Hepatic in Biological News

Ocera Therapeutics licenses novel treatment for acute hepatic encephalopathy from UCLB

... to the compound for the treatment of acute hepatic encephalopathy (AHE). The compound recently ... treatment for patients hospitalised with acute hepatic encephalopathy," said Dr. Laurent Fischer, ... is a significant unmet clinical need to treat hepatic encephalopathy which affects 40-60 percent of ...

It is important to demonstrate the influence of the microenvironment in the process of metastasis

... metastasis, approximately 45 % will develop hepatic metastasis. It is this theme that the ... is research work in which colon cancer -generated hepatic metastasis is analysed, a disease which may be ... The PhD entitled Study of the genes involved in hepatic metastasis of colon cancer and which are ...

The endocannabinoids: Functional roles and therapeutic opportunities

... system may be involved in the pathogenesis of hepatic encephalopathy, a neuropsychiatric syndrome induced by fulminant hepatic failure. Indeed in an animal model the brain ... may play an important role in the pathogenesis of hepatic encephalopathy. Modulation of this system either ...

Empire State Stem Cell Board awards $12.7 million to Albert Einstein College of Medicine

... M.B., B.S., professor of medicine; genetics $1,080,000 Amelioration of hepatic metabolic defects by stem cell-derived human hepatocytes. Jeffrey E. ... of medicine; microbiology & immunology $1,069,157 Roles of microRNAs in hepatic stem cell differentiation; transcriptional control of cancer stem cells in ...

Studies on imaging and tracking transplanted cells

... fetal hepatocytes, the researchers for the first time imaged in vivo human hepatic progenitor cells transplanted into a rodent model. "Our results, ... approach for repeatedly and noninvasively monitoring transplanted hepatic cells," said Zern. Contact: Dr. Mark A. Zern, Transplant Institute, UC ...

US Air Force grant targets medical evacuation procedures

... of traumatic military combat injuries: controlled hemorrhage, hepatic ischemia reperfusion and scald/burn. The controlled hemorrhage model, ... but doesn't reach a field hospital to receive fluids for several hours. hepatic ischemia reperfusion model represents a patient who needs serious ...

Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer

... developed in the framework of the Centre of Network Biomedical Research on hepatic and Digestive diseases (CIBERehd). Hepatocarcinoma is the most frequent form of hepatic cancer. It has a high mortality rate due to, among other causes, the lack ...

Protein protects brain against compound in lead poisoning, liver disease

... have relevance as a secondary genetic modifier of conditions such as acute hepatic porphyrias and lead poisoning, and in drug transport at the blood-brain ... concentrations of 5-ALA are present in people who have lead poisoning or hepatic porphyrias. ...

Powerful integration of lipid metabolic profiling with gene expression analysis

... elucidated the effects on Mouse lipid metabolism by the disruption of hepatic Cytochrome P450 reductase (POR) in a POR deficient knock-out mouse model. ... expression and lipid metabolism in extrahepatic tissues being sensitive to hepatic POR functionality, the lipidome in general is only minimally affected. ...

Internationally acclaimed researcher joins UH faculty thanks to $5.5 million grant

... on other nuclear hormone receptors lends itself to new treatments for metabolic syndrome, including atherosclerosis, Type 2 diabetes and nonalcoholic hepatic steatosis, also known as fatty liver. He also has found evidence that the roles played by estrogen receptors and nuclear hormone receptors in the ...

Link found between immune system and high plasma lipid levels

... the paper. "It reveals a quite unexpected role of hepatic T cells in lipid metabolism." "Those with ... at the mouse livers ?particularly at the enzyme, hepatic lipase. This enzyme is made in the liver and ... expressing LIGHT made and secreted much less hepatic lipase ?and consequently, had higher plasma lipid ...

Interaction between lymph and liver cells may affect immune response

... LSECs are highly specialized endothelial cells that line the walls of hepatic sinusoid cells (gossamer-like structures that form the rich capillary ... that the study furthers the notion that liver cells may be involved in hepatic immune tolerance. "Like any good study," they conclude, "the work of ...

Study shows interruption of antiretroviral therapy increases risk of disease and death

... An important secondary end point was major cardiovascular, renal, or hepatic disease. There were 120 participants in the episodic therapy group and ... in the episodic group experienced significantly more cardiac, renal, and hepatic complications. Observes Dr. El Sadr, "The latter finding is surprising ...

Owl genomics presents a HEPATOCHIP for diagnosis of non-alcoholic steatohepatitis

... hepatitis. NASH is a critical stage in the process that spans from hepatic steatosis to cirrhosis and hepatocarcinoma. NASH is one of the most common ... provides the first product in early diagnosis and therapeutic targets in hepatic diseases. OWL Genomics is devoted to research into the diagnosis and ...

Liver cancer patients with high serum levels of hepatitis B virus face poorer outcomes

... per milliliter is associated with poorer survival in HCC patients with chronic HBV infection, and this association is independent of an individual’s hepatic reserve, tumor and clinical factors,” the authors report. Though the study was limited by a small patient cohort, and the fact that all had ...

Study details hepatitis C ability to block immune system response

... are chronically infected and that between 3-4 million are newly infected annually. HCV is the leading cause of chronic liver disease including hepatic fibrosis, end-stage cirrhosis, and hepatocellular carcinoma. There is no vaccine available to prevent HCV, and current therapies are costly, have ...

New GI technologies improve internal organ visualization

... blood vessels, including the thoracic and abdominal aorta, celiac axis, superior mesenteric artery, splenic vein, portal vein, splenic artery and hepatic veins. During the EUS, the researchers injected contrast to improve vascular visualization, and - performed angiography using several different ...

Insulin pulses keep the liver lean

... CEACAM1 might help to alleviate chronically elevated blood and liver lipids in patients with diabetes. Najjar et al.: "Insulin acutely decreases hepatic fatty acid synthase activity." Publishing in Cell Metabolism, Vol. 2, July 2005, pages 43-53. DOI 10.1016/j.cmet.2005.06.001. www.cellmetabolism.org ...

Attacks of King George III's madness linked to key metabolism molecule

... PGC-1 alpha is an important factor controlling the expression of ALAS-1 in the fasted and fed liver," the authors write. "Moreover, we showed that hepatic [in the liver] PCG-1 alpha is a major determinant of the severity of acute porphyric attacks in mouse models of chemical porphyria." Through a ...

Fat's fate depends on its source

... Resource. Chakravarthy, M.V., Pan, Z., Zhu, Y., Tordjman, K., Schneider, J.G., Coleman, T., Turk, J., and Semenkovich, C.F. (2005). "New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab. 1, 309-322. www.cellmetabolism.org ...

Excess liver gene protects against high-fat diet

... S., Guan, H.-P., Millar, J., Rader, D.J., Wilson, J.M., and Lazar, M.A. (2005). Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha. Cell Metab. 1, 297-308. ...