Hematology in Biological News

UC Davis researchers exploring gene therapy to fight AIDS

... his latest research at the 50th annual meeting of the American Society for hematology in San Francisco on Sunday, December 6, 2008, from 6 to 8 p.m. at the ... gene-therapy experiment," explained Bauer, an assistant professor of hematology and oncology and director of a good manufacturing practice (GMP) ...

Taste, odor intervention improves cancer therapy, according to Virginia Tech, Wake Forest study

... Department, Pinar Omur-Ozbek, also of CEE, Yong Woo Lee of Virginia Tech's School of Biomedical Engineering and Glenn Lesser, a physician of hematology and oncology at Wake Forest. Their joint paper, "Taste and Odor Abnormalities in Cancer Patients", reports the "alteration of taste and smell in ...

DNA repair mechanisms relocate in response to stress

... lead to new targets for anti-cancer drugs that interfere with DNA repair, says Paul Doetsch, PhD, professor of biochemistry, radiation oncology, and hematology and oncology at Emory University School of Medicine. The results were published in the February 1 issue of Molecular and Cellular Biology . The ...

Lancet study supports new, highly effective treatment for blood disorder

... Bethan Psaila, from the department of haematology, Hammersmith Hospital, Imperial College School of Medicine, London, U.K.; Lidia Kovaleva, from the hematology Research Center, Moscow, Russia; Abdulgabar Salama, from Charit-Universittsmedizin, Berlin, Germany; Julian M. Jenkins, Debasish Roychowdhury, ...

Research shows cell's inactive state is critical for effectiveness of cancer treatment

... that lose p53 can actually be killed more readily than those that have p53 intact," said the study's senior author, Stephen Nimer, MD, Chief of the hematology Service and Member of the Molecular Pharmacology and Chemistry Program at MSKCC. "Our findings have important implications for developing therapeutic ...

UC Davis researchers find molecule that targets brain tumors

... cells left behind and systemic chemotherapy to prevent spread to nearby tissues," said Kit Lam, senior author of the study and UC Davis chief of hematology and oncology. "It is unfortunate that this approach does not extend survival significantly. Most patients survive less than one year." To find new ...

UC Davis researchers discover new drug target for inflammatory disease

... immune system. The involvement of integrins to the inflammatory process is of particular interest to study co-author Kit Lam, chief of hematology and oncology with UC Davis Cancer Center. "These two and other integrins are found on cancer cells," Lam explained. "And inflammation certainly ...

Weill Cornell science briefs June/July 2008

... with the disease each year. The research is published in a recent issue of the journal Blood, the official publication of the American Society of hematology (ASH). In Cooley's anemia, hemoglobin -- the oxygen-carrying molecule on red blood cells -- is mutated and non-functioning, resulting in a low ...

New technology enhances therapeutic potential of cord blood stem cells

... Symposium, June 6-7 in Los Angeles. Kent W. Christopherson II, PhD, assistant professor of medicine and researcher in the Sections of hematology and Stem Cell Transplantation at Rush, is researching a CD26 Inhibitor, a small molecule enzyme inhibitor that enhances directional homing of stem ...

Avoiding Spleen Removal for Cooley's Anemia SufferersAvoiding spleen removal for Cooley's anemia suf

... disease each year. The research is published in the latest online issue of the journal Blood, the official publication of the American Society of hematology (ASH). In Cooley's anemia, hemoglobin -- the oxygen-carrying molecule on red blood cells -- is mutated and non-functioning, resulting in a low ...

UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells

... therapy community felt that further biosafety testing was warranted," explained Gerhard Bauer, lead author of the study and an assistant professor of hematology and oncology. "Due to the significantly large number of study animals, our investigation further illuminates the safety of gene therapy using ...

AACR annual meeting showcases developments in understanding and targeting cancers

... technology. This is truly an extraordinary time," said William N. Hait, M.D., Ph.D., president of the AACR and senior vice president for Worldwide hematology and Oncology Research and Development at Johnson & Johnson. "Today, basic cancer research drives cancer medicine and it is increasingly influenced by ...

NHLBI issues first US von Willebrand Disease clinical practice guidelines

... convened an expert panel on VWD whose members were selected for their scientific and clinical knowledge and experience, including specialists in hematology as well as family medicine, obstetrics and gynecology, pediatrics, internal medicine, and laboratory sciences. A draft of the guidelines was posted ...

