Software Tool for Converting Scientific Text into a Database of Functional Relationships
...nd extract new types of relationships by adding or editing linguistic patterns. MedScan users can create information extraction pipelines with different output, set up regular automatic processing of upcoming content for selected sources, and integrate MedScan with other bioinformatics tools for further anal...New study expands understanding of the role of RNA editing in gene control
...ger RNA sequence is altered after transcription by editing enzymes, so that a single gene can produce a numbe...n blood cells, we identified a specific site where editing leads to suppression of the mature miRNA." Nishikura's team demonstrated that two RNA editing enzym...'Sticky' mice lead to discovery of new cause of neurodegenerative disease
...t amino acid, alanine, onto its carrier tRNA. This editing enables the enzyme to reject incorrect amino acids...ossible," she said. "The sticky mouse has a mild editing defect that still allows it to produce offspring. "So, a major question to be explored in human p...Peering into the shadow world of RNA
...ura’s own research has for many years explored RNA editing mechanisms. In particular, she has studied an enzy... specific set of genes,?Nishikura notes. “But when editing occurs, they may target a completely different set of genes.? In recent years, Nishikura says, a g......at these microRNAs can undergo a kind of molecular editing with significant physiological consequences. A sin...heir unedited counterparts. Further, errors in the editing can lead to serious health problems. The team’s findings appear in the February 23 issue of Science....... system extremely well and were able to delete the editing cells during development, for instance, then you would only have lymphocytes that don't express self-receptors at all," he says. For now, the step forward to understand where these self-directed cells are coming from is a big one. "Our objective i...