drug in Biological News

New cancer drug delivery system is effective and reversible

... CHAMPAIGN, Ill. For cancer drug developers, finding an agent that kills tumor cells is only part of the equation. The drug must also spare healthy cells, and ideally its ... report that they have assembled a new cancer drug delivery system that, in cell culture, achieves ...

Drug-proof zebrafish reveal secrets of addiction

... the development of addiction is the switch from drug use to drug abuse, we aimed to gain insight into the ... administration (despite the presence of the drug in the fish's brain) but that appeared to be ...

UCSF researchers identify new drug target for Kaposi's sarcoma

... UCSF researchers have identified a new potential drug target for the herpes virus that causes Kaposi's ... been deemed too difficult to attain. The new drug target, which is known as a protease dimer, could ... the researchers explained. Traditionally, drug development has focused on inhibiting that ...

A crystal ball for brain cancer?

... and predict which ones will be shrunk by the drug Avastin -- before the patient ever starts ... linking high water movement in tumors to positive drug response, the UCLA team predicted with 70 percent ... doctor prescribed the off-label use of Avastin, a drug shown to quell cancers in the breast, colon and ...

Jet-propelled imaging for an ultrafast light source

... molecules containing many thousands of atoms. drug molecules are much smaller, and do their work by ... of a protein's atoms is therefore a great help to drug designers, who like to understand how a drug molecule will dock with a protein to promote or ...

New drug may reduce heart attack damage

... A novel drug that targets a master disease-causing gene can ... trials in preclinical models have found. The drug also reduces incidental cell and tissue death ... Thrombosis and Vascular Biology . "While this drug doesn't prevent the heart attack, it does reduce ...

SRI announces selection by the National Cancer Institute as a Chemical Biology Consortium center

... Biology Consortium" (CBC), a collaborative drug discovery partnership focused on advancing new ... targets. Based on its track record of cancer drug discovery and development, SRI was chosen to lead ... has been successful in generating an extensive drug pipeline translating discoveries into beneficial ...

Study explains potential failure of oral contraceptives with obese women

... consider obesity and other factors that affect drug absorption, distribution, metabolism and other ... Rather, the researchers found that contraceptive drug levels in both obese women and those of normal ... took more than 20 days to reach a "steady state" drug concentration. Women of normal weight who follow ...

UA pharmacy research shows prescribers miss potentially dangerous drug pairs

... correctly identified fewer than half of drug pairs with potentially dangerous drug-drug ... Recipients were asked to classify 14 drug pairs as "contraindicated," "may be used together ... also state that they were "not sure." For the drug pairs, one commonly prescribed medication was ...

DuoCort: New chronotherapy for adrenal insufficiency

... journal for endocrinology. DuoCorts new drug has been developed to produce a physiological ... variability in the pharmacokinetics and the drug release profiles look very like the physiological ... Current therapy is long outmoded, with no major drug improvements since at least the 1960s. ...

CWRU receives $5 million from Ohio Third Frontier Commission

... from Marc Penn (CC), will develop its lead drug product, stromal cell derived factor 1 (SDF-1), ... to develop a combination product comprised of a drug and Oakwood's proprietary sustained release ... tuned to release a specific amount of drug over a prolonged period of time to tell the ...

New nanoparticles could revolutionize therapeutic drug discovery

... proteins being available as potential targets for drug development - opening up exciting possibilities in drug discovery. Understanding the structure of ... first step in developing new drugs, but to date, drug development has been slowed because due to their ...

International collaboration by scientists culminates in novel ion channels database

... of the roles played by Ion channels in drug action is now available for scientists and ... of genes is known to encompass a third of current drug targets and a significant proportion of likely ... for information about mammalian drug targets for students and scientists throughout ...

U of M study finds new insight on therapy for a devastating parasitic disease

... new insight into how a commonly prescribed drug may work to treat those infected by a parasitic ... and intestines and ultimately lead to death. A drug called praziquantel has been used as the main ... scientists have never understood how this drug works to kill the parasitic worms that cause this ...