Lung cancer cells' survival gene seen as drug target

... their own, researchers have found. The gene is a potential target for selective anti-cancer drugs, says Haian Fu, PhD, professor of pharmacology, hematology & oncology at Emory University School of Medicine and Emory Winship Cancer Institute. The research results will be published the week of Dec. 24 ...

Ireland Cancer Center researchers advance stem cell gene therapy

... cells from the damage of chemotherapy regimens. In one of 24 presentations by Ireland Cancer Center researchers at the annual American Society of hematology meeting, Stanton Gerson, MD, and colleagues presented that eight patients were enrolled on the trial and six were infused with their own stem cells ...

Unique pattern of gene expression can indicate acetaminophen overdose

... exposure to toxic versus nontoxic doses with very high accuracy (88.9-95.8 percent), while the more traditional predictors, of clinical chemistry, hematology and pathology were approximately 65 to 80 percent accurate. Although it was not the main focus of our study, we wanted to see how applicable ...

3 out of 4 hospital patients suffer from malnutrition regardless of their pathology

... is between 3,500 and 6,000 (only for food and medication) . Hospital staff, diagnoses, fungibles, etc. are not taken into account). Oncology and hematology being the most resource-consuming services. Patients who undergo heart surgery and those who have a bone marrow transplant cost the most to the ...

OHSU turns innovations into commercial opportunities at record pace

... by OHSU scientists, notably Brian Druker, M.D., director of the OHSU Cancer Institute, and Michael Heinrich, M.D., acting head of the division of hematology and oncology in the OHSU School of Medicine. Druker is internationally recognized for his role in the clinical development of Gleevec (Imatinib), the ...

New tool helps blood specialists improve patient care

... The American Society of hematology (ASH TM ) and American Board of Internal Medicine ... certification, ASH and ABIM have co-developed the hematology Practice Improvement Module (PIM), a web-based ... MD, President and CEO of ABIM. "By completing the hematology PIM, physicians have a convenient and effective ...

Science study holds implications for gene therapy and stem cell biology

... is Christopher Baum, MD, an adjunct associate professor of experimental hematology at Cincinnati Children's, is one of a family of studies on using disabled ... in the molecular and gene therapy program in the Division of Experimental hematology at Cincinnati Children's under the direction of David Williams, MD, and in ...

Scientists create dual-modality microbeads to improve identification of disease biomarkers

... indicate specific diseases, according to Nie, who is also professor of biomedical engineering, chemistry, materials science & engineering, and hematology and oncology at Emory University and the Georgia Institute of Technology. "Some of the biomarkers for Alzheimer’s disease have very low ...

Unique tomatoes tops in disease-fighting antioxidants

... study with Ohio State colleagues David Francis, an associate professor of horticulture and crop science; Steven Clinton, an associate professor of hematology and oncology and human nutrition; Nuray Unlu, a former postdoctoral researcher in food science; and Torsten Bohn, a former postdoctoral fellow in ...

Report calls for improved monoclonal antibodies against solid tumors

... solid tumors account for 85 percent of all cancers. According to review lead author Robert A. Beckman, M.D. of the Department of Clinical hematology and Oncology at Centocor Research & Development, Inc. in Malvern, PA and his co-authors, Louis M. Weiner, M.D. of Fox Chase Cancer Center in ...

Gene therapy study takes aim at prostate cancer

... the study include Thompson, Dr. Brian J. Miles, BCM professor of urology; Dr. Adrian Gee, BCM professor of medicine and pediatrics in the section of hematology oncology; Dr. Thomas M. Wheeler, BCM professor of pathology and urology; Dr. Gustavo E. Ayala, BCM professor of pathology and urology; Dr. Martha P. ...

How bad is malaria anemia? It may depend on your genes

... drug treatment resources are scarce," says the study's primary author, Michael A. McDevitt, M.D., Ph.D., an assistant professor of medicine and hematology at the Johns Hopkins School of Medicine. "There are many difficulties with blood transfusion safety and access in Africa, especially in rural ...

Customized gene chip provides rapid detection of genetic changes in children's cancer

... Saul Surrey, Ph.D., professor of medicine and Associate Director of Research at the Cardeza Foundation for Hematologic Research and the Division of hematology at Jefferson Medical College. If a clinical diagnosis isn't known, the method might provide some clues. The microarrray described in the paper has ...