Association of herpesvirus with lung disorder questioned
...t by vascular lesions in the lung, and may lead to heart failure. Some cases are associated with genetic susceptibility, the investigators noted, but the pathogenesis of most cases is not known. Dr. Katano and colleagues conducted their research using a design similar to that in the earlier study: a retro...Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats
...erol and triglycerides and increases one's risk of heart disease and certain cancers. In the Jan. 28 issue..." the mechanism, decreasing cholesterol levels and heart disease risk, explained Spiegelman, who is also a professor of cell biology at Harvard Medical Schoo...W.M. Keck Foundation funds study of friendly microbes
...and obesity-related disorders such as diabetes and heart disease. Unfortunately, comprehensive analysis of the composition and functions of these microbial communities, in health and in disease, has been hampered because the majority of gut bacteria are difficult or impossible to grow and study outside of...Lack of enzyme turns fat cells into fat burners
...ing down using water) fat, and passingit on to the heart and muscle because there is an increase in oxidationof fat in those organs. It also starts oxidizing glucose. In otherwords, the adipose tissue is becoming a little more oxidative and lessinvolved in the synthesis and storage of fat. We feel this con...Newly discovered virus linked to childhood lung disorders and Kawasaki disease
...Kawasaki disease, the most commoncause of acquired heart disease in children in developed countries. In th... classic signs of Kawasaki disease. In addition to heart disease,the signs can include conjunctivitis, redness of the mouth or throat,rash, redness or swelli...HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs
...g to AIDS may cause serious and potentially lethal heart rhythm disturbances in some patients. The finding ...peutic benefits are still greater than the risk of heart problems linked to their use. They urge physicians to apply this new finding by following their pati...Iron Deficiency Sparks Dramatic Changes In Gene Expression
...fatigue,weakness and cognitive deficits to serious heart complications anddevelopmental disorders. Iron deficiency also contributes to thepathology of hereditary blood disorders, Parkinson's disease andcertain cancers and develops during a number of chronic diseases, theresearchers said.Until now, however,...Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
...e functioning gene and correct glycogen buildup in heart and skeletal muscle. The findings suggest that suc...scle-targeted gene reduced the glycogen content of heart and skeletal muscle and corrected individual muscle fibers. The effect persisted for 24 weeks post-i...Researchers identify target for cancer drugs
... an Assistant Professor of Biology at MIT. At the heart of this new research is a protein called Akt, an important player in the regulation of cell division and survival. Abnormally high activation of Akt has long been implicated in a variety of cancers. If Akt travels to the cell membrane, it is switched...Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
...ing information to your brain, while cells in your heart and arteries work just as hard to keep that brain alive. Every one of these cells -- and others throughout the body -- depends on an internal process called endocytosis to keep the flow of cellular nutrients and information healthy and strong. It's ...Highly adaptable genome in gut bacterium key to intestinal health
...and obesity-related disorders such as diabetes and heart disease The bacterium of the study, called Bacteriodes thetaiotaomicron or B. theta, is among the most abundant species in the human gut microbial community. B. theta breaks down otherwise indigestible carbohydrates, such as dietary fiber, and suppl...Research Gives Hope For Liver Damage
...en outcomes forother diseases, such as cancers and heart trouble, have made dramaticgains, liver damage - described as the new plague of the 21st century -has yet to be understood and in turn, to become treatable. More womenin the UK now die of liver failure than do of cancer of the cervix."There has been ...South America's vast pantanal wetland may become next everglades, UNU experts warn
...lometers ?an area roughly equal to Florida ?in the heart of South America, the Pantanal is the world's largest freshwater wetland, of active interest to U.S. scientists for insights into the lost biodiversity of Florida's famed Everglades, altered by drainage projects starting in the 1940s to make way for ...X-Ray Beams And Fruit Fly 'Flight Simulator' Aid Scientists' View Of Muscle Power
...ection between a fly’s aerodynamic skill and human heart function? Using the nation’s most brilliant X-rays...ular level, the insect’s flight muscle and a human heart are remarkably similar,?Maughan said. “We biologists have always been amazed by how hard these muscl...UF Researchers Map Bacterial Proteins That Cause Tooth Loss
