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A gene's first 'kiss' sets off that affair known as puberty
...gets turned on by a molecule that is produced by a gene aptly named KiSS-1. The couple ?a biochemical equ...ntly by both Harvard and French researchers that a gene called GPR54 is defective in children with a rare disorder that inhibits puberty's onset. To better ...Man and mouse share genome structures
...structure, called chromatin, is a key regulator of gene expression in healthy and diseased cells, Bernstein said. Chromatin is composed of DNA spooled around bundles of histone proteins, and resembles a chain of beads which is then compressed into a working chromosome. Chemical tags placed on the histones...Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats
... in 2002. Experiments including the measurement of gene activity by microarrays showed that saturated and trans fats caused greater activity of the gene that makes PGC-1beta co-activator than did unsaturated fats. The research also showed that when the...A new mechanism of regulating RNA degradation
At first, we thought that gene expression was modulated only by transcription fac...logists and clinicians who want to take control of gene expression in cells to create therapies to treat disease. While cells have a variety of ways to cont...FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
At first, we thought that gene expression was modulated only by transcription fac...logists and clinicians who want to take control of gene expression in cells to create therapies to treat disease. While cells have a variety of ways to cont...Genes In The Interferon System Important In Systemic Lupus Erythematosus
...sinkinaseenzyme," explains Lars Rönnblom.The other gene codes for a transcription factor, which also plays animportant role in regulating the interferon effect. Further functionalanalyses will be necessary to map the molecular mechanisms in detail.Besides the Rheumatology Clinic at Uppsala Akademiska Hosp...Researchers discover way to make cells in the eye sensitive to light
...ter, havediscovered that activating the melanopsin gene in the nerve cellscauses them to become light resp...is quiteremarkable that the activation of a single gene can create a functionalphotoreceptor. It is an important proof of principle that melanopsincan make ...W.M. Keck Foundation funds study of friendly microbes
... genomes and experimentally test predictions about gene functions that come from our computer-assisted analyses." Gordon views the human gut as "a bioreactor programmed with at least 800 different species of bacteria." "Fortunately, these microbes endow us with key metabolic functions that we have not ha...It's not all genetic: Common epigenetic problem doubles cancer risk in mice
...blem that improperly turns on the copy of the IGF2 gene that should remain off. Unlike most genes, the co...ce were crossed with mice carrying a mutation in a gene called APC, which had been tied to colon cancer by researchers studying families with excessive grow...Novel technology detects human DNA mutations
...ing, which is the direct detection of a particular gene and the extent to which it is normal or mutated. T...ates the need for costly, time and labor intensive gene amplification or enzymatic interventions ?two widespread methods currently used to perform such anal...New binding target for oncogenic viral protein
...et for T antigen--a protein called Fbw7. The Fbw7 gene is located in a chromosomal region that is deleted in up to 30% of human tumors. "Fbw7 is itself an important tumor suppressor which makes it an attractive choice for inactivation by Large T," explained Dr. Markus Welcker, the study's first author. ...Neuronal 'traffic jam' marks early Alzheimer's disease
...and others had observed that overexpression of the gene for a key protein that underlies Alzheimer's pathology, called beta amyloid precursor protein (beta-APP), triggers defects in axonal transport. A defective version of beta-APP is cleaved to form an aberrant form of amyloid beta (A-beta) peptide that ...Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
...also cataloged the retention and expansion of some gene families characteristic of more complex organisms....t systematic study of relatively recent horizontal gene transfer into a protist, scientists report evidence in the DNA sequence that E. histolytica likely p...Newly-discovered class of genes determines ?and restricts ?stem cell fate
... regeneration. The researchers found that Pax3, a gene critical in embryonic development of melanocytes ?...s conceptually new since he suggests that a single gene can both tell a cell what it should become and restrict its fate by preventing differentiation. The ...Timing is everything: First step in protein building revealed
...r lead todisease."The ribosome is the end stage of gene expression, and gene expressionkeeps us alive and causes disease," says Lorsch. "If we can betterunderstand how the ribos...Scientists Replicate Hepatitis C Virus in Laboratory
...HCV genome and to act as start and stop buttons to gene activity. The construct was “naked,?meaning that it contained only nucleic acids, the genetic material of the virus, and did not have the HCV viral envelope, a protective shell of lipids and proteins that surrounds the viral RNA in fully-formed HCV. ...Novel antiviral technology inhibits RSV infection in mice
