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Combination therapy boosts effectiveness of telomere-directed cancer cell death
...amined what happens to cancer cells whentelomerase inhibition is combined with inhibition of an enzyme calledtankyrase 1 that is involved in making telomeres accessible totelomerase. The res...GATA: a graphic alignment tool for comparative sequence analysis
...amined what happens to cancer cells whentelomerase inhibition is combined with inhibition of an enzyme calledtankyrase 1 that is involved in making telomeres accessible totelomerase. The res...Enzyme allows B cells to resist death, leading to leukemia
...ormal donor cells.The authors went on to show that inhibition of Lyn was able to restorethe process of cell apoptosis to normal and treatment of malignantcells with drugs that induce cell death decreased both Lyn expressionlevels and activity ?suggesting a direct correlation between high Lynactivity and the abi...U-M scientists find genes that control growth of common skin cancer
...red a subset of tumor cells that were resistant to inhibition ofthe Hedgehog pathway. The new finding has import...r cancers. In contrastto other cancer models where inhibition of Hh signaling leads todurable tumor regression, Dlugosz's new work raises the possibilitythat Hh p...Norovirus, AIDS vaccine and Hepatitis Virus
...nhibit HBV and HCV replication. Results showed 90% inhibition of HBV after twenty-four hours and 90-99% inhibition in HCV five days posttreatment. "We have demonstrated here that replication of HBV and HCV is sensi...Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
...tream, lowering its concentration there. However, inhibition of reductase function by statins also limits the availability of regulatory intermediates that govern reductase activity, contributing to a major increase in active reductase that becomes progressively harder to control, according to the researchers....New component of the 'brakes' on nerve regeneration found
... one TNF receptor member may be involved in myelin inhibition adds a new level of complexity to designing therap...sms of these findings and their relation to myelin inhibition may provide important insights into designing therapeutic strategies to block myelin inhibition and ...Stopping smallpox in its tracks: A new anti-viral approach
...dy demonstrates, for the first time, that chemical inhibition of host cell signaling pathways exploited by infectious agents represents a new avenue for development of anti-viral therapeutics. These inhibitors, which are already in use in human anti-tumor therapy, may have widespread applications in human viral...New drug shows promise as powerful anticancer agent
...sing various laboratory techniques have shown that inhibition of Plk1activity leads to cell death. "Because all signaling pathways that have gone awry in a cancer cell ultimately affect cell proliferation, a reasonable approach to cancer therapy is to develop inhibitors that block the function of a critical mol...Scientists identify molecule that regulates well-known tumor suppressor
...hat without normal PTEN there is a loss of PKB/Akt inhibition that can lead to tumor growth, sometimes cancers with normal PTEN also exhibit abnormally high levels of PKB/Akt activity. In a quest to determine what molecules regulate normal PTEN, Dr. Tak W. Mak from the Ontario Cancer Institute and the Universit...Buying Time Through Hibernation on Demand
...ng machinery called oxidative phosphorylation. The inhibition of this function, in turn, is what the researchers believe causes the organism to shut down metabolically and enter a hibernation-like state. In each case, upon re-exposure to normal room air, the organisms quickly regained normal function and metabo...U-M team recovers ancient whale in Egyptian desert
...ng machinery called oxidative phosphorylation. The inhibition of this function, in turn, is what the researchers believe causes the organism to shut down metabolically and enter a hibernation-like state. In each case, upon re-exposure to normal room air, the organisms quickly regained normal function and metabo...Researchers report new pro-inflammatory role for anti-inflammatory enzyme
...ens via a variety of mechanisms, mostly related to inhibition of metabolic enzymes and destruction of DNA." However, too much NO can be a bad thing. Sustained overproduction of NO can cause septic shock (sepsis). "In sepsis, which is a systemic bacterial infection, the body expresses iNOS which generates relat...Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma
...nt, the scientists observed strong, but transient, inhibition of tumor growth. However, when used over longer durations (twice-weekly injections up to four weeks), the results were striking. "Long-term treatments with this delivery system markedly inhibited tumor growth, with little or no tumor growth in many...Scientists discover that three overlapping signals in embryo help get the backbone right
... source of a cocktail of inhibitors," he said, "so inhibition is just as specific a signal in the embryo as is an activating signal." Since they discovered noggin, Harland and his colleagues have shown that in later stages of development, this protein factor is critical in laying down cartilage to make joints,...MUHC researchers make cancer target breakthrough
