Insulin in Biological News

Nanodiamonds deliver insulin for wound healing

... of the insulin." A substantial amount of insulin can be loaded onto the nanodiamonds, which have a ... The nanodiamond-insulin clusters, by releasing insulin in alkaline wound areas, could accelerate the ... studies, Ho and his colleagues showed that the insulin was very tightly bound to the nanodiamonds when ...

The battle for CRTC2: How obesity increases the risk for diabetes

... the most important factor in the development of insulin resistance, but science's understanding of the ... in the liver, an important step on the path to insulin resistance. In healthy people, a "fasting ... had been well established that obesity promotes insulin resistance through the inappropriate inactivation ...

Study shows CGM devices also benefit people with type 1 diabetes

... Trial (DCCT) showed that with intensive insulin therapy, excellent blood glucose control was ... for at least one year, who either used an insulin pump or took at least three daily insulin injections, and had HbA1c levels below 7.0%. ...

Findings show insulin -- not genes -- linked to obesity

... important for understanding the precise roles of insulin in obesity or Type II diabetes, and to the design ... in fat storage is due to varied rates of insulin processing among cells." The cell culture used ... events, like fat storage, gene expression and insulin signaling," Le said. "We can monitor these ...

Difference in fat storage may explain lower rate of liver disease in African-Americans

... for differences in the likelihood they'll develop insulin resistance and non-alcoholic fatty liver disease, ... issue of Hepatology, African-Americans with insulin resistance might harbor factors that protect them ... high rates of associated risk factors such as insulin resistance, obesity and diabetes among ...

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

... of HIV-1 patients, induce deleterious effects on insulin secretion mediated through the oxidative stress ... account for the decrease in glucose stimulated insulin secretion upon nelfinavir treatment. This study ... of Experimental Biology and Medicine . Although insulin resistance has been clinically observed in HIV-1 ...

Symposium to look at genetic basis of exercise

... aerobic fitness), blood pressure and glucose and insulin metabolism. The researchers compared measures ... an important role in determining an individual's insulin sensitivity and glucose disposal ability in ... with one variant of this gene improved their insulin sensitivity and glucose disposal ability with ...

Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet

... to resistance to fat-induced obesity and related insulin resistance and liver damage," said Kamal Mehta, ... The protein-deficient mice were able to clear insulin to regulate blood sugar more rapidly than normal ... obesity also allowed them to avoid development of insulin resistance associated with diabetes, said Mehta, ...

Plasminogen activator inhibitor type-1 -- a potential link between heart failure and diabetes

... PAI-1 overexpression, known to accompany insulin resistance and type 2 diabetes, as a factor ... of PAI-1 in the heart in transgenic mice rendered insulin resistant, these results suggest that the ... following myocardial infarction in patients with insulin resistance and type 2 diabetes may reflect in ...

Canadian scientist mines drugs database for new diabetes treatment

... tool to identify a new player in the body's insulin secretion process. This finding could spark a ... molecule which they are using to understand how insulin is secreted in response to increases in blood ... discovered that NAADP plays a crucial role in insulin secretion and therefore represents a brand new ...

Scientists mine drugs database for new diabetes treatment

... tool to identify a new player in the body's insulin secretion process. This finding could spark a ... molecule which they are using to understand how insulin is secreted in response to increases in blood ... discovered that NAADP plays a crucial role in insulin secretion and therefore represents a brand new ...

Decreasing insulin resistance prevents obesity-related cardiovascular damage

... Ga. - Knocking out one gene that contributes to insulin resistance appears to prevent much of the ... increases glucose so the body increases insulin production in an effort to use or store this ... toward diabetes, the body begins to miscalculate insulin needs and overproduce; fine control is lost and ...

Is there a relationship between sleep-wake rhythm and diabetes?

... The gene mediates insulin secretion indirectly via the release of ... that this receptor inhibits the release of insulin via the neural hormone melatonin. The melatonin ... at night and declines in daylight, whereas the insulin level is higher during the day than in the night. ...

