Inhibitor in Biological News

UCSF researchers identify new drug target for Kaposi's sarcoma

... are structurally similar," Craik explained. "The inhibitor we found knocks out not only KS, but also the ... here could be a target for a broad-acting inhibitor against the entire viral family." To their ... said, this is the first small-molecule inhibitor of a herpes virus protease to not only act ...

Building memories with actin

... phosphorylation and inactivation of cofilin, an inhibitor of actin filament assembly, the team found. ... pathways. The researchers showed that a ROCK inhibitor stalled actin polymerization and resulted in a ... in LTP, however. The team discovered that the Rac inhibitor prolonged cells' vulnerability to a molecule that ...

Purdue researcher invents molecule that stops SARS

... herpes and cancer, Ghosh said. "The molecular inhibitor we developed is very potent against the SARS ... "This is the first design and discovery of an inhibitor for this class of proteins. We are hopeful that ... structure-based design. "The design of this inhibitor was a challenge because we did not know the ...

Scripps Florida scientists awarded $1.5M to fight major water and food parasites

... number of different parasites, and that synthetic inhibitor libraries have already been developed against this enzyme family. As a result, a wealth of inhibitor leads already exist, many of which have been ... to invasive Entamoeba histolytica." The new inhibitor designed by Roush's laboratory attacks the EhCP1 ...

TGen and Washington University researchers discover new approach to treating endometrial cancer

... Louis discovered that introducing a particular inhibitor drug can turn "off'' receptors responsible for ... endometrial cancer. And, they found that the inhibitor drug proved effective even in cancer tumors ... By introducing a commercially available inhibitor drug, PD173074, TGen researchers showed that they ...

Argyrin: Natural substance raises hope for new cancer therapies

... of a certain protein - a so-called cyclin-kinase inhibitor - in the development of cancer. In the process, ... that mice in which the breakdown of the kinase inhibitor was suppressed by genetic change have a ... line in which the quantity of the cyclin kinase inhibitor can be measured using simple optical methods. ...

New technology enhances therapeutic potential of cord blood stem cells

... A CD26 inhibitor increases the efficiency and responsiveness of ... a CD26 Inhibitor, a small molecule enzyme inhibitor that enhances directional homing of stem cells to ... suggest "the beneficial effects of the CD26 inhibitor usage and the potential of this technology to ...

Scientists determine drug target for the most potent botulinum neurotoxin

... Chemistry. We have found a highly efficient inhibitor of botulinum neurotoxin type A the most potent ... We intend to do further research to tailor the inhibitor for the best results. We are excited about ... Ashraf Ahmed, who initiated the structure-based inhibitor design as part of the Institutes bio-defense ...

New drug targets may fight tuberculosis and other bacterial infections in novel way

... illness. "We have developed the first inhibitor of a key small molecule from Mycobacterium ... the lab. Our next step is to explore whether this inhibitor can stop these pathogens from multiplying in a ... and M. tuberculosis assays confirmed that the new inhibitor does block the production of PGLs. Although it ...

Universitat Autonoma de Barcelona researchers first to clone mice in Spain

... 1% for mice using standard procedures. Valproic acid is an inhibitor of the enzyme histone deacetylase, located at the cell nucleus where the ... used two years ago and research until now has focused on trichostatin, an inhibitor which has significantly improved the efficiency of mouse cloning, raising ...

Newly discovered epidermal growth factor receptor active in human pancreatic cancers

... to be activated in a subset of lung cancers. And, most promising, an EGFR inhibitor named erlotinib already has been through the long and complex Food and ... they found that the only case in 12 cases that had responded to the EGF inhibitor was the only case with an activated EGF receptor. Dr. Pandey would like to ...

New high-throughput screening technique makes probing puzzling proteins possible

... polarization, causing fluorescence polarization values to climb. If an inhibitor binds efficiently with a given protein, it can outcompete a probe, slowing ... in search of those that might inhibit RBBP9. They identified some 20 inhibitor compounds that bound effectively with the enzyme, and further ABPP studies ...

UC Davis bench-to-bedside research: Promising treatment in clinical trials

... Each patient will receive 28 days of treatment. The AR9281 enzyme inhibitor will be studied for safety, tolerability, reduction of blood pressure and ... officer of Arte Therapeutics. "This is the first clinical study of a s-EH inhibitor in patients, and the first study designed to establish proof of concept ...