...ovel antiviral treatment combiningnanoparticle and gene silencing technologies thwarts attacks ofrespirato...ionary new technology known as RNAinterference, or gene silencing, to knock out one of the key proteinsneeded for RSV to multiply in the lungs. The virus ha...Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
...ity groups with a single,standardized platform for gene expression research, they can easilycompare result...ade Affymetrix theindustry-standard technology for gene expression analysis. Over thepast ten years more than 3,000 papers have been published usingGeneChip...Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
...me labs. “Thisstudy is a key first step in moving gene expression data fromsmall-scale bench science into...w this sameresearch group to proceed with a larger gene expression analysis of 600stage I lung adenocarcinomas, with the hopes of confirming a previousassoc...Scientists detect probable genetic cause of some Parkinson's disease cases
...ly suggest that amutation in a recently discovered gene is the most common genetic causeof Parkinson's dis...es, the investigators found that a mutation in the gene LRRK2appears to occur in at least one of every 60 people who have thedisease. Overall, the mutation ...Newly discovered virus linked to childhood lung disorders and Kawasaki disease
...t YaleUniversity used molecular probes targeting a gene that is common inhuman and animal coronaviruses to...ch the sequence of chemical building blocks of the gene differedfrom that of known human coronaviruses. The Yale investigators, termingthe novel virus indic...Ancient olfaction protein is shared by many bugs, offering new pest control target
...ity scientists who had previously identified a key gene essential for the sense of smell in fruit flies no...es a general function in detecting odors. When the gene for Or83b is deleted, the flies can't smell. In the new study, Vosshall, in collaboration with rese...Inexpensive, mass-produced genes core of synthetic biology advances at UH
We ran a similar gene synthesis story earlier ;progress in this area is ... the slow (and tedious) process of genecloning, or gene modification (mutations, deletions, etc). Devices the size of a pager now have greater capabilities ...New Technique for Tracking Gene Regulators
...gulates by more traditionalmethods, evaluating one gene at a time, would be too labor-intensive,expensive,...ing regulated by CREB using thismethod include the gene responsible for causing Huntington’s disease inmice, which is important for making advances in under...Bound for destruction: Ubiquitination protects against improper Notch signaling
... lab in 1910. Later studiesrevealed that the Notch gene encodes a receptor protein that extendsthrough both sides of the cell membrane and which is capable ofinteracting with a ligand partner, such as the protein Delta, presentedon the surface of a neighboring cell. This “juxtracrine?interactioncauses the...Whole genome fine map of rice completed
...s provided a unlimited source of raw materials for gene genesis, creating differences among the grass family. The Chinese Superhybrid Rice Genome Project, initiated by BGI in 2000, focused on the hybrid rice "Liang You Pei Jiu" as the basic research object. The hybrid was developed by the famous rice exp...Genome-wide mouse study yields link to human leukemia
... scientists have discovered a new tumor suppressor gene and a unique chemical signature implicated in the ...the process, the researchers also identified a new gene that when methylated, appears to interrupt normal cell death, a process called apoptosis. "It's giv...Breakthrough Microarray-based Technology for the Study of Cancer
...ic alterations leading to changes in the number of gene copiespresent in cells are important events in the genesis and progression ofcancer," said Michael Bittner of the Translational Genomics ResearchInstitute. "Agilent has now taken array-CGH experiments into a newrealm of resolution, sensitivity, and r...Iron Deficiency Sparks Dramatic Changes In Gene Expression
...d cellsoverproduce Cth2. This protein binds to the gene expression machineryof more than 80 different genes and targets these molecules, calledmessenger RNA, to be destroyed or degraded. Without messenger RNA, agene cannot translate its genetic code into proteins that carry out itsintended functions.Thiel...Scientists find missing enzyme for tuberculosis iron scavenging pathway
...its neighbors in the genome, and the fact that its gene was also regulated by iron, was that Rv1347c was almost certainly a "missing enzyme" from the pathway for biosynthesis of the iron scavenging agent mycobactin," recalls Dr. Baker. "Mycobactin is a small molecule which binds iron very tightly. Bacter...Novel Enzyme Shows Potential As An Anti-HIV Target
...on?, for example, is an essential regulator of HIV gene expression. Without Tat, HIV transcripts don’t rea...on depends on adequate Tat supplies. And since HIV gene expression relies on SIRT1’s enzymatic activity, inhibiting SIRT1 could prove to be a promising anti...Study finds more than one-third of human genome regulated by RNA
