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fibrosis in Biological News

Test helps in fight against lung infections and for treating other life-threatening infections

... serious lung infections in patients with Cystic fibrosis (CF), a population recognized as having among the ... and Dr. Neil Brown, Director, Adult Cystic fibrosis Clinic conducted the clinical research from 2007 ... research involved 14 patients with cystic fibrosis at the University of Alberta hospital CF clinic. ...

American Chemical Society's weekly PressPac -- May 27, 2009

... promise as a potential new treatment for liver fibrosis the disease that leads to cirrhosis scientists ... States. Ram Mahato and colleagues note that fibrosis involves build-up of scar tissue in the liver ... alcohol abuse, toxins, or other factors. Advanced fibrosis can lead to cirrhosis, a condition in which the ...

Cystic fibrosis testing -- next steps

... VA Three reports describing advances in cystic fibrosis genetic testing appear in the May 2009 issue of The Journal of Molecular Diagnostics . Cystic fibrosis is a hereditary disease that affects mucus ... States is affected with cystic fibrosis. Cystic fibrosis is an autosomal recessive disease caused by ...

Two-pronged model could help foil tough cystic fibrosis infections

... that thrive in the lungs of people with cystic fibrosis (CF), unlocking new possibilities against a ... and lung physiology labs studying cystic fibrosis infections. Cystic fibrosis patients are plagued by infections of the ...

Plasminogen activator inhibitor type-1 -- a potential link between heart failure and diabetes

... Histochemical analysis demonstrated 33% more LV fibrosis as well. The increased fibrosis associated with increased PAI-1 was accompanied ... after coronary occlusion accompanied by increased fibrosis and functional derangements indicative of both ...

Nanoemulsion potent against superbugs that kill cystic fibrosis patients

... infections that cause nearly all cystic fibrosis deaths. Cystic fibrosis is an inherited chronic lung disease that affects ... Context Increasingly, cystic fibrosis patients are receiving antibiotic treatments they ...

FSU researcher's discovery leads to $1.5 million grant, potential new treatment of liver fibrosis

... in the life-threatening mechanism of liver fibrosis has helped a researcher at the Florida State ... cause of death in the United States. Liver fibrosis refers to the accumulation of excess scar tissue ... is a normal bodily response to injury, but in fibrosis the scarring begins to accumulate to unacceptable ...

New approach to treating cystic fibrosis lung infection shows promise

... severe lung infections in people with cystic fibrosis (CF). These findings are published in ... research project, funded by the Canadian Cystic fibrosis Foundation, has led to a real alternative to ... Chief Executive Officer of the Canadian Cystic fibrosis Foundation. "In this case, laboratory research ...

Rattlesnake-type poisons used by superbug bacteria to beat our defenses

... cause of death and serious disability in cystic fibrosis patients which is the most common lethal ... about 8,000 people," says Dr Welch. In cystic fibrosis the gene defect means that people are very ... can usually control the infection in cystic fibrosis sufferers but eventually the strain becomes ...

Senescence in liver cells is found by CSHL scientists to help limit acute tissue damage

... in mice. The role of senescence in liver fibrosis Lowe's team studied the relation of ... liver cancer, the role of senescence in limiting fibrosis was two-pronged. "Cell-cycle arrest in the cells that generate the fibrosis places a kind of brake on the process, limiting ...

PTC124 shows activity in cystic fibrosis; Phase 2 proof-of-concept data published in Lancet

... demonstrates activity in nonsense-mutation cystic fibrosis (CF). The data show that treatment with PTC124 ... with CF lack adequate levels of the cystic fibrosis transmembrane conductance regulator (CFTR) ... approximately 10 percent of the cases of cystic fibrosis worldwide. However, in Israel, nonsense ...

UF scientists discover compound that could lead to new blood pressure drugs

... We discovered a compound that reverses the fibrosis that makes the blood vessels more rigid. The ... tested it in hypertensive rats that had developed fibrosis of the heart and kidney. The animals received the ... animals revealed a significant decrease in fibrosis of the heart, kidney and blood vessels, said ...

Computer simulations point to key molecular basis of cystic fibrosis

... the way to new corrective treatments. Cystic fibrosis (CF) is a fatal disease caused by a defective gene that produces a misshapen form of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. People with cystic fibrosis do not have enough CFTR for their cells to work ...

