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Chemists create 'Superbowl' molecule; May lead to better health
...as an open top, much like an open-air stadium. Its general molecular formula is C268H320O52. The tiny molecules can be modified to include other functional groups that give it additional properties, Sherburn says. For instance, one highly active version of the superbowl molecule goes by the name tetrabromo-...It's not all genetic: Common epigenetic problem doubles cancer risk in mice
...ent of colon cancer patients and 10 percent of the general population -- the extra IGF2 stems not from a genetic problem, or mutation, but an "epigenetic" problem that improperly turns on the copy of the IGF2 gene that should remain off. Unlike most genes, the copy of IGF2 that should be silent depends only...New, automated tool successfully classifies and relates proteins in unprecedented way
...further.They are also working on ways to "train" a general system that willwork for different cell types....Current human embryonic stem cell lines contaminated UCSD/Salk team finds
...emcell lines."With this discovery, the preexisting general concern about usinganimal products for deriving human embryonic stem cells has become morespecific, being defined in molecular terms," Varki said."Such issues will, of course, become irrelevant if complete eliminationof Neu5Gc can be achieved by deri...Newly-discovered class of genes determines ?and restricts ?stem cell fate
...factors to have this dual role may represent a new general paradigm for developmental and stem-cell biology. "My idea is that this is a new family of genes--they can both determine the cell type, but also put the breaks on differentiation," says Epstein. "We have named them pangenes, after the Greek god Pan ...Ancient olfaction protein is shared by many bugs, offering new pest control target
...found in almost all olfactory neurons and serves a general function in detecting odors. When the gene for Or83b is deleted, the flies can't smell. In the new study, Vosshall, in collaboration with researchers from Sentigen Biosciences, showed that the function of Or83b is preserved in different insects. Alt...Emory Eye Center Implants Its First Retinal Chips In Patients With Retinitis Pigmentosa
...ressive retinal degeneration in both eyes. It is a general term for a number of diseases that predominantly affect the photoreceptor layer or "light sensing" cells of the retina. Night blindness develops, usually in childhood, followed by loss of peripheral visual field, progressing over many years to tunnel...Mitochondrial DNA mutations play significant role in prostate cancer
.... In a controlsample of 1,019 individuals from the general population, 7.8 percenthad mutations in the COI ge...centof the no-cancer group and in 6.5 percent in a general populationsample of 898 Europeans.To determine whether mtDNA mutations are causally related to prost...An HIV Protein Plays a Surprising Role in Gene Activation
...-coding genes. RNA polymerases join with so-called general transcription factors to form a pre-initiation complex (PIC) on the gene's promoter, where it binds to region rich in thymine (T) and adenine (A) named the TATA box. The first transcription factor to associate with the TATA box is called TFIID, a lar...Scientists discover the cellular roots of graying hair
...t the same pattern occurred.Since cell survival in general is influenced by an “anti-death?genecalled Bcl2, Fisher’s team analyzed mice lacking this gene. In adramatic fashion, the mice lost their melanocyte stem cells shortlyafter birth and quickly went gray. It may be that people who grayprematurely have m...Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
...t the same pattern occurred.Since cell survival in general is influenced by an “anti-death?genecalled Bcl2, Fisher’s team analyzed mice lacking this gene. In adramatic fashion, the mice lost their melanocyte stem cells shortlyafter birth and quickly went gray. It may be that people who grayprematurely have m......t the same pattern occurred.Since cell survival in general is influenced by an “anti-death?genecalled Bcl2, Fisher’s team analyzed mice lacking this gene. In adramatic fashion, the mice lost their melanocyte stem cells shortlyafter birth and quickly went gray. It may be that people who grayprematurely have m...ASU researchers finds novel chemistry at work to provide parrot's vibrant red colors
...cies ?at least in colors visible to us. Parrots in general may not be using color in the classic cases of mate choice or competitive ability," he said. "Exactly why they are so uniformly colored remains an interesting mystery to us ?one we want to investigate." "There is a sea of colors in birds," he added....Transport System Smuggles Medicines Into Brain
...cies ?at least in colors visible to us. Parrots in general may not be using color in the classic cases of mate choice or competitive ability," he said. "Exactly why they are so uniformly colored remains an interesting mystery to us ?one we want to investigate." "There is a sea of colors in birds," he added....Open microfluidic and nanofluidic systems
... have shown that such open systems are possible in general but only if the geometry of the surface channels is carefully matched with their wettability (PNAS 102, 1848-1852 (2005). Many research groups around the world work towards the construction of "labs-on-a-chip" in order to integrate chemical and bioc...The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
...been refined and are now marketed by companies for general structural biology applications. As the PSI pilot centers have put automated structure determination pipelines in place, the number of protein structures they have solved has increased significantly. In the second, third, and fourth years of the pil...Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
... identifying cancer cells is it's a very rapid and general method that potentially can be applied to cancer cells from solid tumors as well as hematological malignancies like leukemia." Naviaux looks forward to examining a wider population of cancer cells to validate the method, combining the resources of h...Boosting HIV screening can increase survival and is cost effective