...gulated by microRNAs. We nowknow that this type of gene control is much more widespread thanpreviously app...lready transformed how many labs are investigating gene functions, andsiRNAs are being developed for clinical applications. Learning moreabout how microRNAs...Live Recombinant Adenovirus Vaccine Technique Explored
...g immune response. The researchers inserted the L1 gene into a live adenovirus such that it would be expressed using the virus' own late-gene expression machinery. L1 is expressed at very high levels in some recombinants. Dr. Ketner believes that the replicating live recombinant adenovirus model shows pr...NYU researchers simulate molecular biological clock
...gulated by microRNAs. We nowknow that this type of gene control is much more widespread thanpreviously app...lready transformed how many labs are investigating gene functions, andsiRNAs are being developed for clinical applications. Learning moreabout how microRNAs...Mitochondrial DNA mutations play significant role in prostate cancer
...e subunit (COI) gene. They then sequenced the COI gene in 260 prostate cancer tissue samplesor blood cells from patients with confirmed cancer who had undergoneradical prostatectomies between 1995 and 2002, and 54 tissue samplesfrom patients who had prostate biopsies but were found to be cancerfree. Twel...Gene therapy converts dead bone graft to new, living tissue
...experiment involving mice. The advance, which uses gene therapy to stimulate the body into treating the fo...ctiveness wear off in just hours. By contrast, the gene therapy method triggers the tissue surrounding the graft to produce the proteins continuously for up...Molecular machine may lead to new drugs to combat human diseases
...al from RNA, which translates DNA's directions for gene behavior. Introns then splice the RNA back together. Scientists are just learning whether many DNA sequences previously believed to have no function actually may play specialized roles in cell behavior. While humans have introns, they don't have Gro...Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
...niversity has identified a new way that a familiar gene is regulated in lung cancer, presenting new possib... relatively accessible for inhalation of potential gene therapy agents. "While this is not likely to cure the cancer," said Slack, "after diagnosis, gene th...An HIV Protein Plays a Surprising Role in Gene Activation
...mechanisms dedicated to the business of regulating gene expression, and retroviruses like HIV have evolved...tor encoded in the HIV genome, is required for HIV gene activation and viral replication. It affects these processes, the current model holds, by stimulatin...Mouse brain tumors mimic those in human genetic disorder
...ans with the disease, have oneabnormal copy of the gene for NF1 in every cell in their body, whilespecific support cells in the brain called astrocytes have two abnormalcopies of this same gene.Their latest paper shows that brain tumor formation in these mice hasseveral of the same distinguishing clinical...Automatic extraction of gene/protein biological functions from biomedical text
...for automatic extraction of information related to gene functions from text has been increasing. Results:... for major eukaryotes. Availability: The extracted gene functions are available at http://prime.ontology.ims.u-tokyo.ac.jp ...Spider Venom Could Yield Eco-Friendly Insecticides
...funnel-web venom. Another strategy is to insert a gene for encoding a spider toxin into viruses that are specific to a particular insect genus, or even a small number of species within a genus. The toxin-enhanced virus would act like a magic insecticide bullet, targeting only cotton bollworms, for exampl...Gene variations explain drug dose required to control seizures
...lepsy. "In time, we hope to have a number of such gene variants that together can explain and predict mor...ariation in the candidate genes. One variant of a gene known as CYP2C9, which encodes a liver enzyme involved in drug metabolism, showed a significant asso...Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
...rate. Using genetically altered mice in which the gene for the enzyme had been rendered nonfunctional, th... demonstrated they could introduce the functioning gene and correct glycogen buildup in heart and skeletal muscle. The findings suggest that such an approac...Enzyme shown to help protect genomic stability
...f DNA containing multiple genes that are closed to gene transcription. Scientists believe one reason for this broad gene silencing is the vital need for genomic stability, for protection against unwanted recombinations of...BRCA1 causes ovarian cancer through indirect, biochemical route
...journal Current Biology. "Before, we thought this gene was a classical tumor suppressor," says Louis Dube... were the case, it would mean that mutation of the gene would allow the cell it's in to grow out of control and create a tumor. Instead, Dubeau notes, "What...Scientists decipher genome of fungus that can cause life-threatening infections
...e, we foundsurprisingly little difference in their gene content."TIGR scientists led by primary investigat...splicing" and"antisense" transcripts, in which the gene on one strand of the DNAdiffers from the counterpart gene on the opposite strand. Researchersalso id...Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
