Glucose in Biological News

The battle for CRTC2: How obesity increases the risk for diabetes

... activated in obese people, triggers aberrant glucose production in the liver, an important step on the ... healthy people, a "fasting switch" only flips on glucose production when blood glucose levels run low during fasting. "The existence of ...

Continuous glucose monitoring technology -- special issue of Diabetes Technology and Therapeutics

... New Rochelle, NY, May 29, 2009Continuous glucose Monitoring (CGM) devices represent a critical step toward achieving automated glucose measurement, offering people with diabetes a promising new tool for maintaining optimal glucose control. A comprehensive review of this rapidly ...

UF makes gene therapy advance in severe genetic disorder

... as two to three hours without needing additional glucose to supplement its diet. But several weeks later ... the therapy, the dog was completely weaned off glucose supplements. "We have never had to use any glucose supplementation since we weaned her off," Mah ...

UCSF discovers new glucose-regulating protein linked with diabetes

... in human muscles to the process that clears glucose out of the bloodstream, shedding light on what ... "Much has been learned from mouse models about glucose metabolism that is relevant to human diabetes, ... In humans, muscles play a key role in clearing glucose from the bloodstream, Brodsky explained. In ...

Study shows CGM devices also benefit people with type 1 diabetes

... goals can further benefit from using continuous glucose monitoring (CGM) devices, according to results of ... with intensive insulin therapy, excellent blood glucose control was obtained, but at the expense of a ... CGM devices or one using standard finger-stick glucose testing for 26 weeks. "The research suggests ...

New evidence of how high glucose damages blood vessels could lead to new treatments

... AUGUSTA, Ga. New evidence of how the elevated glucose levels that occur in diabetes damage blood ... and obesity as well. One aftermath of high glucose levels is low levels of the powerful vasodilator ... the American Heart Association. Most of the glucose in the body goes directly into cells where it's ...

University of Texas at Austin engineer elected to American Academy of Arts and Sciences

... These patents formed the basis of the continuous glucose monitor for diabetes management known as ... developed a technology of coulometrically testing glucose levels using blood samples so small that they ... from diabetes are required to measure their glucose levels several times daily. The technology, the ...

LSUHSC student awarded top national honor for diabetes research

... leads to Ang-(1-7)-mediated restoration of glucose metabolism in diabetic mice." She will present it ... The research team previously demonstrated that glucose tolerance and fasting blood glucose levels in diabetic mice were improved when the ...

Findings show insulin -- not genes -- linked to obesity

... the pancreas after meals to trigger the uptake of glucose from the blood into the liver, muscle or fat ... pathway." The pathway enables cells to take up glucose from the blood. "Only one small variation at ... on cell membranes, signaling the cells to take up glucose from the blood. Cells that are said to be ...

UC Davis bench-to-bedside research: Promising treatment in clinical trials

... will enroll a total of 150 patients with impaired glucose tolerance, mild obesity and mild to moderate ... of blood pressure and various measures of glucose and lipid metabolism. Results are expected the ... proof of concept that s-EH inhibition modulates glucose metabolism or blood pressure in patients with ...

Symposium to look at genetic basis of exercise

... measure of aerobic fitness), blood pressure and glucose and insulin metabolism. The researchers ... an individual's insulin sensitivity and glucose disposal ability in response to exercise. This ... this gene improved their insulin sensitivity and glucose disposal ability with exercise while people with ...

Pure fructose frequently confused with high fructose corn syrup

... by the simultaneous and equivalent intake of glucose a critical and distinguishing factor from pure ... found in fruits and honey. The absence of glucose makes pure fructose fundamentally different from ... syrup. Common dietary sources of fructose and glucose include fruits, vegetables, nuts and sweeteners ...

Decreasing insulin resistance prevents obesity-related cardiovascular damage

... diabetes, you are walking around obese with your glucose control a little bit off and already beating up ... be diabetic but already have trouble with blood glucose control. "We have shown cardiovascular ... dilator of blood vessels. Overeating increases glucose so the body increases insulin production in an ...

