Interaction in Biological News

GUMC discovery highlights new direction for drug discovery

... for tumor formation. The researchers say this interaction is unique and is especially surprising since the ... treatment for other disorders caused by the interaction between two proteins, and may be especially ... of principle that inhibiting protein-protein interaction can work as a novel therapeutic that will target ...

CSHL researchers explain process by which cells 'hide' potentially dangerous DNA segments

... assembly by themselves. Rather, the siRNA-guided interaction relies on the strength with which the velcro-like ... "These results lead us to think that the tight interaction between RITS and the methyl marks is a ... with powerful x-rays. Disrupting each point of interaction between Chp1 and its target by engineering ...

Inhibiting proteins may prevent cartilage breakdown in arthritis patients

... therapeutic targets for arthritis by studying the interaction between two proteins that, if interrupted, may ... to pain. In the MU study, Ray examined the interaction between the proteins AP-1 and SAF-1 and found that the interaction of these proteins plays a significant role in ...

The law of the weakest

... one other species, but will be beaten by a third interaction partner. "In this kind of cyclical concurrence, ... that each participant is superior to one other interaction partner, but will be beaten by a third. In ... inner Coast Range of California. Such cyclical interaction is also familiarly termed "rock-paper-scissors" ...

Studies offer guide as protein interaction mapping comes of age

... kit for determining whether a newly discovered interaction is indeed real, and not a false positive reading ... The kit is a set of four, high-capacity protein interaction tests that have been weighted in relation to a ... Cusick remarks. One solution is the molecular interaction experiment initiative, or MIMIx, which ...

Dancing atoms now understood

... unique precession frequency, which depends on its interaction with surrounding atoms as well as the magnetic field strength. The interaction with surrounding atoms is what makes NMR such a ... and molecular structures. For MRI, it is the interaction of the nuclei with the magnetic field that is ...

Luminescence shines new light on proteins

... probes to measure the behaviour of light and its interaction with proteins abundant in human blood. The ... optical probes in chemistry and in observing the interaction between medical drugs and proteins." The ... the inherent chirality of light to examine the interaction at the molecular level between a probe (the ...

Simian foamy virus found in several people living and working with monkeys in Asia

... findings provide more evidence that Asia, where interaction between people and monkeys is common and ... the huge populations of both and the widespread interaction between the species. People are in close contact ... monitoring and further study of monkey-human interaction could help cut down on the risks associated with ...

ESF conference probes water's mysterious interactions at molecular level

... the European Science Foundation (ESF) focusing on interaction between water and other compounds at the ... level. Some of the greatest puzzles involve the interaction between molecules of water and other compounds as ... precipitating out. This is a function of waters interaction potential, which means the ability or tendency of ...

Answer to troublesome question of why some genetic assoc. studies have failed replication attempts

... complex traits can vary by age and that such an interaction can prevent independent replications of the work ... Rica, Greece, Poland, Iceland, and Germany. The interaction was observed in five of the eight replicate ... significant results. The authors note that this interaction would have been missed in all but one of the ...

Umbilical cord blood cell therapy may reduce signs and symptoms of Alzheimer's disease

... response in the brain associated with the interaction of CD40 and CD40L, two pro-inflammatory ... blood cell-induced disruption of the CD40-CD40L interaction may alleviate the key pathologic changes in the ... immune functioning rather than through direct interaction with neurons. We believe restoring the balance ...

Biophysical Society announces 2008 International Travel Awards

... of these awards is to foster and initiate further interaction between American biophysicists and scientists ... Bioquimicas de La Plata, Argentina, The interaction of Alpha-hemolysin with Specific Microdomains at ... Characterization of C-reactive Protein interaction with Fc-gamma Receptors by Ultrasensitive ...

Fisheries should be regarded as a part of the maritime environment

... Institute, surveyed the role of participation and interaction in decision-making in new circumstances. The ... By such measures it is possible to support interaction between various interests and perspectives and to ... As a consequence, the development of constructive interaction may be retarded, and the credibility of ...