...l disease also are at increased risk of stroke and heart attack, and the disease makes it difficult to cont... an organism that’s in your gums, your lungs, your heart valves, your arteries causing disease.?/p> The next step will be to expose P. gingivalis to othe...UCSD team discovers specialized, rare heart stem cells in newborns
...are, specialized stem cells located in the newborn heart of rats, mice and humans ?has been shown by resear...s are capable of differentiation into fully mature heart tissue. Called isl1+ cells, these cardiac progenitor cells are stem cells that have been programmed...Implanted Devices Detect High-Risk Heart Failure Patients
... to optimize the cardiac function of patients with heart failure have provided new insights into which pati...new view of subtle changes in a key measurement of heart health -- heart rate variability. Patients with little variability -- whose hearts are unable to app......plasmid that is delivered using catheterization to heart tissue that has been damaged from insufficient blo...side of the heart, the VEGF-2 is injected into the heart muscle region with inadequate blood supply. The DNA plasmid is then taken up by the middle muscular ...Special Imaging Study Shows Failing Hearts Are 'Energy Starved'
...t many scientists have conjectured for years about heart failure, and suggest new treatments designed to re...nergy demand and/or augment energy transfer. “The heart consumes more energy per gram than any other organ,?notes Paul A. Bottomley, Ph.D., lead researcher ...International HapMap consortium expands mapping effort
...mon diseases, such as asthma, cancer, diabetes and heart disease. When the project was launched in October 2002, the consortium set September 2005 as the target for completing its map of common patterns of human genetic variation, also known as haplotypes. By the end of February 2005, however, the group a...Vascular structure and function improve with diet and exercise
...t lower the risk of high blood pressure, diabetes, heart attacks and stroke," said presenter and lead autho...nge significantly. Ultrasound measurements of the heart and blood vessels at rest were performed as well. Left ventricular diastolic filling (LVDF) measure...Supercomputer Dedicated To Bioengineering, Computational Biology Installed
... propogation of an electrical impulse thorough the heart wall require us to generate matricies with million...ster will enable completely new simulations of the heart and other biological systems." Traditional supercomputer centers have historically been the workhor...Effective Cancer Treatments Follow The Clock
...ocks function in the brain as well as lung, liver, heart and skeletal muscles. They operate on a 24-hour, circadian (Latin for "about a day") cycle that governs functions like sleeping and waking, rest and activity, fluid balance, body temperature, cardiac output, oxygen consumption and endocrine gland sec...US life expectancy about to decline, researchers say
...rent life-shortening effects of cancer or ischemic heart disease. The findings are contrary to what some s... is associated with an increased risk of diabetes, heart disease, cancer and other complications. Obesity and overweight are the second leading cause of prev...Surprising findings reported about iron overload
..., liver cancer, arthritis, diabetes, impotence and heart failure. "The finding that Asians and Pacific Islanders have high levels of iron in the blood is surprising because they also have the lowest prevalence of the particular gene mutation that is found in Caucasians with the typical form of hemochromat...Use of PET can reduce, may eliminate more strenuous drug development trials with animals
... is used to study the metabolism of the brain, the heart and cancer. A miniature version of PET was developed and is used in much the same way to image small animals. Small animals, especially mice, play a fundamental in the study of human biology and disease. Mice have nearly the same set of genes as hum...NASA links nanobacteria to kidney stones and other diseases
...related conditions, including Alzheimer's disease, heart disease, prostatitis, and some cancers. Further testing for the presence of NB in human bodies can help reduce the risk for kidney stone formation in astronauts and would also be of benefit to the nearly one million Americans who are treated for kidn...Substance protects resilient staph bacteria
... implants such as catheters, artificial joints and heart valves. A substance found on the surface of Staph...nd endocarditis (inflammation of the lining of the heart and its valves). Because of the ability of PGA to promote resistance to innate immune defenses, lea...Chemists identify immune system mechanism for methamphetamine binges
