Estradiol in Biological News

Chronic exposure to estrogen impairs some cognitive functions

... functions. Rats exposed to a steady dose of estradiol were impaired on tasks involving working memory ... made the discovery when studying the effects of estradiol on activities mediated by the prefrontal cortex, ... twice in a row got no reward. Rats exposed to estradiol performed worse than their counterparts on this ...

High levels of estrogen associated with breast cancer recurrence

... blood for concentrations of the steroid hormones estradiol (the primary human estrogen) and testosterone. They analyzed different forms of estradiol and testosterone in the blood, such as how much ... enter a cell. Researchers found that higher estradiol concentrations, in all forms, significantly ...

Sex hormones link to heart risk

... healthy men. "Our studies showed that one of the sex hormones - estradiol - was associated positively with total cholesterol and negatively with ... "Thus, men with the highest concentrations of estrone and estradiol may have the highest level of cardiovascular risk as their levels of ...

Plastics chemical retards growth, function of adult reproductive cells

... follicle growth was impaired after 48 hours of exposure to BPA, Peretz said. Reductions in three key steroid hormones progesterone, testosterone and estradiol were also seen after 120 hours of exposure to BPA. The drop in steroid hormone production was quite dramatic. After 120 hours in a medium that ...

Stress puts double whammy on reproductive system, fertility

... of the release of the gonadotropins luteinizing hormone and follicle-stimulating hormone by the pituitary, and then a suppression of testosterone, estradiol and sexual behavior. In 2000, however, a new reproductive hormone was discovered in birds and dubbed gonadotropin-inhibitory hormone (GnIH) ...

HWI scientist first in world to unravel structure of key breast cancer target enzyme

... as part of this project were estrone sulfatase (2003) and 17beta-hydroxysteroid dehydrogenase type 1 (1996). All three enzymes control the levels of estradiol in different tissues. "This is a dream come true," Dr. Debashis Ghosh, an HWI senior research scientist and a principal investigator who also ...

Clue to genetic cause of fatal birth defect

... UIC researchers had previously discovered this novel enzyme and were focused on its role in converting the weak hormone estrogen into the more potent estradiol in the ovaries and its possible role in breast cancer. Recent research has shown that the HSD17b7 enzyme has an additional role in the last steps ...

Quest for better treatment for effects of menopause

... by a group of women from Bizkaia to two treatments: on the one hand, to raloxifene and, on the other, to a substitutive hormonal treatment combining estradiol (a type of oestrogen) and progesterone (another female sex hormone). The conclusions of Doctor Ruiz del Aguas thesis point to raloxifene, while ...

Study shows lizard moms dress their children for success

... lizards give an extra dose of the hormone estradiol to their eggs in certain social circumstances. ... hormones. That revealed a striking influence of estradiol on back patterns. She also tested eggs from ... and found a wide range of naturally occurring estradiol concentrations in the egg yolks. The ...

High estrogen levels associated with dementia in older men

... "In contrast, higher levels of bioavailable estradiol were associated with an increased risk for ... disease." For each standard deviation increase in estradiol level, the risk for the disease went up by 25 ... in age. The researchers hypothesize that the estradiol association could be explained by increased ...

Researchers uncover mechanisms of estrogen in promoting cell death in breast cancer

... To try to understand how the estrogen estradiol induces apoptosis in cells, V. Craig Jordan, ... The researchers treated MCF-7:5C cells with estradiol and fulvestrant, and they also injected the ... on apoptosis in tumors. They found that estradiol induces apoptosis by activating the so-called ...

Female sex hormones play a vital role in defense against sexually transmitted diseases

... study, female mice received either the hormone estradiol or progesterone, a combination of both, or ... prior to exposing them to the herpes virus. Both estradiol and progesterone are natural hormones found in ... treated with a combination of the two hormones, estradiol and progesterone, were protected, but only if the ...

Ultra low-dose estrogen shown safe for post-menopausal women

... in bone density, without adverse health effects, in the women who took estradiol compared to the women who took placebo. The current study was a ... the women studied by Yaffe and her associates received a daily dose of estradiol ?pure human estrogen ?that was over 44 times smaller and delivered through ...

New brain hormone puts brakes on reproduction

... ovulation, the production of fertile eggs. estradiol and testosterone, in turn, feed back on the ... keeps the body's sex hormones on an even keel. estradiol also works higher in the brain, on the ... mystery. The new study provides an answer: estradiol stimulates cells in the dorsomedial nucleus of ...