Induction in Biological News

REGiMMUNE presents enhanced efficacy data in preclinical transplantation models

... enhanced efficacy in transplantation tolerance induction in models of skin transplantation and acute ... in a poster titled "Donor-Specific Tolerance induction by a Liposomal Formulation of KRN7000 (RGI-2001) ... with Sirolimus in transplantation tolerance induction in mouse models. Study Results ...

Lab-on-a-chip homes in on how cancer cells break free

... is triggered. We refer to this phenomenon as the induction time of the cell," Wildt says. "After this induction time, the cell then snaps back and contracts. We ... The researchers have speculated that the induction time for cancer cells, as compared to ...

Scripps research scientists identify blood component that turns bacteria virulent

... have identified an essential component for the induction of virulence gene expression in response to host ... uptake inside the cell greatly decreased, induction of toxin gene expression did not occur, and ... CO2 activity is not essential to virulence factor induction and that bicarbonate, not CO2, is the signal ...

National Inventors Hall of Fame welcomes 2008 inductees

... information about the 2008 inductees who will be recognized over the induction weekend can be found at the Hall of Fames web site, ... 2002 Nobel Prize in Physics. Inventors may be nominated by anyone for induction into the Hall of Fame, but they must hold a U.S. patent to be considered. ...

Natural compound in broccoli could treat devastating genetic skin disorder

... In EBS patients, skin blisters heal without scarring, correlating with an induction in the expression of the protein K6, to which K5 is related, and of K17 ... found that exposing keratinocytes to sulforaphane caused the selective induction of keratins 16 and 17. Moving to an EBS mouse model with a K14 deficiency, ...

Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients

... is a two-hour infusion administered every 8 weeks, following a standard induction regimen that requires treatment at weeks 0, 2 and 6. As a result, REMICADE ... is a two-hour infusion administered every 6 weeks, following a standard induction regimen that requires treatment at weeks 0, 2 and 6. ...

Vaccine blocks malaria transmission in lab experiments

... vaccine is an essential step in efforts to control the global spread of malaria. In our study, we demonstrate the relative ease of expression and induction of potent transmission-blocking antibodies in mice and non-human primates. This approach provides a compelling rationale and basis for testing a ...

A genetic basis for schizophrenia

... stem cell maintenance factors that have many functions in CNC cells, including the maintenance of precursor pools, timing of migration onset and the induction of cell differentiation. The authors showed that Disc1 disruption results in increased expression of these factors, leading to hindered cell ...

Work in mice will contribute to the study of hereditary diseases that lead to blindness

... This release is available in Spanish . Researchers of the University of Granada (Spain) have used a technique consisting of the induction of neuronal degeneration neuronal for intense light exposure in the mouse's retina that will be helpful for the study of retinitis pigmentosa (RP), a ...

Dioxins in food chain linked to breastfeeding ills

... during early to mid-pregnancy when the most rapid development of the mammary gland occurs. Researchers also found that dioxin altered the induction of milk-producing genes, which occurs around the ninth day of pregnancy, and decreased the number of ductal branches and mature lobules in the ...

Is vitamin D deficiency linked to Alzheimer's disease and vascular dementia?

... There are two primary ways that people lose teeth: dental caries and periodontal disease. Both conditions are linked to low vitamin D levels, with induction of human cathelicidin by 1,25-dihydroxyvitamin D being the mechanism. There is also laboratory evidence for the role of vitamin D in ...

Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer

... agent significantly induced an anti-tumor cellular immune response without the reintroduction of previously harvested tumor antigens. This successful induction of adaptive immunity correlated with inhibition of tumor growth. "On the basis of these findings, MIS416 appears to be a good candidate for ...

NAS annual meeting, April 25-28

... in the auditorium of the National Academy of Sciences building, 2100 C St., N.W., Washington, D.C. PUBLIC EVENTS: APRIL 25, 8 P.M. TO 9 P.M. induction ceremony and signing of the "Registry of Membership" for members elected in 2008. A reception will follow from 9 p.m. to 10 p.m. APRIL 26, 2 ....