IRB Barcelona to coordinate two European projects on biomedicine

... into energy -, and that are responsible for insulin resistance. insulin is a hormone generated by the pancreas and serves ... enter cells. People who suffer from the so-called insulin Resistance Syndrome generally present high levels ...

Leptin's long-distance call to the pancreas

... smiled at one of leptin's mechanisms for curbing insulin release. As Hinoi et al. show, the fat-derived ... the hormone become corpulent, and their sky-high insulin levels eventually lead to diabetes. Leptin can curtail insulin release directly. But there's also a back-door ...

Apple or pear shape is not main culprit to heart woes -- it's liver fat

... excess liver fat appears to be the real key to insulin resistance, cholesterol abnormalities and other ... in turn, linked to elevated triglycerides and to insulin resistance, a key precursor to type 2 diabetes. "Multiple organ systems become resistant to insulin in these adolescent children with fatty liver ...

Fear of hypoglycemia a barrier to exercise for type 1 diabetics

... with exercise." Lack of understanding of insulin metabolism One hundred adults, 50 women and 50 ... demonstrated appropriate knowledge of how insulin is metabolized and processed. Those individuals who best understood how insulin works in their body were shown to be less fearful ...

Researchers at IRB Barcelona produce more data on key genes in diabetes

... will develop type 2 diabetes is the presence of insulin resistance. insulin is produced in the pancreas and is the hormone ... tissues and organs in the body, such as muscles. insulin resistance is characterized by the lack of tissue ...

Apelin hormone injections powerfully lower blood sugar

... apelin might be a promising target for managing insulin resistance and type 2 diabetes. insulin resistance, in which normal amounts of insulin are insufficient to lower blood sugar (glucose) ...

Moderate use averts failure of type 2 diabetes drugs in animal model

... are lost after several years of use, causing insulin secretion to shut down. This typically forces patients to switch to regular insulin injections. "Why this happens isn't clear yet, ... receiving the drug, beta cells began secreting insulin again hours later. Nichols and co-author Maria ...

Don't forget the vitamin A when working with its carrier protein

... between serum RBP and obesity-induced insulin resistance. While some studies validated these ... observations of elevated RBP in obesity and insulin resistance in humans, others have not. Often ... and be a better clinical diagnostic for potential insulin resistance than RBP alone." The authors say, ...

For insulin sensitive overweight patients, 1 session of exercise improves metabolic health

... fat by-products inside the muscle affect insulin resistance. To avoid the build up of fat ... by-products inside the muscle, which affects the insulin sensitivity. The findings also suggest that a ... the research team, "Exercise decreases everyone's insulin resistance and therefore reduces the chances of ...

Battling diabetes with beta cells

... this method, which artificially replicates the insulin cells people need, could ensure that fewer people ... are needed to produce insulin, and a shortage of insulin inhibits the breakdown of food into energy. By ... cells are destroyed beyond repair. Injections of insulin can ease the symptoms, but some sufferers from ...

Treatment corrects severe insulin imbalance in animal studies

... genetically engineered to have abnormally high insulin levels. If this approach succeeds in humans, it ... potentially devastating genetic disease in which insulin levels become dangerously high. "There is ... the insulin-secreting beta cells in the pancreas. insulin levels rage out of control and severely reduce ...

Trans-fatty acids and insulin sensitivity

... that trans-fats do not increase the risk of insulin resistance and diabetes, which may ease at least ... consumption of trans-fats may alter muscle insulin sensitivity, as their unusual molecular shapes ... in turn, reduced fat oxidation may promote insulin resistance. The data in this area has been ...

A single mechanism for hypertension, insulin resistance and immune suppression

... blood pressure, a pre-diabetes condition called insulin resistance, and immune suppression. H. Glenn ... to a potentially very important overlap of an insulin resistance mechanism with hypertension in the ... of several protein receptors, such as the insulin receptor, so ...

Mouse study: When it comes to living longer, it's better to go hungry than go running

... allowed to eat as much as they wanted had higher insulin levels, regardless of whether they exercised. That is, how much the mice ate determined their insulin level, while exercise did not have much effect. High insulin levels are associated with a risk of diabetes. ...