...oss, aggression, psychotic behavior, and potential heart and brain damage. The Skaggs Institute for Chemical Biology (at Scripps) and the National Institute on Drug Abuse provided funding for this study. In addition to Janda and Dickerson, other study co-authors include Noboru Yamamoto and Diana Ruiz, als......ions in people with prosthetic joints, replacement heart valves, and intravenous catheters, and antibiotic resistance makes it tough to battle. Moreover, the mechanism through which the organism becomes so pathogenic once the protective barrier of the skin is removed remains unclear. In their study appear...Discovery Promises Simpler Therapy for Sickle Cell Disease
...ide effects of many disorders, including diabetes, heart attacks, septic shock and sickle cell disease. In... deficiency in oxygen delivery to tissues, such as heart failure, diabetes and pulmonary hypertension. Collaborators on the study include lead author John P...Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
...e to fatty buildups that coat arteries and lead to heart disease, UT Southwestern Medical Center researcher...he space for blood flow and can lead to angina and heart attacks in some people. Fatty buildups occur on the inner lining of an artery and gradually thicken ...Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks
...arn how to replace tissue damaged as a result of a heart attack. The potential for ES cells to replace dam...he chambers of the heart. “After a patient has a heart attack, significant numbers of these cardiac myocytes die, and the damaged heart muscle is replaced ...Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
...oronary artery disease and reduce the incidence of heart attacks--limit cholesterol synthesis by inhibiting reductase function, he said. As a result, cells take up more cholesterol from the bloodstream, lowering its concentration there. However, inhibition of reductase function by statins also limits the ...50-year-old Mystery Solved: Protein Tags Regulate Key Ion Channel
...determines whether "excitable" cells in the brain, heart and skeletal muscles "fire," sending out nervous impulses that become thoughts, heartbeats and basketball dunks. "We found that a little-studied process called sumoylation, previously associated with nuclear proteins, is active and essential outside...Single stem cells from bone heal a broken heart
...l infarction results in irreversible damage to the heart that can cause congestive heart failure. The lasting damage results from the limited ability of the myocardium to regenerate and sel......rwise healthy, both will heal. The prognosis for a heart attack, on the other hand, is not so clear-cut. I...ir, impeding the chances of a full recovery from a heart attack. However, recent evidence suggests that the heart might harbor stem cells after all and that ...UCSD-Salk Team Show Protein’s Gene-Silencing Role In Development of Nervous System
... being expressed in areas of the body, such as the heart and liver, where they shouldn’t be. When these phosphatases are shut off in the nervous system, neuronal stem cells can develop into specialized neurons. The researchers determined that SCPs are a component of a previously identified master gene com...Nanoparticles offer new hope for detection and treatment
...the same MRI equipment that is in standard use for heart or brain scans," says senior author Gregory Lanza, M.D., Ph.D., associate professor of medicine. "We believe the technology is very close to being useful in a hospital setting." Lanza and his colleague Samuel Wickline, M.D., professor of medicine, a...Buying Time Through Hibernation on Demand
...ly froze to death. Before she was resuscitated her heart had stopped beating for two hours and her temperature had plunged to 61 F. "Understanding the connections between random instances of seemingly miraculous, unexplained survival in so-called clinically dead humans and our ability to induce ?and rever...U-M team recovers ancient whale in Egyptian desert
...ly froze to death. Before she was resuscitated her heart had stopped beating for two hours and her temperature had plunged to 61 F. "Understanding the connections between random instances of seemingly miraculous, unexplained survival in so-called clinically dead humans and our ability to induce ?and rever...Study: 'homemade' gene expression technology unreliable
...oint genes affected by drugs being tested to treat heart disease, mental illness, infectious diseases and cancer. In the past, researchers were only able to analyze a few genes at once, and they were often uncertain whether these were of greatest importance. Spencer's group is using the technology in two ...Duke engineers develop new 3-D cardiac imaging probe
...sophagus, the probe creates a picture of the whole heart in the time it takes for current ultrasound technology to image a single heart cross section. The new probe has considerable potential not only for evaluating the condition of th...Double triumph in stem cell quest
... great promise for treating many diseases, such as heart disease, diabetes and Parkinson's, non-matching ES...fferentiate into a number of cell types, including heart muscle cells, neurons and blood stem cells, although the results have not yet been published. Troun...Grizzlies set to invade high Arctic?