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

... stress was responsible for the deleterious effects of the HIV-1 protease inhibitor on insulin production by pancreatic beta-cells and they further ... black seed oil or thymoquione as a protective agent against HIV-1 protease inhibitor induced deleterious effects on pancreatic beta-cells". ...

New potential therapeutic target discovered for genetic disorder -- Barth syndrome

... Sciences , shows the benefits of targeted intervention with an iPLA2-VIA inhibitor that prevents a major symptom of the disease- cardiolipin deficiency. ... of BTHS patients lymphoblasts within a tissue culture with the iPLA2-VIA inhibitor BEL partially restored the tissue cultures cardiolipin homeostasis. ...

Scripps research team defines new painkilling chemical pathway

... lab and a first author of the new paper. But now, a MAGL-specific inhibitor is finally available, thanks to the lab's new work. Key to this success ... chemical technique the group devised and has used fruitfully in other inhibitor hunts. This system enables the rapid engineering and testing of chemical ...

Researchers identify promising gene target for neuroblastoma therapy

... deaths. The discovery is intriguing because a small "targeted" molecule inhibitor caused neuroblastoma cell lines carrying two of the mutations to die when ... with the F1174L mutation. "Our timing is good because there is a new inhibitor of the ALK receptor that is currently showing promise in clinical trials ...

Breast cancer cells recycle to escape death by hormonal therapy

... They will grow if you take away the therapy." Adding a macroautophagy inhibitor promoted robust cell death. "We believe targeting the autophagosome ... cell gets acidic and chloroquine increases pH. "If you add this particular inhibitor of the recycling center, you alter the pH and block its ability to do what ...

UC San Diego researchers identify potential new drug candidates to combat 'bird flu'

... constantly twitching and jiggling, making the goal of finding a specific inhibitor somewhat daunting. It's somewhat like a baseball pitcher attempting to ... example, the route to the development of raltegravir, an anti-integrase inhibitor recently approved by the U.S. Food and Drug Administration to combat HIV, ...

Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure

... has found that a certain type of cancer drug called a tyrosine kinase inhibitor (including the very successful leukemia drug Gleevec), which interferes ... the theory. Dr. Forces group will continue to test the tyrosine kinase inhibitor drugs to better understand how they affect cardiac stem cells. ...

Further breakthroughs for breast cancer patients

... invasive behaviour could be reduced by treating the cells with a specific inhibitor of Src activity, AZD0530. Surprisingly, AZD0530 also made the ... actually prevent drug resistance occurring in the first place. The Src inhibitor AZD0530 developed by AstraZeneca is currently in early clinical trials. If ...

Study helps explain how allergic reactions are triggered

... at Harvard Medical School. This provides the proof of concept that an inhibitor of the CRAC channel should be able to impact mast-cell related diseases, ... including multiple sclerosis, rheumatoid arthritis and cancer, an inhibitor of the CRAC channel could, in the future, help in slowing the progression ...

Stowers Institute's Hawley Lab identifies factors responsible for restart of meiotic cycle

... kinase that restarts meiosis. Matrimony is the first known protein inhibitor of Polo kinase, explains R. Scott Hawley, Ph.D., Investigator, and senior ... strongly expressed in many types of tumor cells, so identifying a specific inhibitor for this protein may aid in the development of improved drugs for treating ...

New inhibitor has potential as cancer drug

... University researchers show, on the basis of animal models, that an inhibitor for heparanase would be extremely interesting as a drug candidate. ... normal cells/tissues. The findings indicate that producing an inhibitor for heparanase is an urgent step in discovering new drugs for cancer. ...

AACR, BCRF award inaugural grants in translational breast cancer research

... a Phase II study, she seeks to learn if the combination of an aromatase inhibitor with an EGFR/HER2 inhibitor will work better in preventing failure of tumors to respond to ...

JCI table of contents: Aug. 16, 2007

... might be prevented, or at least delayed. TITLE: Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered ... by treating mice with both a chemotherapeutic drug and a chemical inhibitor of IDO, but not either agent alone, leading the authors to suggest that ...

Bladder cells feel stretch

... observed in urothelial cells. These phenomena were almost completely attributed to TRPV4 activation, since such responses were eliminated by a TRPV4 inhibitor and reduced in TRPV4-deficient urothelial cells. Dr. Sokabe said, "This is the first report to show that TRPV4 is a primal stretch-detector in ...

