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glioma in Biological News

Computer model predicts brain tumor growth and evolution

... suffering from this type of tumor, a malignant glioma of the brain. Details of the research were ... game. The result: A three-dimensional matrix of a glioma that can be adjusted to see what its growth stage ... validated their computational model with glioma specimens. Bearer studied about 40 different ...

Lithium may help radiation target cancer, spare healthy tissue

... NHEJ pathway. However, none of these effects were observed in malignant glioma (brain tumor) cells, presumably because cancer cells generally utilize a ... the safety and feasibility of lithium treatment in patients with low-grade glioma or brain metastases from small cell lung cancer. "Right now, the ...

TGen researchers discover possible way to block the spread of deadly brain tumors

... meant a fast maturation of NHERF-1 from a candidate gene associated with glioma invasion to positioning it as having a verified role in contributing to ... said. In the study, depletion of NHERF-1 stopped the migration of glioma brain cancer cells, she said. "These results suggest that NHERF-1 plays ...

Invasion of the brain tumors

... outgrowth and promote neuronal cell death, as an important regulator of glioma invasion. The researchers present the first evidence that this neurotrophin receptor can also be a potent mediator of glioma invasion, and they show that the expression of this receptor is sufficient ...

Engineers create intelligent molecules that seek-and-destroy diseased cells

... where it is not doing what we would like it to do," Smolke said. She hopes to translate her technologies into intelligent cellular therapeutics for glioma patients in the next five years. "That's a very optimistic view," she said. "But so far things have been moving quickly." The broader implications ...

Veterinary college researcher studying brain tumors in people and animals

... and are currently enrolling animals from around the region that have been positively diagnosed with a brain mass consistent with the appearance of a glioma on magnetic resonance imaging (MRI). The researchers will be studying tissue samples from affected animals in search of these proteins that are ...

Cancer stem cells linked to radiation resistance

... The researchers first measured the number of glioma stem cells present in the original tissue and ... observed a roughly fourfold jump in the number of glioma stem cells present in the tumor tissue following ... cells, DNA, the researchers hypothesized that the glioma stem cells survive and multiply by somehow fixing ...

Targeted virus compels cancer cells to eat themselves

... The modified adenovirus homed in on malignant glioma cells in mice and induced enough ... promoter regulated adenovirus) infected the glioma cells and induced autophagy by inactivating a ... volume among mice with subcutaneous malignant glioma that got hTERT-Ad and those that received a ...

Unique dual target specificity of kinase inhibitor key for success against cancer

... of a broad range of lethal malignant glioma cells in vitro and in vivo. The findings, ... critical for growth and progression of malignant glioma cells. UCSF colleagues Zachary Knight and Kevan ... Fan in the Weiss lab screened these agents in glioma cell lines. One compound, PI-103, uniquely and ...

Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection

... cells ?have the ability to target and track glioma cells in the brain, even as they migrate. The ... immune responses ?to track down and destroy glioma cells. In 2002, the scientists reported that ... anti-tumor response that tracks to migrating glioma islands and offers long-term protection ?all of ...

Mobile phone use not linked to increased risk of glioma brain tumours

... tumour. There was no relationship for risk of glioma and time since first use of a mobile phone, ... effect. This finding may be due to people with glioma brain tumours linking mobile phone use to the ... phones but the study showed no increased risk of glioma brain tumours with the use of analogue phones. ...

Vaccine for brain tumors shows promising results

... with recurrent, high-grade glioma. glioma is a type of primary tumor that arises from the ... cells. The most common site of involvement of a glioma is the brain. Malignant glioma is currently a fatal disease. The trial ...

Inflammation and drugs to control this activity studied in a variety of tumors sites

... and Bondy used combined data from two studies: the Harris County Adult glioma Study and the Bay Area Adult glioma Study, led by Margaret Wrensch, Ph.D. at the University of California, San ...

Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons

... for multiple cell types. Research has shown that SCF is expressed in glioma cells and as a result of various types of brain injury, but its ... in vivo results in decreased angiogenesis and improved survival in mouse glioma models, whereas overexpression of SCF is associated with a worse prognosis ...

Mouse brain tumors mimic those in human genetic disorder

... rely on several tests to determine whether a child with an optic pathway glioma should undergo treatment for the tumor, including the tumor's size and the ... Gutmann DH. Natural history of neurofibromatosis 1-associated optic nerve glioma formation in mice. Annals of Neurology, January ...

UCSF brain tumor vaccine trial shows promising results

... seek out second opinions and investigate clinical trials. I can tell you I am so glad I did.? “Our goal is to change the management of recurrent glioma from a life threatening disease, in which survival rates are typically 25 to 26 weeks, into a chronic disease with extended survival and improved ...

Newly identified biomarker detects and regulates spread of brain tumors

... or comes back after treatment. The study, ÒAttractin is elevated in the cerebrospinal fluid of patients with malignant astrocytoma and mediates glioma cell migration," is published in the November issue of Clinical Cancer Research. The biomarker, a protein known as "soluble attractin," is ...

Mayo Clinic Cancer Center: Harnessing the measles virus to attack cancer

... the measles virus investigation. "We have shown in the laboratory and in several animal models that measles virus strains can significantly shrink glioma tumors and prolong animal survival. It is very rewarding to see this work maturing to the point of now being able to offer this novel and promising ...

Possible birthplace of malignant brain tumors identified

... matter the most do not have the luxury of time to watch this work unfold. The median interval from diagnosis to death for patients with malignant glioma is currently only 14 months." ...

Radioactive scorpion venom for fighting cancer

... of the venom protein, attached to a radioactive substance called iodine-131 (I-131). When it enters the bloodstream, the compound attaches to the glioma cells, then the I-131 releases radiation that kills the cell. This compound has enabled an experimental treatment for high-grade gliomas, found ...

Infections could contribute to adult brain tumours

... adult brain tumours diagnosed in patients from the North Brabant province of the Netherlands between 1983 and 2001. They found clusters of cases of glioma tumours, which make up about half of all brain tumours, at different time intervals in different geographical locations. This 'space-time ...

Columbia research lifts major hurdle to gene therapy for cancer

... cells died while the normal cells were unaffected. The same virus also selectively killed human cancer cells from melanoma and ovarian, breast, and glioma (brain) tumors. Dr. Fisher's team is now altering the virus and developing additional viruses based on the PEG switch for use in clinical trials ...
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