finger

Fox Chase Cancer Center scientists identify immune-system mutation

...tifies this defect as a point mutation in the zinc finger transcription factor Th-POK. We show that when the normal form of this factor is active in all developing lymphocytes, it can redirect would-be killer cells to the CD4 helper T cell lineage. This indicates that Th-POK is a master regulator of the mat...

Researchers reveal the infectious impact of salmon farms on wild salmon

...tal rivers while still much smaller than your baby finger ?3 cm long ?and weighing only half a gram. "The youngest fish can be only days old when they encounter a farm," says Krkosek. "Some of these fish are so young their egg sacks haven't been fully absorbed ?even fish this small are infected." The ancho...

Grasping metaphors: UC San Diego research ties brain area to figures of speech

...aphors such as "grasping an idea" or "putting your finger on the main argument." ...

Penn Researchers Use Robotic Surgery

...amlessly translating their natural hand, wrist and finger movements at the console into corresponding micro-movements of laparoscopic surgical instruments inside the patient's body. Additionally, the robot is computer controlled to eliminate any tremors and allow for steady, precise movements. "When operat...

Two new retroviruses—transmitted from animals—identified

...amlessly translating their natural hand, wrist and finger movements at the console into corresponding micro-movements of laparoscopic surgical instruments inside the patient's body. Additionally, the robot is computer controlled to eliminate any tremors and allow for steady, precise movements. "When operat...

To translate touch, the brain can quickly rearrange its sense of the body

...lly quite still. If subjects held their left index finger with their right hand while this happened, they felt their left index finger getting longer as they felt their arm move. The team then tested how these bodily illusions rearran...

New lead reported in tumor angiogenesis

...r blood vessels. This physical interaction, like a finger pushing a button, sends a signal within these cells to grow and sprout new capillaries. The finding, while technical in nature, has potentially major implications for anti-angiogenic therapy, one of the hottest areas in cancer research. Dr. Cun-Yu W...

Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy

...lf into small holes in cell membranes just like "a finger in a dike". The U-M study will be published July 17 in Nature as an advance online publication. The study is important because it is the first to show what happens to heart muscle cells called myocytes in the absence of dystrophin, and the first st...

Scientists use gene transfer technology and common virus to block neuropathic pain in animals

Remember how it felt the last time you burned your finger on a hot stove? Imagine what it's like to have that burning pain in your hands or feet all the time and know there's virtually nothing you can do about it. David Fink, M.D.It's called neuropathic pain, and it's a common complication of many diseases...

Surgical Robot 'Scrubs In' At UNC, May Be More Precise Than Conventional Surgery

...ion of tremor. Surgeons can scale, or ratio, their finger movement to that of the robotic instrument. A movement of inches at the console can be scaled down to centimeters in the patient. "This can re-introduce precision in an elderly surgeon, who has all those years of experience but has lost some dexteri...

Screen all at risk for HIV, plus pregnant women

...ion of tremor. Surgeons can scale, or ratio, their finger movement to that of the robotic instrument. A movement of inches at the console can be scaled down to centimeters in the patient. "This can re-introduce precision in an elderly surgeon, who has all those years of experience but has lost some dexteri...

FDA: 'Highly Unlikely' Green Tea Lowers Cancer Risk

...ion of tremor. Surgeons can scale, or ratio, their finger movement to that of the robotic instrument. A movement of inches at the console can be scaled down to centimeters in the patient. "This can re-introduce precision in an elderly surgeon, who has all those years of experience but has lost some dexteri...

Scientists use gene transfer technology and common virus to block neuropathic pain

Remember how it felt the last time you burned your finger on a hot stove? Imagine what it's like to have that burning pain in your hands or feet all the time and know there's virtually nothing you can do about it. It's called neuropathic pain, and it's a common complication of many diseases and medical con...

Biotechnology's newest chemical tool

...lls a tendon inside a synovial sheath, CYBERHAND's finger cables run through a Teflon sheath pulled by a DC ...ial and distal phalanges, those bones between your finger knuckles, are all driven by the same tendon. This approach is called underactuation as there are mor...

New study examines how sense of smell affects mating and aggression in mice

...diately draw your hand away. Or, if you place your finger in an infant's palm, the baby will grasp it instinctively." The current research findings might also be relevant for controlling pest populations, which utilize olfactory cues in a manner similar to mice, according to Shah. ...

Penn Surgeons Use Completely Robotic Surgery to Successfully Treat Prostate Cancer

...amlessly translating their natural hand, wrist and finger movements at the console into corresponding micro-movements of laparoscopic surgical instruments inside the patient’s body. Penn has been using fully robotic surgery for cardiac patients for the past three years and is currently stud...

Scientists learn to predict protein-stabilizing ability of small molecules

...amlessly translating their natural hand, wrist and finger movements at the console into corresponding micro-movements of laparoscopic surgical instruments inside the patient’s body. Penn has been using fully robotic surgery for cardiac patients for the past three years and is currently stud...

Sangamo BioSciences demonstrates its ZFP treatment protects cells from HIV infection

...ction by treatment with Sangamo's proprietary zinc finger DNA-binding protein nucleases (ZFNTM) designed to specifically disrupt the CCR5 gene. In its anti-HIV preclinical research program, Sangamo has designed ZFNs that can be used to disrupt the CCR5 gene, a receptor required for HIV entry into immune ce...