...e growth of both colon and lung cancer tumors with inhibition of the gene. The new target gene is called methylenetetrahydrofolate reductase, or MTHFR. Researchers were able to inhibit the function of the gene by creating antisense--an exact opposite of a tiny section of the MTHFR gene. "MTHFR is involved in t...Researchers make surprise discovery that some neurons can transmit three signals at once
...d depression, involve deficits that prevent normal inhibition of cells. Dr. Kandler's research could eventually provide insight into the biological cause of these disorders and help to identify novel approaches for prevention and treatment. Further study could have particular implications for dyslexia and tinni...'EuroVacc 02' HIV Vaccine Trial Begins
... this way, immune reactions to, and the consequent inhibition of the transporter are reduced. The first injections prime the immune system whereas the second injections further enhance (boost) the immune response. Therefore this combined vaccine strategy is expected to strengthen stimulation of the immune respo...Function of new cancer genes discovered
... An important implication of this research is that inhibition of the NF-kappa B route in cylindromatosis patients could be an adequate form of treatment. Aspirin is a well-known inhibitor of this route and a clinical study into the effectiveness of aspirin ointment in the treatment of cylindromatosis is current...Antiretroviral Therapy May Prevent HIV Transmission From Breastfeeding Mothers To Infants
...mother-to-child transmission through either direct inhibition of HIV replication in the breast milk, or by preventing infection from taking hold in the infant. The high drug concentrations raised the possibility of some risks, as well as benefits, however. Such levels may be high enough to cause adverse effect...Cancer drug slows poxvirus in mice
...M Reeves et al. Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases. Nature Medicine DOI: 10.1038/nm1265 (2005). ...Protein synthesis can be controlled by light, opening way for new scientific, medical applications
...hat it can mediate light-induced protein synthesis inhibition in a living system. While previous studies have f...little has been done in the area of regulating the inhibition of biological processes. "Ultimately, we want to understand the role local protein synthesis plays ...Researchers identify new genes that regulate aging
... one gene is prohibited from working properly, and inhibition of another gene increases the length of life by 20%. The genes discovered affect a wide variety of activities, including insulin signaling, metabolism, and dietary regulation. Genes involved in insulin signaling are particularly interesting because ...USC researchers determine mechanism of action of chemotherapy drug
...volved in protein structure and function, leads to inhibition of enzyme activity and to the death of the cells. ... to the replication and survival of cells, and its inhibition ultimately leads to cell death. "Our studies showed that MGd induces oxidative stress in cancer cel...Divergent life history shapes gene expression in brains of salmon
...ater to reproduce, may actually result from active inhibition of development into a sneaker. Previous studies have found that the proportion of sneakers in various salmon populations varies wildly; it appears that males that grow fastest early in life go on to become sneakers. The study by Aubin-Horth and her ...Endocannabinoids ?the brain's cannabis ?demonstrate novel modes of action to stress
...rine function during stress." Japanese team finds inhibition of excitatory and inhibitory synaptic transmission In an in vitro study, a multi-center Japanese team led by Atsushi Soya focused on the supraoptic nucleus (SON) where vasopressin and oxytocin are synthesized. They found that a synthesized cannbinoi...Insulin pulses keep the liver lean
...it is tempting to speculate that CEACAM1-dependent inhibition of fatty acid synthesis might be compromised as a consequence or even a cause of the insulin-resistant state," wrote Alan Saltiel of the University of Michigan in an accompanying preview. In this case, he added, finding ways to mimic the effects of C...Investigating 'brain shrinkage' in alcoholics
...xperience. When actively drinking, an individual's inhibition processes become impaired and can further contribute to poor decisions and excessive drinking. With prolonged bouts of drinking, dependence may ensue along with neural systems damage, commonly affecting frontal lobe based systems and their functions,...Engineered skin offers clues to melanoma development
...uced invasive melanoma in human tissue. Similarly, inhibition of p53, when combined with Ras and hTERT, resulted...ion of active PI3K, together with CDK4, hTERT, and inhibition of p53, produced invasive melanoma growth indistinguishable from that caused by Ras. By contrast, B-......uced invasive melanoma in human tissue. Similarly, inhibition of p53, when combined with Ras and hTERT, resulted...ion of active PI3K, together with CDK4, hTERT, and inhibition of p53, produced invasive melanoma growth indistinguishable from that caused by Ras. By contrast, B-...Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance
...uced invasive melanoma in human tissue. Similarly, inhibition of p53, when combined with Ras and hTERT, resulted...ion of active PI3K, together with CDK4, hTERT, and inhibition of p53, produced invasive melanoma growth indistinguishable from that caused by Ras. By contrast, B-...Mechanism regulating tooth shape formulation found
