Glycol in Biological News

Drugs needed to preserve eggs for reproduction need to be given in stages

... used cryoprotectants dimethylsulfoxide, ethylene glycol and propylene glycol permeate monkey eggs. Faster permeability is ... and removal times. They found propylene glycol works best in monkeys. The drug penetrated the ...

Infant formula adulteration with melamine underscores need for better detection methods

... for food and drug ingredients allow such adulteration to affect people worldwide, which is what happened in similar instances where toxic diethylene glycol was substituted for the sweetener glycerin in toothpaste and cough syrup. USP is a scientific nonprofit organization that sets official standards for ...

Food counterfeiting, contamination outpace international regulatory systems

... a more premium species; milk and pet food adulterated with melamine; catfish containing banned antibiotics; toothpaste contaminated with diethylene glycol (a base chemical in antifreeze); and canned energy drinks of unknown origin labeled with brand names. Pharmaceutical counterfeiting has attracted ...

Tailor-made recombinant proteins in mammals

... you want on the tagged protein," she says, "You attach small molecule drugs, or polymers that change the pharmacokinetics such as polyethylene glycol polymers, or another protein molecule, or anything you're interested in attaching to a protein." Because of their obvious therapeutic importance, ...

American Chemical Society's Weekly PressPac -- Dec. 17, 2008

... effects. The scientists found that laboratory rats absorbed 10 times more LF if the protein is coated with the polymer, called polyethylene glycol (PEG). In addition, the coated PEG remained active in the bloodstream longer than the uncoated protein. The scientists also showed that the coated ...

UC Davis researchers discover Achilles' heel in pancreatic cancer

... of pancreatic cell lines using arginine deiminase, an enzyme isolated from a Mycoplasma bacteria. The enzyme was modified by adding polyethylene glycol chains to increase size and circulatory time. The researchers found that exposing the pancreatic cancer cell lines to the modified arginine ...

Reversible 3-D cell culture gel invented

... between a gel and a liquid state is known as thixotropy. IBN's thixotropic gel is synthesized from a nanocomposite of silica and polyethylene glycol (PEG) under room temperature, without special storage conditions. This novel material facilitates the safe and convenient culture of cells in 3D ...

Slipping through cell walls, nanotubes deliver high-potency punch to cancer tumors in mice

... words, you don't get this result just by attaching drugs to any nanotubes." The researchers used nanotubes that they had coated with polyethylene glycol (PEG), a common ingredient in cosmetics. The PEG they used was a form that has three little branches sprouting from a central trunk. Stuffing the ...

Cancer drug delivery research at Case Western Reserve University cuts time from days to hours

... body, and has a versatile surface chemistry, large surface-to-volume ratio and variable size and shape. Each Au NP is coated with polyethylene glycol (PEG) ligands, giving it the appearance of a hairy ball, said Burda. These PEG molecules offer several advantages over other materials: they are ...

New organic molecule in space

... interstellar molecules known to date have been found, including the most complex ones such as ethyl alcohol, formaldehyde, formic acid, acetic acid, glycol aldehyde (a basic sugar), and ethylene glycol. Starting from 1965, more than 140 molecular species have been detected in space, in interstellar ...

Videos extract mechanical properties of liquid-gel interfaces

... a gel of polydimethylsiloxane (a common material used in contact lenses and microfluidics devices). Pouring a liquid solution of polypropylene glycol on the gel, they then rotated the top plate to create forces at the liquid/gel interface. The results could be observed by tracking the motion of ...

American Chemical Society's Weekly PressPac -- Nov. 7, 2007

... say. In the new study, Mark Saltzman and colleagues showed that linking the anticancer drug campothecin (CPT) to the polymer polyethylene glycol (PEG), increased drug diffusion to more than a centimeter from the implant site. They also identified a promising CPT-PET compound that could deliver ...

American Chemical Society's Weekly PressPac -- Aug. 8, 2007

... that occurs when the lens of the eye becomes clouded. Christine Jr me and colleagues report development of a method for applying a polyethylene glycol coating to IOLs. In laboratory experiments, researchers showed that the coating reduced accumulation of the protein film and adhesion of cells ...

Many cleaners, air fresheners may pose health risks when used indoors

... a class of chemicals known as ethylene-based glycol ethers; and an examination of the chemistry that ... of chemicals called terpenes. Ethylene-based glycol ethers are common, water-soluble solvents used in ... which household products contain terpenes and glycol ethers, and in what quantities. It compiled a ...

Innovative coating could give medical implants a longer life

... and a longer peptoid polymer resembling the structure of polyethylene glycol (PEG), a widely studied antifouling polymer. "We had a rich chemistry ... characteristics of the antifouling component are similar to polyethylene glycol but it lasts longer because it is a peptoid and enzyme resistant. Plus, ...

Batten down the hatches against HIV

... are also made—to chains of polyethylene glycol. The phospholipids nestle securely onto the outer wall of the carbon nanotubes while the polyethylene glycol chains protrude into the surrounding solution. The required RNA molecules were fastened to the ends of these chains. Once inside the cell, the RNA ...

An artificial cornea is in sight, thanks to biomimetic hydrogels

... content of 80 percent--about the same as biological tissues. It's made of two interwoven networks of hydrogels. One network, made of polyethylene glycol molecules, resists the accumulation of surface proteins and inflammation. The other network is made of molecules of polyacrylic acid, a relative of ...

Triple threat polymer captures and releases

... and release them at room temperature. Wooley mixes two normally incompatible polymers -- a hyperbranched fluoropolymer and a linear polyethylene glycol -- and lets them phase-separate into distinct domains, one interspersed in the other. A chemical process called crosslinking then solidifies the ...

New egg freezing technique offers hope to hundreds of women

... agent or CPA) might affect the eggs as well. Six eggs were frozen using a multi-step procedure that involved increasing concentrations of ethylene glycol (EG) as a CPA. Twelve were frozen using propane-1,2-diol (PrOH) and two different amounts of sucrose as CPAs. After thawing, the eggs were studied ...

Could microbes solve Russia's chemical weapons conundrum?

... RM. They then moni-tored the levels of PHT derivatives in the cultures until the bacteria stopped growing, using monoethanolamine (MEA) and ethylene glycol (EG) ?both residual components of the initial de-toxification process that are present in the RM ?for growth. The results showed that the ...

Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimer's, Parkinson's Disease

... would rather want to study interactions individually." Thus, the Duke chemists capture individual monomers at the end of long chained polyethylene glycol molecules. They then attach one such tethered monomer to a microscope slide and the other to the AFM microscope tip. They can then bring the isolated ...