucose, and DMPA-associated interference with insulin action. Previous findings seem to argue against the theory that weight gain could be due to the drug's perceived effects on increased ...

A genetic basis for schizophrenia

... particularly the dentate gyrus, which is considered the gateway to the hippocampus. In this study, the authors decreased Disc1 expression using RNA interference in the developing mouse hippocampus. The loss of Disc1 resulted in hindered migration of dentate gyrus granule cells to their proper location in the ...

Recruitment of reproductive features into other cell types may underlie extended lifespan in animals

... Longevity-associated mutations have been shown to lead to enhanced immune response including increased control of gene expression through RNA interference (RNAi) in somatic cells. Since it is known that RNAi is among the mechanisms underlying germline cells' enhanced resistance to pathogens and other ...

Healing wounds with lasers, vehicles that drive themselves, other cutting-edge optics

... travel by two different paths, directed from place to place by strategically places mirrors, and converge at a detector, where they produce a striped interference pattern. The pattern can be read out to learn details of the journey taken by the waves. Interferometry is used in many endeavors, such as ...

UCLA scientists discover ultrasonic communication among frogs

... calls that are audible to humans. "Our hypothesis is that these frogs have shifted to use higher frequencies in their communication to avoid the interference of sound produced by rushing water in the lower-frequency range," Arch said. "However, high-frequency sounds do not transmit as far. By producing ...

Coral 'can't escape the heat'

... effects of global warming, corals will not be able to avoid the acidification of the oceans, which is a simple and direct consequence of humanity's interference in the atmosphere. About 40 per cent of the CO2 we release dissolves into the oceans, turning them more acidic." Analysis of corals taken from the ...

Satellites show how Earth moved during Italy quake

... The InSAR technique merges data acquired before and after the earthquake to generate 'interferogram' images that appear as rainbow-coloured interference patterns. A complete set of coloured bands, called 'fringes', represents ground movement relative to the spacecraft of half a wavelength, which is ...

New therapeutic strategy could target toxic protein in most patients with Huntington's disease

... death. Children who have a parent with Huntington's disease have a 50 percent chance of inheriting the disease themselves. Zamore studies how RNA interference can be used to silence genes selectively. In the 1990s, he and other scientists learned they could shut down the production of specific proteins by ...

Making a point: Picoscale stability in a room-temperature AFM

... magnetic forces and other atomic-scale interactions. While extremely sensitive to atomic-scale features, AFMs also are extremely sensitive to interference from acoustic noise, temperature shifts and vibration, among other factors. This makes it difficult or impossible either to hold the probe in one ...

200,000 rice mutants available worldwide for scientific investigation

... sativa genome was sequenced in 2002 and researchers have come a long way since. Advances in technologies such as high-throughput sequencing and RNA interference gene silencing methods should help to accelerate the process of identifying the functions of the remaining genes in the rice genome." He added: "The ...

200,000 rice mutants available worldwide for scientific investigation

... sativa genome was sequenced in 2002 and researchers have come a long way since. Advances in technologies such as high-throughput sequencing and RNA interference gene silencing methods should help to accelerate the process of identifying the functions of the remaining genes in the rice genome." He added: "The ...

Protein function and chromatin structure methods featured in Cold Spring Harbor Protocols

... except in the presence of small ligands. The speed of small-molecule binding makes it an attractive alternative to studying gene function using RNA interference (RNAi). The method is freely accessible on the website for Cold Spring Harbor Protocols ( ...

Lower increases in global temps could lead to greater impacts than previously thought, study finds

... has ratified, calls for "stabilization of greenhouse gas concentrations in the atmosphere at a level that would prevent dangerous anthropogenic interference with the climate system." That level is not defined by the Convention nor has it been clearly defined in subsequent negotiations by parties to the ...

Marine scientists to assess environment before offshore drilling begins in US arctic waters

... for the Chukchi Sea's seabed, or benthos. Information from the work will be used to help identify areas of ecological importance, to minimize interference of drilling with areas of rich natural resources and native subsistence harvesting activities. The data collected by the scientific team will also be ...

