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folding in Biological News

New computer simulation helps explain folding in important cellular protein

... is to investigate the thermodynamics of protein folding through examining the energy landscape," Landau ... characteristics of proteins including possible folding pathways and folding intermediates. Thus, it allows us to bridge the ...

Penn biologists discover how 'silent' mutations influence protein production

... regulation: synonymous mutations determine mRNA folding and thereby the eventual protein level. The ... underlying mechanism." The stability of mRNA folding near the ribosomal binding site explained more ... machinery. According to their analysis, mRNA folding and associated rates of translation initiation ...

Unfolding 'nature's origami'

... 'hit and miss' process, with proteins potentially folding wrongly many times before they form the correct ... says: "There's a fine balance between a protein folding into the correct shape so that it can carry out its job efficiently and it folding incorrectly, which can lead to disease. Just one ...

Protein folding researcher David Baker to receive Sackler Prize in Biophysics

... a cardboard box knows the importance of proper folding to get a useful product. The same is true when ... as a series of layers with different protein folding requirements. Baker has involved people of all ... from around the world in helping with protein folding research. People donate their idle computer time ...

Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding

... have given us about the structures of protein folding and DNA has laid the foundation for ... their final shapes within human cells. It is this folding of proteins that is responsible for much of the ... and Horwich demonstrated that when the protein folding pathway is imperfect, protein can accumulate in ...

Exploding chromosomes fuel research about evolution of genetic storage

... that, unless neutralized, prevents any attempt at folding and coiling due to electrostatic repulsion. The ... charge, and further suggest a critical role in folding the protein as well. The finding raises ... "Cations play a very important role in the folding and charge neutralization of DNA in all ...

Keeping an eye on the surroundings

... processes; it is an active participant. Protein folding is thus a self-organized process in which the ... role. So far, the emphasis in studies of protein folding processes has been on observation of the protein ... in the proteinwater network during protein folding in real time. As they report in the journal ...

Water is 'designer fluid' that helps proteins change shape, scientists say

... known that water plays an important role in the folding process, we usually only look at the motion of ... look at the motion of water molecules during the folding process." Using a technique called terahertz ... window on protein-water rearrangements during the folding process, such as breaking protein-water-hydrogen ...

Researchers reveal insights into hidden world of protein folding

... of the most complex and essential proteins, the folding takes place out of sight, hidden in the inner ... inside the cavity of the chaperonin and what this folding chamber looks like," Frydman said. Learning how a ... the raw protein into the inner recesses of the folding machine, then closes tightly while, inside the ...

Micro-origami: USC folds up micrometer-scale 'voxels' for drug delivery

... they were the places that folded. Then the folding had to be accomplished. First the researchers ... in water, and drying them off did the final folding into shape. The experiments spend considerable ... says the paper, that "the combination of partial folding of structures by magnetic actuation and liquid ...

Stanford researchers make first direct observation of 3-D molecule folding in real time

... researchers are the first to study the energy and folding behavior of a riboswitch in this detailed, ... give a description of the molecule's average folding behavior, which must be interpreted by ... look The researchers who study molecular folding in Block's lab cannot actually see an RNA ...

Biophysical Society announces new and notable symposium speakers

... study to show how a chaperone affects a protein folding pathway. The chaperone was shown to interfere specifically with some folding transitions, and to prevent protein aggregation. ... these single molecule investigations. Studies of folding pathways have so far mainly focused on proteins ...

Proteins pack tighter in crowded native state

... environments affect the stability, structure and folding of proteins, Wittung-Stafshede and Rice graduate ... findings may have serious implications for the folding processes of proteins in cells and the structures ... seconds to minutes). The science of protein folding has grown dramatically in the past decade, due in ...

Engineers study brain folding in higher mammals

... and developmental processes that occur in the folding of the brains surface, or cortex, which gives the ... of comparable volume with a smooth surface. folding is very important in human brain development ... hope that increased understanding of brain folding might someday help prevent such diseases. ...

Structural biology scores with protein snapshot

... but would not usually affect protein folding, whereas key residues for folding would be located elsewhere in the protein to underpin the scaffold for the ... Sanders said. Sanders and his team, who got interested in protein folding because of their work with DAGK, are now pursuing structural studies of ...

Researchers observe single protein dimers wavering between two symmetrically opposed structures

... large number of structures even with a single chain of amino acids, end up folding themselves to a well defined three-dimensional structural basin," says ... which they felt might explain puzzling features of the stability and folding speed of these molecules. To test if this was true, Deniz and his group ...

Sulfurous ping-pong in the urinary tract

... the case in scientific research. The Glockshuber group studies protein folding mechanisms, where bonds between two sulfur atoms in a protein chain, ... associated with ASST. This disulfide bridge is a prerequisite for proper folding of this protein and could also play a role in regulating its catalytic ...

ASBMB taps 8 scientists for top awards

... in the biological sciences. Lindquist is a pioneer in the study of protein folding and has shown that changes in folding can have profound and unexpected influences in fields as wide-ranging as ...

Finding out what the Big Bang and ink jets have in common

... out there is more to commonplace everyday events than meets the eye. The folding of paper, or fall of water droplets from a tap, are two such events, both ... but also other physical systems involving ridges and tips, such as the folding of proteins during their manufacture in biological cells. One question ...

Overexcited neurons not good for cell health

... damage in target cells. Similar results and consequences on protein folding were found to occur upon exposure to the common toxins nicotine and ... evidence that nerve cell activity can directly affect the protein folding process in another cell. (Muscle cells in the case of this study.) Many ...