Nano-tetherball biosensor precisely detects glucose

... created a precise biosensor for detecting blood glucose and potentially many other biological molecules ... engineering. The technology, which detects glucose more precisely than any biosensors in ... part of a catheter to continuously monitor blood glucose for diabetics," Porterfield said. "And it might ...

Is there a relationship between sleep-wake rhythm and diabetes?

... between the sleep-wake rhythm and the fasting glucose level. The finding could open up new ... MAGIC Consortium (MAGIC = Meta-Analyses of glucose and Insulin-related traits Consortium) combined ... which is associated with both elevated fasting glucose levels as well an elevated risk for type 2 ...

Athletes not spared from health risks of metabolic syndrome

... plaque buildup in arteries, insulin resistance or glucose intolerance indicating the body can't properly ... undergo a blood test to see if high cholesterol, glucose and triglyceride levels, too, indicate that he ... based on measures of waist circumference, glucose levels, high-density lipoprotein (HDL, or good ...

Researchers engineer pancreatic cell transplants to evade immune response

... use by the body. Without these cells, too much glucose builds up in the blood. High blood glucose levels damage cells and can eventually lead to ... type 1 diabetes must closely monitor their blood glucose levels and take daily insulin injections for ....

Impaired energy metabolism linked with initiation of plaques in Alzheimer's brain

... been suggested that diminished cerebral use of glucose and oxygen may be an early event in AD ... expanded on their previous work by using glucose deprivation to examine the molecular mechanisms ... in response to energy inhibition. They found that glucose deprivation caused an increase in BACE1 levels ...

High blood sugar's impact on immune system holds clues to improving islet cell transplants

... insulin-producing cells causing high blood glucose levels that may temporarily reduce the attack, ... or an islet cell transplant normalizes blood glucose levels, enabling, among other things, restoration ... were to get a transplant while their blood glucose was high the procedure alone could be lethal. But ...

New genes present drug targets for managing cholesterol and glucose levels

... and sleep patterns to small increases in glucose levels and larger jumps in the risk of diabetes. ... The 12 new genes relate to cholesterol and glucose levels, but several point to somewhat surprising ... high LDL or low HDL. In the paper studying glucose levels, Abecasis and Boehnke collaborated with ...

Discovery of new gene associated with diabetes risk suggests link with body clock

... receptor 1B is associated with high fasting glucose levels and increased risk of type 2 diabetes," ... (MTNR1B) showed a rise of 0.07 mmol/l in fasting glucose level on average and a 9% increase in risk of ... variant inherited from a parent. "High fasting glucose levels are early markers of diabetes and this ...

Master gene plays key role in blood sugar levels

... every few hours and feed them to keep their blood glucose levels up. As long as the glucose levels are high enough, the brain is nourished. If their blood glucose levels drop below a certain level, they suffer ...

Researchers at IRB Barcelona produce more data on key genes in diabetes

... and is the hormone responsible for ensuring that glucose reaches several tissues and organs in the body, ... insulin required for tissues to receive glucose, glucose in blood increases to pathological levels and the ... organelles are responsible for transforming glucose into energy that the cell will then use to ...

Apelin hormone injections powerfully lower blood sugar

... stimulates muscle and fat tissue to take up glucose from the bloodstream by stimulating a known glucose transport pathway. Specifically, apelin activates ... a pivotal role in the control of skeletal muscle glucose and the metabolism of fatty acids. Moreover, ...

Bayhill Therapeutics and the Juvenile Diabetes Research Foundation announce research collaboration

... adults, and last for life. Tight control of blood glucose is critical to both the long- and short-term health of patients. Short-term effects of poor glucose control include diabetic ketoacidosis, which is a ... lead to coma. Long-term effects include elevated glucose levels, blindness, kidney disease, heart disease, ...

Field-hospital-on-a-chip project awarded to nanoengineer from UC San Diego

... medical intervention. "Today's insulin and glucose management systems for patients with diabetes ... the first noninvasive system for monitoring glucose from a patient's sweat. "We are working on a ... Treatment Lactate, oxygen, norepinephrine and glucose are examples as the kinds of injury biomarkers ...