...illions of small sections of chromosomes to detect gene activity. But the scanning results left them with ...e by using standard techniques, or by studying one gene at a time. "Finding them was a complete surprise," Bernstein admits. HOX genes, as noted, play vita...First 'atlas' of key brain genes could speed research on cancer, neurological diseases
...tion of nerves and related structures.Although the gene regulators were pinpointed using mouse brains, themap applies to the human brain as well. “This is the first systematic mapping of all of the major brain areasthat shows what regulatory genes are expressed in those specificlocations,?said Quifu Ma, ...Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
...n on protein expression by jamming the responsible gene with bits of RNA; and microscopy, which looks at the activity of individual living cells by attaching a fluorescent tag to a specific cell component -- in this case clathrin. "This means that now we could suddenly look at a much broader dynamic rang...Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
...tein. For this study, the researchers inserted the gene forthe HER2/neu protein in place of the deleted viral genes and thenpackaged the virus vector into virus-like replicon particles, referredto as “VRP-neu.?When these non-propagating particles are injected intoan animal, the vector directs the animal’s...Researchers find missing genes of ancient organism
...d introns, are sequences that are cut out of whole gene transcripts during the process of tRNA maturation. The known tRNA introns in organisms like yeast, however, appear to have no function. Therefore, modern tRNA introns might be remnants of an old essential process of tRNA biosynthesis. "These results...Scientists identify genetic pathways essential to RNA interference
...ess website at http://www.sciencexpress.org. "The gene activation produced by RNAi is exquisitely specifi...omplementary messenger RNA segments, shutting down gene expression. RNAi occurs naturally in plants and animals and may help control resistance to viral inf...A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
...tein. For this study, the researchers inserted the gene forthe HER2/neu protein in place of the deleted viral genes and thenpackaged the virus vector into virus-like replicon particles, referredto as “VRP-neu.?When these non-propagating particles are injected intoan animal, the vector directs the animal’s...Same mutation aided evolution in many fish species, Stanford study finds
...any times all over the world, nature uses the same gene each time." Sticklebacks evolved from a relativel...rk carries a few surprises. Kingsley said that the gene in question, called Eda, is an old friend to laboratory researchers who have found that mutations in...Gene Therapy For Parkinson's Disease Moves Forward In Animals
An international team of scientists has used gene therapy in two separate studies to renew brain cel...outcry from hopeful Parkinson's patients. But the gene therapy used in monkeys represents a different way to deliver the GDNF to the brain, causing the bod...Researchers trace evolution to relatively simple genetic changes
...scientists have now found that changes in a single gene can produce major changes in the skeletal armor of...wild populations, the research team found that one gene is what makes the difference. "Now, for the first time, we've been able to identify the actual gene...Scientists reveal molecular secrets of the malaria parasite
...ment, scientists have used genomics,proteomics and gene expression studies to trace how malaria parasitese...s that areinteracting with the host as well as new gene targets for vaccines thataim to prevent parasite transmission in the mosquito."The study highlights ...Octopuses occasionally stroll around on two arms, UC Berkeley biologists report
...scientists have now found that changes in a single gene can produce major changes in the skeletal armor of...wild populations, the research team found that one gene is what makes the difference. "Now, for the first time, we've been able to identify the actual gene...Studies reveal methods viruses use to sidestep immune system
... with their hosts, so every time we have evolved a gene with a new function that allows us to fight off a ...search group found that a specific mutation in the gene RIG-I conferred permissiveness to HCV, allowing it to replicate "like gangbusters" in those cells wi...Other ContentshistonehistonehistonehistonehistonehistonehomeoboxhomeostasishomeostasishomeostasishomeostasisconvergentconvergentconvergentconvergenthomozygotehomozygotehormonehormonehormonehormonehormonehormonehormonehormonehormoneOther TagsTuraTuraTuraTuraTuraELLEELLEELLEELLEELLEOther Tagspoisonous 2strokes 2strokes 3strokes 4strokes 5strokes 6strokes 7strokes 8strokes 9strokes 10recurrent 2recurrent 3recurrent 4recurrent 5recurrent 6recurrent 7recurrent 8recurrent 9chemistry 2chemistry 3chemistry 4chemistry 5chemistry 6chemistry 7fat 2fat 3fat 4fat 5fat 6fat 7fat 8fat 9fat 10hazardous 2hazardous 3hazardous 4hazardous 5establishes 2
(Date:8/7/2008)...of Georgia researchers were recently awarded two g...ys to produce biofuels from switchgrass and sunflo...eive grants from a program jointly funded by the U...ent of Energy. The program aims to accelerate rese...llulosic plant material for bioenergy and biofuels...