American Chemical Society's Weekly PressPac -- April 30, 2008

... It usually begins in childhood, requires insulin injections, and afflicts about 800,000 people in ... to help millions of people with diabetes avoid insulin injections, according to an article [ ... pancreatic cells that detect glucose and release insulin and transplanting them into diabetic patients. ...

Pathway found that lets mosquitoes fatten up, slow down for winter

... COLUMBUS, Ohio Two genes that help insulin regulate mosquitoes growth have been identified ... genes in this mosquito that function within the insulin signaling pathway, the mechanism necessary for ... the future. The two genes under study are the insulin receptor, which binds ...

Eliminating germline lengthens fly lifespan, Brown study shows

... responding were responding as if there was less insulin present. Tatar said the team found a possible ... paradox. In reaction to the flies brains boosting insulin production, the insects gonads their ovaries or ... a protein that acts like a sponge, binding to the insulin and blocking its signals throughout the body. So ...

American Chemical Society's Weekly PressPac -- April 16, 2008

... Gel-like material shows promise as oral insulin pill for diabetes Biomacromolecules ... that could help speed the long-awaited arrival of insulin that can be taken in a pill by mouth, rather than ... tests, the gel-like substance containing insulin expands in the acidic environment of the stomach ...

Stem cell breakthrough offers diabetes hope

... including beta cells, which produce the hormone insulin to regulate the blood glucose levels. Diabetes results when there is not enough insulin to meet the bodys demands. There are two forms ... the disease: type-1 diabetes is due to not enough insulin being produced by the pancreas, while type-2 or ...

American Chemical Society's weekly PressPac -- Jan. 9, 2008

... & Engineering News A compound formed during insulin production and once dismissed as irrelevant in ... activity and was a useless byproduct of insulin production. In recent years, however, researchers ... cells to utilize glucose similar to the role that insulin plays for other cell types but only when it binds ...

Mom's obesity during conception phase may set the stage for offspring's obesity risk

... increased serum glucose, triglyceride, insulin and leptin levels in both groups. Strikingly, the serum insulin and leptin levels increased by 2.2 and 2.3 fold ... and that offspring obesity is associated with insulin resistance. The "programming" of ...

Human hormone blocker found to help prevent obesity and diabetes: study

... is capable of promoting weight loss, improving insulin resistance and reversing diabetes in an animal ... the secretion of acids stimulates the releases insulin as part of the digestive process in response to ... "GIP Receptor Antagonism Reverses Obesity, insulin Resistance, and Associated Metabolic Disturbances ...

Too much fructose could leave dieters sugar shocked

... levels to spike, which can block the ability of insulin to regulate how body cells use and store sugar ... first detailed the role of uric acid on insulin resistance and obesity in a 2005 study in rats. ... fructose may have the unique ability to induce insulin resistance and features of the metabolic syndrome ...

Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging

... obese mice, Sirtris small molecule NCEs improve insulin sensitivity, lower plasma glucose levels and ... preclinical model of Type 2 Diabetes and insulin resistance (Zucker fa/fa rats), these SIRT1 activators improved whole-body glucose homeostasis and insulin sensitivity in adipose tissue, skeletal muscle ...

Too much sugar turns off gene that controls the effects of sex steroids

... dispels the earlier assumption that too much insulin reduces SHBG, a view which arose from the ... pre-diabetic individuals have high levels of insulin and low levels of SHBG. This new study proves that insulin is not to blame and that its actually the livers ...

Children's Hospital studying drug with the potential to prevent/delay onset of type 1 diabetes

... underway to study the effectiveness of oral insulin in preventing or delaying the onset of type 1 ... The researchers want to determine if one insulin capsule taken daily can prevent or delay the ... centers around the world, suggested that oral insulin might delay type 1 diabetes by about four years ...

UVa Health System team uncovers gene's role in type 1 diabetes

... start destroying the beta-cells that produce insulin in the pancreas. To shed light on how this ... transplanted islets. Type 1 diabetes requires insulin injections, because the body cannot produce insulin on its own. ...