Telling axons where to go - and grow

...nd axon formation. The authors focus on the RING finger protein Rnf6 due to its similarity to the previously identified protein RLIM, which has been shown to bind to nuclear LIM domains and critically regulate the biological activity of LIM-HD transcription factors. The authors find high levels of Rnf6 p...

Infection 'alarm' yields clues to immune system behavior

...e part of the cells." He explained that a pricked finger usually generates a very localized fight against infection, involving only nearby cells. If TNF's signal was strong enough to set off an immune response involving the entire body, the result could be a high fever and septic shock. "We've developed a ...

Common bacteria pirate natural mechanism to get inside cells

...f a plasma membrane as a balloon and you poke your finger in it," he says. "The protein, dynamin, comes along and forms a necklace around the neck of that balloon, then chops it off," he says of the process that is ongoing with millions of receptors on the cell surface. "Adding nitric oxide to dynamin chan...

Cholesterol gets 'thumbs up' for role in digit development

...imb bud, which eventually develops into the pinkie finger or toe. At the site of its synthesis, Sonic hedgehog concentrations are high. It then diffuses out across the developing limb bud, and the declining concentrations (or gradient) of the protein dictate the identity of the other digits. "Questions ha...

Novel molecular 'signature' marks DNA of embryonic stem cells

...ity. "For genes, this is equivalent to resting one finger on the trigger," said Stuart Schreiber, an author of the Cell paper, the director of the Chemical Biology program at the Broad Institute, and professor at Harvard University. "This approach could be a key strategy for keeping crucial genes quiet, but...

Flu not the only germ threat this time of year

... quite awhile, for at least a day. If you put your finger in your mouth, or touch your eye, or pick your nose, you're a spreader, to put it bluntly. People share cell phones, they shake hands to be social. These are effective ways to transmit disease." While RSV may sound new, the best way to prevent it ?w...

New protein target may advance design of HIV and cancer drugs

...ry & Biology, researchers reported that a zinc finger protein, known as HIV NCp7, can be inhibited when ...If researchers can inhibit the action of this zinc finger protein, they can stop the spread of the virus. "When we target specific viruses with drugs, over ...

Tiny shock absorbers help bacteria stick around inside the body

... combination makes a "catch bond" that acts like a finger trap, and actually gets stronger as drag force is ...ss maintains an optimal force required to keep the finger trap-like FimH anchor from breaking loose. "This system is similar to a set of shock absorbers on y...

'Sticky' mice lead to discovery of new cause of neurodegenerative disease

...isease, researchers are usually quick to point the finger at a wayward gene. Now scientists are learning that some neurodegenerative diseases can develop even though a gene is perfectly normal. The diseases can be caused when the genetic instructions contained in the gene are not executed properly, leading ...

Mirrors in the mind: New studies elucidate how the brain reflects onto itself the actions of others

...his allowed the researchers to investigate whether finger movements made by the experimenter's hand were able to facilitate the subject's own finger movements--this facilitation was measured by the ability of benign stimulation of a particular brain...

Research project tackles 'regeneration' gap

... be 80. But we can’t do things like grow an arm or finger as we did in the early stages of our development. We want to learn how to turn those systems back on in people." Recently, studies have shown humans possess some of the same genes and communication pathways used by some of nature’s most remarkably...

Fungal factories may save hemlock forests

...te growth?" Costa says in his UVM lab, tracing his finger above the soft flat needles. "That's mycelium and likely as not there are spores at the end of each of those." To the untrained eye, the fungus he and Grassano are growing looks much like the pest they hope it will fight. Hiding on the underside of h...

Immunization rates hit record high in poor countries

...te growth?" Costa says in his UVM lab, tracing his finger above the soft flat needles. "That's mycelium and likely as not there are spores at the end of each of those." To the untrained eye, the fungus he and Grassano are growing looks much like the pest they hope it will fight. Hiding on the underside of h...

Insomnia drug can improve brain function

...(PET) scans. They administered motor tests such as finger tapping and walking, and language tests such as spontaneous speech, word repetition, and object naming. They also conducted brain imaging studies to assess brain metabolism and cognitive activation using PET scans. All of these were conducted with bo...

Rapid oral HIV test shows great promise according to MUHC-led research

...al fluid (saliva) and the other from a blood-based finger stick - with traditional blood tests. They demonst...nt of the individuals reported discomfort with the finger testing. Although the oral OraQuick test has been approved by the US Food and Drug Administratio...

When your brain talks, your muscles don't always listen

...sal interosseous muscle. Located between the index finger and the thumb, this muscle contains 120 "motor uni... tiny wires was embedded in the muscle of an index finger of each subject. The electrode was hooked up to a computer to record the electrical impulses as they...

Old memory traces in brain may trigger chronic pain

... By contrast, the acute sensory pain of the burned finger appears in the sensory part of the thalamus. Apkarian also found that the longer a person has been suffering from chronic pain, the more activity in the prefrontal cortex. He was able to predict the years of their suffering from the MRI. “It’...