Why the switch stays on

... the way in which a specific protein-protein interaction prevents the cell from turning one of its ... researchers show for the first time that the interaction between a rogue version of a specific protein ... Mattos likens the abnormal protein-protein interaction to having the light permanently stuck on because ...

Study finds first-ever genetic animal model of autism

... key signs of autism, they showed decreased social interaction with other mice; other traits, such as anxiety, ... pain sensitivity, were unaffected. These social interaction deficits, Dr. Powell says, are hallmark features ... mice and ask whether this reverses their social interaction deficits, Dr. Powell says. For now, the mainstay ...

Cystic fibrosis proteins photographed interacting

... pictures show the first-ever physical evidence of interaction between two proteins involved in Cystic Fibrosis ... each other, the UAB researchers said. When that interaction fails then a dangerous biochemical imbalance ... on its cover. Our findings suggest a direct interaction between these two proteins and their proximity ...

Genetic contributions to human brain morphology and intelligence

... brain areas. However, the mechanisms by which interaction between genes and environment occur throughout ... in DNA-methylation). Additionally, the study of interaction between genes and environmental factors is ... effects of multiple genes and possibly the interaction among genes, also needs investigation as the high ...

Mixing large doses of both acetaminophen painkiller and caffeine may increase risk of liver damage

... in Toxicology, a monthly journal. The toxic interaction could occur not only from drinking caffeinated ... scientists have reported a potentially harmful interaction while taking the painkiller with caffeine, the ... may be more vulnerable to the potentially toxic interaction than others, Nelson says. This includes people ...

How cancer spreads by aggregating platelets

... the cancer cells to metastasize by blocking the interaction between CLEC-2 and podoplanin. Our study ... metastasis. The role of podoplanin-CLEC-2 interaction may not be limited to tumor metastasis, the ... grow. As a result, locking the podoplanin-CLEC-2 interaction may not only prevent cancer metastasis but also ...

Minimum information standards -- all for 1 and 1 for all

... and gene expression data), IntAct (molecular interaction data) and PRIDE (protein identification linked to ... Information required for reporting a Molecular interaction Experiment (MIMIx) guidelines propose the range ... be recorded to document proteomics and molecular interaction data, respectively. The standards aim to reduce ...

Claims of sex-related differences in genetic association studies often not properly validated

... unclear. Appropriate documentation of gene-sex interaction was recorded in 55 claims (12.7 percent); ... or spurious, and reporting of statistical interaction tests was rare, the authors write. We hope ... and post hoc claims should be documented by interaction tests and proper consideration of the ...

Carnegie donates landmark clones to biology

... They just donated 2010 of the clones for genes that function in the cell's interaction with its environment to the Arabidopsis Biological Resource Center (ABRC ... fields from medicine to farming. These genes are now used to unravel the interaction of the membrane proteins amongst each other. Recent research at the ...

University of Miami receives stimulus funds for study of hurricane impacts on structures, ecosystems

... an 8,520 square foot state-of-the-art Surge-Structure-Atmosphere interaction (SUSTAIN) research facility and a Marine Life Science Center. The ... associate professor of Applied Marine Physics and director of UM's Air-Sea interaction Saltwater (ASIST) Facility. "Developing a more complete understanding of ...

Neural stem cell differentiation factor discovered

... stem cells. The self-renewal potential of these cells depends on an intact interaction of the ligand Jagged1 and its receptor Notch1. Addition of EGFL7 blocked the essential interaction and reduced the division of neural stem cells. At the same time, EGFL7 ...

Evolution of a contraceptive for sea lamprey

... The model developed by the UC San Diego research team uncovered a unique interaction between 15alpha-hydroxy-estradiol and an amino acid called methionine, found only in lamprey estrogen receptors. "The unique aspect of this interaction suggests that there are compounds that can bind specifically to the ...

Tracking down the causes of multiple sclerosis

... of pathogens can be overcome quickly and effectively through the targeted interaction of T and B cells. Unlike the T cells, the B cells have hitherto only ... Krishnamoorthy. The new model shows that there most be some kind of interaction between the T and B cells, that the resulting army of B cells triggers the ...