'Shock and kill' research gives new hope for HIV-1 eradication

... researchers then repeated the experiment adding a drug inducing oxidative stress, buthionine sulfoximine ... the non-infected cells were left intact by the drug combination. "I really hope this study may ... to a normal life. Of note, there are testable drug combinations composed of molecules that have ...

International Serious Adverse Events Consortium announces initial study results in its global research collaboration to identify genetic markers related to drug induced liver injury

... that may predict individuals at risk for serious drug induced liver injury (DILI). The SAEC is a ... and the Wellcome Trust. The U.S. Food and drug Administration (FDA) also contributes to the ... community, to both improve the productivity of drug development and to begin the critical process of ...

American Chemical Society's Weekly PressPac -- May 20, 2009

... . Must-reads from C&EN: drug firms take a hit in first quarter The world-wide economic crisis took a toll on drug companies in the first quarter of 2009. In an ... percent and earnings rose by only 1.3 percent. No drug companies lost money, but double digit earnings ...

The challenges of avian influenza virus: Mechanism, epidemiology and control

... of the structure and potential target for the new drug design. For a long time the drug target for influenza viruses was basically ... and polymerase will lead to some new drug leads. Clinically the human cases of H5N1 ...

NIH announces new program to develop therapeutics for rare and neglected diseases

... of Health is launching the first integrated, drug development pipeline to produce new treatments ... this spring, is unusual because TRND creates a drug development pipeline within the NIH and is ... are eager to begin." Developing Drugs The drug development process is complicated and expensive. ...

MCG researcher among first to receive NIH stimulus funding

... investigator. The National Institute on drug Abuse funding also will support Stacey Crawford, ... cocaine is the most frequently reported illicit drug associated with drug-related deaths, and ... renal disease. If that's the case, alternative drug doses or treatments could be used. The study ...

New tool for next-generation cancer treatments using nanodiamonds

... a nanomanufacturing tool to build the implantable drug delivery devices that will apply these treatments. The potential of nanomaterials to revolutionize drug delivery is emergent in early trials, which show ... constrained to studying the effects of a drug on an entire cell population because it is ...

Clinical trials for shingles drug take an important step forward

... A possible new anti-viral drug designated FV-100, which could alleviate the ... in America. Previous research has shown the drug to be up to 10,000 times more potent than existing treatments in early lab tests. The drug was discovered by a team in the Welsh School of ...

Prefilled WFI Syringe Provides a High-Quality Solution for Drug Reconstitution

... of components and systems for injectable drug delivery, and Vetter, a worldwide leading ... prefilled syringe for reconstituting lyophilized drug products. “The Vetter/West WFI syringe combines the best of pharmaceutical components in a drug administration system that we believe customers ...

University awarded £1.7M to develop nanotechnology for use in health care

... techniques to develop new approaches for future drug development. Many medicines currently in use ... in large doses to ensure that enough of the drug is absorbed into the body to be effective. ... their activity and the ability to target the drug to areas where the virus is usually inaccessible. ...

WARF signs license agreement with Pfizer for human embryonic stem cells

... (hES) cell patents for the development of new drug therapies. The WARF license provides Pfizer the rights to work with hES cells for drug research and discovery. Securing appropriate ... is three fold: to use human cells as tools in our drug discovery efforts, to improve the safety of new ...

Drug prevents seizure progression in model of epilepsy

... Carnegie Mellon's Mellon College of Science. "The drug works by inhibiting ion channels whose role in ... completely blocking subsequent seizures. "The drug is orally available, and works in the low ... noting that these characteristics, which mean the drug is effective in low concentrations and can be ...

Brain protein central to both Parkinson's, drug addiction identified

... in mice would be toxic in people, and there is no drug available for people now that blocks or boosts oct3, Tieu and Przedborski said. But such a drug might be useful for Parkinson's, drug addiction, and depression. "How you choose to ...