Experimental treatment halts hypoxic-ischemic brain injury in newborns

... examined the therapeutic effect of injecting PAI-1 into newborn rats suffering from the brain blood flow reduction and systemic hypoxia. The enzyme inhibitor was injected into the intracerebroventricular region of the brain, which includes a system of canals that distribute cerebrospinal fluid throughout ...

Alzheimer's disease drug treats traumatic brain injury, report GUMC researchers

... 2009 International Conference on Alzheimer's Disease, the scientists will show that deactivating these pathways in part by using a gamma secretase inhibitor - a class of Alzheimer's disease drugs currently being tested - reduced loss of neurons in animal models of traumatic brain injury and protected the ...

Pitt team finds molecule that regulates heart size by using zebrafish screening model

... PITTSBURGH, July 5 Using zebrafish, researchers at the University of Pittsburgh have identified and described an enzyme inhibitor that allows them to increase the number of cardiac progenitor cells and therefore influence the size of the developing heart. The findings are ...

Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research

... factor receptor or VEGFR) suppresses the generation of blood vessels in tumors and slows down cancer cell growth. Years later, a small molecule inhibitor of the VEGFR2 kinase function was developed, from which a derivative was approved in 2006 for the treatment of kidney carcinoma and gastro-intestinal ...

Powe Award supports research on how enzymes enable the pathogenicity of 2 human disease organisms

... we can perhaps identify inhibitors that can be developed as antibiotics or antifungal agents," he said. "Since humans do not have siderophores, an inhibitor should not be toxic to us." Using modern biology techniques, Sobrado's group is the first in the world to obtain recombinant functional ...

Huntington's disease deciphered

... looking for a mechanism that could explain all the pieces of the puzzle. They found that at extremely low concentrations, huntingtin was a potent inhibitor of axonal transport, the system within the neuron that shuttles proteins from the cell body where they are synthesized to the synaptic terminals ...

American Society for Microbiology honors Deborah T. Hung

... chemical genetics and small molecular screening to dissect essential steps in pathogenesis. She published her findingsa new small molecule inhibitor of Vibrio cholerae virulence and intestinal colonization, virstatin, which directly inhibited dimerization of the virulence transcriptional activator ...

The challenges of avian influenza virus: Mechanism, epidemiology and control

... the sequence conservation and the atomic structure. This provides the basis for identifying structurally and functionally important regions for inhibitor design. Crystal structures of some parts of the polymerase complex, PA alone or PA with part of PB1, have been solved. Zihe RAO, Yingfang LIU and ...

Clinical trials for shingles drug take an important step forward

... Chris McGuigan, who led the team which discovered the anti-viral drug said: "We believe this drug has the potential to be the most powerful inhibitor ever discovered to treat shingles. "Each year only 25 new medicines are approved for clinical use [worldwide or by the FDA]. Although FV-100 is ...

KINAXOs Cellular Target Profiling reveals mTOR as a new target of Celebrex

... identify the protein kinase mTOR as a new cellular target of celecoxib (Celebrex®, Pfizer). Celecoxib is a non-steroidal, anti-inflammatory Cox-2 inhibitor approved for the treatment of osteoarthritis, rheumatoid arthritis and acute pain. In addition, celecoxib’s anti-proliferative effect has ...

A longer lasting tumor blocker

... to other recent reports, the tumors bounced back when the drug treatment was curtailed. Tumor growth in mice on a similar regiment of an M-CSF inhibitor remained suppressed in the absence of drug. Another distinction between the two inhibitors was the type of vessel growth that was blocked. ...

Joining forces to improve lung cancer treatment

... (Poland) Confirmation that EGFR mutations (deletion in exon 19, missense L858R) are the most important predictors of sensitivity to tyrosine-kinase inhibitor targeted therapies (Italy) Barbara Zolty from the World Health Organization (WHO) will also highlight the importance of preventing lung cancer as ...

Burnham researchers present at 100th AACR Meeting

... two papers: Cyclosporin A Sensitizes Cancer Cells to Death Receptor-Mediated Apoptosis and Chemical Biology Strategy Reveals Pathway-Selective inhibitor of NFκB Activation Induced by Protein Kinase C and Antigen Receptors. Changming Fang, Ph.D., who will also present two papers: Ileal Bile Acid ...