Small molecules mimic natural gene regulators

... attaches itself to the cell's machinery through a key protein-to-protein interaction and spurs the gene into action. The researchers wanted to know whether ... doing its job. This suggests that, for ATFs as for natural activators, interaction with CBP is key to transcriptional activity. "Taken together, the ...

Pliable proteins keep photosynthesis on the light path

... either the properties of the metal cofactors themselves or through their interaction with the protein," said Lin. "In the case of the zinc reaction center, the ... I and II. Of particular interest, are studies that focus on the interaction between chlorophylls and protein, which differs in naturally occurring ...

Alzheimer's, asthma, cancer, malaria and TB focus of new Singapore grants

... disease, building on the group's discovery of an important protein interaction that suppresses neural cell formation in the brains of mice, and that ... people. "In this project, we will investigate whether this protein interaction also occurs in human stem cells and in the adult mouse brain, as well as ...

SUMO protein guides chromatin remodeler to suppress genes

... is a compacted mass of DNA and protein that make up chromosomes. The interaction between SUMO and the enzyme complex is of interest in the study of cancer ... structure to regulate genes within cells. The researchers found that the interaction between SUMO and this enzyme complex is responsible for preventing ...

2009 ASPB Summer Undergraduate Research Fellowship award announcement

... in 2010. David Seung, University of Sydney Mentor: Jan Marc The interaction of abscisic acid and phospholipase D mediated pathways in environmental ... that are critical for its interaction, and show whether the aforementioned interaction is responsible for SAUR19's functionality. Eric Johnson, University of ...

World Congress on Osteoporosis 2010 presents outstanding scientific program

... With its global perspective, the Congress will be an excellent forum for interaction and the exchange of ideas among researchers and clinicians as well as ... What did we learn from genome-wide association studies? T. Spector (UK) interaction between bone and joints in physiology and disease, G. Schett (Germany) ...

Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone

... defective versions of TRN-SR2 will test the suitability of this protein interaction as a new target for drug development. Fedde Groot, Ph.D./Mentor: ... compounds at Harvard University for small molecules that can inhibit the interaction between Vif and APOBEC3G and that might ultimately serve as the basis for ...

Genetic study shows direct link between vitamin D and MS susceptibility 'gene'

... Researchers have found evidence that a direct interaction between vitamin D and a common genetic variant alters the risk of ... even grandchildren." The authors hypothesise that this gene-environment interaction may affect the ability of the thymus, a key component of the immune ...

College students find comfort in their pets during hard times

... is missing in their lives. The pets are not a substitute for human social interaction and support, but they do provide important interaction for these kids who might otherwise feel isolated from their current ...

How mirror neurons allow us to learn and socialize by going through the motions in the head

... running until 2013. The role of mirror neurons at all levels of social interaction is even greater than had been realized, according to convenor of the ESF ... roles in emotions and feelings. However until recently the mechanisms of interaction between these two had been largely unknown. "In the case of emotions, we ...

A novel target for therapeutics against Staph infection

... the researchers show that agents could be designed that inhibit the ClfAFg interaction but do not interfere with the interaction of Fg with the platelet integrin, therefore avoiding unwanted side effects ...

Jupiter's shrinking red spot

... 10 rows away. Moreover, lead scientist Michael Plesniak says, the eddies' interaction with the ventilation system's swirling flow creates a stagnant zone "at ... Miller will describe the heart models in her talk, "Fluid-structure interaction and electrophysiology of the embryonic heart," at 10:43 am on Sunday, ...

Animal and biological science highlights: San Antonio Fluid Dynamics Conference, Nov. 23-25

... Miller will describe the heart models in her talk, "Fluid-structure interaction and electrophysiology of the embryonic heart," at 10:43 am on Sunday, ... 10 rows away. Moreover, lead scientist Michael Plesniak says, the eddies' interaction with the ventilation system's swirling flow creates a stagnant zone "at ...

National and international doctoral training

... the models resulting from this work, they want to better understand the interaction of socio-economic and ecological aspects in the protection of drinking ... regulatory functions within and between cells and organisms. The important interaction of carbohydrates and proteins is to be studied in the cell for its ...