Hemophilia in Biological News

UT scientist receives hemophilia research award

... a Career Development Award from the National hemophilia Foundation. The award will support Smith's ... into the development of a therapy for people with hemophilia A, a bleeding disorder, whose immune systems are resistant to treatment. hemophilia A affects about one in every 5,000 males born in ...

NIH stimulus funding supports Emory biomedical scientists

... of dietary phosphate on a mouse model of prostate cancer. Understanding hemophilia and other clotting disorders: If your blood has trouble clotting, you ... Understanding blood-clotting proteins can improve treatments for inherited hemophilia and cardiovascular disease. This study looks at one particular clotting ...

Mapping a clan of mobile selfish genes

... DNA into pieces. Geneticists have already identified over 40 Alu elements that interrupt genes and cause human diseases, including neurofibromatosis, hemophilia and breast cancer, Devine says. Bennett and Devine tested Alu elements by putting each of 89 family representatives on a small circle of DNA next ...

UF researchers develop improved gene therapy agent

... a different tyrosine in each one and inserting in them the gene that triggers production of the blood-clotting protein Factor IX. Patients with hemophilia B, a common form of the disease, do not naturally produce this protein. In tissue samples and in mice, all the new vectors worked better than a ...

NHLBI issues first US von Willebrand Disease clinical practice guidelines

... especially during surgery, following an injury, or during childbirth. VWD affects 1 out of every 100 to 1,000 people - both males and females. hemophilia mainly affects males. These are the first guidelines on von Willebrand Disease published in the United States and we are pleased to offer ...

Ancient DNA helps UF researchers unearth potential hemophilia therapy

... degree to which these patients have problems from hemophilia stems from how much of this protein, factor VIII, ... More than 18,000 Americans, nearly all men, have hemophilia A, the most common form of the disease, according ... to find a safe way to perform gene therapy in hemophilia patients for years, but problems with the viruses ...

Gene therapy advance treats hemophilia in mouse models

... the development of gene therapy treatment for hemophilia A, a condition in which even a bump on the knee ... to bleeding problems in mice engineered to have hemophilia A, which is also known as factor VIII deficiency. ... potential for developing improved treatment for hemophilia but are not yet applicable to people, cautioned ...

Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers

... treatment of liver-based genetic defects such as hemophilia A and B in humans. Mouse embryonic stem cells ... then injected into the liver reverse a form of hemophilia in mice analogous to hemophilia B in humans, the new study shows. A report of the ...

Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, Stanford study finds

... A new gene therapy technique that has shown promise in skin disease and hemophilia might one day be useful for treating muscular dystrophy, according to a ... the journey towards a cure for the disease and for other diseases such as hemophilia and the skin disease, epidermolysis bullosa. Early trials using her ...

Redesigned protein accelerates blood clotting

... Study holds hope for next generation hemophilia treatment Researchers have doubled the potency of a protein that drives ... causes easy or excessive bleeding in 30,000 Americans. In most cases, hemophilia is caused by a lack of factor VIII, one of several proteins that enable ...

A transplant in time

... In hemophilia, a mutated gene prevents the production of a critical blood-clotting protein. Treatments for hemophilia and other such genetic diseases, when they exist, may consist of risky blood transfusions or expensive enzyme replacement therapy. But what if the ...

Polymer aids in blood clotting, pointing way to new treatment

... uncontrollable bleeding. Such scenarios, Morrissey said, could include treatment for wounds sustained on battlefields or in accidents, or for hemophilia and other diseases with coagulation deficits. "The big picture is that we've found a new function for an ancient molecule," he said. ...

HIV inserts into human genome using a DNA-associated protein

... Retroviral vectors are often used to introduce therapeutic genetic sequences into human chromosomes, such as in the delivery of Factor VIII for hemophilia patients. HIV integrates into active transcription units on chromosomes within the nucleus of human cells. These units are sites that lead to ...

New results validating Pall prion reduction filter disclosed at ISBT Congress

... 13th person with vCJD and Portugal announced its first suspected human case. The UK Haemophilia Society also issued a warning to 6,000 people with hemophilia that they could have caught the disease through infected blood. In the U.S., a second cow just tested positive for BSE. "Considering the lengthy, ...