Shades of 1918? New study compares avian flu with a notorious killer from the past

... Although the 1918 ressortant strains were found to be highly virulent, they were outmatched by H5N1's rapid onset, overwhelming transcription induction of cytokine and chemokine genes and headlong, sustained viral replication with wider distribution in the lungs. As Baskin notes, referring to the ...

The Burnham Buzz, February 2009

... protein (FADD) make up the death inducing signaling complex (DISC). The Fas-FADD DISC is a receptor platform, which once assembled, initiates the induction of programmed cell death. Dr. Riedl determined the X-ray crystal structure of the DISC to 2.7 Angstroms resolution and found that protein-protein ...

UC Davis research shows that newly discovered drug reduces heart enlargement

... a mouse model. The more recent work with the Zhu and Shyy laboratories extends these studies to show the involvement of angiotensin dependent enzyme induction in the process. At the time, Chiamvimonvat said: "We need a better way to control and prevent enlargement of the heart to improve treatment ...

Genetic testing not cost-effective in guiding initial dosing of common blood thinner

... published to date to determine the degree to which pharmacogenetic-guided dosing decreases the risk of major bleeds when compared with standard induction of treatment with warfarin. The team next constructed a model to estimate the cost-effectiveness of a genotype-guided dosing strategy. While ...

Mutant host cell protein sequesters critical HIV-1 element

... stimuli. Importantly, nef mRNA was targeted to and enriched in the stress granules. "Taken together, these results demonstrate that stress granule induction and nef mRNA sequestration account for this translational suppression of Nef expression and offers a new strategy for development of anti-HIV ...

NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays

... continued. Background on the Technical Approach Many clinically relevant drug-to-drug interactions (DDIs) are associated with inhibition and/or induction of a CYP enzyme, such as 3A4. Modification of CYP activities can profoundly affect therapeutic efficacy and lead to life-threatening toxicity. ...

Nuclear science for food security

... especially in developing countries. In Japan alone, the Institute of Radiation Breeding (IRB) calculates that crops developed using mutation induction generated economic returns of nearly US$ 62 billion against US$ 69 million invested during the period 1959 - 2001. That translates into a remarkable ...

Vitamin D found to fight placental infection

... among women. Their discovery suggests that placental innate immunity can be enhanced if pregnant women supplement their diets with vitamin D. induction of cathelicidin production by vitamin D may help the placenta stave off infection by a variety of pathogenic organisms, including staphylococcus, ...

Proteomics study yields clues as to how tuberculosis might be thwarting the immune system

... that enables cells to clean up their own cytoplasm," Shui said. "Not only was LC3-II present in the phagosome, its level was increased upon the induction of autophagy in macrophages, and reduced when autophagy was suppressed. This indicates cross-talking between autophagy and phagocytosis that may play ...

Bayhill Therapeutics and the Juvenile Diabetes Research Foundation announce research collaboration

... relative to placebo. Preliminary data from the 1 mg dose cohort indicate that treatment with BHT-3021 may cause beta cell preservation as well as the induction of immune tolerance to pancreatic autoantigens. Clinical Trial Criteria Key inclusion criteria for this trial include: a diagnosis of type 1a ...

TWAS to hold 25th anniversary celebration Nov. 10-13, 2008

... mathematics, human health and megacities will provide broad perspectives on critical issues related to science and society. There will also be the induction of new Academy members and the awarding of TWAS prizes and medals. A special half-day session on the state of science and technology in Mexico will ...

Astrocytes and synaptic plasticity

... is secreted, pro-BDNF being processed intracellularly. To get to the bottom of things, Bergami et al. investigated the fate of both forms after LTP induction in brain slices from the rat cortex. By fluorescent immunohistochemistry they showed that that neurons indeed secrete both mature and pro-BDNF, but ...

Gene is likely cause of stroke-inducing vascular malformations

... "This was exciting. The activated Notch gene caused BAVM in all of the mice, making it an unprecedented, potent molecular lesion in the induction of the pathology," said Rong Wang, PhD, senior author on the study, associate professor and director of the Laboratory for Accelerated Vascular ...

Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway

... Dr. Zagon said, "brings a paradigm shift to our thinking about a drug widely used in the clinics. Rather than imiquimod activity being mediated by induction of various cytokines, including interferon (IFN)-α, IFN-γ, tumor necrosis factor-α (TNFα) interleukin (IL)-1α, and IL-12 as ...