... that there is a delicate balance of induction and inhibition in determining tooth cusps and that ectodin is a key gene in this developmental control. The team confirmed the importasnce of ectodin to development of teeth by culturing teeth that produce ectodin and teeth that lack ectodin with excess amounts o...Duke Experiments Boost Radiation's Cancer-Killing Effects
...ocked HIF-1 before radiation, there was no overall inhibition of tumor growth. The tumor's center became "necrot...p53 respond more readily to radiation and to HIF-1 inhibition than tumors with a mutated P53 gene. Understanding such factors can aid scientists in determining th...IBM Transforms the Art of Scientific Expeditions
...ocked HIF-1 before radiation, there was no overall inhibition of tumor growth. The tumor's center became "necrot...p53 respond more readily to radiation and to HIF-1 inhibition than tumors with a mutated P53 gene. Understanding such factors can aid scientists in determining th...One bacteria stops another on contact
...wth �� and determining what this contact-dependent inhibition of growth (CDI) system is used for. These genes ar...ploration of the roles of contact-dependent growth inhibition in urinary tract infections and possibly other diseases," said Low. "Aoki has discovered an entirel...Researchers find molecule that inhibits regrowth of spinal nerve cells
...ve that to the extent that overcoming myelin-based inhibition is going to provide some sort of functional recovery for spinal cord injury patients, understanding ephrins is a major step forward," said Dr. Luis Parada, senior author on the paper and director of the Center for Developmental Biology and the Kent W...Promising therapies for haemophilia & heart disease
...troke. Our studies in mouse models have shown that inhibition of P-selectin reduces atherosclerosis (hardening of the arteries) and the work of our collaborators shows that the events leading to deep vein thrombosis are reduced. P-selectin inhibitors have also been shown to be anti-thrombotic in early human tri...Metal-containing compounds show promise as HIV weapon
...ech Republic and Germany studied the structure and inhibition properties of the basic molecule as well as several variants with chains of other atoms hanging off them. The researchers found that at very low concentrations, the new molecules inhibit protease in infected cultured human cells with no obvious toxic...Drug resistant avian influenza viruses more common in Southeast Asia than North America
...ted from humans in Asia are no longer sensitive to inhibition by the amantadine family of drugs." Resistance to the antiviral drug amantadine is caused by substitutions of one of five amino acids in the part of the M2 protein called the transmembrane domain-the part of M2 located within the coat of the influen...Researchers learn how blood vessel cells cope with their pressure-packed job
...ng heart. The researchers also demonstrated that inhibition of either Rho or a related protein called Rho kinase resulted in loss of the healthy alignment of stress fibers as well as alignment of adhesion sites where those stress fibers would attach to the cell membrane."These new results clearly show that Rh...Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
...e extent (or amplitude) of neuronal excitation and inhibition within glomeruli. He retrieved a spatial pattern of synchronized, correlated activity ?the memory trace ?from what appeared to be random fluctuations of neural activity. "The trace is like a fingerprint that disappears over time. It's strongest afte...Compound from marine bacteria shows potential as multiple myeloma therapy
... from the backup of damaged proteins. "Proteasome inhibition is a key therapeutic target and bortezomib (Velcade tm) was the first in a new class of compounds in multiple myeloma. NPI-0052 is a novel proteasome inhibitor with a chemical structure and action that is distinct from bortezomib, and has the promi...Researchers uncover mechanisms of estrogen in promoting cell death in breast cancer
... suggest that, if and when resistance to aromatase inhibition occurs, a strategy of treatment with estrogen ?may be sufficient to kill the cancer and control disease progression." ......hat the age-related problem results from defective inhibition of ubiquitin-proteasome dependent proteoloysis, a ...l-related stimulation of protein synthesis and the inhibition of breakdown." ...Plants give pests sock in the gut
...at naturally expresses Mir1-CP causes a 50 percent inhibition in caterpillar growth. Transgenic black Mexican sweet corn cells that express Mir1-CP inhibit caterpillar growth by 70 percent, Luthe says. Mir1-CP is harmful to caterpillars mainly because of its damaging effect on their peritrophic matrix. This is...Satellites show Amazon parks, indigenous reserves stop forest clearing
...between population density in indigenous areas and inhibition of deforestation. In much of the Amazon, not only can protecting nature be reconciled with human habitation ?it wouldn't happen without the people. Extensive intact forests on indigenous territories are central to large-scale conservation in the A...New drug could reduce tissue damage after heart attack
...ld be possible to undertake clinical trials of CRP inhibition within a couple of years. If the treatment proves...in which CRP levels are greatly increased, and the inhibition of CRP may thus find broad application in medicine." Patents, patent applications and proprietary k...Common bacteria pirate natural mechanism to get inside cells