DNA barcoding of mosquito species deployed in bid to end elephantiasis

... the disease for eradication by 2020 through mass drug administration (MDA). Officials are identifying ... people at risk with annual doses of a combination drug therapy (albendazole / DEC or albendazole / ... by Merck and Co. and GSK respectively). The drug reduces the density of worm larvae in humans. ...

KINAXOs Cellular Target Profiling reveals mTOR as a new target of Celebrex

... in many types of cancer.  As traditional drug development approaches become more and more expensive, drug repositioning has been widely recognized as an ... lead compound selection, target deconvolution, drug reprofiling, and off-target toxicity assessment. ...

American Chemical Society's Weekly PressPac -- April 22, 2009

... and as "molecular switches" for more controlled drug delivery. Conventional photochromic materials, ... of traditional academic research A new academic drug discovery program and others like it are shaking ... industry scientists who have extensive drug discovery experience. To learn more about a ...

Biolex presents Locteron US Phase 2a hepatitis C data at EASL

... approved for sale by the United States Food and drug Administration or by any international regulatory ... hepatitis C patients, and all major hepatitis C drug candidates currently in clinical trials are being ... with PolyActive, an advanced controlled-release drug delivery technology developed by OctoPlus N.V. of ...

Newly discovered epidermal growth factor receptor active in human pancreatic cancers

... a growth factor receptor found and used as a drug target in a subset of breast cancers. After he ... has been through the long and complex Food and drug Administration approval process and is in use for ... of these specific lung cancers. But would the drug work in pancreatic cancers? Dr. Pandey's group ...

Male impotence drugs may deserve a second look in women

... researchers decided to look again, first giving a drug to constrict the internal pudendal arteries in ... state then giving doses of each impotency drug to see the impact. The arteries from male rats ... concentration-dependent relaxation the more drug they got, the more they relaxed - while in ...

Early isolation linked to enhanced response to cocaine

... to physical and health issues. Initial drug use can be motivated by curiosity or peer ... drugs such as cocaine. Stress is known to enhance drug seeking behavior, as well as the psychostimulant ... by an increase response to the same amount of a drug over time. For 5 days, half of the rats from all ...

Early isolation linked to enhanced response to cocaine

... to physical and health issues. Initial drug use can be motivated by curiosity or peer ... drugs such as cocaine. Stress is known to enhance drug seeking behavior, as well as the psychostimulant ... by an increase response to the same amount of a drug over time. For 5 days, half of the rats from all ...

Jefferson researcher awarded Landenberger Foundation grant for ALS research

... Research Foundation grant to identify why drug therapies that showed promise in Amyotrophic ... team will closely examine critical aspects of drug delivery in the central nervous system at the metabolic level with the hope of advancing drug development for ALS. The grant totals $300,000 ...

Tentacles of venom: New study reveals all octopuses are venomous

... venomous ancestor and highlights new avenues for drug discovery. Conducted by scientists from the ... mode of action of venom proteins we can benefit drug design for a range of conditions such as pain ... many creatures have been examined as a basis for drug development, cephalopods (octopuses, cuttlefish ...

New drug shows promise in treating drug-resistant prostate cancer

... Sloan-Kettering Cancer Center, have created a new drug to treat a particularly lethal form of the ... chose to test MDV3100 in clinical trials. The drug has successfully completed Phase 1 and Phase 2 clinical trials, and the Food and drug Administration has agreed to allow Medivation to ...

New medications show promise in treating drug-resistant prostate cancer

... in Sawyers' lab based their designs on a drug that tightly attaches to the site on the androgen ... to the company and would receive royalties on the drug should it prove to be successful. The company ... of 140 patients receiving higher doses of the drug will be reported within the next year, said ...

First tri-continuous mesoporous Silica complex structure developed in Singapore

... difference. Their pores may also be used to trap drug molecules for controlled drug release. Therefore, the ability to tailor the ... would be very attractive for gas separation and drug delivery systems" added Dr. Ying, Executive ...