ectopic

Hirsute Or Hairless? Two Proteins May Spell The Difference

... with elevated TGF-β2 signaling activity displayed ectopic expression of Snail. Knockout mice lacking TGF-β2 also showed higher levels of E-cadherin—normally down-regulated by Snail—than their nonmutant littermates. Altogether, these findings suggest that TGF-β2 signaling transiently induces Snail, which in...

Harmful chemicals may reprogram gene response to estrogen

...act abnormalities, pregnancy complications such as ectopic pregnancies and preterm deliveries, infertility, and a rare vaginal and cervical cancer called clear-cell adenocarcinoma. Other research conducted by NIEHS scientists indicates that women exposed to DES in utero have a higher risk of uterine fibroids...

The synapse is a shotgun

...of broader neurotransmitter distribution is called ectopic release. "We can only be sure of data on this one..."But we are confident that this evidence points to ectopic release, and this means that you can't really trust the traditional textbook view -- in which all th...

Fruit fly research set to revolutionize study of birth defects

...cancer-fighting drug also used to treat psoriasis, ectopic pregnancies, rheumatoid arthritis, and lupus, lasts a long time in the body and causes birth defects in children from women who have it in their systems. The study of the drug's effect on fruit flies has allowed Queen's researchers including graduate...

Malignant melanoma cells secrete protein required for embryo formation

...ived signals, and were consequently able to induce ectopic (abnormal) embryonic skull and backbone (axes) formation. "This finding highlights the convergence of tumorigenic and embryonic signaling pathways. From a translational perspective, Nodal signaling provides a novel target for treatment of aggressiv...

Research identifies protein that signals flowering in squash plants

... the normally non-inducing LD conditions following ectopic expression of FT by the ZYMV vector. Analysis of such induced plants showed that the infection zone of ZYMV was not coincident with the plant’s floral meristems, indicating that FT mRNA is unlikely to be the florigenic signal in this system. Next, he...