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Computers to be used to find blueprint for new influenza drug

...rug that could be taken by people coming down with flu to stop the disease developing. The drug would wo...e coating around the cells in our throats that the flu virus first attacks when a person becomes infected. The flu virus would be deceived into attacking t...

Studies reveal methods viruses use to sidestep immune system

... hepatitis C and West Nile viruses, as well as the flu and the common cold. In a study to appear in a March issue of the Journal of Virology and currently available online, UT Southwestern researchers describe how an essential gene, called RIG-I, turns on a cascade of host immune defenses when the hepat...

NIAID Initiates Trial of Experimental Avian Flu Vaccine

...e in our efforts to prepare to respond to an avian flu pandemic,?adds Dr. Fauci. Sanofi pasteur, Swiftwa...umans have little or no immunity. H5N1 is one such flu virus strain. The last influenza pandemic swept the globe in 1968; many public health officials beli...

Influenza vaccine uses insect cells to speed development

...crobiology Biodefense Research Meeting. "The bird flu may become the next flu pandemic strain. It could happen at any time," says Keyang Wang, a scientist at Protein Sciences Cor...

New book explains antibiotic resistance for a broad audience

...ysicians are refusing to prescribe antibiotics for flu and that patients are being blamed for demanding antibiotics when they shouldn't," says Abigail Salyers of the University of Illinois at Urbana-Champaign who co-authored the book with Dixie Whitt of the same university. "It was this ambivalence and c...

Late peak may have prevented severe flu season from becoming worse

The 2004-2005 flu season was at least as severe as the 2003-2004 sea...This later peak may have prevented the most recent flu season from being even worse. A flu season's severity is reflected in hospital admissions for commu...

When it comes to cell entry, being average has its advantages

...cro-like fastening. Yet scientists have shown that flu viruses can invade cells even without a clathrin coat. Along with Huajian Gao and Wendong Shi from Max Planck, Freund created a mathematical model that can account for this. Particle size plays a key role. According to the team's new model, cells tak...

Enlisting genomics to understand flu evolution

Multiple strains of the flu virus, circulating in a population at the same tim...ut which viral strains will attack during upcoming flu seasons and design more effective flu vaccines. In the first large-scale effort to sequence the flu...

Understanding biases in epidemic models important when making public health predictions

... infectious for an average period of time. For the flu the average infectious period is around 4-5 days, with incredibly few people infectious for less than a couple of days or more than a week. "Models which do not incorporate the latent period or assume unrealistic distributions of the latent and infe...

Inhaling large amounts of salt can cause hypertension

... infectious for an average period of time. For the flu the average infectious period is around 4-5 days, with incredibly few people infectious for less than a couple of days or more than a week. "Models which do not incorporate the latent period or assume unrealistic distributions of the latent and infe...

Field of beams - Novel system uses polarized light pulses to reveal crop health

... infectious for an average period of time. For the flu the average infectious period is around 4-5 days, with incredibly few people infectious for less than a couple of days or more than a week. "Models which do not incorporate the latent period or assume unrealistic distributions of the latent and infe...

New protein vital for immune response is found in surprise location

...ruses include hepatitis C, West Nile, SARS and the flu viruses. Cells altered to produce an overabundance of MAVS were protected from dying from viral infection. "These results raise the possibility that variations in the expression levels of MAVS may endow different individuals with varying ability to...

Virologist finds contagious equine flu in dogs

...virologist has isolated a highly contagious equine flu virus that is spreading a sometimes-fatal respiratory flu among dogs, and is responsible for a major dog-flu outbreak in New York state. There is no evidence ...

Bird samples from Mongolia confirmed as H5N1 avian flu

...pe for successfully preventing the spread of avian flu and protecting both people and animals." ...

WCS says avian flu prevention should focus on farms, markets

...) warn that efforts to control the spread of avian flu across Asia and beyond must focus on better manage...rtners to confirm and track the movements of Avian flu in the region," said Dr. Billy Karesh, head of the WCS team currently in Mongolia. "The best hope fo...

Controlling wildlife trade key to preventing health crises, study says

...hy, foot-and-mouth disease, avian influenza, swine flu and others have cost global economies some $80 billion, the authors of the study say. The results from the poorly regulated trade in wildlife could be even more deadly and more costly. "The cheapest way to contain these threats would be to minimize ...

Less virulent strains of avian influenza can infect humans

...rrier is an important step in the development of a flu virus with pandemic potential. Previous studies ha... for preventing or controlling the spread of avian flu to humans. The authors say their findings highlight the importance of improving disease surveillanc...