New technology illuminates protein interactions in living cells

... in live cells. Each protein is a three-dimensional structure created by folding its linear chain of amino acids. Usually only one shape works for each ... emphasizes that this technology does not monitor the process of protein folding but, rather sees the protein conformations that exist at a given time. ...

New approach builds better proteins inside a computer

... acids will fold into a given proteins characteristic shape. This intricate folding is molded by the complex molecular side chains that project from the ... problems Baker and his colleagues have faced with their algorithm is that folding proteins can get stuck in partially folded structures. Predicting protein ...

Structure of protective protein in the eye lens revealed

... like a long piece of woolen thread. So-called chaperones help them to fold in the desired three-dimensional form after their production. If this folding process fails, the protein thread becomes an inextricable, useless tangle. Small heat shock proteins (sHsps) are a particularly important group ...

Munich researchers discover new target for tailored antibiotics

... research team of Professor Groll, Dr. Eppinger, and Dr. Grwert has now succeeded in cracking the closed-state X-ray structure that shows the precise folding pattern of the protein chain and the chemical environment of the active site cavity. The crystal structure opened the door to a detailed ...

Scientists find a biological 'fountain of youth' in new world bat caves

... The discovery, featured on the cover of the July 2009 print issue of The FASEB Journal ( http://www.fasebj.org ), shows that proper protein folding over time in long-lived bats explains why they live significantly longer than other mammals of comparable size, such as mice. "Ultimately we are ...

6 young ASU faculty earn NSF Career awards

... regulation, transcription initiation and DNA replication. Their binding is characterized by large conformational changes, involving the (partial) folding or unfolding of the protein and the bending or kinking of DNA. Van der Vaart will develop and apply new computational techniques to understand the ...

Caltech scientists control complex nucleation processes using DNA origami seeds

... slowly. "As it cools, the first origami seed and the individual tiles form, as their component DNA molecules begin sticking to each other and folding into shape--but the tiles and origami don't stick to each other yet," Winfree explains. "Then, at a lower temperature, the tiles start to stick to ...

Protein function and chromatin structure methods featured in Cold Spring Harbor Protocols

... protein might mediate long-range interactions, both in cis and in trans in the nucleus. The 6C assay advances our understanding of chromatin folding and provides an important tool to examine the role of specific proteins in nuclear organization. This method is freely accessible on the website for ...

Caltech and UCSD researchers shed light on how proteins find their shapes

... published in the Journal of the American Chemical Society --with Wolynes's protein-folding models to see if they could come up with the precise folding pattern of cytochrome c, a protein that is part of the mitochondrial electron-transfer chain that turns food into cellular energy. At first the ...

New open-source software permits faster desktop computer simulations of molecular motion

... Whether vibrating in place or taking part in protein folding to ensure cells function properly, molecules are never still. Simulating molecular motions provides researchers with information critical to ...

Mystery of infamous 'New England Dark Day' solved by tree rings

... of that day, which became known as 'New England's Dark Day,' include mentions of midday meals by candlelight, night birds coming out to sing, flowers folding their petals,and strange behavior from animals. The mystery of this day has been solved by researchers at the University of Missouri who say evidence ...

Mystery of infamous 'New England Dark Day' solved by 3 rings

... of that day, which became known as 'New England's Dark Day,' include mentions of midday meals by candlelight, night birds coming out to sing, flowers folding their petals,and strange behavior from animals. The mystery of this day has been solved by researchers at the University of Missouri who say evidence ...

June GEOSPHERE media highlights

... use, speed, logistics, and real-time analysis, with competitive accuracy, and it is at least complementary to other methods. Visualization of folding in marble outcrops, Connemara, western Ireland: An application of virtual outcrop technology K.J.W. McCaffrey et al., Earth Sciences Dept., ...

NASA presentations at American Geophysical Union Joint Assembly

... Observed During TC4 Time: Fri., May 30, 1:45 p.m. EDT, Room 305 Session: A53B-02 The presenter examines a number of subvisible cirrus cloud cases, folding together trajectory analyses, temperature soundings, and A-Train satellite cloud and water vapor data to fully understand the history of the air in ...

Seeing Alzheimer's amyloids

... clumps togetheris linked to other neurodegenerative conditions as well, including Parkinsons and Creutzfeldt-Jakob disease. The amyloid way of folding and aggregation seems to be a fundamental property of proteins and peptides explained Grigorieff. We know how most normal proteins fold, but what ...

Ancient protein offers clues to killer condition

... it is not conserved. The fact that the scallop has retained all the functions of its myosin 2 over hundreds of millions of years tells us that this folding is of fundamental functional importance in muscle and that we dont know as much about it as we need to know. In humans, any changes in the ...

Single-celled bacterium works 24-7

... number of vital processes, including energy metabolism, nitrogen fixation, respiration, the translation of messenger RNA (mRNA) to proteins, and the folding of these proteins into proper configurations. The findings have implications down the road for energy production and storage of clean, ...

Green gel

... Francis and Esser-Kahn chose to use a protein that fluoresces green to cross-link their polymer chains. Because the protein maintains its normal folding pattern even after attachment to the polymer, the fluorescence is also maintained: The entire gel fluoresces green. This hybrid material has a ...

Researchers discover the structural alphabet of RNA

... of ribonucleic acid (RNA) from sequence data, providing new tools to understand the role of this important class of cellular regulators. The folding of a single-stranded RNA molecule is determined by the interactions between its constituent nucleotides. The classical approach to RNA modelling ...

Computer simulations point to key molecular basis of cystic fibrosis

... our simulations correlated with known experimental studies is remarkable, Dokholyan said. More importantly, the molecular details of aberrant NBD1 folding provides guidance for the design of small molecule drugs to correct the most prevalent and pathogenic mutation in CFTR. ...
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