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Iron isotopes as a tool in oceanography

... rapidly accelerate. The natural supply of iron to such 'High Nutrient Low Chlorophyll (HNLC) regions is therefore, albeit indirectly, an important determinant of climate. The importance of dissolved iron in seawater derived from bottom (benthic) sediments is increasingly recognised as being important. ...

Trading energy for safety, bees extend legs to stay stable in wind

... laminar flows. Our work shows clearly that the effect of environmental turbulence on flight stability is an important and previously unrecognized determinant of flight performance." Together with Robert Dudley of the University of California, Berkeley, and the Smithsonian Tropical Research Institute, ...

International Serious Adverse Events Consortium announces initial study results in its global research collaboration to identify genetic markers related to drug induced liver injury

... published on May 31, the SAEC and Newcastle University's analysis of a subset of DNA patients has led to the discovery that HLA-B*5701 is a major determinant of liver injury induced by flucloxacillin. Flucloxacillin is an antibiotic widely used in Europe and Australia, mainly in the treatment of ...

NASA uses satellite to unearth innovation in crop forecasting

... satellite data to deliver a kind of space-based humanitarian assistance. They are cultivating the most accurate estimates of soil moisture the main determinant of crop yield changes and improving global forecasts of how well food will grow at a time when the world is confronting shortages. During a ...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

... progresses. Their study traces the intracellular network controlled by the p53 gene, a linchpin of the cell's anti-tumor defense response, as the key determinant of AML's aggressiveness and response to therapy. Most patients with AML receive the same standardized treatment an initial phase of intense ...

Healthy food availability could depend on where you live -- so does the quality of your diet

... Benjamin Caballero, MD, PhD, professor at the Bloomberg School's Department of International Health. Our studies show that where you live is a major determinant of your health. The joint efforts of public health researchers in collaboration with community groups and policymakers will be required to ...

Understanding how oxidative stress impairs endothelial progenitor cell function

... & Redox Signaling that a review of the scientific literature reveals that how EPCs respond to oxidantive stress appears to be a critical determinant in maintaining a healthy cardiovascular system. A comprehensive understanding of how oxidantive stress, the biochemical modification of cells, ...

New CU-Boulder study shows diversity decreases chances of parasitic disease

... raised together, the toad tadpoles were once again buffered from the parasites by the "dilution effect" provided by tree frogs. "Thus, the important determinant of parasite transmission was not total host diversity but the specific composition of the host community," wrote the authors. The trematode has a ...

Athletes' 'sweat and tears' linked to asthma

... airways. As a result, individuals who sweat less also have drier airways. "It now appears that how much fluid your airways secrete could be a key determinant in protecting you from exercise-induced asthma," he said. "So, if athletes sweat, drool, or cry, at least they won't gasp." "Exercise-induced ...

Obesity genes revealed

... melanogaster, research published today in the open access journal BMC Genetics identifies natural variation in the human LAMA5 gene as a key determinant of weight. As the prevalence of obesity and related health problems continues to increase worldwide, there is considerable effort being devoted to ...

UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes

... to identify factors that impact human telomerase localization," said Michael Terns. "Our results indicate that human reverse transcriptase is a key determinant in human telomerase trafficking and is essential for the localization of telomerase RNA both to Cajal bodies and telomeres." While all this ...

Scientists decipher fruit tree genome for the first time

... organism for the study of the evolution of sexual chromosomes in plants. Dr Navajas Prez, who at present is working on the sequencing of the determinant region of the sex in the sexual chromosomes of papaya and whose research career has been focused on different aspects of plants sexual determination, ...

Yale scientists show that a microRNA can reduce lung cancer growth

... used as a model system for studying how organisms develop, grow and age. They went on to show that in humans, let-7 negatively regulates a well-known determinant of human lung cancers, the RAS oncogene . In collaboration with scientists at Asuragen, the Slack lab has studied the tumor suppressor ...

New chemical tool kit manipulates mitochondria, reveals insights into drug toxicity

... are published online February 24 in Nature Biotechnology. Over the last few decades, mitochondria have increasingly been understood as a key determinant of cellular health. On the other hand, mitochondrial dysfunction can lead to many neurodegenerative conditions as well as metabolic diseases such as ...

MIT finds key to avian flu in humans

... and the criteria for how H5N1 can jump to humans. They did so by showing that the shape of the sugars-and not the type of linkage-is the key determinant for human adaptation of these deadly viruses. This new interpretation explains inconsistencies that plagued the previous model, according to ...

Mom's obesity during conception phase may set the stage for offspring's obesity risk

... and genetic background influence offspring's susceptibility to obesity. It goes further, to highlight the role of post-natal obesegenic diet as a determinant in revealing subtle programming imposed by maternal obesity. The results also demonstrate that high levels of adiposity (body fat) occur in the ...

Blood clotting protein linked to rheumatoid arthritis

... of inflammatory cells and fibrin may help arthritis patients. Our study establishes that fibrin is a powerful, although context-dependent, determinant of inflammatory joint disease, said Jay Degen, Ph.D., a researcher in Developmental Biology at Cincinnati Childrens and the studys lead author. These ...

Could vitamin D, a key milk nutrient, affect how you age?

... Previous research has found that shortened LTL is linked to risk for heart disease and could be an indication of chronic inflammation a key determinant in the biology of aging. While there are several lifestyle factors that affect telomere length (obesity, smoking and lack of physical activity), the ...

Insulin's brain impact links drugs and diabetes

... suggest that ADHD risk may have an insulin-dependent component and that control of insulin levels and response to the hormone may be an important determinant of amphetamine efficacy in patients with ADHD, Galli noted. We have described a novel mechanism by which diabetes may affect brain function. ...

Data on life expectancy show many countries clustered in high mortality traps

... to improvements in health. But that paradigm has broadened in recent years to include the view that, "health is also a significant contributing determinant of economic and social development," writes Dean Barry R. Bloom. The new challenge for the international community, he continues, "goes beyond how ...

'Kissing cousins'

... cousins is more than twice the national average, a new study appearing in the October issue of Current Anthropology finds that the greatest single determinant of infant mortality is not closely related parents though this does present a significant risk but short birth intervals. The Bekka Bedouin are ...

Socioeconomic position associated with effectiveness of HIV drugs

... Boston, MA Socioeconomic position is a determinant of antiretroviral treatment effectiveness during initial therapy for HIV-1 infection. The effect was found even among subjects with high rates of ...

Sugary drinks, not fruit juice, may be linked to insulin

... beverages have other unhealthy behaviors that we did not account for, says McKeown. Sugar-sweetened drink consumption may prove to be an important determinant of insulin resistance, but more long-term studies of diverse populations that incorporate the use of more direct measures of insulin resistance are ...

Newly created cancer stem cells could aid breast cancer research

... to only initiate tumors initiated metastasis, which is the main cause of cancer mortality in the clinic. Tan has demonstrated that a critical determinant of eventual metastasis is the identity of the normal cell type that preexists in the breast and becomes the object of mutation and selection, ...

Research shows skeleton to be endocrine organ

... Theyve shown for the first time that the skeleton is an endocrine organ that helps control our sugar metabolism and weight and, as such, is a major determinant of the development of type 2 diabetes. The research, published in the August 10 issue of Cell, demonstrates that bone cells release a hormone ...

Researchers uncover protection mechanism of radiation-resistant bacterium

... protects itself from high doses of ionizing radiation (IR). The results of the recent study, titled "Protein Oxidation Implicated as the Primary determinant of Bacterial Radioresistance" were published in the March 20 edition of PLoS Biology. These discoveries likely will cause a shift in D. radiodurans ...

MRSA toxin acquitted: Study clears suspected key to severe bacterial illness

... association between PVL and CA-MRSA makes the toxin an excellent marker to track community strains, but the assumption that it is the major virulence determinant driving this epidemic is simply not true." These findings are significant because some infectious disease physicians who treat MRSA patients had ...

Malaria treatment efficacy compromised in certain HIV-positive patients

... patients with higher CD4 cell counts. Therefore, "HIV-1 associated immune suppression, rather than infection with HIV-1 per se, is the main determinant of malaria treatment outcome," says Dr. Van geertruyden. This finding exposes a danger that implementing new malaria combination therapies to ...

Other patients bear the real cost of Herceptin

... cut, medical professionals ultimately have to make these decisions. Political pressure, patient advocacy and media hyperbole should not be the determinant of who is treated and with what, they argue. In NICE we have an established system, but it is currently creating more problems than solutions. ...

A new view on Lyme disease: Rodents hold the key to annual risk

... found that even a 3-fold variation in deer numbers had no impact on subsequent nymph abundance. Density of infected nymphs--the principal determinant of Lyme disease risk--varied significantly from year to year, fueled mostly by large fluctuations in total nymph density, which in turn depended ...

Brittle prions are more infectious

... Weissman. "The other key feature was how easy it was to break up the prion and create new seeds, and this propensity to seed could be an important determinant of the prion's physiological impact. And that is what we found experimentally -- that the slower growth of that conformation was more than ...

Mutation in blood stem cells provides clues to cancer development

... The research also provides more insight into why some patients develop leukemia or other malignancies, while others don't, by identifying determinant cancer genes and the signaling pathways leading to the disease. "It will tell us more about cancer and how cancer progresses," Jamieson added. ...

Advanced genomics and proteomics improve the diagnosis and treatment of a deadly lung disease

... large multiprotein complexes and guide those molecules to destinations in the cell where they turn off genes. "The size of these small RNAs is a determinant of their function," Hannon explained. "If the RNAs are too big or too small, they don't make it into the effector complexes." Through its role in ...

Molecule does more than slice and dice RNA

... large multiprotein complexes and guide those molecules to destinations in the cell where they turn off genes. "The size of these small RNAs is a determinant of their function," Hannon explained. "If the RNAs are too big or too small, they don't make it into the effector complexes." Through its role in ...

U-M scientists identify major psoriasis susceptibility gene

... psoriasis ?a disfiguring inflammatory skin disease. Named PSORS1 (SORE-ESS-1), for psoriasis susceptibility 1, the gene is the first genetic determinant of psoriasis to be definitively identified in a large clinical study. Its discovery could lead to new, more effective treatments for psoriasis ...

Researchers Discover Gene That Determines Asthma Susceptibility By Regulating Inflammation

... proper response to allergens in lungs and maintenance of a balance between ROS production. Antioxidant capability regulated by Nrf2 may be a major determinant of susceptibility to allergen-mediated asthma,?says Biswal. “Nrf2 regulated pathways seem to intervene inflammation at several points.?/p> The ...

Attacks of King George III's madness linked to key metabolism molecule

... the expression of ALAS-1 in the fasted and fed liver," the authors write. "Moreover, we showed that hepatic [in the liver] PCG-1 alpha is a major determinant of the severity of acute porphyric attacks in mouse models of chemical porphyria." Through a series of experiments with normal mice and those ...

'EuroVacc 02' HIV Vaccine Trial Begins

... of the vaccines, in particular their ability to generate HIV-specific cell-mediated immune response to HIV, which is considered to be a key determinant of protection against infection. According to the principal clinical investigators Prof. Giuseppe Pantaleo of CHUV in Lausanne and Prof. Jonathan ...

New Estimates For The Causes Of Child Deaths Worldwide

... "Counting the world's children is not all that is involved in making the world's children count. It is important to look at the single most important determinant of childhood death -- which has to be poverty. Childhood mortality is strongly inversely correlated with per-capita health expenditure. In today's ...
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(Date:9/18/2014)... circuit located deep in the primitive brainstem has revealed ... at Harvard School of Medicine and the University at ... only the second "sleep node" identified in the mammalian ... sufficient to produce deep sleep. , Published online in ... that fully half of all of the brain,s sleep-promoting ...
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