glycoprotein

Scientists discover how Ebola virus infects cells

...an et al. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science Express. Published online April 14, 2005. DOI: 10.1126/science.1110656. ...

Newly discovered protein an important tool for sleeping sickness research

...ated with a surface antigen called variant surface glycoprotein (VSG). The human body makes antibodies for VSG, but trypanosomes randomly switch to another antigen when the organisms divide and reproduce. Trypanosomes whose VSG has switched evade the antibodies the human immune system made to fight the original a...

Breakthrough System for Understanding Ocean Plant Life Announced

...ated with a surface antigen called variant surface glycoprotein (VSG). The human body makes antibodies for VSG, but trypanosomes randomly switch to another antigen when the organisms divide and reproduce. Trypanosomes whose VSG has switched evade the antibodies the human immune system made to fight the original a...

Have a taste for fat? Yes! A sensor in the mouth promotes preference for fatty foods

...logical approaches to pinpoint the multifunctional glycoprotein CD36 (also termed fatty acid transporter, FAT) as the sensor for fat. They show that lingual stimulation of CD36 by fatty acids influences behavioral and digestive physiology. CD36 gene inactivation fully abolishes both the spontaneous preference f...

Ebola DNA vaccine produces immune responses in all fully vaccinated volunteers in Phase 1 trial

...losed loops of DNA), one each encoding the surface glycoprotein (GP) from the Zaire strain of Ebola, GP from the Sudan/Gulu strain, and the internal nucleoprotein (NP) from the Zaire strain. Subjects received three doses of vaccine or placebo at one-month intervals via intramuscular needleless injection. Three co...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

...es and expects to obtain a large array of specific glycoprotein variants that were hitherto unobtainable at a commercial scale. The company believes that as the scale-up and recombinant production of proteins in yeast is a well established technology, more easily achieved than mammalian cell culture, it should be...

Minor mutations in avian flu virus increase chances of human infection

...icity for the influenza virus is controlled by the glycoprotein hemagglutinin (HA) on the virus surface. These viral HAs bind to host cell receptors containing complex glycans-carbohydrates-that in turn contain terminal sialic acids. Avian viruses prefer binding to ?2-3-linked sialic acids on receptors of intesti...

DNA to the defense

...e proteins are encoded by VSGs, or variant surface glycoprotein genes. While the immune system attacks most of the parasites in a given host, some trypanosomes rapidly evolve and express new variants of VSG, thereby allowing the parasite to persist and spread through a population. In the current study, Sergio...

UCSD researchers create roadmap to integrin activation

...ost abundant platelet receptor, an integrin called glycoprotein (GP) IIb-IIIa, provides a powerful and flexible tool for studying therapeutic targets along the pathway that impacts the activation process. This activation leads to changes in the cells' surface receptors ?changes that enable platelets to bind to t...

Discovery of an HIV inhibitor in human blood points to new drug class

...gets a conserved region in the HIV-1 transmembrane glycoprotein known as "gp41 fusion peptide." This peptide, which is normally buried in the viral envelope, becomes exposed during the process of viral entry and makes the first direct contact between the viral particle and host cell. Thus, they showed, VIRIP p...

Jefferson scientists find rabies-based vaccine could be effective against HIV

...n preventing disease in rhesus macaques. One was a glycoprotein on the surface of HIV, while the other was an internal protein from simian immunodeficiency virus (SIV). They used the latter because HIV does not cause disease in monkeys. The idea was that such rabies?vehicles, or "vectors," would help attract ...