Transplanting Animal Organs Could Soon Be A Reality

...rrier is an important step in the development of a flu virus with pandemic potential. Previous studies ha... for preventing or controlling the spread of avian flu to humans. The authors say their findings highlight the importance of improving disease surveillanc...

First Whole Genome Map of Genetic Variability in Parkinson’s Disease

...rrier is an important step in the development of a flu virus with pandemic potential. Previous studies ha... for preventing or controlling the spread of avian flu to humans. The authors say their findings highlight the importance of improving disease surveillanc...

Eating, body weight regulated by specific neurons

...rrier is an important step in the development of a flu virus with pandemic potential. Previous studies ha... for preventing or controlling the spread of avian flu to humans. The authors say their findings highlight the importance of improving disease surveillanc...

European Commission funds EBI to do new research on synergies between bioinformatics and medical informatics

...rrier is an important step in the development of a flu virus with pandemic potential. Previous studies ha... for preventing or controlling the spread of avian flu to humans. The authors say their findings highlight the importance of improving disease surveillanc...

UW scientists report a new method to speed bird flu vaccine production

...isarmed viruses that are the seed stock for making flu vaccine in large quantities, life-saving inoculations may be available more readily than before. The work is especially important as governments worldwide prepare for a predicted pandemic of avian influenza. Writing this week (Oct. 31, 2005) in the ...

Drug resistant avian influenza viruses more common in Southeast Asia than North America

...is of a key protein in different subtypes of avian flu viruses shows that resistance to the antiviral dru... that permits hydrogen ions (protons) to enter the flu virion. This influx of protons allows the virus to shed its coat after it enters a cell-an essential...

Volunteers sought for avian flu vaccine study

...nfectious Diseases. The first phase of the avian flu vaccine trial, conducted at various other medical ...nd Cambodia. Public health experts fear that avian flu could lead to a worldwide pandemic if the virus becomes easily transmittable,leading to a public hea...

On a wing and a prayer - Alaska researchers seek clues to bird flu

...ng ground for the evolution of new strains of bird flu - strains that could spread to lower latitudes and...t infect humans. However, recent outbreaks of bird flu in Southeast Asia were caused by a highly pathogenic H5N1 strain and there is increasing evidence th...

Preventing a pandemic: Study suggests strategies for containing a flu outbreak

...could be produced," she said. The danger of avian flu is that the virus could develop into a new strain ...ght jump over to a human already infected with the flu and then mix, or "reassort," with the human flu virus. Because humans would have little or no immune...

UQ scientists break new ground in fight against infection & chronic disease

...ed patients to die from acute infections like bird flu and to acquire chronic inflammatory diseases such as arthritis and inflammatory bowel disease. They are also behind the muscle wasting experienced by patients with cancer. Chronic inflammatory disorders are a substantial burden in social and econom...

Researcher says flu responders can learn from 1918 epidemic

...e of the most sweeping, deadly outbreaks of killer flu that the world has ever seen. While that prospect...high University, who has been researching the 1918 flu pandemic that killed an estimated 50 million worldwide. Higgins, who came to Lehigh after earning h...

Agricultural workers at increased risk for infection with animal flu viruses

...s have a markedly increased risk of infection with flu viruses that infect pigs, according to a study fun...ine viruses, bird (avian) viruses as well as human flu viruses--thereby acting as a virtual virus "mixing bowl," especially on farms where pigs, chickens a...

New vaccine platform may fight infections with causes from influenza to bioterrorism

...lation that cannot be protected against polio, the flu and other infectious agents with existing vaccines that depend on a normal T-cell response. As such, the researchers were motivated to develop CD4+ T-cell–independent therapeutic strategies to meet this growing need. "While we'll need to replicate ...

Science's Breakthrough of the Year: Watching evolution in action

...cine. This year's sequencing of the 1918 pandemic flu virus could have a more immediate impact on medicine. The amazing story of flu genes preserved in permafrost and painstakingly reconstructed has a chilling coda: the deadly flu se...

New possibilities for flu antiviral and vaccine research emerge from 'Spanish flu' virus

...dings reported in Science help explain why Spanish flu was so lethal. The 1918 Spanish flu was a global disaster, killing an estimated 20 to 50 million people, many of them otherwise healthy ...

First big influenza genome study reveals flu evolution

Which flu did you get? TIGR scientists survey five New York flu seasons On the eve of the 2005-06 flu season, scientists at The Institute for Genomic Research (TIG...