...ection by controlling dynamin activity through the inhibition of nitric oxide synthases, enzymes that produce nitric oxide." The new research uses the common bladder infection-producing uropathogenic E. coli as a model to show how nitric oxide unwittingly assists bacterial uptake and survival. "In bladder ce...Tiny RNA molecules fine-tune the brain's synapses
... as brain-derived neurotrophic factor (BDNF), this inhibition was overcome and Limk1 became active again, enhancing spine growth. Greenberg believes that miR-134 ?and other microRNAs his lab is studying ?may play a role in fine-tuning cognitive function by selectively controlling synapse development in respons...Aggression-related gene weakens brain's impulse control circuits
...nsitivity in brain circuits important to cognitive inhibition and memory for negative emotional information may contribute to increased vulnerability of men with L exposed to abuse during childhood," suggested Weinberger. "Since only men showed gene effects in several of these circuits, this could lead to a sit......on of nuclear-encoded genes in sperm, and that its inhibition leads to a marked decrease in sperm motility, actin polymerization, the acrosome reaction and in vitro fertilization rates. Thus, protein translation in sperm is essential for sperm functions that directly contribute to fertilization. Dr. Breitbart...How 'hot' emotional brain interferes with 'cool' processing
...ter activity in a brain region associated with the inhibition of response to emotional stimuli rated the emotional distracters as less distracting. Said Dolcos, "One interpretation of this finding is that, because this region is associated with inhibitory process, people who engage that region more could cope b...Botox could help target resistant tumors for treatment
...ents," said Gallez. "Botulinum toxin could lead to inhibition of contractions of tumor vessels, improve tumor pe...uromuscular contractions of vessels in tumors. The inhibition of this contraction could literally open the gate to improved tumor perfusion by chemotherapeutic dr...Forsyth scientists gain greater understanding of how embryos differentiate left from right
... roles for both physiological parameters. V-ATPase inhibition also abolished the normal localization of serotonin at the 16-cell stage, suggesting that it helps to regulate the early flow of this important neurotransmitter. These data implicate H+-V-ATPase activity in patterning the left right axis of three dif...Researchers reveal lung's unique innate immune system
...t in which the alveolar macrophages circumvent the inhibition by TGFb for brief period of time, in order perform their immune task. This is accomplished through regulation of TGFb activity by a set of cell surface receptors, proteins called integrins. This regulation allows the alveolar macrophages to take on...Therapeutic prospects beyond Vioxx
...brex. They found that genetic disruption of COX-2; inhibition of the enzyme by different inhibitors; and disrupt...at deletion of mPGES-1, in contrast to deletion or inhibition of COX-2, did not predispose the animals to thrombosis or elevate blood pressure. A clue to this sur...Protein found to control tumor growth in certain breast cancers
...ession of the protein resulted in the nearly total inhibition of estrogen-dependent tumor growth in mice, and th...-expression of Nod1 in MCF-7 cells resulted in the inhibition of estrogen-dependent tumor growth in the SCID mice and a reduction of estrogen-induced proliferativ...COX-2 inhibitors significantly reduce risk of cancer
...ps in cancer development, including cell division, inhibition of cell death, angiogenesis (the creation of new blood vessels to nourish growing tumors) and metastasis," says Harris, who is also a member of the OSU Comprehensive Cancer Center. Harris says his research group is only midway through analyzing dat...Mayo Clinic researchers discover cancer cells may move via wave stimulation
...normal balance between growth promotion and growth inhibition is disrupted. Epidermal Growth Factor (EGF) and the EGFR to which it homes and docks are a hot topic in cancer research because EGF promotes growth through binding and activating its receptor and certain tumors exhibit elevated levels of EGFR. In add...Tramiprosate (Alzhemed? preclinical results published in Neurobiology of Aging
...loid cascade, thereby leading to the prevention or inhibition of amyloid deposition and the toxic effects of Aβ peptide in the brain. About the Phase III Clinical Trials for tramiprosate (Alzhemed? Neurochem is currently conducting a multi-center, randomized, double-blind, placebo-controlled and parallel-d...Other ContentsholdingholdingholdingholdingholdingholdingholdingholdingbreathbreathbreathbreathbreathbreathbreathcriteriacriteriacriteriacriteriacriteriacriteriacriteriabeersshapingshapingshapingshapingbiomedicinecachexiaOther Tags
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(Date:10/9/2008)...o conventional wisdom, tropical plant and animal s...th may be threatened by global warming, according ...st Robert K. Colwell and colleagues in this week,s...th,s climate has warmed in recent decades, the geo...and plant species in the US and Europe have moved ...
(Date:10/9/2008)...ssel: you have to worry about hungry starfish and ...t that can change your body temperature 50 degrees...the most variable habitats on Earth," said USC bio...he day bathed in cool Pacific seawater and the oth...y led the first real-time molecular sampling of mu...
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