...ings with HIV infection levels similar to the U.S. general population, one-time screening could deliver excellent return on investment. "HIV is a severe disease that, left untreated, produces substantial morbidity and mortality," said Paltiel. "It has a long asymptomatic phase, which can be diagnosed using ...Vampire bats keep out of trouble by running
...eem to do everything a little differently from the general bat rule," Riskin says about what he refers to as the "cute, adorable, big-eyed and family-oriented" vampire bats. Not only are vampire bats unusual because they run, but also in the way that they power their gait. "Unlike most animals which use the...Multiple Campylobacter Genomes Sequenced
...ith many cases going unreported, up to 0.5% of the general population may unknowingly harbor Campylobacter in their gut annually. Diarrhea, cramps, abdominal pain, and fever develop within 2? days of picking up a pathogenic Campylobacter species, and in most people, the illness lasts for 7?0 days. But the in...Great White shark evolution debate involves WSU Lake Campus geology professor
...eople seem to have a fascination with sharks. "The general public seems to like sharks, and maybe this is because they bring out the fears of our childhood, when they were perceived as scary monsters," he explained. His interest in sharks is apparent when entering his office. The door and walls have picture...Antiretroviral therapy may prevent excess risk of some cancers in people with HIV
...urred 20 times more frequently than they do in the general population without HIV/AIDS. HAART use was not associated with lower risks of Hodgkin lymphoma or other cancers. Although people infected with HIV had increased risks of cancers of the lung, lip, mouth, and pharynx, no cases of these cancers were fou...Increased risk of osteoporosis associated with gene that one in five people have
...of maintaining proper estrogen balance. Within the general population, several variations of the CYP1A1 gene ...the gene, known to be present in 19 percent of the general population, was found in women who had significantly lower blood estrogen levels and higher levels o...Researchers find new genes necessary to make embryo
...ng partial penetrance suggest the possibility of a general architectural motif in genetic networks," said Fabio Piano, an NYU biologist and lead author of the study, "in which genes in critical positions consist largely of older components while new functions added later provide additional layers of regulati...Alzheimer's cognitive decline slowed
...ocol was redesigned to perform the procedure under general anesthesia and all subsequent procedures were performed without complication. Cognitive outcomes were assessed in the six patients who completed the NGF delivery procedure safely. The Mini Mental Status Examination (MMSE), which evaluates cognitive ...Medical molecules designed to respond to visible light that can penetrate tissue
...OR 329)," will be presented by Mongelli during the general poster session, 7 to 9 p.m., Sunday, March 13, in Convention Center Hall D. The poster has also been selected for the Sci_Mix session 7 to 9 p.m. Monday, March 14, in the Convention Center's Sails Pavilion. Co-authors are Brewer; undergraduate chemi...Researchers make gains in understanding antibiotic resistance
...the potential for significant clinical impact. The general strategy of Rib-X to overcome resistance is to create new hybrid antibiotics that possess the ability to bind to interact simultaneously with different, nearby sites on the ribosome represented by different classes of antibiotics," he said. "The ide...Same-Sex Mating Discovered in a Toxic Fungus
...fungal strategy may also contribute to scientists' general understanding of the conditions that favor evolutionary transitions between self-fertilization and sexual reproduction among unrelated individuals, known to occur in the fungal, plant and even animal kingdoms, the researchers said. Christina Hull, n...Test for early detection of prostate cancer shows promise
...berg. “Once this test is refined and approved for general use, it will have an impact on the detection and treatment of prostate cancer,?said Getzenberg. For the current study, Getzenberg and colleagues developed a simple test that would detect EPCA in the blood and then measured the EPCA levels in 46 pati...Different microarray systems more alike than previously thought
... that one lab, the results among platforms were in general agreement and the quality of expensive and inexpen...hers also note that although the technologies show general agreement, the results are far from identical. Additional analyses need to be done to determine whet...Scientists journey to southern Africa to unravel the secret world of elephant communication
...s with a wide range of expertise: Colleen Kinzley, general curator at the Oakland Zoo; Jason Wood, a Stanford geoscientist; Katie Eckert, a University of California-Davis veterinary student; and Dave Shriver, a University of Iowa law student ("I deal with animal harassment issues," he jokes). Equipped with ...Grasping metaphors: UC San Diego research ties brain area to figures of speech
... entirely. When pressed to provide deeper or more general accounts, Ramachandran said, "the patients often came up with elaborate, even ingenious interpretations ?that were completely off the mark." Patient SJ, for example, a former physician who could maintain the flow of normal conversation and even reta...FDA Works To Speed The Advent Of New, More Effective Personalized Medicines