The bioweapon is in the post

...r means to recreate the virus that caused the 1918 flu (New Scientist, 8 October, p 16). In theory, a terrorist group could try to emulate the latter feat, or create a virus such as Variola major, which causes smallpox. However, the Variola genome comprises some 190,000 base pairs of DNA, and while some...

Johns Hopkins flu expert calls for mandatory vaccination of health care workers

Johns Hopkins' senior hospital epidemiologist and flu expert is calling for mandatory vaccination of all... Previous research from Hopkins showed that annual flu shots have been almost 88 percent effective at reducing the risk of flu infection and that they redu...

New U. of Colorado at Boulder flu chip may help combat future epidemics, pandemics

...e the genetic make-up of types and subtypes of the flu virus in about 11 hours, said CU-Boulder Professor...ry department. Current methods for characterizing flu subtypes infecting patients take about four days. The Flu Chip is expected to be in wide use in lab...

Wild birds help to create human flu vaccine

...pe for successfully preventing the spread of avian flu and protecting both people and animals. To conta...s been at the forefront of research into the avian flu pandemic, and this development underscores the importance of their work," said Congresswoman Nita Lo...

Expert dispels bird flu paranoia

The risk of human bird flu infection is small in Australia and people can sti...ist Dr Bob Doneley. "The chances of getting bird flu off a pet bird or your neighbours birds are so infinitesimally small," UQ School of Veterinary Scien...

Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned

...ache that might be experienced with a tetanus or a flu shot, said Dr. Robert Munford, a professor of internal medicine and a collaborator on the study. Based on the protection they observed in the mice injected with ricin mixed with human-produced antibodies, the researchers projected that a RiVax-vacc...

Web model of influenza-host lifecycles will aid scientists in creating anti-viral drugs

..., for example, winter is marked by the outbreak of flu caused by new viruses that the human immune system doesn't recognize. The new Reactome influenza database outlines a typical virus life cycle, which will be updated as more research becomes available. "In the future, the goal is to build out all of...

Duke to test bird flu vaccine dosing

...ll test a modified form of an investigational bird flu vaccine to determine whether the vaccine still tri...curs," he said. The study will use an inactivated flu virus vaccine based on a strain taken from a Vietnamese patient in 2004. "There is no live flu virus...

H5N1 avian flu virus vaccine induces immune responses in healthy adults

...ficials worldwide. The potential for a human avian flu pandemic looms large, say experts, as daily report... 24, 2006, 186 people had been infected with avian flu viruses, and more than half of them had died. Generally, flu viruses are easily transmitted from p...

Sweetgum tree could help lessen shortage of bird flu drug

...ical needed to make a lifesaving drug against bird flu ?a drug that is currently in short supply worldwid... as Tamiflu® ?which is used to fight many types of flu viruses. Some health experts believe that this and similar antiviral drugs could help save lives by ...

UW scientists unravel critical genetic puzzle for flu virus replication

...uch is known about the genes and inner workings of flu viruses, how the microbe organizes its genetic con... of biology. Now, with the help of a long-studied flu virus, an electron microscope and a novel idea of how the virus aligns segments of RNA as it prepare...

Horse antibodies against the bird flu virus H5N1 are effective as treatment in mice

Antibodies against the bird flu virus H5N1, derived from horses, prevent mice infected with H5N1 from dying from the virus. A study published today in the open access journal Respiratory Research ( http://respiratory-research.com ) reveals that a dose of 100 µg of horse anti-seru...

Researchers reverse juvenile diabetes in animal model

... The symptoms of type 1 diabetes can resemble the flu in children. Type 1 diabetes tends to run in families. Brothers and sisters of children with type 1 diabetes have about a 10 percent chance of developing the disease by age 50. The identical twin of a person with type 1 diabetes has a 25 percent to...

Cell barrier shows why bird flu not so easily spread among humans

...or receptor that is the key that permits the avian flu virus to enter a cell. Flu viruses, like many oth...rinary Medicine, is that existing strains of bird flu must undergo key genetic changes to become the type of flu pathogen most feared by biomedical scient...

Medical experts: US unlikely to have enough vaccines to stop avian flu

...p of medical experts who attended a national avian flu conference last fall believe there is little chanc...ugh vaccine or antiviral medication to stop a bird flu pandemic should the virus mutate into a form that can be spread easily from human to human, accordin...