Translational research patented first experimental treatment against idiopathic pulmonary fibrosis

... available in Spanish . Idiopathic pulmonary fibrosis is a disease with unknown cause with a very ... years after being diagnosed. Idiopathic pulmonary fibrosis affects 13 out of 100,000 men and 7 out of ... alveolar tissue. When idiopathic pulmonary fibrosis appears, this regeneration process cannot be ...

Study uncovers clues to cystic fibrosis gene dysfunction and gastrointestinal disease

... offers new insight into the role that the cystic fibrosis gene plays in the development of gastrointestinal disease. The cystic fibrosis transmembrane conductance regulator (CFTR) gene ... of this protein are associated with cystic fibrosis (CF) and a range of digestive diseases, such as ...

CU-Boulder technology used to identify unexpected bacteria in cystic fibrosis patients

... classify pathogens found in the lungs of cystic fibrosis sufferers, said CU-Boulder Professor Norman Pace, ... 60 species of bacteria in samples of 28 cystic fibrosis patients in Denver. Thirteen samples contained ... that can clog organs, according to the Cystic fibrosis Foundation. In addition to causing difficulty ...

Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration

... Galapagos NV (Euronext & LSE: GLPG) and Cystic fibrosis Foundation Therapeutics, Inc. (CFFT), the non-profit affiliate of the Cystic fibrosis Foundation, announced today a new collaboration ... fibrosis. The protein is called CFTR - cystic fibrosis transmembrane conductance regulator. To advance ...

Placenta-derived stem cells may help sufferers of lung diseases

... play a role in the treatment of lung diseases, such as pulmonary fibrosis and fibrotic diseases caused by tuberculosis, chemical exposure, radiation ... as a therapeutic tool for disorders characterized by inflammation and fibrosis is supported in previous studies," says Dr. Ornella Parolini, the study's ...

Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients

... might help doctors predict when patients with idiopathic pulmonary fibrosis (IPF) are becoming dangerously ill and also could point the way to ... work opens an important window into the mystery of why patients with lung fibrosis suddenly decompensate and how to identify these patients for more ...

Researchers identify a molecule that increases the risk of cardiac insufficiency

... people have a life expectancy of less than five years. The accumulation of fibrosis in the heart has been proven to have a significant influence on the ... do not actually inhibit the enzyme lysyl oxidase, nor do they reduce fibrosis or improve heart functions. Other drugs however, which are less commonly ...

Research elucidates way lungs fight bacteria and prevent infection

... interfering with breathing and damaging the airways. Cystic fibrosis is one disease where this work might have particular import, Dr. Chun says. People with cystic fibrosis possess an abnormal gene that causes normal mucus to become thick and ...

Reducing the damage of a heart attack

... journal has selected the study as an issue highlight. "Treatments for fibrosis in the heart are relatively limited, making it important to develop new ... that may one day inhibit the functioning of the protein in order to limit fibrosis within the heart," says Dr. Sato. "Doing so may aid in controlling the ...

New test promises quicker, more accurate evaluation for cystic fibrosis patients

... gene-based blood test that more accurately and quickly measures cystic fibrosis patients' response to therapy than current tests. The test, a measure of ... picture of the biological processes occurring inside the lungs." Cystic fibrosis is the most common lethal inherited disease in the western world, with ...

Closing the gap: Journal launch brings together wound-healing knowledge

... information provided by this paper is highly relevant to tissue repair and fibrosis in other organs and systems." Fibroproliferative diseases affecting ... to launch an online journal covering the extremely relevant area of tissue fibrosis and repair. The opportunity to address key issues in this area of biology ...

American Chemical Society's Weekly PressPac -- Aug. 27, 2008

... #5 EMBARGOED FOR 9 A.M., EASTERN TIME, Sept. 1, 2008 Helping cystic fibrosis patients breathe easier Chemical & Engineering News Researchers are ... drugs that could dramatically improve the health of patients with cystic fibrosis (CF), which remains difficult to treat with today's drugs, according to an ...

RNA emerges from DNA's shadow

... from mutations that cause genes to be incompletely read, including cystic fibrosis and muscular dystrophy. A drug based on the molecule is now entering ... available. Results so far indicate dramatic improvements in both cystic fibrosis and muscular dystrophy sufferers, although it is only suitable for those ...