Cold Spring Harbor Protocols features stem cell differentiation, plant RNAi methods

... featured article for February comes from S.P. Dinesh-Kumar and colleagues at Yale University ( http://plantfunctionalgenomics.yale.edu/ ). RNA interference (RNAi) has become an effective tool for the down-regulation of genes in plants. The most effective means of accomplishing this gene silencing is ...

Apolipoprotein(a): A natural regulator of inflammation

... its important role in clot lysis, plasmin is required for leukocyte recruitment in inflammation. While several in vitro studies have demonstrated the interference of apo(a) in plasminogen leukocyte recruitment, evidence for this in vivo has been lacking. In vivo investigation of Lp(a) function has been ...

New edition of laboratory manual includes cutting-edge techniques to study gene regulation

... a new transcription factor. In addition to chromatin-based techniques such as chromatin immunoprecipitation (ChIP), the new edition incorporates RNA interference (RNAi), mass spectrometry, and bioinformatic and experimental methods that exploit genome sequencing information to examine gene regulation on a more ...

CSHL researchers map changing epigenetic modifications that enable transposons to run amok

... complicated steps masterminded by small molecules of RNA, called small interfering RNA (siRNA). They perform this feat in a phenomenon known as RNA interference (RNAi). The discovery that modifications of heterochromatin -- densely packed, genetically "inactive" regions of DNA -- are targeted by RNAi was made ...

Researchers solve piece of large-scale gene silencing mystery

... fight RNA To determine the pathway regulating nucleolar dominance, Pikaard's team exploited a naturally occurring cellular mechanism known as RNA interference (RNAi). Pikaard likens RNAi to a "search and destroy mission." Fragments of RNA known as small interfering RNAs (siRNAs) prevent specific genes ...

Fear of hypoglycemia a barrier to exercise for type 1 diabetics

... type 1 diabetes answered questionnaires to assess their barriers to physical activity. The biggest fear was hypoglycaemia and other barriers included interference with work schedule, loss of control over diabetes and low levels of fitness. When questioned further, only 52 of the participants demonstrated ...

Acoustical Meeting, Nov. 10-14, 2008 in Miami, Florida

... pitch categories for the Mandarin listeners. In contrast, the English listeners could perform the musical pitch pattern identification task without interference from any pre-existing pitch categories. However, in the pitch discrimination task -- where listeners do not compare the input to stored categories ...

UC Davis researchers discover a key to aggressive breast cancer

... the normal tissues. The researchers next conducted a series of laboratory experiments using human breast cancer cell lines and a technique called RNA interference that allows for selective depletion of cellular proteins. Interestingly, they found the same results in the human breast cancers that they found ...

Modest CO2 cutbacks may be too little, too late for coral reefs

... on Climate Change (UNFCCC) greenhouse gases in the atmosphere need to be stabilized at levels low enough to "prevent dangerous anthropogenic interference with the climate system." But scientists have come to realize that an even more acute danger than climate change is lurking in the world's oceansone ...

Fires regenerate African grassland

... an area measuring 500 by 500 metres in Etosha National Park because it has one dominant grass species and because it was possible to rule out interference such as grazing and other human influences. Etosha National Park in the north of Namibia is the second largest nature reserve in Africa, measuring ...

Researchers identify cancer-causing gene in many colon cancers

... and are involved in the proliferation of colon cancer cells, the research team ran three screening tests. In the first two, they used RNA interference to shut down more than a thousand genes one by one and recorded the instances where beta-catenin activity decreased and the cells stopped growing. ...

MGH researcher Gary Ruvkun named a co-recipient of the Lasker Award

... the microRNAs of both lin-4 and let-7 are released from their precursor hairpin RNA molecules by the enzyme Dicer, which is also critical to the RNA interference process that Mello and Fire had discovered and for which they received the 2006 Nobel Prize. It now appears that the human genome contains ...