Food for thought -- regulating energy supply to the brain during fasting

... high-performance fuel will do. If no food-derived glucose is available, the body must manufacture its own ... in the form of protein and converting it to glucose in the liver, a process known as gluconeogenesis. ... question has always been how is the production of glucose turned on, and how is shut off again?" ...

JDRF-funded clinical trial demonstrates continuous glucose monitoring improves blood sugar control

... Patients with type 1 diabetes who used continuous glucose monitoring (CGM) devices to help manage their ... very important, because they show that continuous glucose monitors are more than simply devices of ... findings of previous studies, better control of glucose levels over the long term can be expected to ...

Treatment corrects severe insulin imbalance in animal studies

... high risk for insulin imbalance, in which blood glucose levels are too low (hypoglycemia) or too high, ... withhold food from those mice, their blood glucose levels become low, a condition called fasting ... had significantly higher levels of fasting blood glucose compared to mice that were not treated with the ...

Limiting fructose may boost weight loss, UT Southwestern researcher reports

... fat from fructose," Dr. Parks said. Fructose, glucose and sucrose, which is a mixture of fructose and ... to decide whether the body needs to store the glucose as glycogen, burn it for energy or turn the glucose into triglycerides. When there's a lot ...

Exercise could be the heart's fountain of youth

... increase their uptake of energy in the form of glucose (blood sugar). But after endurance exercise ... session the participants' hearts doubled their glucose uptake during high-energy demand, just as younger ... explains that if heart muscle doesn't take in glucose in response to increased energy needs, it goes ...

UCLA researchers clarify function of glucose transport molecule

... structure of a class of proteins known as sodium glucose co-transporters (SGLTs), which pump glucose into cells. These transport proteins are used in ... high-resolution, three-dimensional picture of a glucose transport protein. The research is published in ...

Post-exercise caffeine helps muscles refuel

... metabolites and hormones in the blood, including glucose and insulin. The entire two-session process ... double-blind, placebo-controlled experiment. glucose and insulin levels higher with caffeine ingestion ... drink resulted in higher levels of blood glucose and plasma insulin several signaling proteins ...

Mouse model developed at UT Southwestern mimics hyperglycemia, aids in diabetes research

... beta cells had regenerated and their blood glucose levels returned to normal after two months. ... clear whether these transient bouts of elevated glucose can cause permanent damage in the vasculature that persists even after normal glucose levels have been restored. Dr. Zhao Wang, a ...

Genetic variation linked to sugary food

... Their study, entitled Genetic Variant in the glucose Transporter Type 2 (GLUT 2) is Associated with ... sugar (glucose) into cells. The gene is called glucose transporter type 2 or GLUT2. The researchers ... fructose (simple sugar such as corn syrup) and glucose (carbohydrates), regardless of age or sex. ...

Genetic breakthrough explains dangerously high blood glucose levels

... sequence that controls the variability of blood glucose levels in people. This is a potentially significant discovery because high blood glucose levels in otherwise healthy people often are ... of healthy, non-diabetic individuals whose blood glucose levels were in the normal range. They discovered ...

Bypassing the insulin highway

... a neutrophil releases a protein that can suppress glucose production in the liver without targeting ... defensins which seem to have a connection with glucose levels. During bacterial infection, defensin ... glucose-producing genes and decreased cellular glucose levels, but did not activate or alter the ...

People with diabetes may have all natural citrus supplement

... people with type 2 diabetes lower their blood glucose numbers after a meal and their LDL-cholesterol ... consistently shown that Diabetinol improves blood glucose numbers. This time we saw a sizeable change in glucose intolerance in just a short time. This is good ...

Human hormone blocker found to help prevent obesity and diabetes: study

... and body weight were recorded daily while plasma glucose and insulin concentrations were monitored at 5-7 ... play a key role in obesity-related diseases). glucose tolerance and insulin sensitivity tests were ... body weight, energy intake, and circulating glucose concentrations. The levels remained elevated ...

UT-Houston's Northrup and colleagues uncover genetic link to spina bifida

... an association between genes regulating glucose metabolism and spina bifida. The decade-long ... variants in a dozen genes that take part in glucose metabolism to look for a link between genetic ... Reproductive Sciences, the study titled Genes in glucose Metabolism and Association with Spina Bifida, ...