...o one day take up home on Ellesmere Island, in the heart of polar bear country? Could polar bears in the wild interbreed with brown bears, their evolutionary close cousins, as has occurred at least once in captivity? What impact will grizzlies, already known to prey on polar bear cubs, have on these northe...Red delicious, Northern Spy apples have most antioxidants, chemists find
...and tissues, appear to play a role in the onset of heart disease and prostate, colon and other cancers. Polyphenols ?phytochemicals that act like astringents ?are major sources of antioxidants in apples, but which polyphenols are most active in the fruit has perplexed scientists. Tsao and his colleagues u...FDA Warns About Antipsychotic Drugs and Elderly
...d, most seemed to be either heart-related (such as heart failure or sudden death) or from infections (pneumonia). The atypical antipsychotics fall into three drug classes based on their chemical structure. Because the increase in mortality was seen with atypical antipsychotic medications in all three chem...Cellular Defects in Premature Aging Disease are Reversible
...r and body fat, joint stiffness, osteoporosis, and heart problems. The condition is fatal, with heart disease being the leading killer, and affected children usually die before they reach their late tee...Discovery clarifies role of peptide in biological clock
...s well," Herzog said. "We're getting closer to the heart and soul of circadian rhythmicity by uncoupling the (biological) clock." ...Breakthrough isolating embryo-quality stem cells from blood
...h could repair apparently permanent damage such as heart disease or Parkinson's. The cells are currently taken from aborted human foetuses, an issue which has led to controversy and opposition in many parts of the world. Any alternative source, such as voluntary adult donations, could spark a boom in new c......ke it a prime model of cardiovascular fitness. The heart has the amazing ability to adapt to altered physio...ke may provide insights into how remodeling of the heart occurs in adapting to prolonged exercise and in response to some diseases. The python does not eat ...Mouse with designer liver has enhanced glucose tolerance, insulin response
... development of new drugs for Alzheimer’s disease, heart disease and several forms of cancer. Today the Burnham Institute employs over 700, including more than 550 scientists. The majority of the Institute’s funding derives from federal sources, but private philanthropic support is essential to continuing ...Gov't Creates Gene Database of Normal Human Tissues
... in skeletal muscle, smooth muscle tissue, and the heart -- all organs that share a common way of functioning. To illustrate the kind of useful data that can emerge from using this tool, Khan's team analyzed 100 samples of the most common pediatric solid tumor cancer, neuroblastoma (NB), which accounts fo...NHGRI targets 12 more organisms for genome sequencing
...sk of developing common, complex illnesses such as heart diseases, diabetes and cancer. Building a catalog of rat SNPs will assist researchers trying to find genetic variations associated with common, complex diseases in rats, which can then be used to help identify similar genetic variations that may be i...Nanobacteria in clouds could spread disease, scientists claim
...ious diseases such as the formation kidney stones, heart disease, and HIV is also slowly being recognised by the scientific community. "Experiments have shown that nanobacteria are excreted from the body in urine and their dispersal from the ground into the atmosphere and stratosphere appears to be inevit...Venom doc tracks down snake bioweapons
...ment of diseases, including cancer, arthritis, and heart disease. "There is something peculiarly fascinating in the use of a deadly toxin as a life-saving medicine," Fry says. "The natural pharmacology that exists within animal venoms is a tremendous resource waiting to be tapped." By comparing the amino ...Columbia study shows widely used artery clearing device does not help patients during heart attack
...remove fatty debris from blocked arteries during a heart attack does not improve patient outcomes. The pro...g debris from the arteries in angioplasties during heart attacks, but it showed that there was no benefit to the patient. "It's not entirely clear why the d...Amazon symposium to address large-scale conservation
...ge beef and grain. The paving of highways into the heart of the region will facilitate the export of Amazon products to world markets as it creates new corridors for explosive frontier expansion. These mounting threats to the Amazon require large-scale, integrated approaches to conservation that cross trad...Tamoxifen-like drug suggests new ways to selectively block estrogen
...moxifen or raloxifene at preventing breast cancer, heart disease and bone loss without increasing the risk of endometrial cancer." Tamoxifen and raloxifene are the best-known members of a class of drugs known as specific estrogen receptor modulators or SERMs. These drugs mimic some effects of estrogen and...Researchers reveal secret of key protein in brain and heart function
...iated protein 97 (SAP97) found in abundance in the heart and head, where it is believed to play a role in everything from cardiac contractions to memory creation. Results are published in The Journal of Biological Chemistry. Dale Mierke, associate professor of medical science at Brown, said that knowing h...