(Date:8/7/2008)...ity of Houston department of health and human perf...cruit 500 participants for a study promoting healt...y will take place entirely in the virtual world of... is part of the UH Texas Obesity Research Center,s... an enjoyable way for participants to learn about ...
(Date:8/7/2008)...teers who take part in conservation efforts may do... trying to protect, a University of Alberta case s...those who keep and monitor special birdhouses on t... take part in the conservation project for egoisti...e were areas of overlap, we found that common moti...
(Date:8/7/2008)... J. Fox Foundation for Parkinson,s Research (MJFF)...rence on Monday, September 15, in Chicago. , Ch... Center for Brain Repair and Jean-Schweppe Armour ...ity Medical Center, the conference will bring toge...novel research advances impacting development of i...
Breaking Biology News(10 mins):UGA gets $2.5 million in grants to study plants to make biofuels 2UGA gets $2.5 million in grants to study plants to make biofuels 3TORC at UH turns to virtual world of Second Life for new study 2For the birds or for me? Why do conservationists really help wildlife? 2Hershey Center for Applied Research Supports Acceleration of Scientific Research and Development 5140 1Hershey Center for Applied Research Supports Acceleration of Scientific Research and Development 5140 2Hershey Center for Applied Research Supports Acceleration of Scientific Research and Development 5140 3Doctors Discover Marker for Meconium Passage During Delivery 18553 1Doctors Discover Marker for Meconium Passage During Delivery 18553 2The Lucian Leape Institute at the National Patient Safety Foundation Announces the Appointment of Two New Members 18550 1The Lucian Leape Institute at the National Patient Safety Foundation Announces the Appointment of Two New Members 18550 2Lab in a drop 3198 2/ 1(Date:8/7/2008)...ld ID millions who don,t know they have disease ,...A widely used test to monitor blood sugar levels i...s of people with undetected diabetes, according to...ts. , The hemoglobin A1c test (HbA1c) shows ho...o in the previous 120 days, the average life span ...
(Date:8/7/2008)...SNewswire/ -- Vapotherm, the,global leader in High...,clearance from the Food and Drug Administration (...umidification system to integrate gas,blending, fl...device for,the optimal conditioning of nasal cannu...currently used in neonatal, pediatric and,adult ap...
(Date:8/7/2008)...High Quality Nursing Home Care;,Helps Preserve, St... Mo., Aug. 7 /PRNewswire-USNewswire/ -- Citing the...itical frontline-caregiver,infrastructure, the Coa...,Senator Pat Roberts for helping to lead a success...h Administration from moving forward with a new,re...
(Date:8/7/2008)...women,s kids from previous relationship , ...men ages 18 to 44 are more than twice as likely as...ld, a new federal report says. , The report use...wth, which showed that more than 1.2 million men a...easons why more men adopt than women aren,t outlin...
Breaking Medicine News(10 mins):Health News:Blood Sugar Test May Also Aid Diabetes Detection 2Health News:Vapotherm(R) Precision Flow(TM) Receives FDA 510(k) Clearance 2Health News:Senator Pat Roberts Praised for Leading Successful Effort to Derail $6.2 Million Kansas Medicare Cuts 2| Copyright © 2003-2008 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |