Calculating gene and protein connections in a Parkinson's disease model
... these biases and allows for combined analysis.
In this combined analysis, both data types are integrated with molecular interactions data into a diagram
that connects the experimentally identified proteins and genes. While this typically results in an extraordinarily complicated diagram, sometimes ...
Penn scientists discover cells reorganize shape to fit the situation
... PHILADELPHIA - Flip open any biology textbook and you're bound to see a complicated diagram
of the inner workings of a cell, with its internal scaffolding, the cytoskeleton, and how it maintains a cell's shape. Yet the fundamental question ...
Researchers discover critical detail of cellular defense against genetic mistakes
... Researchers are closing in on a completed diagram
of how human cells protect themselves against constant genetic mistakes that contribute to most diseases, according to a study to be published in the ...
A switch that controls whether cells pass point of no return
... key tumor suppressor gene, and E2F is a transcription factor that governs the expression of all the genes important for cells to grow.
The wiring diagram
is fundamentally the same. Its very likely that different organisms have evolved a very conserved design principle to regulate their growth, said ...
UF botanists: Flowering plants evolved very quickly into 5 groups
... you can do it in a single day now.
By laboriously arranging the sequences, the researchers slowly built a kind of family tree for plants a diagram
of relationships among plant lineages showing diversification over the eons. Based on known rates of genetic change double-checked against fossils of ...
UNC nanotech spin-off forms new venture with Siemens
... on a napkin. We have limited medical knowledge but we understand the basic physics of X-rays.
Zhou, Lu and other collaborators grew their napkin diagram
and the grant-funded research into Xintek, a small nanotechnology start-up company that licensed technology from UNC and Duke University. Two years ...
New study to explore cellular circuitry
... team seeking to create the first complete wiring diagram
of a living cell. By wiring diagram, researchers ... of the interplay between them. When complete, the diagram
has the potential to reveal cellular approaches ... and computer scientists in an attempt to diagram
Saccharomyces cerevisiae, a type of yeast. ...
NYU biologists map out early stages of embryo formation
... has mapped out a preliminary molecular diagram
of the early stages of embryo formation, offering ... biological systems--in this case, an engineering diagram
for embryo formation. Using a new way to combine ... researchers were able to develop a first-draft diagram
for the early embryo at the molecular level, ...
Researchers discover key to human embryonic stem-cell potential
... almost any part of the body. We've uncovered a key part of the wiring diagram
for these cells and can now see how this is accomplished."
Once an ... cell ceases to be a stem cell.
The new work provides the first wiring diagram
of human embryonic stem-cell regulatory circuitry. "This gives us a ...
Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits
... published in the Feb. 8 PNAS supports the concept of a basic wiring diagram
for all eukaryotes.
Researchers in California, Israel, and Germany have ... National Academy of Sciences supports both the concept of a basic wiring diagram
for all eukaryotic cells, and the idea that more selective pharmaceuticals ...
Study of protein folds offers insight into metabolic evolution
... called the Molecular Ancestry Network (MANET: http://www.manet.uiuc.edu/index.php ) which links these data sources into a new global network diagram
of metabolic pathways.
The researchers added color, representing evolutionary age, to their diagrams of metabolic networks (for an example, see ...
Executable biology -- Computer science sheds light on animal development
... By applying the techniques of computer engineering to a mechanistic diagram
describing the development of the Nematode C. elegans, a group of researchers in Switzerland has been able to tease out what laboratory experiments ...
Two nerve cells in direct contact
... both eyes, and it was this non-linearity that we wanted to investigate further," said Alexander Borst.
The next step was to analyse the circuit diagram
of the tangential cells of the lobula plate in detail. This was based on a multitude of experiments in which the connections between the cells within ...
Protein connections: A network to understand disease
... you have patients with diseases, and those diseases look alike, like the ataxias," said Vidal. "We are in the business of understanding the wiring diagram
of cells. In each cell, there are 20,000 to 25,000 proteins, and they interact with one another. We know that many diseases are basically related ...
Long-term changes in experience cause neurons to sprout new long-lasting connections
... conditions return to normal. The researchers also plan more detailed study of the circuitry itself, to understand the changes in the brain's wiring diagram
caused by spine growth. ...
New potential drug target in tuberculosis
... it a particularly interesting target where traditional drugs have lost their efficacy."
A structural picture of the protein - a kind of technical diagram
of its building plan - has yielded important clues about its activity. Qingjun Ma from Wilmanns' group purified LipB and obtained crystals of the ...
Scientists narrow the time limits for the human and chimpanzee split
... gauge of its rate of evolutionary change. By calibrating this rate with the known time of divergence of a species on another branch of the tree-like diagram
that shows relationships among species, scientists can estimate the time when the species they are studying evolved. In this case, the calibration ...
Researchers discover how malaria parasite disperses from red blood cells
... schizont" stage, the red blood cell resembles a lop-sided fried egg, with the parasites visible as a sphere near the center of the cell. (A diagram
of the entire sequence appears at http://www.nichd.nih.gov/new/releases/malaria_graphic.cfm .) The cell's lop-sided appearance probably results ...
Brain Scans Reveal How Gene May Boost Schizophrenia Risk
... the prefrontal cortex functions optimally when dopamine activity is neither too low nor too high, corresponding to the top of an upside-down "U" (see diagram
below). In this model, people with val fall on the left (rising) slope, with lower dopamine levels, while those with met fall on the right (falling) ...
Open microfluidic and nanofluidic systems
... use a polymeric liquid that freezes quickly and can then be scanned directly with the tip of an atomic force microsope. However, the same morphology diagram
should also apply to other liquids and other substrate materials. It should also remain valid if one further shrinks the surface channels and, in ...