Integrins as receptors give insight into rotavirus and diarrhea

... receptor." She said she hopes to study the signaling aspect of the enterotoxin more closely because it could hold the clue to the mechanism of induction of diarrheal disease. "There may be ways to block the interaction between the enterotoxin and the receptor to treat diarrheal disease," said ...

Watson-inspired innovation in research at Cold Spring Harbor Laboratory

... cases, one of its authors. Topics include mobile genetic elements; DNA replication and cell-cycle regulation; cell behavior and architecture; tumor induction and cancer genetics; neuron biology; and the invention of techniques. Life Illuminated is the second volume of an intellectual history of the ...

UIC scientists discover how some bacteria survive antibiotics

... data with the knowledge of the structure of the ribosome tunnel, we were able to identify some of the key molecular players involved in the induction mechanism," said Vazquez-Laslop. "We only researched response to erythromycin-like drugs because the majority of the genetics were already known," ...

Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia

... atrial tachycardia is associated with mitochondrial dysfunction and oxidative stress followed by the activation of the NF-kB signalling pathway with induction of NF-kB target gene expression in atrial tissue. Their study will appear in the May 08 issue of Experimental Biology and Medicine. Multiple ...

New study finds uncontrollable stress worsens symptoms of endometriosis

... rats (n=4) had endometriosis but did not swim. The sham-stress group (n=3) did not have the disease nor did they swim. Sixty days after the induction of the endometriosis the rats were sacrificed and examined for the presence of endometriotic vesicles (small structures inside cells used to ...

Where college students live can impact their weight, eating and exercise habits

... rats (n=4) had endometriosis but did not swim. The sham-stress group (n=3) did not have the disease nor did they swim. Sixty days after the induction of the endometriosis the rats were sacrificed and examined for the presence of endometriotic vesicles (small structures inside cells used to ...

Researcher discovers pathway plants use to fight back against pathogens

... attack of a pathogen, and then activate defense responses by triggering a complex signaling cascade in plants. One of the defense responses is the induction and accumulation of anti-microbial defense chemicals, known as phytoalexins. In his study, Zhang found the specific signaling path, known as a ...

Biophysical Society announces 2008 International Travel Awards

... of Medical Sciences and G.T.B. Hospital, University of Delhi, India , Dose Dependent Effect of Organophasphate Compound on Oxidative Stress and induction of DNA Damage. Rajaram Swaminathan, Indian Institute of Technology, Guwahati, India, How Does SDS, CTAB and DTT Affect the Size, Rotational ...

An ambulance man for muscle damage

... by inhibiting another protein called FoxO. FoxO is a transcription factor, a protein that plays a crucial role in skeletal muscle atrophy through the induction of genes involved in cell cycle repression and protein degradation. Suppressing the effects of FoxO, calcineurin ensures that proliferating cells ...

Curry-derived molecules might be too spicy for colorectal cancers

... actions, including the suppression of genes that promote cell growth (for example, the destruction of the pro-cancerous protein catenin), and induction of programmed cell death (apoptosis) in colorectal cancer. Unfortunately, natural curcumin has what researchers term low bioavailability -- the ...

Potential new therapeutic molecular target to fight cancer

... of the cancer center's cancer cell biology program. According to Spiegel, the study demonstrated that SphK2 is important for p53-independent induction of expression of p21, a cyclin-dependent kinase inhibitor. This p21 regulates the cell cycle, and apoptosis or programmed cell suicide, mediated by ...

Interleukin-8, key marker for colorectal cancer treatment

... found in CRLM in comparison to related primary colorectal tumors. Thus, this study not only suggests a correlation between IL-8 expression and the induction and progression of colorectal carcinoma, but also clearly points to a correlation between IL-8 expression and the development of CRLM. "Monitoring ...

Flies can turn off their immune response

... as important to turn the immune system off to avoid damage to oneself by friendly fire. The fruit fly Drosophila has served as a good model for the induction of an innate immune response, pointing to conserved pathways and mechanisms. Recent work shows that the flys immune response is more subtly regulated ...