...umer." This free session will allow members of the general public the opportunity to hear about the science behind personalized medicine, an issue of critical importance to both consumers and FDA. Presentations will be from experts in the field and there will be time for questions. For more information ; f......oration with Proteome Systems," said Taia Ergueta, general manager of Agilent's Proteomics and LC/MS business. "It illustrates our ongoing commitment to making leading-edge life science research accessible to more scientists and more laboratories. Using Agilent's protein separation and LC/MS products and Pro...Double triumph in stem cell quest
...Institute of Child Health in London, summed up the general feeling afterwards: "It just seems too easy." ......ignity and the protection of human life. While in general agreement, some delegates said they opposed banning therapeutic cloning. The Declaration, negotiated by a Working Group last month, also banned "genetic engineering techniques that may be contrary to human dignity" and called for a prevention of the ...Confocal imaging promises early detection of skin cancer
...project EDISCIM. “The process involves visits to a general practitioner and a hospital specialist. With our new system, we hope to replace these visits with just one visit and by detecting skin cancer as early as possible, to offer patients the most complete treatment.?/p> Doctors can choose from some 40...Product improves peptide identification for proteomics research
...y and with greater confidence," said Taia Ergueta, general manager of Agilent's Proteomics and LC/MS business. "The LC/MSD Trap XCT Ultra improves performance for a wide range of demanding applications in metabolite characterization, natural products screening, product degradation studies and food and enviro......gratory history of the human race. Members of the general public from all over the world can supply their DN...h added that this is the first time members of the general public can join a genetics project of this scale. Michael F. Hammer, a research scientist at UA's A...Molecular thermometers on skin cells detect heat and camphor
The human brain is like a general in a bunker. Floating in its bubble of cerebrospinal fluid, it has no direct window to the outside world, so the only way for the brain to observe, comprehend, and order the body into action is to rely on information it receives. This information com...To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists
...d the isolated confines of a hospital and into the general population. If one could design drugs to halt the enzymes that make mutations in bacteria, this could be a way of combating the evolution of antibiotic resistance. The Dramatic Effect of LexA Inhibition Halting evolution is exactly what Romesberg ...UCLA study assesses cost-effectiveness of Hepatitis B drugs
...ss with other treatments." Spiegel notes that the general cost-effectiveness standard accepted by society and many insurers for treating a chronic condition like hepatitis B is roughly $50,000 or less per quality-adjusted life-year gained, which is a standard measure used in assessing the outcome of health ...Young Blood Revives Aging Muscles, Stanford Researchers Find
...ided less frequently. Rando said that it may be a general phenomenon that a person's inability to repair tissues with age-whether it's muscle, liver, skin or brain-is a matter of the regenerative cell's environment rather than the cells themselves. Rando said that finding the youth-promoting factors in the...Natural Killers Could Lead to New Hepatitis Treatments
...ical the researchers used in their experiment is a general immune activator and does not reflect what occurs during an actual infection, he noted. Such knowledge would offer important insights into the mechanism of inflammation and liver damage due to infections, he said. ...Bugs, even 'bad' ones, can be educationally beneficial, new book says
...use to get rid of pests. The book is written for a general audience. "Many basic biological concepts such as evolution and genetics can be learned through pests," Waldbauer said. For example, he described recent evidence of how a new species of fruit fly is evolving based on how its diet differentiates it f...New book explains antibiotic resistance for a broad audience
...s of textbooks and attempt to write a book for the general public about antibiotics and resistance to them." Revenge of the Microbes provides the scientific information readers will need to form opinions and make informed decisions regarding the use of antibiotics. The authors have carefully sifted through ...Newer imaging techniques may lead to over-treatment
...ng oral anticoagulant therapy when compared to the general population," Dr. Prologo said. It is imperative that "clinicians consider the risk-benefit ratio of therapy in patients with previously undetectable small clots in the peripheral pulmonary vasculature," he added. Dr. Prologo recommends a large-scale...NYU, Rockefeller researchers find complexity of regulation by microRNA genes
...tions for gene regulation, but also to produce new general insights into how gene regulation is organized in the genome," says Rajewsky, who holds an affiliated appointment at NYU's Courant Institute of Mathematical Sciences. Rajewsky's research program on bioinformatics predictions of regulatory elements i...Aircraft Cabin Ventilation Influences The Transmission Of Diseases In-flight
... industry and medical community should educate the general public on health issues related to air travel and infection. They write that good hand hygiene has been proven to reduce the risk of disease transmission, and air travellers should make it part of their normal travel routine. Dr Gendreau comments: "...Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show It's Snot
...ring physical and social functioning, vitality and general health, according to the Mayo Clinic researchers. ...The first impact factor for PLoS Biology ?13.9
...Academy of Sciences. In fact, in ISI's category of general biology journals, PLoS Biology is ranked number 1. PLoS Biology was launched in October 2003, as an open-access home to the very best in biological research. By any measure, the impact of this launch was impressive. The on-line publication of the fi...Does vitamin C help prevent or treat the common cold? Maybe not, after all.
