Erythematosus in Biological News

Steps toward Stopping Autoimmune Disease

... genetic study has identified multiple genes linked to systemic lupus erythematosus (SLE), or lupus, a debilitating autoimmune disease that affects an ... Lupus Research (ALR) formed and supported the International Systemic Lupus erythematosus Genetics (SLEGEN) Consortium, charging scientists with searching for ...

Genes linked with lupus are revealed, giving hope for new treatments

... Genetics. In an international genetic study of more than 3,000 women, researchers found evidence of an association between Lupus (systemic lupus erythematosus or SLE) and mutations in several different genes. The findings, by scientists from Imperial College London and institutions in the USA and ...

DNA variations signal lupus risk

... in the journal Nature Genetics . The study, the largest of its kind to date, is the work of the International Consortium for Systemic Lupus erythematosus (SLEGEN), of which UAB is a member. SLE is the medical term for systemic lupus erythematosus, a common form of the disease. Looking at the genomes ...

UT Southwestern secures $5 million NIH grant for lupus research

... grant from the National Institutes of Health to fund the Center of Research Translation, which will investigate the autoimmune disease systemic lupus erythematosus (SLE). There are a limited number of these centers around the country, so this is a major accomplishment for UT Southwestern, said Dr. David Karp, ...

Lupus gene finding prompts call for more DNA samples

... called for more patients to volunteer DNA samples to enable them to further study the underlying causes of the disease. Lupus or Systemic Lupus erythematosus (SLE) is an autoimmune disease which frequently causes skin rash, joint pains and malaise, but can also lead to inflammation of the kidneys and ...

HGS announces positive Phase 2 LymphoStat-B at ACR meeting

... flares over time, and was well tolerated through 2.5 years on treatment in combination with standard of care in patients with active systemic lupus erythematosus (SLE). The results will be the subject of an oral presentation today in Boston at the Annual Scientific Meeting of the American College of ...

Study identifies genetic risk factor for rheumatoid arthritis, lupus

... variation has been identified that increases the risk of two chronic, autoimmune inflammatory diseases: rheumatoid arthritis (RA) and systemic lupus erythematosus (lupus). These research findings result from a long-time collaboration between the Intramural Research Program (IRP) of the National Institute of ...

Yale scientists identify structure for RNA quality control

... of RNA quality control. In the autoimmune disorders systemic lupus erythematosus and Sjogren's syndrome, Ro is known to be an autoantigen, and autoimmune ... of RNA quality control. In the autoimmune disorders systemic lupus erythematosus and Sjogren's syndrome, Ro is known to be an autoantigen, and autoimmune ...

A revolution in the monitoring of unborn babies

... will be especially helpful in monitoring fetuses whose mothers have medical conditions like diabetes, autoimmune conditions such as systemic lupus erythematosus and Sjogren’s syndrome and obstetric cholestasis. It will also be useful in monitoring fetuses identified as growing poorly or where it is suspected ...

Big hips, big belly? It's in your genes, Joslin-led study shows

... system, as it does in MS. "The mounting evidence that relates Epstein-Barr virus infection to other autoimmune diseases, particularly systemic lupus erythematosus (lupus), suggests that Epstein-Barr virus may have a broad role in predisposing to autoimmunity," or failure of the immune system to recognize the ...

Epstein-Barr virus may be associated with multiple sclerosis

... system, as it does in MS. "The mounting evidence that relates Epstein-Barr virus infection to other autoimmune diseases, particularly systemic lupus erythematosus (lupus), suggests that Epstein-Barr virus may have a broad role in predisposing to autoimmunity," or failure of the immune system to recognize the ...

How can we protect patients with weakened immune systems from influenza?

... A third group of adult patients suffers from autoimmune diseases, those in which an abnormal immune system turns on itself: systemic lupus erythematosus and Sjogren's syndrome. Core research facilities will assist all the projects in systematically measuring T cell and B cell counts and developing ...

Researchers map of genetic variations implicated in disease

... described. The COX haplotype has been associated with susceptibility to a wide range of diseases, including type 1 diabetes, systemic lupus erythematosus and myasthenia gravis. The PGF haplotype provides protection against type 1 diabetes and predisposes to other diseases such as multiple sclerosis and ...

Genes In The Interferon System Important In Systemic Lupus Erythematosus

... Two genes with very strong associations with the disease systemic lupus erythematosus (SLE) have been identified by a team of scientists headed by researchers at the Department of Medical Sciences at Uppsala University. The findings ...