dogma

Scientists rid stem cell culture of key animal cells

...differentiated state is critical. The feeder cell dogma now can be overturned, says lead investigator Ren-He Xu, a senior scientist at WiCell, a private, nonprofit research institute. "This work completely gets rid of the need for feeder cells," says Xu. "It also significantly reduces the daily labor of p...

The very unexpected life and death of a leukemic cell

...death rates of the CLL cells. This challenges the dogma that CLL is a purely accumulative disorder where leukemic cells accumulate because they cannot die. Clearly CLL is a disease in which there is a dynamic interplay between rates of cell division and cell death. The data could enable physicians to pred...

Human Eggs Can Develop From Ovarian Surface Cells In Vitro

...m cell research, and cast doubt on the established dogma on the fetal origin of eggs in adult human ovaries. It is now well established that fetal mammalian eggs originate from somatic stem cells. More recent research of adult human ovaries has shown that oocytes and granulosa cells (the layer of small ce...

Stem cells in bone marrow replenish mouse ovaries

...g provides direct evidence to overturn a long-held dogma in reproductive biology, that female mice generate egg cells only during fetal development and thus are born with a finite stock of eggs that declines throughout life. The new report significantly extends earlier work from the same research team repo...

Mechanism for the captation of nutrients in plants- unknown to date

...aptation This discovery breaks with a fundamental dogma in basic plant science holding that all substances penetrate the interior of the cell through the participation of specific transporters present in the plasma membranes - a model implying that, if hundreds of substances enter vegetable cells and each...

Sugar helps control cell division

...llers of cell division, say the researchers. "The dogma for decades has been that the cycle of cell division is controlled by the appearance and disappearance of certain proteins called cyclins, but experiments have shown that you can knock out any of these and still get perfectly normal cell division," s...

Role of microRNA identified in thyroid cancer

... the process of malignant growth," says He. Old dogma held that a gene carries a recipe for a molecule of messenger RNA which, in turn, carries a blueprint for the creation of a particular protein. Any mutation in the gene could affect the production of the protein. But recent studies have shown that pr...

Bacteria that cause tooth decay able to survive without important biochemical pathway

...mouth. "We were met with skepticism ?because the dogma was that this biochemical pathway is key for all living cells," said study investigator Jeannine Brady, Ph.D., an associate professor of oral biology at the UF College of Dentistry. "As far as we know, this is the first example of any bacteria that c...

Living taste cells produced outside the body

...urn into functional taste cells. Although previous dogma had held that induction was somehow dependent on interactions with the nervous system, the current findings suggest otherwise. Ozdener explains, "By producing new taste cells in an in vitro system, our results demonstrate that direct stimulation from...

'Accelerated evolution' converts RNA enzyme to DNA enzyme in vitro

...l known organisms operate according to the central dogma of molecular biology-that the transfer of sequential genetic information proceeds from nucleic acid to nucleic acid, and from nucleic acid to protein. But a far different situation exists with regard to the transfer of catalytic function, which does ...

Molecule by molecule, new assay shows real-time gene activity

...biological processes in living cells." The central dogma of molecular biology holds that DNA is transcribed into mRNA, which is then translated into proteins. But several technical hurdles have hampered study of these key processes. Researchers' current understanding of this two-step pathway is built upon ...

MiRNA fingerprint identified in platelet formation

...mportant force in biology. For decades, scientific dogma has held that messenger RNA (mRNA) was responsible for carrying out DNA instructions, or code, for protein production in the cell. Little was known, however, about how cells actually regulated that process. But over the past 10 years, researchers ha...

New insight into machinery of immune cells' 'tentacles'

...emained elusive," said Pendergast. "The prevailing dogma was that this function is mediated by a protein called WASp. However, mice lacking WASp can still form immunological synapses, so we proposed that there was another unidentified pathway that regulated the process." In their experiments, the research...

Researchers find molecular 'brake' to cell death

...ng says. These new findings "overturn a scientific dogma so long accepted that it has become a textbook standard when talking about apoptosis," he continues. Researchers agree that the seminal event that leads to initiation of apoptosis is the release of a key protein known as cytochrome c (CC) from a ce...

Bone marrow may restore cells lost in vision diseases

...o travel to the injury site to make repairs. "The dogma has been that we're born with a fixed amount of RPE, but there is growing evidence retinal progenitor cells exist in the adult," said Lawrence Rizzolo, Ph.D., a Yale University associate professor of anatomy and experimental surgery and of ophthalmol...

History-hunting geneticists can still follow familiar trail

...arly going against the dogma. This study shows the dogma is safe in mammals and probably in vertebrates, as well."...

Quality not quantity important for immune response to HIV

...sponse, the more effective it would be. It is this dogma that has influenced development of HIV vaccines, with the vaccines attempting to stimulate a large response. However, Professor Goulder and colleagues found that the type of CTC response is crucial and that some types of response may have a negati...

From hot springs to rice farms, scientists reveal new insights into the secret lives of archaea

...nts and other herbivorous animals. That was the dogma taught for decades in biology classes-until September 2005, when David Stahl of the University of Washington showed that bacteria do not have a monopoly on nitrification. In a unique laboratory experiment, Stahl and his colleagues demonstrated for th...

Gene-bender proteins may sway to DNA

... colleagues deviate slightly from the conventional dogma that it is the protein that bends the DNA. She said the results raise important questions about the role that the DNA "bendability" plays in guiding the correct bending protein to the appropriate site on the DNA. Ansari said the research adds to t...

Interaction between lymph and liver cells may affect immune response

...ectly interacting with hepatocytes contradicts the dogma that naïve T cells cannot gain access to peripheral non-lymphoid tissues," the authors state, adding that the study furthers the notion that liver cells may be involved in hepatic immune tolerance. "Like any good study," they conclude, "the work of W...

White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells

...ge of cancer cells of so many different types. The dogma of cancer fighters has always postulated that there are many different cancers. "This new research in mice suggests that there may be some things that most cancers have in common," said Willingham, a pathologist and head of the Section on Tumor Biolo...

Unicellular microRNA discovery

...a unicellular organism. “The finding changes the dogma that miRNAs only exist in multicellular organisms, and adds an important piece into the blooming small RNA world. A pressing question we have now is what these miRNAs are exactly doing in the green alga. I hope we will know the answers soon,?says Dr...

Link found between immune system and high plasma lipid levels

...rite: "Our data may help to explain the long time dogma that chronic inflammation is associated with hyperlipidemia, the mechanisms of which have not been well defined. Whether this is an intended and advantageous product of inflammation or untoward consequences of combating pathogens or autoimmunity re...

Penn researchers link cell's protein recycling systems

...branes inside the cell for bulk digestion. “The dogma has been that the autophagy-lysosomal and the proteasomal systems are trains that run on different tracks, with similar purposes, but no point of intersection,” explains senior author J. Paul Taylor, MD, PhD, Assistant Professor of Neurology. “The ne...