...cold? The authors looked at 23 studies done in the general population, using doses of up to 2g daily, and found that vitamin C did not reduce the risk. They conclude that "the lack of effect of prophylactic vitamin C supplementation on the incidence of common cold in normal populations throws doubt on the ut...Two studies document rise of superbugs in the environment
...ctions, but is becoming increasingly common in the general community, as has been reported recently in the medical literature. It can cause problems ranging from skin infections to severe bloodstream infections and even death. Researchers at the Baylor College of Medicine and Texas Children's Hospital condu...By creating molecular bridge, scientists change function of a protein
...hors conclude that their new method may provide "a general approach to engineering biomolecules and biosystems such as receptors, enzymes, antibodies, ribosymes, DNAzymes and viruses with novel functions." Zhao is a member of the Institute for Genomic Biology and the Center for Biophysics and Computational ...Enlisting genomics to understand flu evolution
...fecting thousands. "The key thing here is that the general notion of epidemic flu is that there's a series of successions by variants of the flu we got the previous year." But the new study shows that persistently cocirculating minor strains--which might be accumulating mutations with little obvious epidemio...First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology
...ed Dr. Etches. "The technology described here is a general method for inserting DNA encoding proteins of essentially any size and complexity while achieving high levels of protein expression. Moreover, it is the only technology to date that restricts deposition of the therapeutic protein to egg white." "Mon...Biologists determine genetic blueprint of social amoeba
..."You can make direct analogies, or you could learn general principles about how cells regulate their behavior. Both things will apply in the studies we do." He and the other members of the international sequencing team found that there are more protein coding genes in the organism than they had thought and ...Scalpel-free surgery could reduce risk of HIV and hepatitis exposure for health care workers
...ry. The researchers studied 709 consecutive adult general surgery operations performed between July 2003 and June 2004 in the community surgical service at The Johns Hopkins Hospital including inpatient, emergency department and outpatient surgical procedures. Data were collected on HIV, hepatitis B and hep...Men Estimate Men's Risks Of Common Disorders Higher Than Women Do, And Vice Versa
...cintyre, from the University of Glasgow, said: "In general these lay perceptions mirror professions perceptions. However, what is unexpected is that when there was a gender difference in attribution of relative likelihood, respondents tended to perceive the risks as higher for their own sex than for the oppo...... important subject like genomics accessible to the general public." "Ecce Homology" uses a combination of dynamic media, computer vision and computer graphics to visualize genomic data. Custom software turns genes ?incomprehensibly long strings of As, Cs, Ts and Gs ?into luminous pictograms that resemble C...Other ContentsmetabolicmetabolicmetabolicmetabolicmetabolicmetabolicmetabolicmetabolicmetabolicmercurymercurymercurymercurymetabolizemetabolizemetabolizemetabolizemetabolizemetabolizemetacarpalmetastaticmetastaticmetastaticmetastaticmetastaticmetastasismetastasismetastasismetastasisOther TagsshedshedshedshedChannelChannelChannelChannelIonIonIonIonIonIonIonIonIonIonRegulateRegulateyearyearyearyearsoilLowLowLowLowLowLowLowLowdroughtsuggestssuggestssuggestsNeedNeedNeedNeedOther Tagspremium 2premium 3sub 2anything 2anything 3anything 4anything 5anything 6anything 7anything 8anything 9anything 10beings 2beings 3beings 4beings 5neutralizing 2interactive 2
(Date:9/4/2008)... Heidelberg, 5 September 2008 Even scientists def...tle surprise that the media also have various ways...new study appearing in the October 2008 issue of ...ased on the analysis of 300 articles in British an...The Daily Mail from the UK; and Aftenposten, Dagbl...