Cystic fibrosis proteins photographed interacting

... physical evidence of interaction between two proteins involved in Cystic fibrosis (CF) disease. Researchers at the University of Alabama at Birmingham ... High Resolution Imaging Facility and the Gregory Fleming James Cystic fibrosis Research Center at UAB. Other collaborators are from Ohio State ...

Cystic fibrosis patients may breathe easier, thanks to bioengineered antimicrobials

... at the University of Illinois may have found a way to help cystic fibrosis patients fight off deadly infections. While not a cure, this work has ... antimicrobial activity. Although much work remains, future cystic fibrosis patients might use an inhaler to deliver genetically modified ...

MIT unraveling secrets of red tide

... generate red tides, but could also help speed up efforts to develop cystic fibrosis drugs from a compound closely related to the toxin. Red tides, also known ... red tide toxins, has shown potential as a powerful treatment for cystic fibrosis (CF). It can also protect against the effects of the toxins. "Now that ...

New test can detect both genetic and chromosomal abnormalities in embryos

... the first time they have been able to demonstrate that the test can work in cells taken from embryos that have already been diagnosed with the cystic fibrosis gene mutation using conventional preimplantation genetic diagnosis (PGD). Gary Harton, PGD scientific director of the Genetics & IVF Institute in ...

CSHL scientists harness logic of 'Sudoku' math puzzle to vastly enhance genome-sequencing capability

... DNA from thousands of members of orthodox Jewish communities. The organization's aim is to prevent genetic diseases such as Tay-Sachs or cystic fibrosis that occur frequently within specific ethnic populations. The team's new method will now allow the many thousands of DNA samples gathered by Dor ...

Protein linked to change in tissue that surround and support breast tumors

... they found that the tissue in mice with the splice variant of AIB1 was thicker than that seen in mice with too much of the parent protein. This fibrosis may be related to the hard, scar-like tissue frequently seen around a breast tumor, Furth says. "What we don't know is whether generation of this ...

American Society for Microbiology honors Melissa B. Miller

... laboratory research in clinical microbiology or antimicrobial agents. Dr. Miller has contributed significantly to the fields of cystic fibrosis microbiology and detection and epidemiology of MRSA, and is known for her research on the development and application of molecular assays for use in ...

Liver disease 'shrunk' by blood-pressure drug

... losartan, a drug normally prescribed for hypertension, on 14 patients in Spain, who had Hepatitis C. The illness was at an advanced stage causing fibrosis - scarring in the liver - which would usually have progressed to liver failure. Half of the patients in the trial saw the scars in their liver ...

'Disordered' amino acids may really be there to provide wiggle room for signaling protein

... is representative of a large class of proteins with an array of biological roles, including signaling pathways implicated in diseases such as cystic fibrosis and breast cancer. "Here we have a molecule that serves an important role in how cells function and survive, but it contains these puzzling 'junk' ...

Tips from the American Journal of Pathology

... glomerular filtration rate in human patients. The biomarkers identified by Dr. Bttinger, Dr. Kretzler, and colleagues "predict progressive renal fibrosis in mice and may [therefore] be useful molecular predictors of [chronic kidney disease] progression in humans." Ju W, Eichinger F, Bitzer M, Oh J, ...

Sugar on bacteria surface serves as base for a web of resistance

... COLUMBUS, Ohio The bacteria responsible for chronic infections in cystic fibrosis patients use one of the sugars on the germs' surface to start building a structure that helps the microbes resist efforts to kill them, new research ...

Research yields potential target for cancer, wound healing and fibrosis

... and other factors involved in inflammation and wound healing. An overabundance of fibrillar fibronectin around the cell is characteristic of fibrosis and excessive scarring. Therefore, understanding how cells regulate the ability of integrins to control the abundance of fibrillar fibronectin is of ...

No hiding place for infecting bacteria

... to treat. P. aeruginosa biofilms cause disease in burns, wounds, contact lens infections and are particularly prevalent in the lungs of cystic fibrosis patients. "We specifically targeted the F-actin protein with a negatively charged peptide, and the DNA with the enzyme DNase, which both ...

Gene therapy demonstrates benefit in patients with rheumatoid arthritis

... by an investigator at Beth Israel Deaconess Medical Center (BIDMC). Originally conceived as a means of treating genetic diseases, such as cystic fibrosis and hemophilia, gene therapy involves implanting a normal gene to compensate for a defective gene in the patient. The first clinical trial to test ...
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