Hepatocytes in Biological News

It is important to demonstrate the influence of the microenvironment in the process of metastasis

... to combat it. To this end, liver cells - hepatocytes and myofibroblasts - are isolated, and both ... produce in each case and compare it with both the hepatocytes and myofibroblasts. More than 44,000 genes ... of genes is regulated in the same way by both hepatocytes and myofibroblasts, but there are other groups ...

New chimeric mouse model for human liver diseases, drug testing

... cells is to populate mouse livers with human hepatocytes in the hope of creating a natural environment, ... system that allows them to transplant human hepatocytes into immunodeficient mice, which can now be used ... in the Laboratory of Genetics, but mouse and rat hepatocytes may function in very different ways when it comes ...

Model tissue system reveals cellular communication via amino acids

... the development of a three-dimensional model of liver tissue in which hepatocytes (liver cells) are embedded in a layer of collagen and covered with a layer ... was secreted by the endothelial layer of the liver model, taken up by hepatocytes and used to synthesize new collagen, leading to faster recovery of ...

Studies on imaging and tracking transplanted cells

... useable imaging and tracking data. Bioluminescent imaging of human fetal hepatocytes In a study conducted by Dr. Mark A. Zern and colleagues at the ... of bioluminescent imaging to track transplanted immortalized human fetal hepatocytes injected into mice was evaluated. According to the researchers, it was ...

Interaction between lymph and liver cells may affect immune response

... liver sinusoidal endothelial cells (LSECs) and hepatocytes (liver cells) using electron microscopy. LSECs ... order to cross the endothelial barrier, and that hepatocytes can function as APCs. In fact, this T cell ... are capable of directly interacting with hepatocytes contradicts the dogma that naïve T cells cannot ...

Cycles of cell death, proliferation key to liver cancer

... was the finding that while NF-ƒÛB activation in hepatocytes (liver cells) prevents liver cancer, its ... what precedes inflammation ¡V the injury of hepatocytes caused by toxic chemicals, which sets in motion ... research showed that the absence of IKKƒÒ in hepatocytes led to increased c-Jun N-terminal kinase (JNK) ...

Gene therapy advance treats hemophilia in mouse models

... a way to get these cells to make more of it. In effect, we're using the hepatocytes as a factory to make this protein and secrete it into the bloodstream." To better target the hepatocytes in the mice, the team took the disabled protein coat from the baculovirus ...

Soft-cell approach cuts animal tests

... using animals. For example, when assessing the toxicity of formaldehyde, which is known to have a toxic effect on the liver, liver type cells such as hepatocytes can be chosen. The in vitro technique is cheap and portable, so scientists can measure immediate toxicity events, rather than waiting for ...

New culture method for hepatitis C virus uses primary hepatocytes and patient serum

... days. This is similar to what has been reported during clinical HCV infection, possibly due to the host's natural defenses. Interestingly, cultured hepatocytes responded to viral replication by displaying signs of distress and cell death and by expressing interferon-beta, a cellular antiviral, in an effort ...

Evolutionary conservation of a mechanism of longevity from worms to mammals

... lifespan in three different genetic backgrounds tested. Moreover, when the livers of these mice where analyzed, the authors found that a subset of hepatocytes exhibited loss of heterozygosity (effectively becoming mclk1-/- cells) and had undergone clonal expansion. The authors suggest that these mclk null ...