(Date:9/4/2008)..., WALNUT CREEK, Calif. Subtle genetic changes tha... such as the dexterity characteristic of the human...o reproduce in a model system, have nevertheless g...ists. In findings published online in the Septembe...from the U.S. Department of Energy,s Lawrence Berk...
(Date:9/4/2008)..., Let,s raise our water glasses and toast to Amer...of EPA,s highest priorities is ensuring America ha...erborne contaminants. Today, EPA announced the awa...ersities, one non-profit, and one research institu...drinking water contaminants; including the harmful...
(Date:9/4/2008)... Huntsville, Ala. -- A team including researchers ...ty, together with colleagues from a number of othe...nalysis of genomic variation in the brain cancer g...Cancer Genome Atlas (TCGA) research network, a col...stitute and the National Human Genome Research Ins...
Breaking Biology News(10 mins):What is a gene? 2Thumbs up -- a tiny ancestral remnant lends developmental edge to humans 2Thumbs up -- a tiny ancestral remnant lends developmental edge to humans 3To your health: EPA announces safe drinking water research 2Collaboration between researchers yields more comprehensive portrait of brain cancer 2Atkins Diet Can Raise Heart Risks 5635 1Atkins Diet Can Raise Heart Risks 5635 2Atkins Diet Can Raise Heart Risks 5635 3Atkins Diet Can Raise Heart Risks 5635 4Imaging Diagnostic Systems Expands Key Patent Coverage 1703 1Imaging Diagnostic Systems Expands Key Patent Coverage 1703 2Imaging Diagnostic Systems Expands Key Patent Coverage 1703 3Lilly Receives NCQA Design Certification for Depression Care Management Program 768 1Lilly Receives NCQA Design Certification for Depression Care Management Program 768 2Lilly Receives NCQA Design Certification for Depression Care Management Program 768 3 246 37 million from National Institutes of Health to find new ways to treat psoriasis 5632 1 246 37 million from National Institutes of Health to find new ways to treat psoriasis 5632 2 246 37 million from National Institutes of Health to find new ways to treat psoriasis 5632 3(Date:9/4/2008)... may be shortchanging their golden years by tappin...iversity of Illinois expert who has studied the fe..., More than three of every four Americans trim th...iming benefits early, a choice many might forego i... consequences, law professor Richard L. Kaplan say...
(Date:9/4/2008)...ncology contract research organization, has publis...uanced Approach to Get Into the Clinic Faster.&quo...al research scientist with 35 years of experience,...mmonly viewed as straightforward investigations ru...rue integration with preclinical, regulatory and c...
(Date:9/4/2008)...NORWICH, England and ONGAR, Ireland,Sept. 4 /PRNe...ofield Media,Europe Ltd, announced on the 29th Aug... publication from Silverdog Publishing., Health a... the iconic,Health and Safety at Work Act 1974 and.... It has been relied upon by blue-chip corporates,...
(Date:9/4/2008)...-FirstCall/ -- ULURU Inc. (Amex:,ULU) today announ...Weisel,Partners Healthcare Conference at 3:15 p.m....out ULURU Inc.:, ULURU Inc. is an emerging specia...ent of a portfolio of wound management, plastic su...nd consumers improved clinical,outcomes through co...
Breaking Medicine News(10 mins):Health News:New guide explores making the most of Social Security 2Health News:New guide explores making the most of Social Security 3Health News:Oncology Clinical Research Scientist Recommends a Nuanced Preclinical Study Process to Speed Drug Development 2Health News:Oncology Clinical Research Scientist Recommends a Nuanced Preclinical Study Process to Speed Drug Development 3Health News:Schofield Publishing Enters the Newsletter Market 2[0] New guide explores making the most of Social Security[0] Oncology Clinical Research Scientist Recommends a Nuanced Preclinical Study Process to Speed Drug Development [0] Schofield Publishing Enters the Newsletter Market[0] ULURU Inc. to Present at the Thomas Weisel Partners Healthcare Conference 2008
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