Multiple disease-related research gets green light from the NIH

... levels in diseased tissues. These high levels of fibrin are thought to clog blood vessels and cause ... to demonstrate that, despite the risks it poses, fibrin also performs critical protective functions ... immune responses. The researchers showed that fibrin deposition is essential for survival during ...

Blood clotting protein linked to rheumatoid arthritis

... by the engagement of inflammatory cells with fibrin matrices through a specific integrin receptor, ... localized interaction of inflammatory cells and fibrin may help arthritis patients. Our study establishes that fibrin is a powerful, although context-dependent, ...

GenWay Biotech obtains exclusive rights to AMDL's DR-70 cancer test in US and Canada

... screening. However, a growing body of data reveals that the test is effective as a general cancer screen as well. The DR-70 ELISA assay quantifies fibrin and Fibrinogen Degradation Products (FDP) in the blood, which are elevated in the presence of a malignant tumor and increase as the malignancy grows. ...

Exploring the molecular origin of blood clot flexibility

... blood protein fibrinogen, which is converted to fibrin during clotting. A blood clot needs to have the ... about the function of differently formed fibrin clots in the circulating blood or in a wound. For ... Recent research by other scientists showed that a fibrin fiber could stretch four to five times its ...

A new approach to growing heart muscle

... better properties. The approach uses a fibrin gel to support rat cardiac cells temporarily, before the fibrin breaks down as the cells organize into tissue. ... from these results we can say that utilizing a fibrin hydrogel yields a product that is ready within a ...

Stem cells from muscles can repair cartilage

... Group 1 was treated with MDSCs embedded in fibrin glue. Group 2 was treated with MDSCs that had ... Group 3, the control group, was treated with fibrin glue. The results showed well-integrated ... healing," the authors state. They note that using fibrin glue enabled the cells to settle even in narrow ...

Engineering the heart piece by piece

... or BEHM. That paper describes the use of an innovative technique, using a fibrin hydrogel, that is faster than others, but still yields tissue with ... The gel was able to support rat cardiac cells temporarily, before the fibrin broke down as the cells multiplied and organized into tissue within a few ...

Inhibiting blood to save the brain

... lesions and less severe MS symptoms. Blocking the interaction between Mac-1 and fibrinogen after the first episode of paralysis using the fibrin peptide prevented subsequent relapses. It also prevented further microglia activation and damage to myelin in the diseased mice, allowing them to ...

Polymer aids in blood clotting, pointing way to new treatment

... compound accelerates two parts of the coagulation cascade -- the contact-activation pathway and factor V, a protein that forms thrombin -- leading to fibrin and clots. Finally, he said, polyphosphate delays the breakdown of clots, which causes renewed bleeding. "The net effect is accelerating the rate ...