Potential vaccine developed for deadly leishmaniasis disease

... ?the empty envelope of the influenza virus. These flu virus shells contain none of the infectious genetic material in full-fledges flu viruses. The virosome also acts as an "adjuvant," boosting the immune response of the candidate vacc...

New influenza vaccine takes weeks to mass produce

...oday at the 2006 ASM Biodefense Research The next flu pandemic could happen any time," says Keyang Wang, a scientist at Protein Sciences Corporation (PSC) and a researcher on the study. "The most effective method to control such an outbreak is the widespread use of a vaccine, preferably in a pro-active...

Flu not the only germ threat this time of year

The flu hasn't even hit hard yet this year, but it seems l...ere are a lot more infectious invaders besides the flu to worry about. They don't get the big headlines, but they still knock people down for days or weeks...

Researchers reveal lung's unique innate immune system

...that could infect the lower airways, such as a new flu strain or bioterrorist agents," said Raz. The researchers' data outlines a complex circuit in which the alveolar macrophages circumvent the inhibition by TGFb for brief period of time, in order perform their immune task. This is accomplished thro...

How can we protect patients with weakened immune systems from influenza?

The flu is bad enough for healthy people, but the disease ... added concerns over potential threats -- an avian flu pandemic or the use of flu as a weapon of biological warfare -- put anti-flu measures into the categ...

Avian flu modeled on supercomputer, explores vaccine and isolation options for thwarting a pandemic

...ould be particularly effective in slowing pandemic flu spread in the U.S.," added Longini. The results show that advance preparation of a modestly effective vaccine in large quantities appears to be preferable to waiting for the development of a well-matched vaccine that may not become available until a...

Tamoxifen for breast cancer prevention does not benefit most women

...e 1.67-percent risk level. In comparison, annual flu shots cost about $980 per year of life saved for patients ages 65 and older; colonoscopy every 10 years costs about $11,000 per year of life saved for people 50 and older; and annual mammography costs about $58,000 per year of life saved for women ag...

Scientists aim to thwart use of flu as bioweapon

...birds infected with the deadly H5N1 strain of bird flu are gradually broadening the scope of that disease...tists are discussing ways to better understand the flu and also how to prevent the possibility that terrorists could somehow modify flu as a bioweapon to m...

High-dose flu vaccines appear to safely boost immunity in elderly

... virus have been available for 50 years to prevent flu and its complications, according to background inf...ecrease with age, however, and currently available flu vaccines are not always effective in the elderly. Recommended vaccines contain 15 micrograms (ìg) o...

Bird flu study highlights need to vaccinate flocks effectively

...s could make the spread of deadly strains of avian flu such as H5N1 worse, scientists at the Universities...commercial poultry against highly pathogenic avian flu like H5N1 is proving controversial because it is thought that it can lead to unseen transmission bet...

H5N1 vaccine could be basis for life-saving stockpile

... the team mixed genes from a safe, laboratory bird flu virus with a gene for the hemagglutinin (HA) protein from the H5N1 virus isolated in Hong Kong. The virus uses the HA proteins on its surface to infect cells in the respiratory tract. The resulting vaccine had the outside appearance of a dangerous vi...

Scientists to employ Arctic ice and polar bears to protect diversity of world's crops

... the team mixed genes from a safe, laboratory bird flu virus with a gene for the hemagglutinin (HA) protein from the H5N1 virus isolated in Hong Kong. The virus uses the HA proteins on its surface to infect cells in the respiratory tract. The resulting vaccine had the outside appearance of a dangerous vi...
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(Date:10/6/2008)...UPTON, NY - During October and November 2008, some...ons - including scientists from the U.S. Departmen... - will take part in an international field experi...ponents of the climate system of the southeastern ...y understood and poorly represented in global clim...
(Date:10/6/2008)...BETHESDA, Md. (Oct. 6, 2008) − The American ...e Ike Relief Fund to provide unrestricted grants o...ents and postdoctoral fellows who suffered losses ...it the Texas coast on Sept. 13 and also affected o...eted to students and fellows who are either APS me...
(Date:10/6/2008)... TEMPE, Ariz. From majestic African elephants to...Earth are in a state of crisis. One in four mammal...ccording to the Global Mammal Assessment, the most... , Writing in the October 10 issue of Science, ...ls: Diversity, Threat, and Knowledge") and unveili...
(Date:10/5/2008)...Chemicals used in the environment to kill bacteria...er published in the October issue of the journal ...ed biocides, can make the potentially lethal bacte...from the cell even more efficiently, potentially m...tics. , Biocides are used in disinfectants and a...
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